Recent advances from the Trakhtenberg lab have uncovered promising targetable regulators of neuronal self-repair, which fail to self-activate sufficiently in the injured mammalian CNS and thus require therapeutic activation. To find out more, see the below links to a Cover Page research article in Experimental Neurology, a research report in Brain Research, and research reports in Cell Press’s journals, Molecular Therapy Advances and Molecular Therapy Nucleic Acids.

 

“Experimental upregulation of Lancl1 promotes axon regeneration after optic nerve injury in vivo” (PMID 42002019)

 

“Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice” (PMID 42386070)

 

“Neurodevelopmental miR-135a-1-3p and miR-135b-3p promote long-distance axon regeneration after injury in the central visual pathway” (PMID 42656966)

 

“Vacuolar ATPase subunit Atp6v0c transgene promotes neuroprotection and long-distance axon regeneration in injured retinal ganglion neurons” (PMID 42023031)

 

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