Join us at the American Society of Cell Biology Annual Meeting 2024:
- December 14, 2024: session Biophysical Modeling of the Cell by Margaret Johnson & Michael Blinov.
- December 15, 2024: workshop Mathematical Modeling for Cell Biology by Leslie Loew.
Join us at the Biophysical Society Annual Meeting 2025:
- February 18 , 2025: workshop on Multiscale Biophysical Modeling of the Cell by Leslie Loew.
Join us for the 26th ONLINE Annual Workshop on Computational Cell Biology:
CCAM at UConn Health
Is developing new approaches for in vivo measurements and manipulation of molecular events within the cell, and new computational approaches for organizing such data into quantitative models.
CCAM integrates new microscope technologies for making quantitative in vivo live cell measurements with new physical formulations and computational tools that will produce spatially realistic quantitative models of intracellular dynamics.
To investigate the relationships between experimental and computational worlds, we use a tripartite approach described as:
- Measure - develop new tools for measuring spatially resolved dynamic behavior of molecules in cells.
- Model - develop new methods for spatial modeling of biological systems.
- Manipulate - develop new techniques for manipulating the spatial distribution of molecules in living cells.
These three analytical approaches, (measurement, modeling and manipulation) are integrated and interdependent, e.g., models generate predictions that can be validated with new measurements, as well as experimental approaches that manipulate intracellular signals and structures. These approaches allow us to tackle fundamental questions of how the spatial organization of molecules in cell is established and how it is utilized to control cell function. CCAM hosts a confluence of expertise in physics, chemistry, experimental cell biology and software engineering immersed in a biomedical research setting that values interdisciplinary collaborations, and our Training Program in Systems Biology provides a new model for interdisciplinary training in cell biology. CCAM is the home of the Virtual Cell, a computational environment for cell biological modeling developed as a NIH-designated National Resource, and also hosts a variety of projects in biophotonics and live cell microscope imaging methods as well as a state-of-the-art user microscopy facility for nonlinear, confocal, and widefield microscopy.
Inclusivity Statement
CCAM is committed to fostering an inclusive and tolerant research environment. We support students and faculty of all races, religions, ethnicities, differing physical abilities, sexual orientations, and gender identities.
UConn maintains a number of resources to promote inclusivity and to report complaints:
Office of Institutional Equity
Ombuds Office
Dean of Students Office Bias Reporting
Office for Diversity and Inclusion
School of Medicine Office of Multicultural and Community Affairs
Upcoming Events
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Jan
24
CAM Presentation: Milda Stanislauskas 12:00pm
CAM Presentation: Milda Stanislauskas
Friday, January 24th, 2025
12:00 PM
CGSB, 400 Farmington Ave
CAM Presentation
Speaker: Milda Stanislauskas
Title: TBD
Via Webex: https://uconnhealth.webex.com/uconnhealth/j.php?MTID=mdacf393cf6a2ee5314a3b76525ea5e57
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Jan
30
CCAM Seminar Series - Dr. John Hickey 4:00pm
CCAM Seminar Series - Dr. John Hickey
Thursday, January 30th, 2025
04:00 PM
Grossman Auditorium (UConn Health)
CCAM Seminar Series
Speaker: Dr. John Hickey, Assistant Professor, Biomedical Engineering, Duke University
Title: “Transforming pixels to pathways: spatial-omics across biological scales”
Abstract: Advancements in single-cell multiplexed imaging such as spatial-omics coupled with sophisticated computational algorithms have greatly augmented our views into complex tissue microenvironments at the single cell level. In this seminar, I will present the approaches we have developed to deconstruct intricate tissue datasets and connect them across scales from molecular to multicell modules. Particularly, I will share three vignettes of cell organizational rules we found within 1] the healthy human intestine, 2] progression from metaplasia to cancer in Barrett’s esophagus, and 3] melanomas treated with effective and ineffective T cell therapies.
Guest Host: Dr. Eran Agmon
Contact Information:
More -
Jan
31
CAM Presentation: Ji Yu 12:00pm
CAM Presentation: Ji Yu
Friday, January 31st, 2025
12:00 PM
CGSB, 400 Farmington Ave
CAM Presentation
Speaker: Ji Yu
Title: TBD
Via Webex: https://uconnhealth.webex.com/uconnhealth/j.php?MTID=mdacf393cf6a2ee5314a3b76525ea5e57
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Feb
6
CCAM Seminar Series - Dr. Adam Siepel 4:00pm
CCAM Seminar Series - Dr. Adam Siepel
Thursday, February 6th, 2025
04:00 PM
Grossman Auditorium (UConn Health)
CCAM Seminar Series
Speaker - Dr. Adam Siepel, Professor, Chair, Simons Center for Quantitative Biology, Cancer Center Co-Leader, Cold Spring Harbor Laboratory
Title: TBD
Guest Host: Dr. Michael Guertin
Contact Information:
More -
Feb
7
CAM Presentation: Dr. Ion Moraru 12:00pm
CAM Presentation: Dr. Ion Moraru
Friday, February 7th, 2025
12:00 PM
CGSB, 400 Farmington Ave
CAM Presentation
Speaker: Dr. Ion Moraru
Title: TBD
Via Webex: https://uconnhealth.webex.com/uconnhealth/j.php?MTID=mdacf393cf6a2ee5314a3b76525ea5e57
News
- NPJ SysBio published a review on immune digital twins by Dr. Blinov and colleaguesNovember 30, 2024. Dr. Michael Blinov and colleagues published a review on “Immune digital twins for complex human pathologies: applications, limitations, and challenges”, outlining the crucial aspects of an immune digital twin design and discussing the use of digital twins in drug discovery. NPJ Syst Biol Appl . 2024 Nov 30;10(1):141. doi:10.1038/s41540-024-00450-5
- John Templeton Foundation Grant to Explore E. coli Community AssemblyNovember 11, 2024. Dr. Eran Agmon, in collaboration with Liam Longo (Tokyo Institute of Technology) and Hiroki Kojima (University of Tokyo), has secured a grant from the John Templeton Foundation for a pioneering study on microbial community formation. The project, A-Life Meets B-Life, will leverage simulations (A-Life, or Artificial Life) and E. coli bioreactor experiments […]
- Dr. Abhijit Deb Roy gave a seminar at UConn StorrsOctober 22, 2024. Dr. Abhijit Deb Roy gave a seminar titled “Deciphering the tubulin code of mechanobiology” to the Molecular and Cell Biology Department at UConn Storrs. https://events.uconn.edu/molecular-and-cell-biology/event/274328-mcb-seminar-series-abhijit-deb-roy
- Dr. Eran Agmon Presents on Compositional Systems Biology in BilbaoOctober 17, 2024. Dr. Eran Agmon recently shared his insights at a John Templeton-funded workshop on Goal-Directed Systems in Bilbao, Spain. His talk, titled A Compositional Framework for Modeling Biological Agents, introduced a new approach to systems biology, advocating for modular, compositional models that better reflect the natural organization of biological systems. Dr. Agmon discussed […]
- Dr. Tasnif Rahman Joins Agmon LabOctober 10, 2024. The Agmon Lab is thrilled to welcome Dr. Tasnif Rahman, our newest postdoctoral researcher, who brings a blend of expertise in tissue engineering, computational biomechanics, and microbiology. Tasnif’s research will focus on developing multi-scale computational models to study the interactions between bacterial communities and host tissues, a vital area in understanding microbial […]