Crocker Lab publishes landmark study in PNAS on negative impact of popular anti-aging treatment.

In the March 18 issue of Proceeding of the National Academy of Sciences, the Crocker lab have published a study describing an unexpected negative impact of two drugs, dasanitib and quercetin (D+Q), which has been used in combination to offset the effects of aging. These drugs are called senolytics because they are intended to selectively kill off the zombie cells that can accumulate with advanced age. In this study, the Crocker lab discovered that D+Q triggers the loss of myelin in the brain that warrants concern for the prophylactic use of D+Q. But, their study also report that these drugs trigger a response in the myelinating cells that could elucidate the nature of demyelination in diseases like multiple sclerosis. Click here to read this study:

https://doi.org/10.1073/pnas.2524897123

 

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