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24th On-site Workshop, Computational Cell Biology

June 26-28, 2023
Farmington, CT, USA

CCAM at UConn Health

Is developing new approaches for in vivo measurements and manipulation of molecular events within the cell, and new computational approaches for organizing such data into quantitative models.

CCAM integrates new microscope technologies for making quantitative in vivo live cell measurements with new physical formulations and computational tools that will produce spatially realistic quantitative models of intracellular dynamics.

To investigate the relationships between experimental and computational worlds, we use a tripartite approach described as:

  • Measure - develop new tools for measuring spatially resolved dynamic behavior of molecules in cells.
  • Model - develop new methods for spatial modeling of biological systems.
  • Manipulate - develop new techniques for manipulating the spatial distribution of molecules in living cells.

These three analytical approaches, (measurement, modeling and manipulation) are integrated and interdependent, e.g., models generate predictions that can be validated with new measurements, as well as experimental approaches that manipulate intracellular signals and structures. These approaches allow us to tackle fundamental questions of how the spatial organization of molecules in cell is established and how it is utilized to control cell function. CCAM hosts a confluence of expertise in physics, chemistry, experimental cell biology and software engineering immersed in a biomedical research setting that values interdisciplinary collaborations, and our Training Program in Cell Analysis and Modeling provides a new model for interdisciplinary training in cell biology. CCAM is the home of the Virtual Cell, a computational environment for cell biological modeling developed as a NIH-designated National Resource, and also hosts a variety of projects in biophotonics and live cell microscope imaging methods as well as a state-of-the-art user microscopy facility for nonlinear, confocal, and widefield microscopy.

Inclusivity Statement

CCAM is committed to fostering an inclusive and tolerant research environment. We support students and faculty of all races, religions, ethnicities, differing physical abilities, sexual orientations, and gender identities.

UConn  maintains a number of resources to promote inclusivity and to report complaints:

Office of Institutional Equity
Ombuds Office
Dean of Students Office Bias Reporting
Office for Diversity and Inclusion
School of Medicine Office of Multicultural and Community Affairs

Collage of various images, cells, people, building

Upcoming Events

  1. Apr 7 Hybrid CAM Presentation - CANCELLED12:00pm
  2. Apr 14 Hybrid CAM Presentation - Boris Slepchenko12:00pm
  3. Apr 20 Hybrid CCAM Seminar Series - Edward Stites4:00pm
  4. Apr 21 Hybrid CAM Presentation - Paola Vera-Licona12:00pm
  5. Apr 27 Hybrid CCAM Seminar Series - Juan Fuxman Bass4:00pm
All Events »

News

  • Guertin lab finds Twist2 is a novel regulator in adipogenesis.
    02-21-23. Adipose tissue development impacts many metabolic functions and adipocyte dysregulation contributes to conditions such as obesity, diabetes, and coronary artery disease. Full characterization and interpretation of the molecular changes and regulatory factors that drive differentiation, such as adipogenesis, and responses to stimuli will someday permit selectively steering diseased cells within a human body toward […]
  • Guertin lab has a new publication on ANKLE1 in cancer.
    03-01-23. The Guertin lab characterized the normal physiological role of the protein ANKLE1 in red blood cell development and how increased expression of Ankle1 leads to an increased risk of developing breast cancer. Background: GWAS analyses have identified thousands of regions associated with physiological phenotypes and disease risk phenotypes. Integrative GWAS and eQTL analyses can often […]
  • Publication for Corey Acker working with Imperial College London
    11-11-22. Congratulations to Corey on his recent collaborative publication, Voltage imaging reveals the dynamic electrical signatures of human breast cancer cells Commun Biol. 2022 Nov 11;5(1):1178. doi: 10.1038/s42003-022-04077-2. Peter Quicke, Yilin Sun, Mar Arias-Garcia, Melina Beykou, Corey D Acker, Mustafa Djamgoz, Chris Bakal, Amanda J Foust. Recent studies at the Imperial College London and The […]
  • Ann Cowan has new publication using FCS
    12-06-22. Congratulations to Ann on her recent publication, Liu, Y., E.M. Bafaro, A.E. Cowan, and R.E. Dempski. 2022. The transmembrane domains mediate oligomerization of the human ZIP4 transporter in vivo. Sci Rep. 12:21083. The work used Fluorescence Correlation Spectroscopy (FCS), performed in CCAM,  to determine the oligomerization state of wild-type or mutant zinc transporter protein ZIP4 […]
  • VCell tutorial at ICSB 2022 in Berlin
    09-12-22. Michael Blinov and Ion Moraru will give a VCell tutorial at the 21st International Conference on Systems Biology – the premier meeting on systems studies in biology, human evolution disease and planetary health. The meeting will take place in Berlin, Germany on October 8th-12th. The tutorial will be on October 9th at 12:30pm local […]