Join us at the Biophysical Society Annual Meeting 2025:
- February 18, 2025: workshop on Multiscale Biophysical Modeling of the Cell by Leslie Loew.
Join us for the 26th ONLINE Annual Workshop on Computational Cell Biology:
CCAM at UConn Health
Is developing new approaches for in vivo measurements and manipulation of molecular events within the cell, and new computational approaches for organizing such data into quantitative models.
CCAM integrates new microscope technologies for making quantitative in vivo live cell measurements with new physical formulations and computational tools that will produce spatially realistic quantitative models of intracellular dynamics.
To investigate the relationships between experimental and computational worlds, we use a tripartite approach described as:
- Measure - develop new tools for measuring spatially resolved dynamic behavior of molecules in cells.
- Model - develop new methods for spatial modeling of biological systems.
- Manipulate - develop new techniques for manipulating the spatial distribution of molecules in living cells.
These three analytical approaches, (measurement, modeling and manipulation) are integrated and interdependent, e.g., models generate predictions that can be validated with new measurements, as well as experimental approaches that manipulate intracellular signals and structures. These approaches allow us to tackle fundamental questions of how the spatial organization of molecules in cell is established and how it is utilized to control cell function. CCAM hosts a confluence of expertise in physics, chemistry, experimental cell biology and software engineering immersed in a biomedical research setting that values interdisciplinary collaborations, and our Training Program in Systems Biology provides a new model for interdisciplinary training in cell biology. CCAM is the home of the Virtual Cell, a computational environment for cell biological modeling developed as a NIH-designated National Resource, and also hosts a variety of projects in biophotonics and live cell microscope imaging methods as well as a state-of-the-art user microscopy facility for nonlinear, confocal, and widefield microscopy.
Inclusivity Statement
CCAM is committed to fostering an inclusive and tolerant research environment. We support students and faculty of all races, religions, ethnicities, differing physical abilities, sexual orientations, and gender identities.
UConn maintains a number of resources to promote inclusivity and to report complaints:
Office of Institutional Equity
Ombuds Office
Dean of Students Office Bias Reporting
Office for Diversity and Inclusion
School of Medicine Office of Multicultural and Community Affairs

Upcoming Events
-
Feb
21
CAM Presentation: 2025 BPS Meeting Review 12:00pm
CAM Presentation: 2025 BPS Meeting Review
Friday, February 21st, 2025
12:00 PM
CGSB, 400 Farmington Ave
CAM Presentation
Speakers: TBD
Title: TBD
Via Webex: https://uconnhealth.webex.com/uconnhealth/j.php?MTID=mdacf393cf6a2ee5314a3b76525ea5e57
-
Feb
24
26th Annual Workshop on Computational Cell Biology (Online Format) All Day
26th Annual Workshop on Computational Cell Biology (Online Format)
Monday, February 24th, 2025
All Day
Online
The 26th Annual Workshop on Computational Cell Biology will take place online on February 24-28, 2025. It is designed to enable cell biologists and biophysicists to develop models of their experimental systems. We will teach how to use VCell (https://vcell.org/), COPASI (https://copasi.org/ ) and SpringSalad (https://vcell.org/ssalad) software to develop spatial and non-spatial models using deterministic, stochastic, agent- and rule-based approaches. Please check the websites for extensive tutorials and examples of models.
The course includes introductions to VCell, COPASI, and SpringSaLaD, presented by their developers and by modelers. The workshop will include a combination of plenary sessions, invited speakers, and advanced tutorials convenient for audiences across the globe. Participants will have an opportunity to get “hands-on” help developing models in support of their research. Throughout the 5 days, there will be one-on-one sessions with experienced modelers designed to help with your projects.
To participate in these sessions, please email the following information to Dr. Michael Blinov blinov@uchc.edu, by January 15, 2025: your name, institution, lab head (if you are a student), and 1-2 page proposal outlining your research project and modeling needs. If you already know, please describe how VCell, COPASI, and/or SpringSaLaD may help your project. This information will allow us to determine if our software is applicable to your project. As a NIH Biomedical Technology Resource, we are charged with supporting NIH-funded research through collaborative projects.
Registration is free and will be available later. Organized by the Center for Cell Analysis and Modeling (CCAM) at the University of Connecticut School of Medicine (UConn Health). Instructors: Michael Blinov, Ann Cowan, Stefan Hoops, Leslie Loew, Pedro Mendes, Ion Moraru, Jim Schaff, and Boris Slepchenko.
Contact Information:
More -
Feb
25
26th Annual Workshop on Computational Cell Biology (Online Format) All Day
26th Annual Workshop on Computational Cell Biology (Online Format)
Tuesday, February 25th, 2025
All Day
Online
The 26th Annual Workshop on Computational Cell Biology will take place online on February 24-28, 2025. It is designed to enable cell biologists and biophysicists to develop models of their experimental systems. We will teach how to use VCell (https://vcell.org/), COPASI (https://copasi.org/ ) and SpringSalad (https://vcell.org/ssalad) software to develop spatial and non-spatial models using deterministic, stochastic, agent- and rule-based approaches. Please check the websites for extensive tutorials and examples of models.
The course includes introductions to VCell, COPASI, and SpringSaLaD, presented by their developers and by modelers. The workshop will include a combination of plenary sessions, invited speakers, and advanced tutorials convenient for audiences across the globe. Participants will have an opportunity to get “hands-on” help developing models in support of their research. Throughout the 5 days, there will be one-on-one sessions with experienced modelers designed to help with your projects.
To participate in these sessions, please email the following information to Dr. Michael Blinov blinov@uchc.edu, by January 15, 2025: your name, institution, lab head (if you are a student), and 1-2 page proposal outlining your research project and modeling needs. If you already know, please describe how VCell, COPASI, and/or SpringSaLaD may help your project. This information will allow us to determine if our software is applicable to your project. As a NIH Biomedical Technology Resource, we are charged with supporting NIH-funded research through collaborative projects.
Registration is free and will be available later. Organized by the Center for Cell Analysis and Modeling (CCAM) at the University of Connecticut School of Medicine (UConn Health). Instructors: Michael Blinov, Ann Cowan, Stefan Hoops, Leslie Loew, Pedro Mendes, Ion Moraru, Jim Schaff, and Boris Slepchenko.
Contact Information:
More -
Feb
26
26th Annual Workshop on Computational Cell Biology (Online Format) All Day
26th Annual Workshop on Computational Cell Biology (Online Format)
Wednesday, February 26th, 2025
All Day
Online
The 26th Annual Workshop on Computational Cell Biology will take place online on February 24-28, 2025. It is designed to enable cell biologists and biophysicists to develop models of their experimental systems. We will teach how to use VCell (https://vcell.org/), COPASI (https://copasi.org/ ) and SpringSalad (https://vcell.org/ssalad) software to develop spatial and non-spatial models using deterministic, stochastic, agent- and rule-based approaches. Please check the websites for extensive tutorials and examples of models.
The course includes introductions to VCell, COPASI, and SpringSaLaD, presented by their developers and by modelers. The workshop will include a combination of plenary sessions, invited speakers, and advanced tutorials convenient for audiences across the globe. Participants will have an opportunity to get “hands-on” help developing models in support of their research. Throughout the 5 days, there will be one-on-one sessions with experienced modelers designed to help with your projects.
To participate in these sessions, please email the following information to Dr. Michael Blinov blinov@uchc.edu, by January 15, 2025: your name, institution, lab head (if you are a student), and 1-2 page proposal outlining your research project and modeling needs. If you already know, please describe how VCell, COPASI, and/or SpringSaLaD may help your project. This information will allow us to determine if our software is applicable to your project. As a NIH Biomedical Technology Resource, we are charged with supporting NIH-funded research through collaborative projects.
Registration is free and will be available later. Organized by the Center for Cell Analysis and Modeling (CCAM) at the University of Connecticut School of Medicine (UConn Health). Instructors: Michael Blinov, Ann Cowan, Stefan Hoops, Leslie Loew, Pedro Mendes, Ion Moraru, Jim Schaff, and Boris Slepchenko.
Contact Information:
More -
Feb
27
26th Annual Workshop on Computational Cell Biology (Online Format) All Day
26th Annual Workshop on Computational Cell Biology (Online Format)
Thursday, February 27th, 2025
All Day
Online
The 26th Annual Workshop on Computational Cell Biology will take place online on February 24-28, 2025. It is designed to enable cell biologists and biophysicists to develop models of their experimental systems. We will teach how to use VCell (https://vcell.org/), COPASI (https://copasi.org/ ) and SpringSalad (https://vcell.org/ssalad) software to develop spatial and non-spatial models using deterministic, stochastic, agent- and rule-based approaches. Please check the websites for extensive tutorials and examples of models.
The course includes introductions to VCell, COPASI, and SpringSaLaD, presented by their developers and by modelers. The workshop will include a combination of plenary sessions, invited speakers, and advanced tutorials convenient for audiences across the globe. Participants will have an opportunity to get “hands-on” help developing models in support of their research. Throughout the 5 days, there will be one-on-one sessions with experienced modelers designed to help with your projects.
To participate in these sessions, please email the following information to Dr. Michael Blinov blinov@uchc.edu, by January 15, 2025: your name, institution, lab head (if you are a student), and 1-2 page proposal outlining your research project and modeling needs. If you already know, please describe how VCell, COPASI, and/or SpringSaLaD may help your project. This information will allow us to determine if our software is applicable to your project. As a NIH Biomedical Technology Resource, we are charged with supporting NIH-funded research through collaborative projects.
Registration is free and will be available later. Organized by the Center for Cell Analysis and Modeling (CCAM) at the University of Connecticut School of Medicine (UConn Health). Instructors: Michael Blinov, Ann Cowan, Stefan Hoops, Leslie Loew, Pedro Mendes, Ion Moraru, Jim Schaff, and Boris Slepchenko.
Contact Information:
More
News
- Dr. Kshitiz publication in Advanced Materials TechnologiesJanuary 22, 2025. A collaboration led by Kazunori Hoshino lab in UConn Storrs, Kshitiz lab at CCAM tested how human endometrial cells change their mechanics in anticipation of decidualization. A recent paper published in Advanced Materials Technologies describes how cells become stiffer, but amazingly, when cells from placenta interact with them, they reverse this stiffening.
- Dr. Yu’s PNAS paper using microscopy to study cystic fibrosisJanuary 21, 2025. Dr. Ji Yu is part of the team that recently published PNAS paper on how CFTR impacts monocyte adhesion. Mutations in CFTR contribute to inflammatory pathogenesis of cystic fibrosis. The study utilized super-resolution microscopy to show that the mutations caused defects in integrin clustering but not their activations.
- Dr. Agmon published with the Allen Institute in microPublicationJanuary 20, 2025. Dr. Eran Agmon, in collaboration with the Allen Institute for Cell Science, published a manuscript in the journal microPublication on “Comparing simulations of actin filament compression reveals tradeoff between computational cost and capturing supertwist”.
- Dr. Kshitiz’s paper in Cells & DevelopmentJanuary 4, 2025. Kshitiz lab has been drawing parallels between MFI to cancer (which are your own cells transformed) and the non-cancer cells of your body. The paper published in Cells & Development shows how the placental cells reverse the mother’s defenses and let themselves be invaded by the fetal cells. Specifically, the maternal cells […]
- CCAM at CellBio 2025December 14-18, 2024. CCAM faculty attended the American Society of Cell Biology Annual Meeting 2024 in San Diego. Michael Blinov and Margaret Johnson (John Hopkins University) led the session on Biophysical Modeling of the Cell on December 14th. On December 15th, Leslie Loew, Ann Cowan, Stephan Hoops (U Virginia) taught COPASI and VCell tutorials during […]