12-11-21. Congratulations to Drs. Ji Yu and Ud Din who recently published a paper in Scientific Reports. The paper, “Training a deep learning model for single‑cell segmentation without manual annotation” presents a convolutional neural network (CNN) segmentation method that uses a marker-controlled segmentation algorithm that is suitable for use where cells are tightly packed together. (Training a deep learning model for single-cell segmentation without manual annotation. Din, Nizam Ud; Yu, Ji Scientific reports 2021 Dec;11(1):23995.)

Single-cell segmentation of bright-field (left) and fluorescence (middle) microscopy images using a neural-network model trained in a self-supervised fashion. Image on the right shows the consistency of the two segmentation results.

 

12-17-21. Pedro recently published another paper,  MYC dosage compensation is mediated by miRNA-transcription factor interactions in aneuploid cancer. The paper, published in iScience, identifies a network of transcription factors and microRNAs that compensate for MYC gene over-expression and allows certain cancerous cells to survive in those conditions. This was discovered with a new computational method that uses COPASI and the findings were confirmed experimentally. Congratulations Pedro!

12-15-21. Congratulations to Pedro Mendes on a new publication, Understanding Lactobacillus paracasei
and Streptococcus oralis biofilm interactions through agent-based modeling, published in mSphere 6:e0087521. Along with other UConn Health investigators, they studied the interactions between two bacterial species that form biofilms in the oral cavity. The research combined experiments and agent-based simulations to understand the mechanism of interaction.

9-03-21. Congratulations to Les Loew on his paper, “Fast Optical Investigation of Cardiac Electrophysiology by Parallel Detection in Multiwell Plates,” published in Frontiers in Physiology. In the paper they discuss MULTIPLE, a cost-effective optical approach for studying cardiac electrophysiology. 

12-03-21. Ann Cowan and Les Loew are authors on another paper with the Carlier lab. This paper was published in The Biophysicist, Teaching Mathematical Modeling of Cellular Systems with the VCell MathModel, 2021 Dec 3. Congratulations on this paper and their continued collaborative work.