Saint Francis Hospital and Medical Center (SFHMC) has been an anchor institution in north central Connecticut since 1897. In 2015, Saint Francis became part of Trinity Health Of New England, an integrated health care delivery system that is a member of Trinity Health, Livonia, MI, one of the largest multi-institutional Catholic health care delivery systems in the nation.

Saint Francis Hospital and Medical Center, licensed for 617 beds and 65 bassinets, is a major teaching hospital and the largest Catholic hospital in New England. A regional referral center, Saint Francis provides sophisticated, contemporary medicine with major clinical concentrations in cardiology, oncology, women's services, behavioral health, emergency/trauma care and rehabilitation. Other Saint Francis entities include the Mount Sinai Rehabilitation Hospital, home to the Mandell Center for Multiple Sclerosis, the Comprehensive Women’s Health Center, the Connecticut Joint Replacement Institute, the Hoffman Heart and Vascular Institute of Connecticut, Smilow Cancer Hospital Yale-New Haven at Saint Francis, and Trinity Health Of New England Medical Group.

Saint Francis' dedication to education is evident. Full-time chairs of every department hold faculty appointments at the UConn medical school. All attending staff teach residents, medical students and each other. A fully integrated computer information system makes order entry and patient records easily accessible, and the medical library is accessible both locally and remotely.