02-18-22. Congratulations to Boris Slepchenko on his latest publication with CCAM alumnus Masoud Nickaeen, A model of actin-driven endocytosis explains differences of endocytic motility in budding and fission yeast. In this article they showed that a molecularly explicit model of forces exerted by actin filaments on endocytic invaginations explains the differences in endocytic invaginations between budding and fission yeast.

12-11-21. Congratulations to Drs. Ji Yu and Ud Din who recently published a paper in Scientific Reports. The paper, “Training a deep learning model for single‑cell segmentation without manual annotation” presents a convolutional neural network (CNN) segmentation method that uses a marker-controlled segmentation algorithm that is suitable for use where cells are tightly packed together. (Training a deep learning model for single-cell segmentation without manual annotation. Din, Nizam Ud; Yu, Ji Scientific reports 2021 Dec;11(1):23995.)

Single-cell segmentation of bright-field (left) and fluorescence (middle) microscopy images using a neural-network model trained in a self-supervised fashion. Image on the right shows the consistency of the two segmentation results.

 

12-17-21. Pedro recently published another paper,  MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer. The paper, published in iScience, identifies a network of transcription factors and microRNAs that compensate for MYC gene over-expression and allows certain cancerous cells to survive in those conditions. This was discovered with a new computational method that uses COPASI and the findings were confirmed experimentally. Congratulations Pedro!

12-15-21. Congratulations to Pedro Mendes on a new publication, Understanding Lactobacillus paracasei
and Streptococcus oralis biofilm interactions through agent-based modeling, published in mSphere 6:e0087521. Along with other UConn Health investigators, they studied the interactions between two bacterial species that form biofilms in the oral cavity. The research combined experiments and agent-based simulations to understand the mechanism of interaction.

9-03-21. Congratulations to Les Loew on his paper, “Fast Optical Investigation of Cardiac Electrophysiology by Parallel Detection in Multiwell Plates,” published in Frontiers in Physiology. In the paper they discuss MULTIPLE, a cost-effective optical approach for studying cardiac electrophysiology.