Wednesday, April 25th, 2018
12:00 PM - 01:30 PM
Research in Progress (RIP)
"The role of TIMP-1 in the development of hypersensitivity using a model of cutaneous inflammation"
Tuesday, May 1st, 2018
04:00 PM - 05:00 PM
UConn HealthLow Learning Center
Sponsored by the Kim Family Fund
"Sensory-motor integration regulates olfactory learning"
Yu Zhang, PhD, Professor, Department of Organismic & Evolutionary Biology Center for Brain Science, Harvard University, Cambridge, MA
During sensory-guided locomotion, such as chemotactic movement in response to odors, the position and locomotory pattern of an animal are constantly changing. Therefore, sensory-motor integration is critical for the animal to steer the movement towards the goal. However, the underlying mechanisms remain largely unknown. Here, we show that the complex activity in a C. elegans interneuron, RIA, integrates the information of odor and locomotory pattern to mediate olfactory chemotaxis. Previously, we have shown that the activity in RIA neurite compartmentalizes in the axonal domains that are localized on the dorsal or ventral side of the animal and represents the dorsal or ventral head bending, respectively, during the sinusoidal body waves on the dorsal-ventral plane. The motor-encoding activity of RIA restricts head bending. We now show that these two activity patterns interact to integrate sensory and motor information, directing odor-guided chemotactic movements. Learning modulates the sensorimotor integration to generate experience-dependent changes in behavioral response. Together, our findings provide mechanistic insights into the neural circuits of learning at all levels from sensory perception to motor execution.
Host: Dr. Zhao-Wen Wang, firstname.lastname@example.org
Wednesday, May 2nd, 2018
12:00 PM - 01:30 PM
4th Year Research in Progress (RIP)
"Establishing a morphological phenotype in Angelman Syndrome and Chromosome 15q Duplication Syndrome stem cell-derived neurons"
Friday, May 4th, 2018
04:00 PM - 06:00 PM
Target Audience: Department of Neuroscience & their Program Members