Dr. Jianbin Ruan’s Paper Published in Nature

Congratulations to Dr. Jianbin Ruan for having his paper, "Structural Basis for GSDMB pore formation and it's Targeting by IpaH7.8", published in the journal Nature. This paper presents the cryo-EM structures of both Gasdermin B (GSDMB) pore and GSDMB in complex with a Shigella effector, IpaH7.8. The study sheds light on the structural mechanisms that govern GSDMB-mediated pyroptosis, which is regulated by pathogenic bacteria and alternative splicing. This work is a significant contribution to the field and is sure to have a lasting impact on future research in this area. 

Dr. Beiyan Zhou