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Center for Cell Analysis and Modeling

Systems Biology at UConn Health

Our Mission

We develop computational and experimental approaches to tackle exciting questions in biology and medicine, bringing a systems biology approach to biomedical research. Quantitative experimental methods aim to measure the dynamic behavior of molecules in cells and tissues. We integrate these experimental data within computational models to produce quantitative, comprehensive, and mechanistic models of cellular and molecular dynamics.

The center hosts a confluence of expertise in cell biology, biochemistry, genomics, physics, chemistry, mathematics and computer science. We foster a biomedical research environment that values interdisciplinary collaborations. Our Ph.D. program in Systems Biology provides unique graduate training in systems and computational biology. We also provide research experiences for undergraduates.

CCAM is home to several computational resources including Virtual Cell and COPASI for modeling and simulation of cellular mechanistic models, maintained under the NIH-funded National Resource for Mechanistic Modeling of Cellular Systems, Vivarium for multiscale simulation and whole-cell models, and many other experimental tools for imaging and molecular genetics. The center also hosts a state-of-the-art high-performance computing center and a microscopy facility.

The center’s values extend beyond rigorous and open science. Our research has benefited greatly from inclusive excellence and the diversity of ideas and backgrounds of all our researchers over the years. CCAM continuously strives to improve the environment in which we perform research and pursue education.

CCAM is committed to fostering an inclusive and tolerant research environment. We support students and faculty of all races, religions, ethnicities, differing physical abilities, sexual orientations, and gender identities.

UConn  maintains a number of resources to promote inclusivity and to report complaints:

Office of Institutional Equity
Ombuds Office
Dean of Students Office Bias Reporting
Office for Diversity and Inclusion
School of Medicine Office of Multicultural and Community Affairs

Collage of various images, cells, people, building

Upcoming Events

  1. Jun 27 CAM Research in Progress: Tasnif Rahman 12:00pm
  2. Jul 4 CAM Presentation: Cancelled 12:00pm
  3. Jul 8 Doctoral Dissertation Oral Defense of Milda Stanislauskas 1:00pm
  4. Jul 11 CAM Presentation: Kshitiz 12:00pm
  5. Jul 18 CAM Presentation: Summer Students 12:00pm
All Events »

News

  • Ryan Spangler: New University Director to Lead Vivarium and Whole-Cell Modeling Development
    May 7, 2025.  CCAM is thrilled to welcome Ryan Spangler as our new University Director, joining the Agmon Lab to lead software development for the Vivarium framework and our next-generation E. coli whole-cell model. Ryan brings nearly 20 years of experience in research software engineering, with a career spanning major institutions at the forefront of systems biology. His recent positions include senior software […]
  • Advancing Space Biotechnology Through Whole-Cell Models: AFOSR Symposium
    March 18, 2025.  Dr. Eran Agmon recently presented his research at the AFOSR-sponsored workshop, Advancing Space Biotechnology through Whole-Cell Models and Functional Annotation. The symposium brought together leaders in synthetic biology, genomics, and computational modeling to explore how whole-cell models can drive innovation in space-based biotechnology. Dr. Agmon presented his work on building a multiscale simulation […]
  • The 26th Annual CompCellBio workshop
    February 28, 2025. The 26th Computational Cell Biology workshop took place ONLINE for the 5 days, February 24-28th. Cell biologists and biophysicists leaned how to use VCell (https://vcell.org/), COPASI (https://copasi.org/ ) and SpringSalad (https://vcell.org/ssalad) software to develop spatial and non-spatial models using deterministic, stochastic, agent- and rule-based approaches. The course included introductions to VCell, COPASI, and […]
  • Dr. Blinov’s publication in NPJ SysBio
    February 4, 2025. Dr. Blinov’s publication in NPJ Systems Biology and Applications details how to use AI tools to investigate systems biology resources related to mathematical modeling: Kannan, M., Bridgewater, G., Zhang, M., & Blinov, M. L. (2025). Leveraging public AI tools to explore systems biology resources in mathematical modeling. npj Systems Biology and Applications, 11(1), 15: […]
  • Dr. Kshitiz publication in Advanced Materials Technologies
    January 22, 2025. A collaboration led by Kazunori Hoshino lab in UConn Storrs, Kshitiz lab at CCAM tested how human endometrial cells change their mechanics in anticipation of decidualization. A recent paper published in Advanced Materials Technologies describes how cells become stiffer, but amazingly, when cells from placenta interact with them, they reverse this stiffening.