Systems Biology at UConn Health

Our Mission

We develop computational and experimental approaches to tackle exciting questions in biology and medicine, bringing a systems biology approach to biomedical research. Quantitative experimental methods aim to measure the dynamic behavior of molecules in cells and tissues. We integrate these experimental data within computational models to produce quantitative, comprehensive, and mechanistic models of cellular and molecular dynamics.

The Center for Cell Analysis and Modeling (CCAM) hosts a confluence of expertise in cell biology, biochemistry, genomics, physics, chemistry, mathematics and computer science. We foster a biomedical research environment that values interdisciplinary collaborations. Our Ph.D. program in Systems Biology (opens in a new tab) provides unique graduate training in systems and computational biology. We also provide research experiences for undergraduates.

CCAM is home to several computational resources including Virtual Cell (opens in a new tab) and COPASI (opens in a new tab) for modeling and simulation of cellular mechanistic models, maintained under the NIH-funded National Resource for Mechanistic Modeling of Cellular Systems, Vivarium for multiscale simulation and whole-cell models, and many other experimental tools for imaging and molecular genetics. The center also hosts state-of-the-art high-performance computing (opens in a new tab) and microscopy (opens in a new tab) facilities.

The center’s values extend beyond rigorous and open science. Our research has benefited greatly from inclusive excellence and the diversity of ideas and backgrounds of all our researchers over the years. CCAM continuously strives to improve the environment in which we perform research and pursue education.