The next Computational Cell Biology workshop will be announced soon. Check our previous workshops at https://compcellbio.org/previous-workshops
Watch the previous online workshop lectures at https://www.youtube.com/@compcellbiol8898
CCAM at UConn Health
Is developing new approaches for in vivo measurements and manipulation of molecular events within the cell, and new computational approaches for organizing such data into quantitative models.
CCAM integrates new microscope technologies for making quantitative in vivo live cell measurements with new physical formulations and computational tools that will produce spatially realistic quantitative models of intracellular dynamics.
To investigate the relationships between experimental and computational worlds, we use a tripartite approach described as:
- Measure - develop new tools for measuring spatially resolved dynamic behavior of molecules in cells.
- Model - develop new methods for spatial modeling of biological systems.
- Manipulate - develop new techniques for manipulating the spatial distribution of molecules in living cells.
These three analytical approaches, (measurement, modeling and manipulation) are integrated and interdependent, e.g., models generate predictions that can be validated with new measurements, as well as experimental approaches that manipulate intracellular signals and structures. These approaches allow us to tackle fundamental questions of how the spatial organization of molecules in cell is established and how it is utilized to control cell function. CCAM hosts a confluence of expertise in physics, chemistry, experimental cell biology and software engineering immersed in a biomedical research setting that values interdisciplinary collaborations, and our Training Program in Systems Biology provides a new model for interdisciplinary training in cell biology. CCAM is the home of the Virtual Cell, a computational environment for cell biological modeling developed as a NIH-designated National Resource, and also hosts a variety of projects in biophotonics and live cell microscope imaging methods as well as a state-of-the-art user microscopy facility for nonlinear, confocal, and widefield microscopy.
INCLUSIVITY STATEMENT
CCAM is committed to fostering an inclusive and tolerant research environment. We support students and faculty of all races, religions, ethnicities, differing physical abilities, sexual orientations, and gender identities.
UConn maintains a number of resources to promote inclusivity and to report complaints:
Office of Institutional Equity
Ombuds Office
Dean of Students Office Bias Reporting
Office for Diversity and Inclusion
School of Medicine Office of Multicultural and Community Affairs

Upcoming Events
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Jun
13
CAM Research in Progress: Dr. Michael Blinov 12:00pm
CAM Research in Progress: Dr. Michael Blinov
Friday, June 13th, 2025
12:00 PM
CGSB, 400 Farmington Ave
CAM Research in Progress
Speaker: Dr. Michael Blinov
Title: “Using AI to Assist VCell Modelers”
Via Webex: https://uconnhealth.webex.com/uconnhealth/j.php?MTID=mdacf393cf6a2ee5314a3b76525ea5e57
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Jun
20
CAM Research in Progress: Leslie Loew 12:00pm
CAM Research in Progress: Leslie Loew
Friday, June 20th, 2025
12:00 PM
CGSB, 400 Farmington Ave
CAM Research in Progress
Speaker: Leslie Loew
Title: “Merging theory and simulations to understand reactions confined to membranes”
Via Webex: https://uconnhealth.webex.com/uconnhealth/j.php?MTID=mdacf393cf6a2ee5314a3b76525ea5e57
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Jun
27
CAM Presentation: Tasnif Rahman 12:00pm
CAM Presentation: Tasnif Rahman
Friday, June 27th, 2025
12:00 PM
CGSB, 400 Farmington Ave
CAM Presentation
Speaker: Tasnif Rahman
Title: TBD
Via Webex: https://uconnhealth.webex.com/meet/pmendes
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Jul
4
CAM Presentation: Cancelled 12:00pm
CAM Presentation: Cancelled
Friday, July 4th, 2025
12:00 PM
CGSB, 400 Farmington Ave
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Jul
8
Doctoral Dissertation Oral Defense of Milda Stanislauskas 1:00pm
Doctoral Dissertation Oral Defense of Milda Stanislauskas
Tuesday, July 8th, 2025
01:00 PM
CGSB, 400 Farmington Ave.
Doctoral Dissertation Oral Defense of Milda Stanislauskas
Title: “Investigating mechanical signaling in cells through live cell imaging of genetically encoded tension sensors”
Major Advisor: Dr. Yi Wu
Location: Cell & Genome Sciences Building, Edmund & Arlene Grossman Auditorium, R1210, 400 Farmington Ave.
Via Webex:
https://uchc.webex.com/uchc/j.php?MTID=m9805b829e2d0616366ac6bee068ad042
Meeting Number: 2870 003 0074
Meeting Password: PublicDefense
Contact Information:
More
News
- Ryan Spangler: New University Director to Lead Vivarium and Whole-Cell Modeling DevelopmentMay 7, 2025. CCAM is thrilled to welcome Ryan Spangler as our new University Director, joining the Agmon Lab to lead software development for the Vivarium framework and our next-generation E. coli whole-cell model. Ryan brings nearly 20 years of experience in research software engineering, with a career spanning major institutions at the forefront of systems biology. His recent positions include senior software […]
- Advancing Space Biotechnology Through Whole-Cell Models: AFOSR SymposiumMarch 18, 2025. Dr. Eran Agmon recently presented his research at the AFOSR-sponsored workshop, Advancing Space Biotechnology through Whole-Cell Models and Functional Annotation. The symposium brought together leaders in synthetic biology, genomics, and computational modeling to explore how whole-cell models can drive innovation in space-based biotechnology. Dr. Agmon presented his work on building a multiscale simulation […]
- The 26th Annual CompCellBio workshopFebruary 28, 2025. The 26th Computational Cell Biology workshop took place ONLINE for the 5 days, February 24-28th. Cell biologists and biophysicists leaned how to use VCell (https://vcell.org/), COPASI (https://copasi.org/ ) and SpringSalad (https://vcell.org/ssalad) software to develop spatial and non-spatial models using deterministic, stochastic, agent- and rule-based approaches. The course included introductions to VCell, COPASI, and […]
- Dr. Blinov’s publication in NPJ SysBioFebruary 4, 2025. Dr. Blinov’s publication in NPJ Systems Biology and Applications details how to use AI tools to investigate systems biology resources related to mathematical modeling: Kannan, M., Bridgewater, G., Zhang, M., & Blinov, M. L. (2025). Leveraging public AI tools to explore systems biology resources in mathematical modeling. npj Systems Biology and Applications, 11(1), 15: […]
- Dr. Kshitiz publication in Advanced Materials TechnologiesJanuary 22, 2025. A collaboration led by Kazunori Hoshino lab in UConn Storrs, Kshitiz lab at CCAM tested how human endometrial cells change their mechanics in anticipation of decidualization. A recent paper published in Advanced Materials Technologies describes how cells become stiffer, but amazingly, when cells from placenta interact with them, they reverse this stiffening.