***Due to COVID-19 Restrictions, all seminars are virtual until further notice.***
CCAM Events are typically held in the CCAM Conference Room, R1673
Cell & Genome Sciences Building (CGSB)
400 Farmington Avenue
Farmington, CT 06030
CCAM Seminars - Thursdays, 12 p.m., September - June.
(Please note calendar for possible time changes.)
CCAM Lab Meetings - Fridays, 12 p.m., year round.
Upcoming Events
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Sep
24
CAM Journal Club - Mendes12:00pm
CAM Journal Club - Mendes
Friday, September 24th, 2021
12:00 PM - 01:00 PM
UConn Health Virtual
CAM Journal Club
Speaker: Pedro Mendes
Title: "Identifying the combinatorial control of signal-dependent transcription
factors."
https://doi.org/10.1371/journal.pcbi.1009095
Meeting Link: https://uconnhealth.webex.com/meet/pmendesContact Information: Tiffany, jespersen@uchc.edu
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Sep
30
CCAM Seminar Series - Dimitris Vavylonis12:00pm
CCAM Seminar Series - Dimitris Vavylonis
Thursday, September 30th, 2021
12:00 PM - 01:00 PM
UConn Health Virtual
CCAM Seminar Series
Speaker: Dimitris Vavylonis, Department of Physics, Lehigh University
Title: "Cytoskeletal and membrane flows for cell polarization and motility"
Abstract: The ability of cells to polarize, move by crawling, or divide,
requires coordinated interactions of the cytoskeleton with membranes
as well as with signaling systems organizing on membranes. Predictive
models of these mechanisms of subcellular organization
requires accounting of how interactions at the molecular level lead to
collective behavior involving patterns, flows and forces over cellular
scales. I will
describe two recent examples of how mathematical and computational
modeling by our group was combined with experiments by collaborators
to understand membrane and cytoskeletal flow and turnover at regions
of cell extension. In the first example, we showed
that polarized exocytosis causes lateral membrane flows away from
regions of membrane insertion. In rod-shaped fission yeast cells, this
causes membrane-bound inhibitors of Cdc42 with sufficiently low
diffusion and/or detachment rates to deplete, thus patterning the
growing cell tip in a way that establishes its rod shape. In the
second example, we looked at actin cytoskeleton retrograde flows in
regions
of cell protrusion. Using filament-level kinetic and mechanical models
we provided an explanation of how distributed turnover through
severing and annealing generates structural changes of Arp2/3-complex
dendritic networks. We also provide a filament-level implementation of
the clutch mechanism and force transmission through the whole
lamellipodial actin network flowing over focal adhesions.
Host: Dr. Pedro Mendes
Meeting Link:
https://uconn-cmr.webex.com/uconn-cmr/j.php?MTID=m4f1c0eb4fb8d0f91e88024860e765c45
Join by meeting number
Meeting number (access code): 2620 495 1243
Meeting password: BpdHg2r4tF2
Tap to join from a mobile device (attendees only)
+1-415-655-0002,,26204951243## US Toll
Join by phone
+1-415-655-0002 US Toll
Global call-in numbers
Join from a video system or application
Dial 26204951243@uconn-cmr.webex.com
You can also dial 173.243.2.68 and enter your meeting number.
If you are a host, click here to view host information.Contact Information: Tiffany: jespersen@uchc.edu
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Oct
1
CAM Presentation - Kshitiz12:00pm
CAM Presentation - Kshitiz
Friday, October 1st, 2021
12:00 PM - 01:00 PM
UConn Health Virtual
CAM Presentation
Speaker: Kshitiz
Title: TBAContact Information: Tiffany; jespersen@uchc.edu
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Oct
8
CAM Presentation - Bruce Mayer12:00pm
CAM Presentation - Bruce Mayer
Friday, October 8th, 2021
12:00 PM - 01:00 PM
UConn Health Virtual
CAM Presentation
Speaker: Bruce Mayer
Title: TBAContact Information: Tiffany; jespersen@uchc.edu
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Oct
15
CAM Presentation - Mike Guertin12:00pm
CAM Presentation - Mike Guertin
Friday, October 15th, 2021
12:00 PM - 01:00 PM
UConn Health Virtual
CAM Presentation
Speaker: Mike Guertin
Title: TBAContact Information: Tiffany; jespersen@uchc.edu
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