A Cytometrist's Guide to Coordinating and Performing Effective COVID-19 Research. Chattopadhyay PK, Filby A, Jellison ER, Ferrari G, Green C, Cherian S, Irish J, Litwin V; other members of the ISAC COVID‐19 Work Group. Cytometry A. 2020 Aug 16. doi: 10.1002/cyto.a.24210. Online ahead of print. PMID: 32881296 Free PMC article.

Adler AJMittal PHagymasi ATMenoret AShen CAgliano FWright KTGrady JJKuo CLBallesteros EClaffey KPVella AT, 2020. GRK2 enforces androgen receptor dependence in the prostate and prostate tumors. Oncogene 39:2424-2436. PMC7072002

Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration. Manoukian OS, Baker JT, Rudraiah S, Arul MR, Vella AT, Domb AJ, Kumbar SG.J Control Release. 2020 Jan 10;317:78-95. doi: 10.1016/j.jconrel.2019.11.021. Epub 2019 Nov 19.PMID: 31756394 Review.

GRK2 enforces androgen receptor dependence in the prostate and prostate tumors. Adler AJ, Mittal P, Hagymasi AT, Menoret A, Shen C, Agliano F, Wright KT, Grady JJ, Kuo CL, Ballesteros E, Claffey KP, Vella AT.Oncogene. 2020 Mar;39(11):2424-2436. doi: 10.1038/s41388-020-1159-x. Epub 2020 Jan 20.PMID: 31959897

Evaluation of a bioengineered ACL matrix's osteointegration with BMP-2 supplementation. Mengsteab PY, Conroy P, Badon M, Otsuka T, Kan HM, Vella AT, Nair LS, Laurencin CT.PLoS One. 2020 Jan 7;15(1):e0227181. doi: 10.1371/journal.pone.0227181. eCollection 2020.PMID: 31910231

Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age. Willis CM, Nicaise AM, Bongarzone ER, Givogri M, Reiter CR, Heintz O, Jellison ER, Sutter PA, TeHennepe G, Ananda G, Vella AT, Crocker SJ.Sci Rep. 2020 Jan 21;10(1):828. doi: 10.1038/s41598-020-57663-x.PMID: 31964978

Replens prevents preterm birth by decreasing type I interferon strengthening the cervical epithelial barrier. Nold C, Jensen T, O'Hara K, Stone J, Yellon SM, Vella AT.Am J Reprod Immunol. 2020 Jan;83(1):e13192. doi: 10.1111/aji.13192. Epub 2019 Oct 14.PMID: 31549469

Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration. Ferrigno B, Bordett R, Duraisamy N, Moskow J, Arul MR, Rudraiah S, Nukavarapu SP, Vella AT, Kumbar SG.Bioact Mater. 2020 Apr 7;5(3):468-485. doi: 10.1016/j.bioactmat.2020.03.010. eCollection 2020 Sep.PMID: 32280836

Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection. Agliano F, Fitzgerald KA, Vella AT, Rathinam VA, Medvedev AE.Front Cell Infect Microbiol. 2020 Jan 22;9:481. doi: 10.3389/fcimb.2019.00481. eCollection 2019.PMID: 32039056

Cookenham, T., Lanzer, K.G., Gage, E., Lorenzo, E.C., Carter, D., Coler, R.N., Baldwin, S.L., Haynes, L., Reily, W.W., Blackman, M.A. (2020) Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity. Vaccine in press.

Keilich, S.R., Lorenzo, E.C., Torrance, B.L., Harrison, A.G., Bartley, J.M., Haynes, L. (2020) Vaccination mitigates influenza-induced muscular declines in aged mice. Geroscience May 29. doi: 10.1007/s11357-020-00206-z.

Frasca, D., Blomberg, B.B., Garcia, D., Keilich, S.R., Haynes, L. (2020) Age-related factors that affect B cell responses to vaccination in mice and humans. Imm. Rev. Jun 2. doi: 10.1111/imr.12864.

Straight, C.R., Ringham, O.R., Bartley, J.M., Keilich, S.R., Kuchel, G.A., Haynes, L., Miller, M.S. (2020) Influenza infection has fiber type-specific effects on cellular and molecular skeletal muscle function in aged mice. J. Gerontol. A Biol. Sci. Med. Sci. in press.

McElhaney, J.E., Verschoor, C.P., Andrew, M.K., Haynes, L., Kuchel, G.A., Pawelec, G. (2020) The immune response to influenza in older humans: beyond immune senescence. Immun. Ageing 7;17:10.

McElhaney, J.E., Andrew, M.K., Haynes, L., Kuchel, G.A., McNeil, S.A., Pawelec, G. (2020) Influenza Vaccination: Accelerating the Process for New Vaccine Development in Older Adults. Interdiscip. Top. Gerontol. Geriatr. 43:98-112.

Loeb, N., Andrew, M.K., Loeb, M., Kuchel, G.A., Haynes, L., McElhaney, J.E., Verschoor, C.P. (2020) Frailty is associated with increased hemagglutination-inhibition titres in a 4-year randomized trial comparing standard and high dose influenza vaccination. Open Forum Infect Dis ofaa148,

Wen L, Fan Z, Mikulski Z, Ley, K. Imaging of the immune system - towards a subcellular and molecular understanding. Journal of Cell Science. 2020; 133, jcs234922.

Fan Z, Mikulski Z, McArdle S, Sundd P, Ley K. Super-STORM: Molecular Modeling to Achieve Single-molecule Localization with STORM Microscopy. STARprotocol. 2020; 100012.

Procedures for Flow Cytometry-Based Sorting of Unfixed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infected Cells and Other Infectious Agents. Reifel KM, Swan BK, Jellison ER, Ambrozak D, Baijer J, Nguyen R, Monard S, Lyon G, Fontes B, Perfetto SP. Cytometry A. 2020 Jun 3. doi: 10.1002/cyto.a.24040. Online ahead of print. PMID: 32488957

Chimera RNA interference knockdown of γ-synuclein in human cortical astrocytes results in mitotic catastrophe. Le T, Winham CL, Andromidas F, Silver AC, Jellison ER, Levesque AA, Koob AO. Neural Regen Res. 2020 Oct;15(10):1894-1902. doi: 10.4103/1673-5374.280329. PMID: 32246638

Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age. Willis CM, Nicaise AM, Bongarzone ER, Givogri M, Reiter CR, Heintz O, Jellison ER, Sutter PA, TeHennepe G, Ananda G, Vella AT, Crocker SJ. Sci Rep. 2020 Jan 21;10(1):828. doi: 10.1038/s41598-020-57663-x. PMID: 31964978

Nichols FC, Clark RB, Liu Y, Provatas AA, Dietz CJ, Zhu Q, Wang YH, Smith MB. Glycine Lipids of Porphyromonas gingivalis Are Agonists for Toll-Like Receptor 2. Infect Immun2020 Mar 23;88(4)doi: 10.1128/IAI.00877-19. Print 2020 Mar 23. PubMed PMID: 31932327; PubMed Central PMCID: PMC7093120.

Wasko NJ, Nichols F, Clark RB. Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis. Autoimmun Rev2020 Jan;19(1):102430doi: 10.1016/j.autrev.2019.102430. Epub 2019 Nov 15. Review. PubMed PMID: 31734400.​


Ge, S., Jiang, X., Paul, D., Song, L., Wang, X. and Pachter, J.S. Human ES-derived MSCs correct TNF-a-mediated alterations in a blood-brain barrier model. Fluids Barriers CNS. In press.

Morales Del Valle C, Maxwell JR, Xu MM, Menoret A, Mittal P, Tsurutani N, Adler AJ and Vella AT, 2019. Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-Like Mechanism. Cell Rep. 27:1434-1445.

Ebrahimi-Nik H, Michaux J, Corwin WL, Keller G, Shcheglova, Pak H, Coukos G, Baker B, Mandoiu II Bassani-Sternberg M, Srivastava PK. Mass spectrometry driven exploration reveals nuances of neoepitope-driven tumor rejection. JCI Insight 2019 June 20,

Karandikar SH, Zhang C, Meiyappan A, Barman I, Finck C, Srivastava PK, Pandey R. Reagent-Free and Rapid Assessment of T Cell Activation State Using Diffraction Phase Microscopy and Deep Learning. Anal Chem. 2019 Mar 5;91(5):3405-3411. doi: 10.1021/acs.analchem.8b04895. Epub 2019 Feb 22. PMCID:PMC6423970

Karandikar SH, Sidney J, Sette A, Selby MJ, Korman AJ, Srivastava PK. Identification of epitopes in ovalbumin provide insights for cancer neoepitopes. JCI Insight. 2019 Apr 18; 4(8): e127882 doi: 10.1172/jci.insight.127882 PMID: 30869653

Sun H*, Fan Z*, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K. A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling Journal of Leukocyte Biology. 2019; Epub ahead of print. (*co-first authors

Fan Z, Mikulski Z, McArdle S, Sundd P, Ley K. Super-STORM: using molecular structure modeling to sharp images of single molecule localization microscopy. STARprotocol. 2019; in press.

Konstorum A, Vella AT, Adler AJ and Laubenbacher RC. A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors, 2019. Sci Rep. 9:10862. PMC6659676  (

Suarez-Ramirez, J.E. Chandiran, K. Brocke, S. and Cauley. L.S.*. (2019). Immunity to respiratory infection is reinforced through early proliferation of lymphoid TRM cells and prompt arrival of effector CD8 T cells in the lungs. Frontiers in Immunology 10:1370. PMID: 31258537​

Systemic TLR2 tolerance enhances central nervous system remyelination. Wasko NJ, Kulak MH, Paul D, Nicaise AM, Yeung ST, Nichols FC, Khanna KM, Crocker S, Pachter JS, Clark RB. J Neuroinflammation.  2019 Jul 27;16(1):158. doi: 10.1186/s12974-019-1540-2. PMID:31351476

Multiple Sclerosis, the Microbiome, TLR2, and the Hygiene Hypothesis”   Nicholas J WaskoFrank NicholsRobert B Clark.  Autoimmunity Reviews 2019 Nov 15 [Online ahead of print]  (Publish date: Jan. 2020).  PMID: 31734400 DOI: 10.1016/j.autrev.2019.102430

Yu X, Zhu Y, Xiao X, Wang P, Cheng G. Progress towards Understanding the Mosquito-Borne Virus Life Cycle. Trends Parasitol. 2019 Dec;35(12):1009-1017. doi: 10.1016/ Epub 2019 Oct 25. Review. PubMed PMID: 31669148.

Wang P, Li S, Zhao Y, Zhang B, Li Y, Liu S, Du H, Cao L, Ou M, Ye X, Li P, Gao X, Wang P, Jing C, Shao F, Yang G, You F. The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING. J Biol Chem. 2019 Nov 8;294(45):16494-16508. doi: 10.1074/jbc.RA119.009172. Epub 2019 Aug 15. PubMed PMID: 31416833; PubMed Central PMCID: PMC6851339.

Zhu Y, Tong L, Nie K, Wiwatanaratanabutr I, Sun P, Li Q, Yu X, Wu P, Wu T, Yu C, Liu Q, Bian Z, Wang P, Cheng G. Host serum iron modulates dengue virus acquisition by mosquitoes. Nat Microbiol. 2019 Sep 16;. doi: 10.1038/s41564-019-0555-x. [Epub ahead of print] PubMed PMID: 31527795.

Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F. The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host Microbe. 2019 Sep 11;26(3):369-384.e8. doi: 10.1016/j.chom.2019.08.010. PubMed PMID: 31513772.

Liu Y, Liu H, Xie Y, Zhang B, Zou X, Ou M, Ye X, Han Y, Wu J, Chen X, Dong S, Zhu K, Guo C, Wang P, Zhai H, Jing C, Yang G. Identification of genetic variations in Necator americanus through resequencing by whole genome amplification. J Int Med Res. 2019 Sep;47(9):4353-4364. doi: 10.1177/0300060519862069. Epub 2019 Jul 23. PubMed PMID: 31331217; PubMed Central PMCID: PMC6753555.

Ketkar H, Yang L, Wormser GP, Wang P. Lack of efficacy of ivermectin for prevention of a lethal Zika virus infection in a murine system. Diagn Microbiol Infect Dis. 2019 Sep;95(1):38-40. doi: 10.1016/j.diagmicrobio.2019.03.012. Epub 2019 Mar 29. PubMed PMID: 31097261; PubMed Central PMCID: PMC6697611.

Wang P, Zhang R. Chikungunya Virus and (Re-) Emerging Alphaviruses. Viruses. 2019 Aug 24;11(9). doi: 10.3390/v11090779. PubMed PMID: 31450552; PubMed Central PMCID: PMC6784149.

Zhou B, Qi F, Wu F, Nie H, Song Y, Shao L, Han J, Wu Z, Saiyin H, Wei G, Wang P, Ni T, Qian F. Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression. MBio. 2019 Jul 30;10(4). doi: 10.1128/mBio.00937-19. PubMed PMID: 31363026; PubMed Central PMCID: PMC6667616.


Systemic TLR2 tolerance enhances central nervous system remyelination. Wasko NJ, Kulak MH, Paul D, Nicaise AM, Yeung ST, Nichols FC, Khanna KM, Crocker S, Pachter JS, Clark RB. J Neuroinflammation. 2019 Jul 27;16(1):158. doi: 10.1186/s12974-019-1540-2. PMID: 31351476

Human ES-derived MSCs correct TNF-α-mediated alterations in a blood-brain barrier model. Ge S, Jiang X, Paul D, Song L, Wang X, Pachter JS. Fluids Barriers CNS. 2019 Jul 1;16(1):18. doi: 10.1186/s12987-019-0138-5. PMID: 31256757

Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism. Jastrzebski S, Kalinowski J, Mun S, Shin B, Adapala NS, Jacome-Galarza CE, Mirza F, Aguila HL, Drissi H, Sanjay A, Canalis E, Lee SK, Lorenzo JA. J Immunol. 2019 Jul 1;203(1):105-116. doi: 10.4049/jimmunol.1801032. Epub 2019 May 20. PMID:31109956​

PI3K activation increases SDF-1 production and number of osteoclast precursors, and enhances SDF-1-mediated osteoclast precursor migration. Adapala NS, Root S, Lorenzo J, Aguila H, Sanjay A. Bone Rep. 2019 Mar 22;10:100203. doi: 10.1016/j.bonr.2019.100203. eCollection 2019 Jun. PMID:30989092​

γ-Synuclein Induces Human Cortical Astrocyte Proliferation and Subsequent BDNF Expression and Release. Winham CL, Le T, Jellison ER, Silver AC, Levesque AA, Koob AO. Neuroscience. 2019 Jul 1;410:41-54. doi:10.1016/j.neuroscience.2019.04.057. Epub 2019 May 10. PubMed PMID: 31078687.

Xu MM, Ménoret A, Nicholas SE, Günther S, Sundberg EJ, Zhou B, Rodriguez A, Murphy PA, Vella AT. Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci. Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1480-H1494. doi: 10.1152/ajpheart.00088.2019. Epub 2019 Apr 12. PubMed PMID: 30978132.

Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ. Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10488-10493. doi: 10.1073/pnas.1816911116. Epub 2019 May 8. PubMed PMID: 31068461; PubMed Central PMCID: PMC6535008.

Morales Del Valle C, Maxwell JR, Xu MM, Menoret A, Mittal P, Tsurutani N, Adler AJ, Vella AT. Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-like Mechanism. Cell Rep. 2019 Apr 30;27(5):1434-1445.e3. doi: 10.1016/j.celrep.2019.04.016. PubMed PMID: 31042471; PubMed Central PMCID: PMC6508096.

Li C, Menoret A, Farragher C, Ouyang Z, Bonin C, Holvoet P, Vella AT, Zhou B. Single cell transcriptomics based-MacSpectrum reveals novel macrophage activation signatures in diseases. JCI Insight. 2019 Apr 16;5. doi: 10.1172/jci.insight.126453. PubMed PMID: 30990466; PubMed Central PMCID: PMC6542613.

Ketkar H, Yang L, Wormser GP, Wang P. Lack of efficacy of ivermectin for prevention of a lethal Zika virus infection in a murine system. Diagn Microbiol Infect Dis. 2019 Mar 29;. doi: 10.1016/j.diagmicrobio.2019.03.012. [Epub ahead of print] PubMed PMID: 31097261.

Du S, Liu Y, Liu J, Zhao J, Champagne C, Tong L, Zhang R, Zhang F, Qin CF, Ma P, Chen CH, Liang G, Liu Q, Shi PY, Cazelles B, Wang P, Tian H, Cheng G. Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments. Nat Commun. 2019 Mar 22;10(1):1324. doi: 10.1038/s41467-019-09256-0. PubMed PMID: 30902991; PubMed Central PMCID: PMC6430813.

Cao L, Yang G, Gao S, Jing C, Montgomery RR, Yin Y, Wang P, Fikrig E, You F. HIPK2 is necessary for type I interferon-mediated antiviral immunity. Sci Signal. 2019 Mar 19;12(573). doi: 10.1126/scisignal.aau4604. PubMed PMID: 30890658.

Wu P, Yu X, Wang P, Cheng G. Arbovirus lifecycle in mosquito: acquisition, propagation and transmission. Expert Rev Mol Med. 2019 Mar 13;21:e1. doi: 10.1017/erm.2018.6. Review. PubMed PMID: 30862324.

Ketkar H, Herman D, Wang P. Genetic Determinants of the Re-Emergence of Arboviral Diseases. Viruses. 2019 Feb 12;11(2). doi: 10.3390/v11020150. Review. PubMed PMID: 30759739; PubMed Central PMCID: PMC6410223.

Wu P, Sun P, Nie K, Zhu Y, Shi M, Xiao C, Liu H, Liu Q, Zhao T, Chen X, Zhou H, Wang P, Cheng G. A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses. Cell Host Microbe. 2019 Jan 9;25(1):101-112.e5. doi: 10.1016/j.chom.2018.11.004. Epub 2018 Dec 27. PubMed PMID: 30595552.

Morales Del Valle C, Maxwell JR, Xu MM, Menoret A, Mittal P, Tsurutani N, Adler AJ, Vella AT. 2019 Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-like Mechanism. Cell Rep. Apr 30;27(5):1434-1445.e3. doi: 10.1016/j.celrep.2019.04.016. PMC6508096

Agliano F, Rathinam VA, Medvedev AE, Vanaja SK, Vella AT. 2019. Long Noncoding RNAs in Host-Pathogen Interactions. Trends Immunol. Apr 30. pii: S1471-4906(19)30075-4. PMC in Progress.

Li C, Menoret A, Farragher C, Ouyang Z, Bonin C, Holvoet P, Vella AT, Zhou B. 2019. Single cell transcriptomics based-MacSpectrum reveals novel macrophage activation signatures in diseases. Journal of Clinical Investigation-Insight. Apr 16;5. pii: 126453. PMC in progress.

Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ. 2019. Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis. Proc Natl Acad Sci U S A. May 8. pii: 201816911. Doi: PMC in progress.

Xu MM, Ménoret A, Nicholas SE, Günther S, Sundberg EJ, Zhou B, Rodriguez A, Murphy PA, Vella AT. 2019. Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci. Am J Physiol Heart Circ Physiol. Apr 12. doi: 10.1152/ajpheart.00088.2019. PMC in Progress.

Xu MM, Murphy PA, Vella AT. 2019. Activated T effector seeds: Cultivating atherosclerotic plaque through alternative activation. Am J Physiol Heart Circ Physiol. Mar 29. doi: 10.1152/ajpheart.00148.2019. PMC in Progress.

Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism. Jastrzebski S, Kalinowski J, Mun S, Shin B, Adapala NS, Jacome-Galarza CE, Mirza F, Aguila HL, Drissi H, Sanjay A, Canalis E, Lee SK, Lorenzo JA. J Immunol. 2019 Jul 1;203(1):105-116. doi: 10.4049/jimmunol.1801032. Epub 2019 May 20. PMID:31109956​



Shinde P, Bharat V, Rodriguez-Oquendo A, Zhou B, Vella AT. 2018. Understanding how combinatorial targeting of TLRs and TNFR family costimulatory members promote enhanced T cell responses. Expert Opin Biol Ther. Oct;18(10):1073-1083. PMC in progress.

Nold C, Stone J, O'Hara K, Davis P, Kiveliyk V, Blanchard V, Yellon SM, Vella AT. 2018. Block of Granulocyte-Macrophage Colony-Stimulating Factor Prevents Inflammation-Induced Preterm Birth in a Mouse Model for Parturition. Reprod Sci. 2019 Apr;26(4):551-559. PMC6421621.

Ménoret A, Buturla JA, Xu MM, Svedova J, Kumar S, Rathinam VAK, Vella AT. 2018. T cell-directed IL-17 production by lung granular γδ T cells is coordinated by a novel IL-2 and IL-1β circuit. Mucosal Immunol. 2018. Sep;11(5):1398-1407.

Ryan JM, Mittal P, Menoret A, Svedova J, Wasser JS, Adler AJ, Vella AT. 2018. A novel biologic platform elicits profound T cell costimulatory activity and antitumor immunity in mice. Cancer Immunol Immunother. 2018 Jan 11. PMC5862768

Mittal P, Abblett R, Ryan JM, Hagymasi AT, Agyekum-Yamoah A, Svedova J, Reiner SL, St Rose MC, Hanley MP, Vella AT, and Adler AJ. 2018. An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells. J Immunol. 2018 Jan 5. PMC5809300.

Li C, Xu MM, Wang K, Adler AJ, Vella AT, and Zhou B. 2018. Macrophage polarization and meta-inflammation. Transl Res. Jan;191:29-44. PMC5776711.

Benoun JM, Peres NG, Wang N, Pham OH, Rudisill VL, Fogassy ZN, Whitney PG, Fernandez-Ruiz D, Gebhardt T, Pham QM, Puddington L, Bedoui S, Strugnell RA, McSorley SJ. Optimal protection against Salmonella infection requires noncirculating memory. Proc Natl Acad Sci U S A. 115:10416-10421, 2018. PMC6187142.

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis. Banerjee I, Behl B, Mendonca M, Shrivastava G, Russo AJ, Menoret A, Ghosh A, Vella AT, Vanaja SK, Sarkar SN, Fitzgerald KA, Rathinam VAK. Immunity. 2018 Aug 14. pii: S1074-7613(18)30326-1. doi: 10.1016/j.immuni.2018.07.006. [Epub ahead of print]

An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells. Mittal P, Abblett R, Ryan JM, Hagymasi AT, Agyekum-Yamoah A, Svedova J, Reiner SL, St. Rose M-C, Hanley MP, Vella AT and Adler AJ, 2018. J. Immunol. 200:1513-1526. PMID29305435, PMC5809300.

A novel biologic platform elicits profound T cell costimulatory activity and antitumor immunity in mice. Ryan JM, Mittal P, Menoret A, Svedova J, Wasser JS, Adler AJ and Vella AT, 2018. Cancer Immunol. Immunother. 67:605-613. PMID29327109 PMC5862768.

Masters, A.R., Jellison, E.R., Puddington, L., Khanna, K.M., Haynes, L. (2018) Attrition of T cell zone fibroblastic reticular cell number and function in aged spleens. Immunohorizons 2:155-163.

Lorenzo, E.C., Bartley, J.M., Haynes, L. (2018) The impact of aging on CD4+ T cell responses to influenza infection. Biogerontology doi: 10.1007/s10522-018-9754-8. PMID:29616390.

Baldwin, S.L., Hsu, F-C, VanHoeven, N, Gage, E., Granger, B., Guderian, J.A., Larsen, S.E., Lorenzo, E.C., Haynes, L., Reed, S.G., Coler, R.N. (2018) Improved immune responses in young and aged mice with adjuvanted vaccines against H1N1 influenza infection. Front. Immunol. 9; article 295. PMID:29515589.

Parham, K., Kuchel, G.A., McElhaney, J.E., Haynes, L. (2018) A relationship between blood levels of otolin-1 and vitamin D. Otol. Neurotol. 2018 Apr;39(4):e269-e273. PMID:29533337.

Ritzel RM, Lai YJ, Crapser JD, Patel AR, Schrecengost A, Grenier JM, Mancini NS, Patrizz A, Jellison ER, Morales-Scheihing D, Venna VR, Kofler JK, Liu F, Verma R, McCullough LD. Aging alters the immunological response to ischemic stroke. Acta Neuropathol. 2018 May 11. doi: 10.1007/s00401-018-1859-2. [Epub ahead of print] PubMed PMID: 29752550; PubMed Central PMCID: PMC6015099.

Grenier JM, Yeung ST, Qiu Z, Jellison ER, Khanna KM. Combining Adoptive Cell Therapy with Cytomegalovirus-Based Vaccine Is Protective Against Solid Skin Tumors. Front Immunol. 2018 Jan 16;8:1993. doi: 10.3389/fimmu.2017.01993. eCollection 2017. PubMed PMID: 29387061; PubMed Central PMCID: PMC5775971.

Yu J, Zanotti S, Walia B, Jellison E, Sanjay A, Canalis E. The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone. Am J Pathol. 2018 Jan;188(1):149-159. doi: 10.1016/j.ajpath.2017.09.010. Epub 2017 Oct PubMed PMID: 29037852; PubMed Central PMCID: PMC5745525.

Pattabiraman G, Murphy M, Agliano F, Karlinsey K, Medvedev AE. IRAK4 activity controls immune responses to intracellular bacteria Listeria monocytogenes and Mycobacterium smegmatis. J Leukoc Biol. 2018 May 11. doi: 10.1002/JLB.2A1117-449R. [Epub ahead of print] PMID: 29749650.

Ménoret A, Buturla J.A, Xu M.M, Svedova J, Kumar S, Rathinam V.A., Vella A.T. T cell-Directed IL-17 Production by Lung Granular gd T cells is Coordinated by a Novel IL-2 and IL-1β Circuit. Mucosal Immunology. 2018 June 15. doi: 10.1038/s41385-018-0037-0. [Epub ahead of print] PMID: 29907868.

Li, C., Xu, M.M., Wang, K., Adler, A.J., Vella, A.T., and Zhou, B. Macrophage polarization and meta-inflammation. Transl Res, 2018. 191: p. 29-44. PMID: 29154757.

Ma J, Ketkar H, Geng T, Lo E, Wang L, Xi J, Sun Q, Zhu Z, Cui Y, Yang L, Wang P. Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling. Front Microbiol. 2018 Jun 25;9:1350. doi: 10.3389/fmicb.2018.01350. eCollection 2018. PubMed PMID: 29988497; PubMed Central PMCID: PMC6026624.

Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, Geng T, Mordue DG, Fujimoto T, Cheng G, You F, Lin R, Fikrig E, Wang P. UBXN3B positively regulates STING-mediated antiviral immune responses. Nature communications. 2018; 9(1):2329. PubMed [journal] PMID: 29899553, PMCID: PMC5998066.

Zou J, Chen Z, Liang C, Fu Y, Wei X, Lu J, Pan M, Guo Y, Liao X, Xie H, Wu D, Li  M, Liang L, Wang P, Wang Q. Trefoil Factor 3, Cholinesterase and Homocysteine: Potential Predictors for Parkinson's Disease Dementia and Vascular Parkinsonism Dementia in Advanced Stage. Aging and disease. 2018; 9(1):51-65. PubMed [journal] PMID: 29392081, PMCID: PMC5772858.

Sun P, Zhang S, Qin X, Chang X, Cui X, Li H, Zhang S, Gao H, Wang P, Zhang Z, Luo J, Li Z. Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1. Autophagy. 2018; 14(2):336-346. PubMed [journal] PMID: 29166823, PMCID: PMC5902195.


Addressing current challenges in cancer immunotherapy with mathematical and computational modelling. Konstorum A, Vella AT, Adler AJ, Laubenbacher RL, 2017. J. R. Soc. Interface 14:20170150. PMID28659410 PMC5493798.

Basole, C., Nguyen, R. K., Lamothe, K., Vang, A., Clark, R. B., Epstein, P. M., Baillie, G.S. and Brocke, S. (2017) PDE8 controls CD4+ T cell motility through the PDE8A-Raf-1 kinase signaling complex. Cell Sign 40, 62 PMID: 28851628 DOI: 10.1016/j.cellsig.2017.08.007.

Bartley, J.M., Zhou, X., Kuchel, G.A., Weinstock, G.M., Haynes, L. (2017) Impact of age, caloric restriction, and influenza infection on mouse gut microbiome: an exploratory study of the role of age-related microbiome changes on influenza responses. Front. Immunol. 8; article 1164. PMID:28979265.

Tabtabai, R., Haynes, L., Kuchel, G.A., Parham, K. (2017) Age-Related Increase in Blood Levels of Otolin-1 in Humans. Otol. Neurotol. 38(6):865-869. PMID:28498270.

Liu W, Ménoret A, Vella AT. Responses to LPS boost effector CD8 T-cell accumulation outside of signals 1 and 2. Cell Mol Immunol. 14(3):254-253 (2017). PMID: 26189366.

Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes. Granados HM, Draghi A 2nd, Tsurutani N, Wright K, Fernandez ML, Sylvester FA, Vella AT. PLoS One. 2017 Sep 6;12(9):e0183887. doi: 10.1371/journal.pone.0183887. eCollection 2017.

Chen, J., Pitmon, E., and Wang, K. Microbiome, inflammation and colorectal cancer. Semin Immunol, 2017. 32: p. 43-53. PMID: 28982615.

Zhu Y, Zhang R, Zhang B, Zhao T, Wang P, Liang G, Cheng G. Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system. Nature communications. 2017; 8(1):1262. PubMed [journal] PMID: 29093445,PMCID: PMC5665997.

Sze A, Olagnier D, Hadj SB, Han X, Tian XH, Xu HT, Yang L, Shi Q, Wang P, Wainberg MA, Wu JH, Lin R. Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference. Viruses. 2017; 9(10). PubMed [journal] PMID: 28972551, PMCID: PMC5691638.

Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017;546(7660):667-670. NIHMSID: NIHMS932104 PubMed [journal] PMID: 28636595, PMCID:PMC5787375.

Wang L, Yang L, Fikrig E, Wang P. An essential role of PI3K in the control of West Nile virus infection. Scientific reports. 2017; 7(1):3724. PubMed [journal] PMID: 28623344, PMCID: PMC5473900.

Liu Y, Liu J, Du S, Shan C, Nie K, Zhang R, Li XF, Zhang R, Wang T, Qin CF, Wang P, Shi PY, Cheng G. Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes. Nature. 2017; 545(7655):482-486. NIHMSID: NIHMS867392 PubMed [journal] PMID: 28514450, PMCID: PMC5885636.

Xiao X, Yang L, Pang X, Zhang R, Zhu Y, Wang P, Gao G, Cheng G. A Mesh-Duox pathway regulates homeostasis in the insect gut. Nature microbiology. 2017; 2:17020. NIHMSID: NIHMS846205 PubMed [journal] PMID: 28248301, PMCID: PMC5332881.

Hu Y, O'Boyle K, Auer J, Raju S, You F, Wang P, Fikrig E, Sutton RE. Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα. PLoS pathogens. 2017; 13(2):e1006187. PubMed [journal] PMID: 28152074, PMCID: PMC5308826.

Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F. Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. Journal of virology. 2017; 91(1). PubMed [journal] PMID: 27795421, PMCID: PMC5165211.

IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages. Li C, Ying W, Huang Z, Brehm T, Morin A, Vella AT, Zhou B. Endocrinology. 2017 Sep 1;158(9):2837-2847. doi: 10.1210/en.2017-00053. PMID: 28645193.

Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus. Ganugula R, Arora M, Jaisamut P, Wiwattanapatapee R, Jørgensen HG, Venkatpurwar VP, Zhou B, Rodrigues Hoffmann A, Basu R, Guo S, Majeti NVRK. Br J Pharmacol. 2017 Jul;174(13):2074-2084. doi: 10.1111/bph.13816. Epub 2017 May 30. PMID: 28409821, PMCID: PMC5466524.

Assessment of histone tail modifications and transcriptional profiling during colon cancer progression reveals a global decrease in H3K4me3 activity. Triff K, McLean MW, Konganti K, Pang J, Callaway E, Zhou B, Ivanov I, Chapkin RS. Biochim Biophys Acta. 2017 Jun;1863(6):1392-1402. doi: 10.1016/j.bbadis.2017.03.009. Epub 2017 Mar 16. PMID: 28315775, PMCID: PMC5474136.

Bardoxolone Methyl and a Related Triterpenoid Downregulate cMyc Expression in Leukemia Cells. Jin UH, Cheng Y, Zhou B, Safe S. Mol Pharmacol. 2017 May;91(5):438-450. doi: 10.1124/mol.116.106245. Epub 2017 Mar 8. PMID: 28275049, PMCID: PMC5399643.

Epistasis and destabilizing mutations shape gene expression variability in humans via distinct modes of action. Yang E, Wang G, Yang J, Zhou B, Tian Y, Cai JJ. Hum Mol Genet. 2016 Nov 15;25(22):4911-4919. doi: 10.1093/hmg/ddw314. PMID: 28171656.

Nutrition, microRNAs, and Human Health. Cui J, Zhou B, Ross SA, Zempleni J. Adv Nutr. 2017 Jan 17;8(1):105-112. doi: 10.3945/an.116.013839. Print 2017 Jan. Review. PMID: 28096131, PMCID: PMC5227982.

Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy. Adler AJ, Mittal P, Ryan JM, Zhou B, Wasser JS, Vella AT. Immunotherapy. 2017 Jan;9(1):71-82. doi: 10.2217/imt-2016-0097. Review. PMID: 28000531, PMCID: PMC5619014​.

Acharya N, Penukonda S, Shcheglova T, Hagymasi AT, Basu S, Srivastava PK. Endocannabinoid system acts as a regulator of immune homeostasis in the gut. Proc Natl Acad Sci USA. 2017 May 9;114(19):5005-5010. doi: 10.1073 PMID: 28439004.

Srivastava PK. George Klein  (1925-2016) A Prescient, Luminous Voice. Cancer Immunol Res. 2017 Apr;5(4):272. doi: 10.1158/2326-6066.CIR-17-0105. Review. PMID: 28373213.

Corwin WL, Ebrahimi-Nik H, Floyd SM, Tavousi P, Mandoiu II, Srivastava PK. Tumor Control Index as a new tool to assess tumor growth in experimental animals. J Immunol Methods. 2017 Jun;445:71-76. doi: 10.1016/j.jim.2017.03.013. Epub 2017 Mar 20. PMID: 28336396.

Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination. Kim S, Bielawski J, Yang H, Kong Y, Zhou B, Li J. Glia. 2018 Mar;66(3):654-669. doi: 10.1002/glia.23272. Epub 2017 Nov 29. PMID: 29193293.

Deficiency in IRAK4 activity attenuates manifestations of murine lupus. Murphy, M., Pattabiraman, G., Manavalan, T. T., and Medvedev, A. E. Eur J Immunol. 2017 47:880-891. PMCID: PMC5575829.

The R753Q polymorphism in Toll-like receptor 2 (TLR2) attenuates innate immune responses to mycobacteria and impairs MyD88 adapter recruitment to TLR2. Pattabiraman, G., Panchal, R., and Medvedev, A. E. J Biol Chem. 2017 292(25):10685-10695. PMCID: PMC5481573.

Therapeutic blockade of CD54 attenuates pulmonary barrier damage in T cell-induced acute lung injury. Svedova J, Ménoret A, Mittal P, Ryan JM, Buturla JA, Vella AT. Am J Physiol Lung Cell Mol Physiol. 2017 May 4 (2017) [Epub ahead of print]. PMID: 28473322.

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Chen S1, Lu W2, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1432-E1440. doi: 10.1073/pnas.1700232114. Epub 2017 Feb 6. PMID 28167773.

YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Taniguchi K1,2,3,4,5, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648. doi: 10.1073/pnas.1620290114. Epub 2017 Jan 27. PMID: 28130546.

Splenomegaly, myeloid lineage expansion and increased osteoclastogenesis in osteogenesis imperfecta murine. Matthews BG, Roeder E, Wang X, Aguila HL, Lee SK, Grcevic D, Kalajzic I. Bone. 2017 Oct;103:1-11. doi: 10.1016/j.bone.2017.06.004. Epub 2017 Jun 7. PMID: 28600151.

IL-15-deficient mice develop enhanced allergic responses to airway allergen exposure. Mathias CB, Schramm CM, Guernsey LA, Wu CA, Polukort SH, Rovatti J, Ser-Dolansky J, Secor E, Schneider SS, Thrall RS, Aguila HL. Clin Exp Allergy. 2017 May;47(5):639-655. doi: 10.1111/cea.12886. Epub 2017 Feb 7. PMID: 28093832.

A Refined Bead-Free Method to Identify Astrocytic Exosomes in Primary Glial Cultures and Blood Plasma. Willis CM, Ménoret A, Jellison ER, Nicaise AM, Vella AT, Crocker SJ.  Front Neurosci. 2017 Jun 15;11:335. doi: 10.3389/fnins.2017.00335. eCollection 2017. PMID: 28663721.

Multiparity improves outcomes after cerebral ischemia in female mice despite features of increased metabovascular risk. Ritzel RM, Patel AR, Spychala M, Verma R, Crapser J, Koellhoffer EC, Schrecengost A, Jellison ER, Zhu L, Venna VR, McCullough LD. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5673-E5682. doi: 10.1073/pnas.1607002114. Epub 2017 Jun 23.

Dual Immunization with SseB/Flagellin Provides Enhanced Protection against <i>Salmonella</i> Infection Mediated by Circulating Memory Cells. Lee SJ, Benoun J, Sheridan BS, Fogassy Z, Pham O, Pham QM, Puddington L, McSorley SJ. J Immunol. 2017 Aug 15;199(4):1353-1361. doi: 10.4049/jimmunol.1601357. Epub 2017 Jul 14. PMID: 28710253 [PubMed - in process] Similar articles.

CD169+ macrophages orchestrate innate immune responses by regulating bacterial localization in the spleen. Perez OA, Yeung ST, Vera-Licona P, Romagnoli PA, Samji T, Ural BB, Maher L, Tanaka M, Khanna KM. Sci Immunol. 2017 Oct 6;2(16). pii: eaah5520. doi: 10.1126/sciimmunol.aah5520. PMID: 28986418.


Vang, A. G., Basole, C., Dong, H., Nguyen, R. K., Housley, W., Guernsey, L., Adami, A. J., Thrall, R. S., Clark, R. B., Epstein, P. M. and Brocke, S. (2016) Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation. Front Pharmacol. 7, 259 PMID: 27601994 DOI: 10.3389/fphar.2016.00259.

McElhaney JE, Kuchel GA, Zhou X, Swain SL, Haynes L. (2016) T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines. Front. Immunol Feb 25;7:41. PMID:26941738.

Leifer CA, Medvedev AE. Molecular mechanisms of regulation of Toll-like receptor signaling. J Leukoc Biol. 2016 Nov;100(5):927-941. Epub 2016 Jun 24. PMID: 27343013; PMCID: PMC5069093.

Sayej WN, Ménoret A, Maharjan AS, Fernandez M, Wang Z, Balarezo F, Hyams JS, Sylvester FA, Vella AT. Characterizing the inflammatory response in esophageal mucosal biopsies in children with eosinophilic esophagitis. Clin Transl Immunology. 2016 Jul 1;5(7):e88. doi: 10.1038/cti.2016.30. eCollection 2016 Jul. PubMed PMID: 27525061; PubMed Central PMCID: PMC4973319.

Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F. TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice. Journal of immunology (Baltimore, Md. : 1950). 2016; 197(11):4425-4435. NIHMSID: NIHMS820852 PubMed [journal] PMID: 27798161, PMCID: PMC5123688.

Liu J, Liu Y, Nie K, Du S, Qiu J, Pang X, Wang P, Cheng G. Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes. Nature microbiology. 2016; 1(9):16087. NIHMSID: NIHMS784820 PubMed [journal] PMID: 27562253, PMCID: PMC5003325.

Wang K, Wang J, Sun T, Bian G, Pan W, Feng T, Wang P, Li Y, Dai J. Glycosphingolipid GM3 is Indispensable for Dengue Virus Genome Replication. International journal of biological sciences. 2016; 12(7):872-83. PubMed [journal] PMID: 27313500, PMCID: PMC4910605.

Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature microbiology. 2016; 1. NIHMSID: NIHMS781987 PubMed [journal] PMID: 27170846, PMCID: PMC4861079.

Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature microbiology. 2016; 1:16023. PubMed [journal] PMID: 27572642.

Cheng G, Liu Y, Wang P, Xiao X. Mosquito Defense Strategies against Viral Infection. Trends in parasitology. 2016; 32(3):177-186. NIHMSID: NIHMS728587 PubMed [journal] PMID: 26626596, PMCID: PMC4767563.

Wang P. Exploration of West Nile Virus Infection in Mouse Models. Methods in molecular biology (Clifton, N.J.). 2016; 1435:71-81. PubMed [journal] PMID: 27188551.

Regulatory T Cells and Cancer: A Two-Sided Story. Wang K, Vella AT. Immunol Invest. 2016 Nov;45(8):797-812. Epub 2016 Sep 7. PMID: 27603750.

Long noncoding RNAs as regulators of Toll-like receptor signaling and innate immunity. Murphy MB, Medvedev AE. J Leukoc Biol. 2016 99:839-50. PMID: 26965636.

Endotoxin Tolerance Inhibits Lyn and c-Src Phosphorylation and Association with Toll-Like Receptor 4 but Increases Expression and Activity of Protein Phosphatases. Xiong Y, Murphy M, Manavalan TT, Pattabiraman G, Qiu F, Chang HH, Ho IC, Medvedev AE. J Innate Immun. 2016;8:171-184. PMCID: PMC4801746.

Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles. Paul D, Baena V, Ge S, Jiang X Jellison ER, Kiprono T, Agalliu D5, Pachter JS. J Neuroinflammation. 2016 Nov 16;13(1):292.

Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury. Ritzel RM, Crapser J, Patel AR, Verma R1, Grenier JM, Chauhan A, Jellison ER, McCullough LD. J Immunol. 2016 Apr 15;196(8):3318-30. doi: 10.4049/jimmunol.1502021. Epub 2016 Mar 9.

Differentiation of distinct long-lived memory CD4 T cells in intestinal tissues after oral Listeria monocytogenes infection. Romagnoli PA, Fu HH, Qiu Z, Khairallah C, Pham QM, Puddington L, Khanna KM, Lefrançois L, Sheridan BS. Mucosal Immunol. 2017 Mar;10(2):520-530. doi: 10.1038/mi.2016.66. Epub 2016 Jul 27. PMID: 27461178 [PubMed - in process] Free PMC Article.
Similar articles.

Ryan JM, Wasser JS, Adler AJ, Vella AT. Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too? Expert Opin Biol Ther. 2016;16(5):655-74.Vanaja SK, Russo AJ, Behl B, Banerjee I, Yankova M, Deshmukh SD, Rathinam VAK. (2016) Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation. Cell 165, 1–14, May 19, 2016.

IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper Immune Senesence: Significance of the Stromal Microenvirnoment CD8+ T cells. Yang, Rui; Masters, April R; Fortner, Karen A; Champagne, Devin P; Yanguas-Casás, Natalia; Silberger, Daniel J; Weaver, Casey T; Haynes, Laura; Rincon, Mercedes The Journal of experimental medicine 2016 Sept.

Immune Senesence: Significance of the Stromal Microenvirnoment. Masters, April R; Haynes, Laura, Su, Dong-Ming; Palmer, Donald B Clinical and Experimental Immunology 2016 Aug.

IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans. Zhou, Xin; Hopkins, Jacob W; Wang, Chongkai; Brahmakshatriya, Vinayak; Swain, Susan L; Kuchel, George A; Haynes, Laura; McElhaney, Janet E Oncotarget 2016 June.

Vaccine efficacy and T helper cell differentiation change with aging. Lefebvre, Julie S; Lorenzo, Erica;  Masters, April R; ​Hopkins, Jacob W; Eaton, Sharron M; Smiley, Stephen T; Haynes, Laura Oncotarget 2016 June​.

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus. Champagne, Devin P; Hatle, Ketki M; Fortner, Karen A; D'Alessandro, Angelo; Thornton, Tina M; Yang, Rui; Torralba, Daniel; Tomás-Cortázar, Julen; Jun, Yong Woong; Ahn, Kyo Han; Hansen, Kirk C; Haynes, Laura; Anguita, Juan; Rincon, Mercedes Immunity 2016 May.

Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses. Lefebvre, Julie S; Masters, April R; Hopkins, Jacob W; Haynes, Laura Scientific reports 2016 Jan;625051.

Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy. Bartley, Jenna M; Pan, Sarah J; Keilich, Spencer R; Hopkins, Jacob W; Al-Naggar, Iman M; Kuche, George A; Haynes, Laura. Aging 2016 Feb.

Svedova J, Tsurutani N, Liu W, Khanna KM, Vella AT. TNF and CD28 Signaling Play Unique but Complementary Roles in the Systemic Recruitment of Innate Immune Cells after Staphylococcus aureus Enterotoxin A Inhalation. J Immunol. 2016;196(11):4510-21.

Tsurutani N, Mittal P, St. Rose MC, Ngoi SM, Svedova J, Menoret A, Treadway FB, Laubenbacher R, Suárez-Ramírez JE, Cauley LS, Adler AJ, and Vella AT. 2016. Costimulation Endows Immunotherapeutic CD8 T Cells with IL-36 Responsiveness during Aerobic Glycolysis. J. of Immunol. 196:124-134.

Shah MS, Kim E, Davison LA, Knight JM, Zoh RS, Goldsby JS, Callaway ES, Zhou B, Ivanov I, Chapkin RS (2016) Data describing the effects of dietary bioactive agents on colonic stem cell microRNA and mRNA expression. Data in Brief. 6: 398-404.

Chen X, Zhang Y, Shi, Y, Lian H, Tu H, Han S, Yin J, Peng B, Zhou B, He X, Liu W (2016) MiR-129 triggers autophagic flux by regulating a novel Notch-1/E2F7/Beclin-1 axis to impair the viability of human malignant glioma cells, Oncotarget Epub Jan 25,2016

Ying W, Tseng A, Chang RC, Wang H, Lin YL, Kanameni S, Brehm T, Morin A, Jones B, Splawn T, Crisitiello MF, Golding MC, Bazer FW, Safe S, Zhou B* (2016) miR-150 regulates obesity-associated insulin resistance by controlling B cell functions. Scientific Reports. 6: 20176 (2016).

Ménoret A, Crocker SJ, Rodriguez A, Rathinam VA, Clark RB, and Vella AT. 2016. Transition from identity to bioactivity-guided proteomics for biomarker discovery with focus on the PF2D platform. Proteomics Clin Appl. Jan;10(1):8-24.


Srivastava PK. Master of Immunology: Neoepitopes of Cancers: Looking Back, Looking Ahead. Cancer Immunol Res. 2015 Sep;3(9):969-77. Doi: 10.1158-2326-6066. CIR-15-0134. Review. PMID: 26342008.

M Clement,Jessica; Duan,Fei; Srivastava,Pramod K.* Smoking-induced immune deviation contributes to progression of bladder and other cancers. OncoImmunology, 2015, 4, 9, e1019199, Taylor & Francis.

Consensus nomenclature for CD8+ T cell phenotypes in cancer. Apetoh,Lionel; Smyth,Mark J.; Drake,Charles G.; Abastado,Jean-Pierre; Apte,Ron N.; Ayyoub,Maha; Blay,Jean-Yves; Bonneville,Marc; Butterfield,Lisa H.; Caignard,Anne; Castelli,Chiara; Cavallo,Federica; Celis,Esteban; Chen,Lieping; Colombo,Mario P.; Comin-Anduix, Bego; Coukos,Georges; Dhodapkar,Madhav V.; Dranoff,Glenn; Frazer,Ian H.; Fridman,Wolf-Hervé; Gabrilovich,Dmitry I.; Gilboa,Eli; Gnjatic,Sacha; Jäger, Dirk; Kalinski,Pawel; Kaufman,Howard L.; Kiessling,Rolf; Kirkwood,John; Knuth,Alexander; Liblau,Roland; Lotze,Michael T.; Lugli,Enrico; Marincola,Francesco; Melero,Ignacio; Melief,Cornelis J.; Mempel,Thorsten R.; Mittendorf,Elizabeth A.; Odun,Kunle; Overwijk,Willem W.; Palucka,Anna Karolina; Parmiani,Giorgio; Ribas,Antoni; Romero,Pedro; Schreiber,Robert D.; Schuler,Gerold; Srivastava,Pramod K. ;Tartour,Eric; Valmori,Danila; van,der Burg; van,der Bruggen; van,den Eynde; Wang,Ena; Zou,Weiping; Whiteside,Theresa L.; Speiser,Daniel E.; Pardoll,Drew M.; Restifo,Nicholas P.; Anderson,Ana C. OncoImmunology, 2015, 4, 4, e998538, Taylor & Francis.

Ying W, Tseng A, Chang RC, Morin A, Brehm T, Triff K, Nair V, Zhuang G, Song H, Kanameni S, Wang H, Golding MC, Bazer FW, Chapkin RS, Safe S, Zhou B* (2015) microRNA-223 is a crucial mediator for PPARγ regulated alternative macrophage activation. J Clin Invest. 125(11): 4149-4159.

Shah MS, Kim E, Davison LA, Knight JM, Zoh RS, Goldsby JS, Callaway ES, Zhou B, Ivanov I, Chapkin RS (2016) Comparative Effects of diet and carcinogen on microRNA expression in the stem cell niche of the mouse colonic crypt. Biochim Biophys Acta. (BBA) Epub Oct 19, 2015, 1862: 121-134.

Sharma N, Benechet AP, Lefrancois L, Khanna KM. 2015. CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, but the Subsequent Expansion and Trafficking Patterns of Effector T Cells after Infection Are Dysregulated in the Absence of CCR7 Migratory Cues. J. Immunol. 2015 Dec 1: 195(11):5226-36.

Ménoret A, Svedova J, Behl B, and Vella AT. 2015. Trace Levels of Staphylococcal Enterotoxin Bioactivity Are Concealed in a Mucosal Niche during Pulmonary Inflammation. PLoS One. 2015 Oct 28;10(10):e0141548.

Mittal P, St Rose MC, Wang X, Ryan JM, Wasser JS, Vella AT, Adler AJ. 2015. Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy. J of Immunol. 195:5816-26.

Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling. Murphy MB1, Xiong Y1, Pattabiraman G1, Manavalan TT1, Qiu F1, Medvedev AE2. J Leukoc Biol. 2015 Aug 26. pii: jlb.2VMA0515-229RR. [Epub ahead of print]

Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance. Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE. J Biol Chem. 2015 Jul 31;290(31):19218-32. doi: 10.1074/jbc.M115.640128. Epub 2015 Jun 16.

E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses. Medvedev AE1, Murphy M1, Zhou H2, Li X2. Immunol Rev. 2015 Jul;266(1):109-22. doi: 10.1111/imr.12298.

IL-15 receptor α signaling constrains the development of IL-17-producing γδ T cells. Colpitts SL1, Puddington L1, Lefrançois L2. Proc Natl Acad Sci USA. 2015 Aug 4;112(31):9692-7. doi: 10.1073/pnas.1420741112. Epub 2015 Jul 20.

Liu W, Menoret A, Vella AT. 2015. Responses to LPS boost effector CD8 T-cell accumulation outside of signals 1 and 2. Cell. Mol. Immunol. 2015 Jul 20. doi: 10.1038/cmi.2015.69. [Epub ahead of print]

Early Effector CD8 T Cells Display Plasticity in Populating the Short-Lived Effector and Memory-Precursor Pools Following Bacterial or Viral Infection. Plumlee CR, Obar JJ, Colpitts SL, Jellison ER, Haining WN, Lefrancois L, Khanna KM. Sci Rep. 2015 Jul 20;5:12264. doi: 10.1038/srep12264.

Label-free and depth resolved optical sectioning of iron-complex deposits in sickle cell disease splenic tissue by multiphoton microscopy. Vigil G. D., Adami A. J., Ahmed T. Khan A., Chapman S., Andemariam B., Thrall R. S., and Howard S. S. J Biomed Opt 20, 066001 (2015). PMID: 26042382.

Hill TM, Gilchuk P, Cicek BB, Osina MA, Boyd KL, Durrant DM, Metzger DW, Khanna KM, Joyce S. 2015. Border Patrol Gone Awry: Lung NKT Cell Activation by Francisella tularensis Exacerbates Tularemia-Like Disease. PLoS Pathoq. 2015 Jun 11;11(6).

Qiu Z, Huang H, Grenier JM, Perez OA, Smilowitz HM, Adler B, Khanna KM. 2015. Cytomegalovirus-Based Vaccine Expressing a Modified Tumor Antigen Induces Potent Tumor-Specific CD8(+) T-cell Response and Protects Mice from Melanoma. Cancer Immunol Res. 2015 May; 3(5): 536-46.

Long-term exposure to house dust mite leads to suppression of allergic airway disease despite persistent lung inflammation. Bracken S. J., Adami A. J., Szczepanek S. M., Ehsan M., Natarajan P., Guernsey L. A., Shahriari N., Rafti E., Matson A. P., Schramm C. M., and Thrall R. S Int Arch Allergy Immunol 166, 243–258 (2015). PMID: 25924733 PMCID: PMC4485530.

The sickle cell mouse lung: proinflammatory and primed for allergic inflammation. Andemariam B., Adami A. J., McNamara J. T., Secor E. R., Guernsey L. A., and Thrall R. S. Transl Res (2015 Mar 16). doi:10.1016/j.trsl.2015.03.001 PMID: 25843670.

Age- and location-related changes in microglial function. Ritzel RM, Patel AR, Pan S, Crapser J, Hammond M, Jellison E, McCullough LD. Neurobiol Aging. 2015 Feb 23. pii: S0197-4580(15)00116-5. doi: 10.1016/j.neurobiolaging.2015.02.016. [Epub ahead of print] PMID: 25816747

Why is coinfection with influenza virus and bacteria so difficult to control? Cauley LS and Vella AT. 2015. Discov Med. Jan;19(102):33-40.

The role of PGE2 in intestinal inflammation and tumorigenesis. Montrose DC, Nakanishi M, Murphy RC, Zarini S, McAleer JP, Vella AT, and Rosenberg DW. 2015. Prostaglandins Other Lipid Mediat. 116-117:26-36.


Therapeutic targeting of the inflammome.
Wright KT, Giardina C and Vella AT. 2014. Biochem Pharmacol. 92:184-191.

Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity.
Duan F, Duitama J, Al Seesi S, Ayres CM, Corcelli SA, Pawashe AP, Blanchard T, McMahon D, Sidney J, Sette A, Baker BM, Mandoiu II, Srivastava PK. J Exp Med. 2014 Sep 22. pii: jem.20141308.

CD11a Is Essential for Normal Development of Hematopoietic Intermediates.
Bose TO, Colpitts SL, Pham QM, Puddington L, Lefrançois L. J Immunol. 2014 Aug 8. pii: 1301820. [Epub ahead of print] PMID: 25108025.

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4.
Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM, Mani S. Immunity. 2014 Aug 21;41(2):296-310. doi: 10.1016/j.immuni.2014.06.014. Epub 2014 Jul 24.

Visualizing T Cell Migration in situ.
Benechet AP, Menon M, Khanna KM. Front Immunol. 2014 Jul 29;5:363. doi: 10.3389/fimmu.2014.00363. eCollection 2014.

A Distinctive Colonic Mucosal Cytokine Signature in New Onset, Untreated Pediatric Crohn Disease.
Sylvester FA, Draghi A, Menoret A, Fernandez ML, Wang Z, Vella AT. J Pediatr Gastroenterol Nutr. 2014 Jul 2. [Epub ahead of print]

Differential proteomics identifies PDIA3 as a novel chemoprevention target in human colon cancer cells.
Ménoret A, Drew DA, Miyamoto S, Nakanishi M, Vella AT, Rosenberg DW. Mol Carcinog. 2014 Feb;53 Suppl 1:E11-22. doi: 10.1002/mc.21986. Epub 2012 Dec 19.

Oral infection drives a distinct population of intestinal resident memory CD8+ T cells with enhanced protective function.
Sheridan BS, Pham QM, Lee YT, Cauley LS, Puddington L, and L Lefrançois. 2014. Immunity. 40: 747-757.

Baseline serum C-reactive protein and death from colorectal cancer in the NHANES III cohort.
Swede H1, Hajduk AM, Sharma J, Rawal S, Rasool H, Vella AT, Tobet RE, Stevens RG. Int J Cancer. 2014 Apr 15;134(8):1862-70. doi: 10.1002/ijc.28504. Epub 2013 Oct 31.

Pro-inflammatory role of natural killer cells in the development of allergic airway disease.
Mathias CB, Guernsey LA, Zammit D, Brammer C, Wu CA, Thrall RS, Aguila HL. Clin Exp Allergy. 2014 Apr;44(4):589-601. doi: 10.1111/cea.12271.

CCR2+ Ly6C(hi) inflammatory monocyte recruitment exacerbates acute disability following intracerebral hemorrhage.
Hammond MD, Taylor RA, Mullen MT, Ai Y, Aguila HL, Mack M, Kasner SE, McCullough LD, Sansing LH. J Neurosci. 2014 Mar 12;34(11):3901-9. doi: 10.1523/JNEUROSCI.4070-13.2014.

Pannexin1 channels act downstream of P2X 7 receptors in ATP-induced murine T-cell death.
Shoji KF, Sáez PJ, Harcha P, Aguila HL, Sáez JC. Channels (Austin). 2014 Mar 3;8(2). [Epub ahead of print]

Lung-resident memory CD8 T cells (TRM) are indispensable for optimal cross-protection against pulmonary virus infection.

Wu T, Hu Y, Lee YT, Bouchard KR, Benechet A, Khanna K, Cauley LS. J Leukoc Biol. 2014 Feb;95(2):215-24. doi: 10.1189/jlb.0313180. Epub 2013 Sep 4.

Pillars article: preferential localization of effector memory cells in nonlymphoid tissue.
Science. 2001. 291: 2413-2417.Masopust D, Vezys V, Marzo AL, Lefrançois L. J Immunol. 2014 Feb 1;192(3):845-9. PMID: 24443507.

Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation.
Paul D, Ge S, Lemire Y, Jellison ER, Serwanski DR, Ruddle NH, Pachter JS. J Neuroinflammation. 2014 Jan 21;11:10. doi: 10.1186/1742-2094-11-10.

Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
Kalantari, Parisa; DeOliveira, Rosane B; Chan, Jennie; Corbett, Yolanda; Rathinam, Vijay; Stutz, Andrea; Latz, Eicke; Gazzinelli, Ricardo T; Golenbock, Douglas T; Fitzgerald, Katherine A (2014 Jan.) Cell reports 1 (6) 196-210.

Sex and genetic factors determine osteoblastic differentiation potential of murine bone marrow stromal cells.
Zanotti S, Kalajzic I, Aguila HL, Canalis E. PLoS One. 2014 Jan 28;9(1):e86757. doi: 10.1371/journal.pone.0086757. eCollection 2014.



Striving for synergy: how to improve cancer immunotherapy through multiple agonist costimulation.
Adler AJ, Vella AT. Immunotherapy. 2013 Dec;5(12):1271-3. doi: 10.2217/imt.13.129. No abstract available.

Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac.
Vang AG, Housley W, Dong H, Basole C, Ben-Sasson SZ, Kream BE, Epstein PM, Clark RB, Brocke S. Biochem J. 2013 Dec 15;456(3):463-73. doi: 10.1042/BJ20130064.

Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells.
Dong H, Claffey KP, Brocke S, Epstein PM. Springerplus. 2013 Dec 18;2:680. doi: 10.1186/2193-1801-2-680. eCollection 2013.

Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells.
Secor ER Jr, Szczepanek SM, Castater CA, Adami AJ, Matson AP, Rafti ET, Guernsey L, Natarajan P, McNamara JT, Schramm CM, Thrall RS, Silbart LK. Evid Based Complement Alternat Med. 2013;2013:702196. doi: 10.1155/2013/702196. Epub 2013 Dec 5.

Bacterial lipodipeptide, Lipid 654, is a microbiome-associated biomarker for multiple sclerosis.
V. Farrokhi, R. Nemati, F. Nichols, X. Yao, E. Anstadt, M. Fujiwara, J.Grady, D. Wakefield, W. Castro, J. Donaldson, R. Clark. Clinical & Translational Immunology (2013) 2, e8; doi:10.1038/cti.2013.11 Published online 15 November 2013.

Immune response to mutant neo-antigens: Cancer’s lessons for aging.
Geyer RJ, Tobet R, Berlin RD, Srivastava PK. Oncoimmunology. 2013 Nov 1;2(11):e26382. Epub 2013 Oct 15.

Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system.
Shah S, Bohsali A, Ahlbrand SE, Srinivasan L, Rathinam VA, Vogel SN, Fitzgerald KA, Sutterwala FS, Briken V. J Immunol. 2013 Oct 1;191(7):3514-8. doi: 10.4049/jimmunol.1301331. Epub 2013 Aug 30.

Transcriptional regulation of IL-15 expression during hematopoiesis.
Colpitts SL, Stonier SW, Stoklasek TA, Root SH, Aguila HL, Schluns KS, Lefrançois L. J Immunol. 2013 Sep 15;191(6):3017-24. doi: 10.4049/jimmunol.1301389. Epub 2013 Aug 21.

Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.
Bossaller L, Rathinam VA, Bonegio R, Chiang PI, Busto P, Wespiser AR, Caffrey DR, Li QZ, Mohan C, Fitzgerald KA, Latz E, Marshak-Rothstein A. J Immunol. 2013 Sep 1;191(5):2104-14. doi: 10.4049/jimmunol.1300341. Epub 2013 Aug 5.

Rapid αβ T-cell responses orchestrate innate immunity in response to Staphylococcal enterotoxin A.
Kumar S, Colpitts SL, Ménoret A, Budelsky AL, Lefrancois L, Vella AT. Mucosal Immunol. 2013 Sep;6(5):1006-15. doi: 10.1038/mi.2012.138. Epub 2013 Jan 16.

Serine lipids of Porphyromonas gingivalis are human and mouse Toll-like receptor 2 ligands.
Clark RB, Cervantes JL, Maciejewski MW, Farrokhi V, Nemati R, Yao X, Anstadt E, Fujiwara M, Wright KT, Riddle C, La Vake CJ, Salazar JC, Finegold S, Nichols FC. Infect Immun. 2013 Sep;81(9):3479-89. doi: 10.1128/IAI.00803-13. Epub 2013 Jul 8.

Maternal allergy is associated with surface-bound IgE on cord blood basophils.
Matson AP, Cloutier MM, Dhongade A, Puddington L, Rafti E. Pediatr Allergy Immunol. 2013 Sep;24(6):614-21. doi: 10.1111/pai.12113.

Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer.
Medvedev AE. J Interferon Cytokine Res. 2013 Sep;33(9):467-84. doi: 10.1089/jir.2012.0140. Epub 2013 May 15. Review.

IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance.
Xiong Y, Pennini M, Vogel SN, Medvedev AE. J Leukoc Biol. 2013 Aug;94(2):291-300. doi: 10.1189/jlb.0812401. Epub 2013 May 21.

Antigen and transforming growth factor Beta receptors contribute to long term functional and phenotypic heterogeneity of memory CD8 T cells.
Hu Y, Cauley L. Front Immunol. 2013 Aug 12;4:227. doi: 10.3389/fimmu.2013.00227. eCollection 2013.

IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance.
Xiong Y, Pennini M, Vogel SN, Medvedev AE. J Leukoc Biol. 2013 Aug;94(2):291-300. doi: 10.1189/jlb.0812401. Epub 2013 May 21.

Transgenic sickle cell disease mice have high mortality and dysregulated immune responses after vaccination.
Szczepanek SM, Secor ER Jr, Bracken SJ, Guernsey L, Rafti E, Matson A, Thrall RS, Andemariam B. Pediatr Res. 2013 Aug;74(2):141-7. doi: 10.1038/pr.2013.85. Epub 2013 May 31.

Environmental Cues Dictate the Fate of Individual CD8+ T Cells Responding to Infection.
Plumlee CR, Sheridan BS, Cicek BB, Lefrançois L. Immunity. 2013 Aug 7. doi:pii: S1074-7613(13)00322-1. 10.1016/j.immuni.2013.07.014]

RKIP contributes to IFN-γ synthesis by CD8+ T cells after serial TCR triggering in systemic inflammatory response syndrome.
Wright KT, Vella AT. J Immunol. 2013 Jul 15;191(2):708-16. doi: 10.4049/jimmunol.1203486. Epub 2013 Jun 12.

γδ T cells exhibit multifunctional and protective memory in intestinal tissues.
Sheridan BS, Romagnoli PA, Pham QM, Fu HH, Alonzo F 3rd, Schubert WD, Freitag NE, Lefrançois L. Immunity. 2013 Jul 25;39(1):184-95. doi: 10.1016/j.immuni.2013.06.015.

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
Sokolovska A, Becker CE, Ip WK, Rathinam VA, Brudner M, Paquette N, Tanne A, Vanaja SK, Moore KJ, Fitzgerald KA, Lacy-Hulbert A, Stuart LM. Nat Immunol. 2013 Jun;14(6):543-53. doi: 10.1038/ni.2595. Epub 2013 May 5.

Harnessing the antigenic fingerprint of each individual cancer for immunotherapy of human cancer: genomics shows a new way and its challenges.
Srivastava PK, Duan F. Cancer Immunol Immunother. 2013 May;62(5):967-74. doi: 10.1007/s00262-013-1422-x. Epub 2013 Apr 19. Review.

Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery.
Jacome-Galarza CE, Lee SK, Lorenzo JA, Aguila HL. J Bone Miner Res. 2013 May;28(5):1203-13. doi: 10.1002/jbmr.1822.

Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.
Conlon J, Burdette DL, Sharma S, Bhat N, Thompson M, Jiang Z, Rathinam VA, Monks B, Jin T, Xiao TS, Vogel SN, Vance RE, Fitzgerald KA. J Immunol. 2013 May 15;190(10):5216-25. doi: 10.4049/jimmunol.1300097. Epub 2013 Apr 12.

CD11a regulates effector CD8 T cell differentiation and central memory development in response to infection with Listeria monocytogenes.
Bose TO, Pham QM, Jellison ER, Mouries J, Ballantyne CM, Lefrançois L. Infect Immun. 2013 Apr;81(4):1140-51. doi: 10.1128/IAI.00749-12. Epub 2013 Jan 28.

Vaccines against advanced melanoma.
Blanchard T, Srivastava PK, Duan F. Clin Dermatol. 2013 Mar-Apr;31(2):179-90. doi: 10.1016/j.clindermatol.2012.08.005. Review.

A potential new pathway for PD-L1 costimulation of the CD8-T cell response to Listeria monocytogenes infection.
Xu D, Fu HH, Obar JJ, Park JJ, Tamada K, Yagita H, Lefrançois L. PLoS One. 2013;8(2):e56539. doi: 10.1371/journal.pone.0056539. Epub 2013 Feb 11. PMID: 23409193.

Splenic priming of virus-specific CD8 T cells following influenza virus infection.
Turner DL, Bickham KL, Farber DL, Lefrançois L. J Virol. 2013 Apr;87(8):4496-506. doi: 10.1128/JVI.03413-12. Epub 2013 Feb 6. PMID: 23388712.

Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Wang D, Höing S, Patterson HC, Ahmad UM, Rathinam VA, Rajewsky K, Fitzgerald KA, Golenbock DT. J Biol Chem. 2013 Feb 15;288(7):4594-601. doi: 10.1074/jbc.M112.443077. Epub 2013 Jan 4.

CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion.
St Rose MC, Taylor RA, Bandyopadhyay S, Qui HZ, Hagymasi AT, Vella AT, Adler AJ. Immunol Cell Biol. 2013 Feb;91(2):173-83. doi: 10.1038/icb.2012.74. Epub 2013 Jan 8.