Congratulations to Dr. Vijay Rathinam and Dr. Puja Kumari for having their paper, 'Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis’ published in the journal Nature Cell Biology. The paper first-authored by Dr. Puja Kumari, a postdoctoral fellow in the Rathinam lab, identified extracellular vesicles (EVs) secreted by host cells capture circulating bacterial ipopolysaccharide (LPS) and escort it to the cytosol of cells enabling non-canonical inflammasome sensing and cell death. The findings from this study provide insights into cytosolic immune surveillance of systemic microbial products.

Congratulations to Dr. Beiyan Zhou and Dr. Anthony Vella on the award of their NIH R01 grant through the National Heart, Lung and Blood Institute entitled, “ASCVD risk assessment in T2DM facilitated by novel computational immunology programs”.