A critical role of TRPM2-NMDAR coupling in excitotoxicity during ischemic stroke. Ischemic stroke is a major cause of death worldwide. To develop better therapies, Dr. Yue’s group focuses on investigating the mechanisms of ischemic neuronal death, which is classically thought to be induced by N-Methyl-D-aspartate receptors (NMDAR)-mediated excitotoxicity during ischemic stroke. However, all NMDAR antagonists failed […]
Keaven Caro awarded T32 Institutional Training Grant
Keaven Caro, an MD/PhD student in the Martinelli lab was awarded a position on the T32 Institutional Training Grant in Regenerative Engineering of Musculoskeletal Tissues (NIAMS, AR079114) directed by Dr. Cato Laurencin, University Professor, The Connecticut Convergence Institute for Translation in Regenerative Engineering. The goal of this unique funding is to promote research relevant to […]
3 year AHA Transformational Project Award to Dr. Verma
After an ischemic stroke, injured or newborn neurons do not survive due to impaired vasculature in ischemic tissue. Inadequate blood supply in the infarct area exacerbate not only tissue damage but also prevent recovery. This led to the hypothesis that improving blood supply to the peri-infarct tissue would increase trophic support and thus improve post-stroke […]