Join us at the Biophysical Society Annual Meeting 2025:

Join us for the 26th ONLINE  Annual Workshop on Computational Cell Biology:

  • February 24-28, 2025: Lectures, tutorials and one-on-one training on VCell and COPASI.

CCAM at UConn Health

Is developing new approaches for in vivo measurements and manipulation of molecular events within the cell, and new computational approaches for organizing such data into quantitative models.

CCAM integrates new microscope technologies for making quantitative in vivo live cell measurements with new physical formulations and computational tools that will produce spatially realistic quantitative models of intracellular dynamics.

To investigate the relationships between experimental and computational worlds, we use a tripartite approach described as:

  • Measure - develop new tools for measuring spatially resolved dynamic behavior of molecules in cells.
  • Model - develop new methods for spatial modeling of biological systems.
  • Manipulate - develop new techniques for manipulating the spatial distribution of molecules in living cells.

These three analytical approaches, (measurement, modeling and manipulation) are integrated and interdependent, e.g., models generate predictions that can be validated with new measurements, as well as experimental approaches that manipulate intracellular signals and structures. These approaches allow us to tackle fundamental questions of how the spatial organization of molecules in cell is established and how it is utilized to control cell function. CCAM hosts a confluence of expertise in physics, chemistry, experimental cell biology and software engineering immersed in a biomedical research setting that values interdisciplinary collaborations, and our Training Program in Systems Biology provides a new model for interdisciplinary training in cell biology. CCAM is the home of the Virtual Cell, a computational environment for cell biological modeling developed as a NIH-designated National Resource, and also hosts a variety of projects in biophotonics and live cell microscope imaging methods as well as a state-of-the-art user microscopy facility for nonlinear, confocal, and widefield microscopy.

Inclusivity Statement

CCAM is committed to fostering an inclusive and tolerant research environment. We support students and faculty of all races, religions, ethnicities, differing physical abilities, sexual orientations, and gender identities.

UConn  maintains a number of resources to promote inclusivity and to report complaints:

Office of Institutional Equity
Ombuds Office
Dean of Students Office Bias Reporting
Office for Diversity and Inclusion
School of Medicine Office of Multicultural and Community Affairs

Collage of various images, cells, people, building

Upcoming Events

  1. Jan 24 CAM Presentation: Milda Stanislauskas 12:00pm
  2. Jan 30 CCAM Seminar Series - Dr. John Hickey 4:00pm
  3. Jan 31 CAM Presentation: Ji Yu 12:00pm
  4. Feb 6 CCAM Seminar Series - Dr. Adam Siepel 4:00pm
  5. Feb 7 CAM Presentation: Dr. Ion Moraru 12:00pm
All Events »

News

  • Dr. Agmon published with the Allen Institute in microPublication
    January 20, 2025. Dr. Eran Agmon, in collaboration with the Allen Institute for Cell Science, published a manuscript in the journal microPublication on “Comparing simulations of actin filament compression reveals tradeoff between computational cost and capturing supertwist”.
  • CCAM at CellBio 2025
    December 14-18, 2024. CCAM faculty attended the American Society of Cell Biology Annual Meeting 2024 in San Diego. Michael Blinov and Margaret Johnson (John Hopkins University) led the session on Biophysical Modeling of the Cell on December 14th. On December 15th, Leslie Loew, Ann Cowan, Stephan Hoops (U Virginia) taught COPASI and VCell tutorials during […]
  • John Templeton Foundation Grant to Explore E. coli Community Assembly
    November 11, 2024. Dr. Eran Agmon, in collaboration with Liam Longo (Tokyo Institute of Technology) and Hiroki Kojima (University of Tokyo), has secured a grant from the John Templeton Foundation for a pioneering study on microbial community formation. The project, A-Life Meets B-Life, will leverage simulations (A-Life, or Artificial Life) and E. coli bioreactor experiments […]
  • Dr. Abhijit Deb Roy gave a seminar at UConn Storrs
    October 22, 2024. Dr. Abhijit Deb Roy gave a seminar titled “Deciphering the tubulin code of mechanobiology” to the Molecular and Cell Biology Department at UConn Storrs. https://events.uconn.edu/molecular-and-cell-biology/event/274328-mcb-seminar-series-abhijit-deb-roy
  • Dr. Agmon Presents on Compositional Systems Biology in Bilbao
    October 17, 2024. Dr. Eran Agmon recently shared his insights at a John Templeton-funded workshop on Goal-Directed Systems in Bilbao, Spain. His talk, titled A Compositional Framework for Modeling Biological Agents, introduced a new approach to systems biology, advocating for modular, compositional models that better reflect the natural organization of biological systems. Dr. Agmon discussed […]