Melatonin is a sleep-promoting hormone acting through melatonin receptors. However, the downstream molecular target(s) for its sleep-promoting effect has remained elusive. In a recent study from Dr. Wang’s lab (Niu et al., PNAS 117: 25128-25137, 2020), it was found that melatonin promotes sleep in C. elegans by activating the BK channel (also known as SLO-1 in worms […]
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Cold Spring Harbor Visitor of the Week: Annie Yao
Annie Yao is a MD/PhD Candidate in Dr. Riqiang Yan’s lab and recently trained at last month’s Ion Channels in Synaptic and Neural Circuit Physiology course. To read more about Annie’s research and scientific journey, please follow this link: Visitor of the Week: Annie Yao — Current Exchange (cshl.edu) Credit to Current Exchange, a […]
Activation of macrophage TRPM2 and CD36 promotes atherosclerosis
Atherosclerosis is the major cause of ischemic heart disease and stroke, the leading causes of mortality worldwide. To develop better therapies, Dr. Yue’s group focuses on investigating the underlying mechanism of atherosclerosis, the root cause of cardiovascular diseases and brain stroke. The prominent feature of atherosclerosis is the formation of foam cells, the lipid-laden macrophages. Foam cells accelerate […]