Schwann cells ensheath the stromal axons of the cornea. But how these specialized glial cells are adapted to maintain corneal transparency is an important question because corneal refraction is an important aspect of vision. The research groups led by Drs. Paola Bargagna-Mohan and Royce Mohan have used a powerful approach to illuminate the genes expressed in these Schwann cells. Appearing in the online version of the Journal of Neuroscience Research they employed single cell RNA sequence analysis to unravel novel genes previously not known to be expressed in Schwann cells and druggable targets. This valuable information could potentially hold promise for the understanding nerve regeneration, pain and wound healing in the cornea.
Read more about this study in an article published in the UConn Today, November 20, 2020, “Unique Schwann Cells: The Eyes have it.”