23rd Annual CCB Workshop
Online, May 23 - 25, 2022.
The CCB Workshops provides hands-on help to cell biologists and biophysicists as they develop models of their own systems using Virtual Cell, COPASI or SpringSaLaD software.
Click here for more details about this free workshop and learn how to register.
A separate in-person workshop will be held July 25-27, 2022 in Farmington, CT, USA; watch for more details.
CCAM at UConn Health
Is developing new approaches for in vivo measurements and manipulation of molecular events within the cell, and new computational approaches for organizing such data into quantitative models.
CCAM integrates new microscope technologies for making quantitative in vivo live cell measurements with new physical formulations and computational tools that will produce spatially realistic quantitative models of intracellular dynamics.
To investigate the relationships between experimental and computational worlds, we use a tripartite approach described as:
- Measure - develop new tools for measuring spatially resolved dynamic behavior of molecules in cells.
- Model - develop new methods for spatial modeling of biological systems.
- Manipulate - develop new techniques for manipulating the spatial distribution of molecules in living cells.
These three analytical approaches, (measurement, modeling and manipulation) are integrated and interdependent, e.g., models generate predictions that can be validated with new measurements, as well as experimental approaches that manipulate intracellular signals and structures. These approaches allow us to tackle fundamental questions of how the spatial organization of molecules in cell is established and how it is utilized to control cell function. CCAM hosts a confluence of expertise in physics, chemistry, experimental cell biology and software engineering immersed in a biomedical research setting that values interdisciplinary collaborations, and our Training Program in Cell Analysis and Modeling provides a new model for interdisciplinary training in cell biology. CCAM is the home of the Virtual Cell, a computational environment for cell biological modeling developed as a NIH-designated National Resource, and also hosts a variety of projects in biophotonics and live cell microscope imaging methods as well as a state-of-the-art user microscopy facility for nonlinear, confocal, and widefield microscopy.
CCAM is committed to fostering an inclusive and tolerant research environment. We support students and faculty of all races, religions, ethnicities, differing physical abilities, sexual orientations, and gender identities.
UConn maintains a number of resources to promote inclusivity and to report complaints:
Upcoming EventsAll Events »
- Pedro Mendes Publication using COPASI12-17-21. Pedro recently published another paper, MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer. The paper, published in iScience, identifies a network of transcription factors and microRNAs that compensate for MYC gene over-expression and allows certain cancerous cells to survive in those conditions. This was discovered with a new computational method that […]
- Mendes Publication12-15-21. Congratulations to Pedro Mendes on a new publication, Understanding Lactobacillus paracasei and Streptococcus oralis biofilm interactions through agent-based modeling, published in mSphere 6:e0087521. Along with other UConn Health investigators, they studied the interactions between two bacterial species that form biofilms in the oral cavity. The research combined experiments and agent-based simulations to understand the […]
- Loew Publication9-03-21. Congratulations to Les Loew on his paper, “Fast Optical Investigation of Cardiac Electrophysiology by Parallel Detection in Multiwell Plates,” published in Frontiers in Physiology. In the paper they discuss MULTIPLE, a cost-effective optical approach for studying cardiac electrophysiology.
- Cowan and Loew Publication12-03-21. Ann Cowan and Les Loew are authors on another paper with the Carlier lab. This paper was published in The Biophysicist, Teaching Mathematical Modeling of Cellular Systems with the VCell MathModel, 2021 Dec 3. Congratulations on this paper and their continued collaborative work.
- Acker Publication11-18-21. A new review co-authored by Corey Acker is published in Frontiers in Physiology: Cardiac Electrophysiology (https://doi.org/10.3389/fphys.2021.769586). The review highlights optical methods for cardiac research presented at the first NOtiCE (novel optics-based approaches for cardiac electrophysiology) meeting in Florence, Italy in Sept. 2018 where Corey was an invited speaker. Congratulations Corey!