Dr. Zhao-Wen Wang received a new award of 2.83 million from NIH

Melatonin is a sleep-promoting hormone acting through melatonin receptors. However, the downstream molecular target(s) for its sleep-promoting effect has remained elusive. In a recent study from Dr. Wang’s lab (Niu et al., PNAS 117: 25128-25137, 2020), it was found that melatonin promotes sleep in C. elegans by activating the BK channel (also known as SLO-1 in worms […]

Activation of macrophage TRPM2 and CD36 promotes atherosclerosis

Atherosclerosis is the major cause of ischemic heart disease and stroke, the leading causes of mortality worldwide. To develop better therapies, Dr. Yue’s group focuses on investigating the underlying mechanism of atherosclerosis, the root cause of cardiovascular diseases and brain stroke. The prominent feature of atherosclerosis is the formation of foam cells, the lipid-laden macrophages. Foam cells accelerate […]