**Save the Date - 23rd Annual CCB Workshop**
We are pleased to announce both an online and an in-person Computational Cell Biology Workshop for 2022.
The online workshop will be hosted May 23-25, 2022, while the in-person workshop will be held July 25-27, 2022.
Additional information will be posted as we approach the registration dates for the two workshops.
CCAM at UConn Health
Is developing new approaches for in vivo measurements and manipulation of molecular events within the cell, and new computational approaches for organizing such data into quantitative models.
CCAM integrates new microscope technologies for making quantitative in vivo live cell measurements with new physical formulations and computational tools that will produce spatially realistic quantitative models of intracellular dynamics.
To investigate the relationships between experimental and computational worlds, we use a tripartite approach described as:
- Measure - develop new tools for measuring spatially resolved dynamic behavior of molecules in cells.
- Model - develop new methods for spatial modeling of biological systems.
- Manipulate - develop new techniques for manipulating the spatial distribution of molecules in living cells.
These three analytical approaches, (measurement, modeling and manipulation) are integrated and interdependent, e.g., models generate predictions that can be validated with new measurements, as well as experimental approaches that manipulate intracellular signals and structures. These approaches allow us to tackle fundamental questions of how the spatial organization of molecules in cell is established and how it is utilized to control cell function. CCAM hosts a confluence of expertise in physics, chemistry, experimental cell biology and software engineering immersed in a biomedical research setting that values interdisciplinary collaborations, and our Training Program in Cell Analysis and Modeling provides a new model for interdisciplinary training in cell biology. CCAM is the home of the Virtual Cell, a computational environment for cell biological modeling developed as a NIH-designated National Resource, and also hosts a variety of projects in biophotonics and live cell microscope imaging methods as well as a state-of-the-art user microscopy facility for nonlinear, confocal, and widefield microscopy.
CCAM is committed to fostering an inclusive and tolerant research environment. We support students and faculty of all races, religions, ethnicities, differing physical abilities, sexual orientations, and gender identities.
UConn maintains a number of resources to promote inclusivity and to report complaints:
Upcoming EventsAll Events »
- Acker Publication11-18-21. A new review co-authored by Corey Acker is published in Frontiers in Physiology: Cardiac Electrophysiology (https://doi.org/10.3389/fphys.2021.769586). The review highlights optical methods for cardiac research presented at the first NOtiCE (novel optics-based approaches for cardiac electrophysiology) meeting in Florence, Italy in Sept. 2018 where Corey was an invited speaker. Congratulations Corey!
- Mattada Publication11-24-21. Congratulations to Sathyan on his co-author publication in The EMBO Journal, UBR7 acts as a histone chaperone for post-nucleosomal histone H3 . In the paper they identified UBR7 as a histone chaperone specifically for pre-existing histone H3. The result suggests that UBR7 may be acting as a chaperone that maintains epigenetic memory during transcription […]
- Loew Publication09-09-2021 Les Loew is co-author on a paper with collaborators from the Pollard lab at Yale, just published online in Biophysical Journal (PMID 34509503). The work was started by Les some time ago to computationally explore molecular details of actin assembly and was recently revived by a graduate student in the Pollard lab. Congrats to […]
- Welcome Sathyan Mattada9-01-2021. Welcome to Dr. Sathyan Mattada, who is joining the faculty in CCAM and the Department of Genetics and Genome Sciences. Dr. Mattada works in association with Michael Guertin’s lab exploring mechanisms of transcriptional regulation using inducible rapid degradation systems.
- Pedro Mendes interviewed on NBC Connecticut news8-31-21. See Pedro Mendes’ interview with Dan Corcoran of NBC Connecticut news here. Dr. Mendes discusses the implications of his COVID-19 infection models and trajectories for the current surge. You can also find an article in the Hartford Courant by Alex Putterman that extensively quotes Dr. Mendes on the current COVID-19 infection numbers in CT […]