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Join us at the American Society of Cell Biology Annual Meeting 2024:

Join us at the Biophysical Society Annual Meeting 2025:

Join us for the 26th ONLINE  Annual Workshop on Computational Cell Biology:

  • February 24-28, 2025: Lectures, tutorials and one-on-one training on VCell and COPASI.

CCAM at UConn Health

Is developing new approaches for in vivo measurements and manipulation of molecular events within the cell, and new computational approaches for organizing such data into quantitative models.

CCAM integrates new microscope technologies for making quantitative in vivo live cell measurements with new physical formulations and computational tools that will produce spatially realistic quantitative models of intracellular dynamics.

To investigate the relationships between experimental and computational worlds, we use a tripartite approach described as:

  • Measure - develop new tools for measuring spatially resolved dynamic behavior of molecules in cells.
  • Model - develop new methods for spatial modeling of biological systems.
  • Manipulate - develop new techniques for manipulating the spatial distribution of molecules in living cells.

These three analytical approaches, (measurement, modeling and manipulation) are integrated and interdependent, e.g., models generate predictions that can be validated with new measurements, as well as experimental approaches that manipulate intracellular signals and structures. These approaches allow us to tackle fundamental questions of how the spatial organization of molecules in cell is established and how it is utilized to control cell function. CCAM hosts a confluence of expertise in physics, chemistry, experimental cell biology and software engineering immersed in a biomedical research setting that values interdisciplinary collaborations, and our Training Program in Systems Biology provides a new model for interdisciplinary training in cell biology. CCAM is the home of the Virtual Cell, a computational environment for cell biological modeling developed as a NIH-designated National Resource, and also hosts a variety of projects in biophotonics and live cell microscope imaging methods as well as a state-of-the-art user microscopy facility for nonlinear, confocal, and widefield microscopy.

Inclusivity Statement

CCAM is committed to fostering an inclusive and tolerant research environment. We support students and faculty of all races, religions, ethnicities, differing physical abilities, sexual orientations, and gender identities.

UConn  maintains a number of resources to promote inclusivity and to report complaints:

Office of Institutional Equity
Ombuds Office
Dean of Students Office Bias Reporting
Office for Diversity and Inclusion
School of Medicine Office of Multicultural and Community Affairs

Collage of various images, cells, people, building

Upcoming Events

  1. Oct 11 CAM Journal Club: Dr. Yi Wu 12:00pm
  2. Oct 18 CAM Presentation: Dr. Paola Vera-Licona 12:00pm
  3. Oct 25 CAM Presentation: Dr. Eran Agmon 12:00pm
  4. Oct 31 CCAM Seminar Series - Dr. Augustin Luna 4:00pm
  5. Nov 1 CAM Presentation: Dr. Michael Guertin 12:00pm
All Events »

News

  • Cell Signaling: Principles and Methods (2nd ed) by Dr. Mayer
    October 2, 2024. The second edition of Cell Signaling: Principles and Methods is coming out this month. CCAM faculty member Bruce Mayer is one of the authors of the popular cell signaling textbook, which was originally published in 2014. The second edition is has been thoroughly updated and includes two new chapters.   Cell Signaling: Principles and Methods […]
  • Dr. Leslie Loew named 2025 Biophysical Society Fellow
    September 27, 2024. Congratulations to Dr. Leslie Loew, named a 2025 Biophysical Society Fellow for inventing fluorescent sensors of membrane potential and leadership in the development of computational cell biology. Biophysical Society Announces 2025 Society Fellows
  • Dr. Kshitiz Receives NIH Funding to Address Placenta Accreta
    September 16, 2024. Dr. Kshitiz, associate professor at CCAM, receives the $2.5 million NIH grant to understand how previous scars from cesarean surgery can pave the way for aggressive invasion of the placenta into the mother’s uterus, and sometimes beyond. Kshitiz will be working alongside Dr. Molly Brewer from the Department of Obstetrics and Gynecology. […]
  • Jinhong Dong received 2024 Ann Cowan Outstanding Student Award
    September 4, 2024. Jinhong Dong was awarded the 2024 Ann Cowan* Outstanding Student Award in Systems Biology, which recognizes a student with exceptional academic and scholarly achievements in the previous academic year. Jinhong presented at the 2023 International Conference of Systems Biology and the 2024 Cold Spring Harbor Systems Biology meeting. Jinhong’s thesis work addresses […]