Sponsored by the Kim Family Fund

“The Use of Induced Pluripotent Stem Cells to Model Age-related Macular Degeneration”.

Presenter:
Mark Anthony Fields, MPH, PhD
Assistant Professor of Ophthalmology and Visual Science
Yale School of Medicine, New Haven, CT

Host: Dr. Royce Mohan, mohan@uchc.edu

Research in Progress (RIP)

"Use of isogenic stem-cell derived neurons to study Angelman Syndrome"

Carissa Sirois
Graduate Assistant
Chamberlain Lab

Hosted by:
Bansal/Mohan Labs

Target Audience: Department of Neuroscience & their Program Members

Sponsored by the Kim Family Fund

"Single cell RNA sequencing resolves cellular heterogeneity and captures developmental dynamics in the developing cerebellum"

James Li, Ph.D.,
Professor, Genetics and Genome Sciences, UConn Health, Farmington, CT

Citation: Heng, X., Guo, Q., Leung, A. W., & Li, J. Y. (2017). Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. eLife, 6, 1324. http://doi.org/10.7554/eLife.23253

Research in Progress (RIP)

"Cellular Senescence Underlies Myelin Defect of Neural Progenitor Cells from PPMS Patients"

Alexandra Nicaise
Graduate Assistant
Crocker Lab

Sponsored by the Kim Family Fund

***JOINT SEMINAR***
Neuroscience & Molecular Biology and Biophysics (MBB)***

Presenter:
Stephen M. Strittmatter, MD, PhD, Vincent Coates Professor of Neurology and Professor of Neuroscience; Director, Cellular Neuroscience, Neurodegeneration and Repair; Director, Memory Disorders Clinic; Director, Yale Alzheimer’s Disease Research Center, Yale School of Medicine, New Haven, CT.

Title: "Mechanisms of Synapse Loss in Alzheimer's Disease”

Citation link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547898/

Host: Dr. Lawrence Klobutcher, klobutcher@uchc.edu

Research in Progress (RIP)

"BDNF causes release of endogenous cannabinoids at CA1 inhibitory synapses."

Rajamani Selvam
Graduate Assistant
Levine Lab

Sponsored by the Kim Family Fund

"Cochlear Synaptopathy in Noise-Induced and Age-Related Hearing Loss"

Sharon Kujawa, Ph.D., Director of Audiology at Mass. Eye & Ear Infirmary,
Associate Professor Otology and Laryngology, Harvard Medical School, MA

Related Citation: https://www.ncbi.nlm.nih.gov/pubmed/?term=Adding+Insult+to+Injury%3A+Cochlear+Nerve+Degeneration+after+%E2%80%9CTemporary%E2%80%9D+Noise-Induced+Hearing+Loss


Host: Dr. Leslie Bernstein, lbernstein@uchc.edu

Research in Progress (RIP)

"The role of TIMP-1 in the development of hypersensitivity using a model of cutaneous inflammation"


Brittany Knight
Graduate Assistant
Baumbauer Lab

Sponsored by the Kim Family Fund

"Sensory-motor integration regulates olfactory learning"

Yu Zhang, PhD, Professor, Department of Organismic & Evolutionary Biology Center for Brain Science, Harvard University, Cambridge, MA

During sensory-guided locomotion, such as chemotactic movement in response to odors, the position and locomotory pattern of an animal are constantly changing. Therefore, sensory-motor integration is critical for the animal to steer the movement towards the goal. However, the underlying mechanisms remain largely unknown. Here, we show that the complex activity in a C. elegans interneuron, RIA, integrates the information of odor and locomotory pattern to mediate olfactory chemotaxis. Previously, we have shown that the activity in RIA neurite compartmentalizes in the axonal domains that are localized on the dorsal or ventral side of the animal and represents the dorsal or ventral head bending, respectively, during the sinusoidal body waves on the dorsal-ventral plane. The motor-encoding activity of RIA restricts head bending. We now show that these two activity patterns interact to integrate sensory and motor information, directing odor-guided chemotactic movements. Learning modulates the sensorimotor integration to generate experience-dependent changes in behavioral response. Together, our findings provide mechanistic insights into the neural circuits of learning at all levels from sensory perception to motor execution.


Host: Dr. Zhao-Wen Wang, zwwang@uchc.edu

4th Year Research in Progress (RIP)

"Establishing a morphological phenotype in Angelman Syndrome and Chromosome 15q Duplication Syndrome stem cell-derived neurons"

Judy Bloom
Graduate Assistant
Loew Lab

Hosted by:
Chen/Wang/Ma Labs

Target Audience: Department of Neuroscience & their Program Members