A novel strategy to dissect multifaceted macrophage function in human diseases. Karlinsey K, Qu L, Matz AJ, Zhou B.J Leukoc Biol. 2022 Dec;112(6):1535-1542. doi: 10.1002/JLB.6MR0522-685R. Epub 2022 Jun 21.PMID: 35726704

Macrophages at the Crossroad of Meta-Inflammation and Inflammaging. Obesity and Adipose Tissue Dysfunction: From Pediatrics to Adults. Menendez A, Wanczyk H, Walker J, Zhou B, Santos M, Finck C.Genes (Basel). 2022 Oct 15;13(10):1866. doi: 10.3390/genes13101866.PMID: 36292751 Free PMC article.

Extracellular RNAs from immune cells under obesity-a narrative review. Karlinsey K, Matz A, Qu L, Zhou B.ExRNA. 2022 Aug 30;4:18. doi: 10.21037/exrna-22-15.PMID: 36866026 Free PMC article.

MicroRNA-regulated B cells in obesity. Matz AJ, Qu L, Karlinsey K, Zhou B.Immunometabolism (Cobham). 2022 Aug 5;4(3):e00005. doi: 10.1097/IN9.0000000000000005. eCollection 2022 Jul.PMID: 35966635 Free PMC article.

Impact of microRNA Regulated Macrophage Actions on Adipose Tissue Function in Obesity. Matz A, Qu L, Karlinsey K, Zhou B.Cells. 2022 Apr 14;11(8):1336. doi: 10.3390/cells11081336.PMID: 35456015 Free PMC article.

Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue. Rosina M, Ceci V, Turchi R, Chuan L, Borcherding N, Sciarretta F, Sánchez-Díaz M, Tortolici F, Karlinsey K, Chiurchiù V, Fuoco C, Giwa R, Field RL, Audano M, Arena S, Palma A, Riccio F, Shamsi F, Renzone G, Verri M, Crescenzi A, Rizza S, Faienza F, Filomeni G, Kooijman S, Rufini S, de Vries AAF, Scaloni A, Mitro N, Tseng YH, Hidalgo A, Zhou B, Brestoff JR, Aquilano K, Lettieri-Barbato D.Cell Metab. 2022 Apr 5;34(4):533-548.e12. doi: 10.1016/j.cmet.2022.02.016. Epub 2022 Mar 18.PMID: 35305295 Free PMC article.

TRPM2 deficiency in mice protects against atherosclerosis by inhibiting TRPM2-CD36 inflammatory axis in macrophages. Zong P, Feng J, Yue Z, Yu AS, Vacher J, Jellison ER, Miller B, Mori Y, Yue L.Nat Cardiovasc Res. 2022 Apr;1(4):344-360. doi: 10.1038/s44161-022-00027-7. Epub 2022 Mar 28.PMID: 35445217 Free PMC article.

A method for rapid flow-cytometric isolation of endothelial nuclei and RNA from archived frozen brain tissue. Kimble AL, Silva J, Omar OM, Murphy M, Hensel JA, Nicholas SE, Jellison ER, Reese B, Murphy PA.Lab Invest. 2022 Feb;102(2):204-211. doi: 10.1038/s41374-021-00698-z. Epub 2021 Nov 13.PMID: 34775494 Free PMC article.

Targeting p21^Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Langhi Prata LGP, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M.Cell Metab. 2022 Jan 4;34(1):186. doi: 10.1016/j.cmet.2021.12.014.PMID: 34986334 Free PMC article. No abstract available.

Targeting p21^Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Prata LGPL, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M.Cell Metab. 2022 Jan 4;34(1):75-89.e8. doi: 10.1016/j.cmet.2021.11.002. Epub 2021 Nov 22.PMID: 34813734 Free PMC article.

Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer. Tesfay L, Paul BT, Hegde P, Brewer M, Habbani S, Jellison E, Moore T, Wu H, Torti SV, Torti FM.Sci Rep. 2022 Nov 19;12(1):19936. doi: 10.1038/s41598-022-24391-3. PMID: 36402786 Free PMC article.

Editorial: Horizons in aging, immune system and infectious diseases. Camell C, Haynes L.Front Aging. 2022 Sep 20;3:1034531. doi: 10.3389/fragi.2022.1034531. eCollection 2022.PMID: 36204084 Free PMC article.

Sex differences in susceptibility to influenza A virus infection depend on host genotype. Sabikunnahar B, Lahue KG, Asarian L, Fang Q, McGill MM, Haynes L, Teuscher C, Krementsov DN.PLoS One. 2022 Sep 16;17(9):e0273050. doi: 10.1371/journal.pone.0273050. eCollection 2022.PMID: 36112601 Free PMC article.

Cellular senescence is a key mediator of lung aging and susceptibility to infection. Torrance BL, Haynes L.Front Immunol. 2022 Aug 31;13:1006710. doi: 10.3389/fimmu.2022.1006710. eCollection 2022.PMID: 36119079 Free PMC article.

Editorial: Insights in aging and the immune system: 2021. Haynes L, Bharath LP.Front Aging. 2022 Aug 25;3:999299. doi: 10.3389/fragi.2022.999299. eCollection 2022.PMID: 36091470 Free PMC article.

Advanced biological age is associated with improved antibody responses in older high-dose influenza vaccine recipients over four consecutive seasons. Verschoor CP, Belsky DW, Andrew MK, Haynes L, Loeb M, Pawelec G, McElhaney JE, Kuchel GA.Immun Ageing. 2022 Aug 23;19(1):39. doi: 10.1186/s12979-022-00296-7.PMID: 35999604 Free PMC article.

Natural immunity helps overcome the age-related decline of SARS-CoV-2 vaccine immunogenicity. Verschoor CP, Haynes L.Lancet Healthy Longev. 2022 Jul;3(7):e449-e450. doi: 10.1016/S2666-7568(22)00146-5. Epub 2022 Jul 4.PMID: 35813277 Free PMC article.

Markers of systemic inflammation are positively associated with influenza vaccine antibody responses with a possible role for ILT2(+)CD57(+) NK-cells. Picard E, Armstrong S, Andrew MK, Haynes L, Loeb M, Pawelec G, Kuchel GA, McElhaney JE, Verschoor CP.Immun Ageing. 2022 May 26;19(1):26. doi: 10.1186/s12979-022-00284-x.PMID: 35619117 Free PMC article.

Editorial: Women in Aging Research. Borrás C, Haynes L, Zhang J.Front Aging. 2022 May 20;3:913488. doi: 10.3389/fragi.2022.913488. eCollection 2022.PMID: 35821849 Free PMC article.

Senescence-induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics. Lorenzo EC, Torrance BL, Keilich SR, Al-Naggar I, Harrison A, Xu M, Bartley JM, Haynes L.Aging Cell. 2022 Jan;21(1):e13525. doi: 10.1111/acel.13525. Epub 2021 Dec 27.PMID: 34962049 Free PMC article.

Heat-Shock Proteins. Hagymasi AT, Dempsey JP, Srivastava PK. Curr Protoc. 2022 Nov;2(11):e592. doi: 10.1002/cpz1.592.PMID: 36367390

Macrophages at the Crossroad of Meta-Inflammation and Inflammaging. Qu L, Matz AJ, Karlinsey K, Cao Z, Vella AT, Zhou B. Genes (Basel). 2022 Nov 9;13(11):2074. doi: 10.3390/genes13112074. PMID: 36360310 Free PMC article. Review.

Concentration of vaginal and systemic cytokines obtained early in pregnancy and their impact on preterm birth. Nold C, Barros A, Rogi C, Sulzer C, Quental A, Reid S, Serdah M, Vella AT. J Matern Fetal Neonatal Med. 2022 Dec;35(25):9271-9276. doi: 10.1080/14767058.2022.2026916. Epub 2022 Jan 10. PMID: 35012420

Optimal CD8⁺ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape. Karginov TA, Ménoret A, Vella AT. Nat Commun. 2022 Jun 20;13(1):3540. doi: 10.1038/s41467-022-31228-0. PMID: 35725727 Free PMC article.

Splice factor polypyrimidine tract-binding protein 1 (Ptbp1) primes endothelial inflammation in atherogenic disturbed flow conditions. Hensel JA, Nicholas SE, Kimble AL, Nagpal AS, Omar OMF, Tyburski JD, Jellison ER, Ménoret A, Ozawa M, Rodriguez-Oquendo A, Vella AT, Murphy PA. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2122227119. doi: 10.1073/pnas.2122227119. Epub 2022 Jul 18. PMID: 35858420 Free PMC article.

Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling. Agliano F, Karginov TA, Ménoret A, Provatas A, Vella AT. iScience. 2022 Feb 15;25(3):103932. doi: 10.1016/j.isci.2022.103932. eCollection 2022 Mar 18. PMID: 35243268 Free PMC article.

Evaluating the glycolytic potential of mouse costimulated effector CD8⁺ T cells ex vivo. Agliano F, Ménoret A, Vella AT. STAR Protoc. 2022 Jun 3;3(2):101441. doi: 10.1016/j.xpro.2022.101441. eCollection 2022 Jun 17. PMID: 35677608 Free PMC article. For complete details on the use and execution of this protocol, please refer to Agliano et al. (2022)

Nexinhib20 Inhibits Neutrophil Adhesion and β₂ Integrin Activation by Antagonizing Rac-1-Guanosine 5'-Triphosphate Interaction. Liu W, Cronin CG, Cao Z, Wang C, Ruan J, Pulikkot S, Hall A, Sun H, Groisman A, Chen Y, Vella AT, Hu L, Liang BT, Fan Z. J Immunol. 2022 Oct 15;209(8):1574-1585. doi: 10.4049/jimmunol.2101112. Epub 2022 Sep 7.PMID: 36165184

Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study. Chen Y, Fu W, Zheng Y, Yang J, Liu Y, Qi Z, Wu M, Fan Z, Yin K, Chen Y, Gao W, Ding Z, Dong J, Li Q, Zhang S, Hu L. Eur Heart J. 2022 Oct 7;43(37):3556-3574. doi: 10.1093/eurheartj/ehac034. PMID: 35165707 Free PMC article.

Roles of mitochondria in neutrophils. Cao Z, Zhao M, Sun H, Hu L, Chen Y, Fan Z.Front Immunol. 2022 Aug 19;13:934444. doi: 10.3389/fimmu.2022.934444. eCollection 2022.PMID: 36081497 Free PMC article. Review.

Editorial: Adhesion molecules and autoimmune diseases.   Fan Z, Sun H.Front Immunol. 2022 Aug 18;13:1009708. doi: 10.3389/fimmu.2022.1009708. eCollection 2022. PMID: 36059500 Free PMC article. 

Integrin Regulators in Neutrophils. Pulikkot S, Hu L, Chen Y, Sun H, Fan Z.Cells. 2022 Jun 25;11(13):2025. doi: 10.3390/cells11132025. PMID: 35805108 Free PMC article. 

Direct Binding of Rap1 to Talin1 and to MRL Proteins Promotes Integrin Activation in CD4⁺ T Cells. Lagarrigue F, Tan B, Du Q, Fan Z, Lopez-Ramirez MA, Gingras AR, Wang H, Qi W, Sun H.J Immunol. 2022 Mar 15;208(6):1378-1388. doi:10.4049/jimmunol.2100843.  Epub 2022 Feb 23.PMID: 35197328 Free PMC article.

Bone Marrow Transplantation Rescues Monocyte Recruitment Defect and Improves Cystic Fibrosis in Mice. Fan Z, Pitmon E, Wen L, Miller J, Ehinger E, Herro R, Liu W, Chen J, Mikulski Z, Conrad DJ, Marki A, Orecchioni M, Kumari P, Zhu YP, Marcovecchio PM, Hedrick CC, Hodges CA, Rathinam VA, Wang K, Ley K. J Immunol. 2022 Feb 1;208(3):745-752. doi: 10.4049/jimmunol.1901171. Epub 2022 Jan 14.PMID: 35031577 Free PMC article.

Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production. Orecchioni M, Kobiyama K, Winkels H, Ghosheh Y, McArdle S, Mikulski Z, Kiosses WB, Fan Z, Wen L, Jung Y, Roy P, Ali AJ, Miyamoto Y, Mangan M, Makings J, Wang Z, Denn A, Vallejo J, Owens M, Durant CP, Braumann S, Mader N, Li L, Matsunami H, Eckmann L, Latz E, Wang Z, Hazen SL, Ley K. Science. 2022 Jan 14;375(6577):214-221. doi: 10.1126/science.abg3067. Epub 2022 Jan 13.PMID: 35025664 Free PMC article.

Tlr2/4-Mediated Hyperinflammation Promotes Cherubism-Like Jawbone Expansion in Sh3bp2 (P416R) Knockin Mice. Fujii Y, Monteiro N, Sah SK, Javaheri H, Ueki Y, Fan Z, Reichenberger EJ, Chen IP.JBMR Plus. 2021 Oct 30;6(1):e10562. doi: 10.1002/jbm4.10562. eCollection 2022 Jan.PMID: 35079675 Free PMC article.

CTLs Get SMAD When Pathogens Tell Them Where to Go. Suarez-Ramirez JE, Cauley LS, and Chandiran K.J Immunol. 2022 Sep 15;209(6):1025-1032. doi: 10.4049/jimmunol.2200345. PMID: 36130123 

UBXN3B Controls Immunopathogenesis of Arthritogenic Alphaviruses by Maintaining Hematopoietic Homeostasis. Geng T, Yang D, Lin T, Cahoon JG, Wang P.  mBio. 2022 Dec 20;13(6):e0268722. doi: 10.1128/mbio.02687-22. Epub 2022 Nov 15. PubMed PMID: 36377866; PubMed Central PMCID: PMC9765034.

Neighboring mutation-mediated enhancement of dengue virus infectivity and spread.  Chen L, Zhang X, Guo X, Peng W, Zhu Y, Wang Z, Yu X, Shi H, Li Y, Zhang L, Wang L, Wang P, Cheng G.  EMBO Rep. 2022 Nov 7;23(11):e55671. doi: 10.15252/embr.202255671. Epub 2022 Oct 5. PubMed PMID: 36197120; PubMed Central PMCID: PMC9638853.

A Retinol Derivative Inhibits SARS-CoV-2 Infection by Interrupting Spike-Mediated Cellular Entry. Tong L, Wang L, Liao S, Xiao X, Qu J, Wu C, Zhu Y, Tai W, Huang Y, Wang P, Li L, Zhang R, Xiang Y, Cheng G.  mBio. 2022 Aug 30;13(4):e0148522. doi: 10.1128/mbio.01485-22. Epub 2022 Jul 13. PubMed PMID: 35862773; PubMed Central PMCID: PMC9426596.

Diabetes and COVID-19, a link revealed.  Xiao X, Tong L, Bogan JS, Wang P, Cheng G.  Life Med. 2022 Aug;1(2):64-66. doi: 10.1093/lifemedi/lnac011. eCollection 2022 Aug. PubMed PMID: 36820103; PubMed Central PMCID: PMC9936808.

A volatile from the skin microbiota of flavivirus-infected hosts promotes mosquito attractiveness.  Zhang H, Zhu Y, Liu Z, Peng Y, Peng W, Tong L, Wang J, Liu Q, Wang P, Cheng G. Cell. 2022 Jun 28;. doi: 10.1016/j.cell.2022.05.016. [Epub ahead of print] PubMed PMID: 35777355.

Lipases secreted by a gut bacterium inhibit arbovirus transmission in mosquitoes. Yu X, Tong L, Zhang L, Yang Y, Xiao X, Zhu Y, Wang P, Cheng G.  PLoS Pathog. 2022 Jun;18(6):e1010552. doi: 10.1371/journal.ppat.1010552. eCollection 2022 Jun. PubMed PMID: 35679229; PubMed Central PMCID: PMC9182268.

A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2. Tong L, Xiao X, Li M, Fang S, Ma E, Yu X, Zhu Y, Wu C, Tian D, Yang F, Sun J, Qu J, Zheng N, Liao S, Tai W, Feng S, Zhang L, Li Y, Wang L, Han X, Sun S, Yang L, Zhong H, Zhao J, Liu W, Liu X, Wang P, Li L, Zhao G, Zhang R, Cheng G.  Nat Metab. 2022 May;4(5):547-558. doi: 10.1038/s42255-022-00567-z. Epub 2022 May 9. PubMed PMID: 35534727.

Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation. Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z.  J Leukoc Biol. 2022 Apr;111(4):771-791. doi: 10.1002/JLB.1A0720-471R. Epub 2021 Sep 8. PubMed PMID: 34494308; PubMed Central PMCID: PMC8901796.

Intrinsic cardiac adrenergic cells contribute to LPS-induced myocardial dysfunction.  Yang D, Dai X, Xing Y, Tang X, Yang G, Harrison AG, Cahoon J, Li H, Lv X, Yu X, Wang P, Wang H. Commun Biol. 2022 Jan 25;5(1):96. doi: 10.1038/s42003-022-03007-6. PubMed PMID: 35079095; PubMed Central PMCID: PMC8789803.

Cancer Immunology and Immunotherapy: From Defining Basic Immunology to Leading the Fight Against Cancer. Adler AJ. Immunol Invest. 2022 Nov;51:2128. doi: 10.1080/08820139.2022.2144347. PMID: 36343204

Shigella "Osp"pression of innate immunity. Wright SS, Vanaja SK*. Cell. 2022 Jun 23;185(13):2205-2207. doi: 10.1016/j.cell.2022.05.027. Preview. PubMed PMID: 35750030.

Citrobacter rodentium(ϕStx2dact), a murine infection model for enterohemorrhagic Escherichia coli. Thorpe CM, Pulsifer AR, Osburne MS, Vanaja SK, Leong JM. Current Opinion in Microbiology. 2022 Feb;65183-190. doi: 10.1016/j.mib.2021.11.013. Review. PubMed PMID: 34929548; PubMed Central PMCID: PMC9069446.

Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors.  Xiong X, Tian S, Yang P, Lebreton F, Bao H, Sheng K, Yin L, Chen P, Zhang J, Qi W, Ruan J, Wu H, Chen H, Breault DT, Wu H, Earl AM, Gilmore MS, Abraham J, Dong M. Cell. 2022 Mar 31;185(7):1157-1171.e22. doi: 10.1016/j.cell.2022.02.002. Epub 2022 Mar 7.  PMID: 35259335; PMCID: PMC8978092.

Increased Levels of Circulating Cell-Free mtDNA in the Plasma of Subjects With Late-Life Depression and Frailty: A Preliminary Study.  Ampo E, Mendes-Silva AP, Goncalves V, Bartley JM, Kuchel GA, Diniz BS. Am J Geriatr Psychiatry. 2022 Mar;30(3):332-337. doi: 10.1016/j.jagp.2021.07.012. Epub 2021 Jul 29. PubMed PMID: 34412934; PubMed Central PMCID: PMC8799751.

SMAD4 and TGFβ are architects of inverse genetic programs during fate-determination of antiviral CTLs. Chandiran K, Suarez-Ramirez JE, Hu Y, Jellison ER, Ugur Z, Low JS, McDonald B, M Kaech SM, Cauley LS.Elife. 2022 Aug 9;11:e76457. doi: 10.7554/eLife.76457. Online ahead of print.PMID: 35942952

A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients. Li C, Phoon YP, Karlinsey K, Tian YF, Thapaliya S, Thongkum A, Qu L, Matz AJ, Cameron M, Cameron C, Menoret A, Funchain P, Song JM, Diaz-Montero CM, Tamilselvan B, Golden JB, Cartwright M, Rodriguez A, Bonin C, Vella A, Zhou B, Gastman BR.J Exp Med. 2022 Jan 3;219(1):e20202084. doi: 10.1084/jem.20202084. Epub 2021 Nov 22. PMID: 34807232

AtheroSpectrum Reveals Novel Macrophage Foam Cell Gene Signatures Associated With Atherosclerotic Cardiovascular Disease Risk.Li C, Qu L, Matz AJ, Murphy PA, Liu Y, Manichaikul AW, Aguiar D, Rich SS, Herrington DM, Vu D, Johnson WC, Rotter JI, Post WS, Vella AT, Rodriguez-Oquendo A, Zhou B. Circulation. 2022 Jan 18;145(3):206-218. doi: 10.1161/CIRCULATIONAHA.121.054285. Epub 2021 Dec 16. PMID: 34913723

An unbiased approach to defining bona fide cancer neoepitopes that elicit immune-mediated cancer rejection. Brennick CA, George MM, Moussa MM, Hagymasi AT, Seesi SA, Shcheglova TV, Englander RP, Keller GL, Balsbaugh JL, Baker BM, Schietinger A, Mandoiu II, Srivastava PK.Brennick CA, et al. J Clin Invest. 2021 Feb 1;131(3):e142823. doi: 10.1172/JCI142823.J Clin Invest. 2021. PMID: 33320837

Reversion analysis reveals the in vivo immunogenicity of a poorly MHC I-binding cancer neoepitope. Ebrahimi-Nik H, Moussa M, Englander RP, Singhaviranon S, Michaux J, Pak H, Miyadera H, Corwin WL, Keller GLJ, Hagymasi AT, Shcheglova TV, Coukos G, Baker BM, Mandoiu II, Bassani-Sternberg M, Srivastava PK.Ebrahimi-Nik H, et al. Nat Commun. 2021 Nov 5;12(1):6423. doi: 10.1038/s41467-021-26646-5.Nat Commun. 2021. PMID: 34741035

Lymphocyte Activation Gene-3 Regulates Dendritic Cell Metabolic Programing and T Cell Priming Function.  Garcia Cruz D, Giri RR, Gamiotea Turro D, Balsbaugh JL, Adler AJ, Rodriguez A. J Immunol. 2021 Nov 1;207(9):2374-2384. doi: 10.4049/jimmunol.2001188. Epub 2021 Sep 29. PMID: 34588222

Senescence-induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics. Lorenzo EC, Torrance BL, Keilich SR, Al-Naggar I, Harrison A, Xu M, Bartley JM, Haynes L. Aging Cell. 2022 Jan;21(1):e13525. doi: 10.1111/acel.13525. Epub 2021 Dec 27.PMID: 34962049

Targeting Aging: Lessons Learned From Immunometabolism and Cellular Senescence. Martin DE, Torrance BL, Haynes L, Bartley JM. Front Immunol. 2021 Jul 21;12:714742. doi: 10.3389/fimmu.2021.714742. eCollection 2021.PMID: 34367184

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo. Wang B, Wang L, Gasek NS, Zhou Y, Kim T, Guo C, Jellison ER, Haynes L, Yadav S, Tchkonia T, Kuchel GA, Kirkland JL, Xu M.Nat Aging. 2021 Oct;1(10):962-973. doi: 10.1038/s43587-021-00107-6. Epub 2021 Oct 7.PMID: 35024619

Moving geroscience from the bench to clinical care and health policy. Sierra F, Caspi A, Fortinsky RH, Haynes L, Lithgow GJ, Moffitt TE, Olshansky SJ, Perry D, Verdin E, Kuchel GA.J Am Geriatr Soc. 2021 Sep;69(9):2455-2463. doi: 10.1111/jgs.17301. Epub 2021 Jun 19.PMID: 34145908

Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation. Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z. J Leukoc Biol. 2021 Sep 8. doi: 10.1002/JLB.1A0720-471R. Online ahead of print .PMID: 34494308

Tlr2/4-Mediated Hyperinflammation Promotes Cherubism-Like Jawbone Expansion in Sh3bp2 (P416R) Knockin Mice.Fujii Y, Monteiro N, Sah SK, Javaheri H, Ueki Y, Fan Z, Reichenberger EJ, Chen IP.JBMR Plus. 2021 Oct 30;6(1):e10562. doi: 10.1002/jbm4.10562. eCollection 2022 Jan.PMID: 35079675

Peripheral blood RNAseq links neutrophilic inflammation to clinical glioma metastasis. Wu Y, Fan Z. BMC Med. 2021 Dec 3;19(1):296. doi: 10.1186/s12916-021-02174-3.PMID: 34856994

Mechanistic Insights into Gasdermin Pore Formation and Regulation in Pyroptosis. Wang C, Ruan J. J Mol Biol. 2021 Oct 8:167297. doi: 10.1016/j.jmb.2021.167297. Online ahead of print.PMID: 34627790

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo. Wang B, Wang L, Gasek NS, Zhou Y, Kim T, Guo C, Jellison ER, Haynes L, Yadav S, Tchkonia T, Kuchel GA, Kirkland JL, Xu M.Nat Aging. 2021 Oct;1(10):962-973. doi: 10.1038/s43587-021-00107-6. Epub 2021 Oct 7.PMID: 35024619

Targeting p21^Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Langhi Prata LGP, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Cell Metab. 2022 Jan 4;34(1):186. doi: 10.1016/j.cmet.2021.12.014. PMID: 34986334

A method for rapid flow-cytometric isolation of endothelial nuclei and RNA from archived frozen brain tissue. Kimble AL, Silva J, Omar OM, Murphy M, Hensel JA, Nicholas SE, Jellison ER, Reese B, Murphy PA.Lab Invest. 2022 Feb;102(2):204-211. doi: 10.1038/s41374-021-00698-z. Epub 2021 Nov 13.PMID: 34775494

Identification of splice regulators of fibronectin-EIIIA and EIIIB by direct measurement of exon usage in a flow-cytometry based CRISPR screen. Hensel JA, Heineman BD, Kimble AL, Jellison ER, Reese B, Murphy PA.Sci Rep. 2021 Oct 6;11(1):19835. doi: 10.1038/s41598-021-99079-1.PMID: 34615942

Appearance of claudin-5⁺ leukocyte subtypes in the blood and CNS during progression of EAE. Krajewski D, Paul D, Ge S, Jellison E, Pachter JS. J Neuroinflammation. 2021 Dec 21;18(1):296. doi: 10.1186/s12974-021-02328-3.PMID: 34933669

Mitofusin-2 regulates leukocyte adhesion and β2 integrin activation. Liu W, Hsu AY, Wang Y, Lin T, Sun H, Pachter JS, Groisman A, Imperioli M, Yungher FW, Hu L, Wang P, Deng Q, Fan Z. J Leukoc Biol. 2021 Sep 8. doi: 10.1002/JLB.1A0720-471R. Online ahead of print.PMID: 34494308

A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host.Yu X, Shan C, Zhu Y, Ma E, Wang J, Wang P, Shi PY, Cheng G.Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2113015118. doi: 10.1073/pnas.2113015118.PMID: 34620704

β2 integrin activation and signal transduction in leukocyte recruitment. Sun H, Hu L, Fan Z. Am J Physiol Cell Physiol. 2021 Aug 1;321(2):C308-C316. doi: 10.1152/ajpcell.00560.2020. Epub 2021 Jun 16.PMID: 34133240 Review.

Editorial: Imaging and Mechanism of Leukocyte Recruitment and Function in Inflammation and Infections. Sun H, Huo Y, Fan Z. Front Cell Dev Biol. 2021 May 7;9:690003. doi: 10.3389/fcell.2021.690003. eCollection 2021.PMID: 34026766 Free PMC article. No abstract available.

The Activation and Regulation of β2 Integrins in Phagocytes and Phagocytosis. Sun H, Zhi K, Hu L, Fan Z. Front Immunol. 2021 Mar 31;12:633639. doi: 10.3389/fimmu.2021.633639. eCollection 2021.PMID: 33868253 Free PMC article. Review.

Visualization of integrin molecules by fluorescence imaging and techniques. Cai C, Sun H, Hu L, Fan Z. Biocell. 2021;45(2):229-257. doi: 10.32604/biocell.2021.014338. Epub 2021 Feb 19.PMID: 34219865 Free PMC article.

Distinct integrin activation pathways for effector and regulatory T cell trafficking and function. Sun H, Lagarrigue F, Wang H, Fan Z, Lopez-Ramirez MA, Chang JT, Ginsberg MH.J Exp Med. 2021 Feb 1;218(2):e20201524. doi: 10.1084/jem.20201524.PMID: 33104169 Free PMC article.

Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis. Marki A, Buscher K, Lorenzini C, Meyer M, Saigusa R, Fan Z, Yeh YT, Hartmann N, Dan JM, Kiosses WB, Golden GJ, Ganesan R, Winkels H, Orecchioni M, McArdle S, Mikulski Z, Altman Y, Bui J, Kronenberg M, Chien S, Esko JD, Nizet V, Smalley D, Roth J, Ley K.J Exp Med. 2021 Mar 1;218(3):e20200551. doi: 10.1084/jem.20200551.PMID: 33275138 Free PMC article.

Kindlin-3 recruitment to the plasma membrane precedes high-affinity β2-integrin and neutrophil arrest from rolling. Wen L, Marki A, Roy P, McArdle S, Sun H, Fan Z, Gingras AR, Ginsberg MH, Ley K.Blood. 2021 Jan 7;137(1):29-38. doi: 10.1182/blood.2019003446.PMID: 32777822 Free PMC article.

Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense. Kumari P, Russo AJ, Wright SS, Muthupalani S, Rathinam VA. Cell Rep. 2021 Apr 20;35(3):109012. doi: 10.1016/j.celrep.2021.109012. PMID: 33882312

Editorial overview: Innate immunity, from host defense and beyond. Rothlin CV, Rathinam VA, Ghosh S. Curr Opin Immunol. 2021 Feb;68:iii-v. doi: 10.1016/j.coi.2021.02.005. PMID: 33648718 No abstract available.

Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin. Russo AJ, Vasudevan SO, Méndez-Huergo SP, Kumari P, Menoret A, Duduskar S, Wang C, Pérez Sáez JM, Fettis MM, Li C, Liu R, Wanchoo A, Chandiran K, Ruan J, Vanaja SK, Bauer M, Sponholz C, Hudalla GA, Vella AT, Zhou B, Deshmukh SD, Rabinovich GA, Rathinam VA. Nat Immunol. 2021 Feb;22(2):154-165. doi: 10.1038/s41590-020-00844-7. Epub 2021 Jan 4. PMID: 33398185

UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling. Ketkar H, Harrison AG, Graziano VR, Geng T, Yang L, Vella AT, Wang P.J Immunol. 2021 Jun 1;206(11):2682-2691. doi: 10.4049/jimmunol.1901337. Epub 2021 May 21.PMID: 34021047

Glucose-mediated proliferation of a gut commensal bacterium promotes Plasmodium infection by increasing mosquito midgut pH. Wang M, An Y, Gao L, Dong S, Zhou X, Feng Y, Wang P, Dimopoulos G, Tang H, Wang J.Cell Rep. 2021 Apr 20;35(3):108992. doi: 10.1016/j.celrep.2021.108992.PMID: 33882310

Interaction of Viruses with the Insect Intestine. Ma E, Zhu Y, Liu Z, Wei T, Wang P, Cheng G.Annu Rev Virol. 2021 Sep 29;8(1):115-131. doi: 10.1146/annurev-virology-091919-100543. Epub 2021 Apr 19.PMID: 33872516

Differential roles of RIG-I-like receptors in SARS-CoV-2 infection. Yang D, Geng T, Harrison AG, Wang P.bioRxiv. 2021 Feb 11:2021.02.10.430677. doi: 10.1101/2021.02.10.430677. Preprint.PMID: 33594370 

A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system. Yang D, Lin T, Li C, Harrison AG, Geng T, Wang P.iScience. 2021 Jun 1;24(6):102678. doi: 10.1016/j.isci.2021.102678. eCollection 2021 Jun 25.PMID: 34169243 

UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling. Ketkar H, Harrison AG, Graziano VR, Geng T, Yang L, Vella AT, Wang P.J Immunol. 2021 Jun 1;206(11):2682-2691. doi: 10.4049/jimmunol.1901337. Epub 2021 May 21.PMID: 34021047

Granulocyte-macrophage colony-stimulating factor initiates amniotic membrane rupture and preterm birth in a mouse model. Nold C, Esteves K, Jensen T, Vella AT. Am J Reprod Immunol. 2021 Aug;86(2):e13424. doi: 10.1111/aji.13424. Epub 2021 Apr 6.PMID: 33772943

Verschoor, C.P., Haynes, L., Pawlelec, G., Loeb, M., Andrew, M.K., Kuchel, G.A., McElhaney, J.E. (2021) Key determinants of cell-mediated immune responses: a randomized trial of high dose versus standard dose split-virus influenza vaccine in older adults. Front. Aging doi: 10.3389/fragi.2021.649110.

Sierra, F., Caspi, A., Fortinsky, R.H., Haynes, L., Lithgow, G.L., Moffit, T.E., Olshansky, S.J., Perry, D., Verdin, E.E., Kuchel, G.A. (2021) Moving geroscience from the bench to clinical care and health policy. JAGS in press.

Verschoor C.P., Andrew M.K., Loeb M., Pawelec G., Haynes L., Kuchel G.A., McElhaney J.E. (2021) Antibody and cell-mediated immune responses are correlates of protection against influenza infection in vaccinated older adults. Vaccines (Basel) 9(1):25. doi: 10.3390/vaccines9010025.

Biosafety during a pandemic: shared resource laboratories rise to the challenge. Aspland AM, Douagi I, Filby A, Jellison ER, Martinez L, Shinko D, Smith AL, Tang VA, Thornton S.Cytometry A. 2021 Jan;99(1):68-80. doi: 10.1002/cyto.a.24280. Epub 2021 Jan 4.PMID: 33289290 Free PMC article. Review.

An unbiased approach to defining bona fide cancer neoepitopes that elicit immune-mediated cancer rejection.Brennick CA, George MM, Moussa MM, Hagymasi AT, Seesi SA, Shcheglova TV, Englander RP, Keller GL, Balsbaugh JL, Baker BM, Schietinger A, Mandoiu II, Srivastava PK.J Clin Invest. 2021 Feb 1;131(3):e142823. doi: 10.1172/JCI142823.PMID: 33320837

A critical role for STING signaling in limiting pathogenesis of Chikungunya virus. Geng, Tingting; Lin, Tao; Yang, Duomeng; Harrison, Andrew G; Vella, Anthony T; Fikrig, Erol; Wang, Penghua. The Journal of infectious diseases. 08 November 2020.

CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses. Lin, Tao; Geng, Tingting; Harrison, Andrew G; Yang, Duomeng; Vella, Anthony T; Fikrig, Erol; Wang, Penghua. Viruses. 2020 Nov;12(11).

Mechanisms of SARS-CoV-2 Transmission and Pathogenesis. Harrison AG, Lin T, Wang P. Trends Immunol. 2020 Oct.

Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice.Yang, Long; Geng, Tingting; Yang, Guang; Ma, Jinzhu; Wang, Leilei; Ketkar, Harshada; Yang, Duomeng; Lin, Tao; Hwang, Jesse; Zhu, Shu; Wang, Yanlin; Dai, Jianfeng; You, Fuping; Cheng, Gong; Vella, Anthony T; Flavell, Richard A; Fikrig, Erol; Wang, Penghua. Communications biology. 2020 Oct;3(1):556.

Bonney, E.A., Krebs, K., Kim, J., Prakash, K., Torrance, B.L., Haynes, L., Rincon, M. (2020) Protective intranasal immunization against influenza virus in infant mice is dependent on IL-6. Front. Immunol. October 2020 | Volume 11 | Article 568978.

Cookenham, T., Lanzer, K.G., Gage, E., Lorenzo, E.C., Carter, D., Coler, R.N., Baldwin, S.L., Haynes, L., Reily, W.W., Blackman, M.A. (2020) Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity. Vaccine 38(33):5256-5267.

Russo AJ, Vasudevan SO, Méndez-Huergo SP, Kumari P, Menoret A, Duduskar S, Wang C, Pérez Sáez JM, Fettis MM, Li C, Liu R, Wanchoo A, Chandiran K, Ruan J, Vanaja SK, Bauer M, Sponholz C, Hudalla GA, Vella AT, Zhou B, Deshmukh SD, Rabinovich GA, Rathinam VA. 2021. Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin. Nat Immunol. 2021 Jan 4. doi: 10.1038/s41590-020-00844-7. Epub ahead of print. PMID: 33398185.

Lin T, Geng T, Harrison AG, Yang D, Vella AT, Fikrig E, Wang P. 2020. CXCL10 Signaling Contributes to the Pathogenesis of Arthritogenic Alphaviruses. Viruses. Nov 2;12(11):E1252. doi: 10.3390/v12111252.

Mengsteab PY, Otsuka T, McClinton A, Shemshaki NS, Shah S, Kan HM, Obopilwe E, Vella AT, Nair LS, Laurencin CT. 2020. Mechanically superior matrices promote osteointegration and regeneration of anterior cruciate ligament tissue in rabbits. Proc Natl Acad Sci U S A. Nov 3:202012347. doi: 10.1073/pnas.2012347117. Online ahead of print.

Yang L, Geng T, Yang G, Ma J, Wang L, Ketkar H, Yang D, Lin T, Hwang J, Zhu S, Wang Y, Dai J, You F, Cheng G, Vella AT, Flavell RA, Fikrig E, Wang P. 2020. Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice. Commun Biol. 2020 Oct 8;3(1):556. doi: 10.1038/s42003-020-01285-6. PMC7545163

Biosafety during a pandemic: shared resource laboratories rise to the challenge. Aspland AM, Douagi I, Filby A, Jellison ER, Martinez L, Shinko D, Smith AL, Tang VA, Thornton S.  Cytometry A. 2020 Dec 2:10.1002/cyto.a.24280. doi: 10.1002/cyto.a.24280. Epub ahead of print. PMID: 33289290; PMCID: PMC7753791. https://onlinelibrary.wiley.com/doi/10.1002/cyto.a.24280

A Cytometrist's Guide to Coordinating and Performing Effective COVID-19 Research. Chattopadhyay PK, Filby A, Jellison ER, Ferrari G, Green C, Cherian S, Irish J, Litwin V; other members of the ISAC COVID-19 Work Group. Cytometry A. 2020 Aug 16:10.1002/cyto.a.24210. doi: 10.1002/cyto.a.24210. Epub ahead of print. PMID: 32881296; PMCID: PMC7461086. https://onlinelibrary.wiley.com/doi/10.1002/cyto.a.24210

Procedures for Flow Cytometry-Based Sorting of Unfixed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infected Cells and Other Infectious Agents. Reifel KM, Swan BK, Jellison ER, Ambrozak D, Baijer J, Nguyen R, Monard S, Lyon G, Fontes B, Perfetto SP. Cytometry A. 2020 Jul;97(7):674-680. doi: 10.1002/cyto.a.24040. Epub 2020 Jun 3. PMID: 32488957; PMCID: PMC7300747. https://onlinelibrary.wiley.com/doi/full/10.1002/cyto.a.24040

Chimera RNA interference knockdown of γ-synuclein in human cortical astrocytes results in mitotic catastrophe. Le T, Winham CL, Andromidas F, Silver AC, Jellison ER, Levesque AA, Koob AO. Neural Regen Res. 2020 Oct;15(10):1894-1902. doi: 10.4103/1673-5374.280329. PMID: 32246638; PMCID: PMC7513975. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7513975/

Reinhold and S. Brocke, The differential roles of zinc in immune responses and their potential implications in antiviral immunity against SARS-CoV-2, Clinical Nutrition, https://pubmed.ncbi.nlm.nih.gov/33349484/

Fan Z, Mikulski Z, McArdle S, Sundd P, Ley K. Super-STORM: Molecular Modeling to Achieve Single-molecule Localization with STORM Microscopy. STARprotocol. 2020; 1(1): 100012.

Sun H*, Fan Z*, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K. A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling. Journal of Leukocyte Biology. 2020; 107(2): 175-183. (*co-first authors)

Cai C, Sun H, Hu L, Fan Z. Visualization of integrin molecules by fluorescence imaging and techniques. Biocell. 2020, in press.

Sun H, Lagarrigue F, Wang H, Fan Z, Lopez-Ramirez MA, Chang JT, Ginsberg MH. Distinct integrin activation pathways for effector and regulatory T cell trafficking and function. Journal of Experimental Medicine. 2021; 218 (2): e20201524.

Marki A, Buscher K, Lorenzini C, Meyer M, Saigusa R, Fan Z, Yeh YT, Hartmann N, Dan JM, Kiosses WB, Golden GJ, Ganesan R, Winkels H, Orecchioni M, McArdle S, Mikulski Z, Altman Y, Bui J, Kronenberg M, Chien S, Esko JD, Nizet V, Smalley D, Roth J, Ley K. Elongated neutrophil-derived structures are blood-borne microparticles formed by rolling neutrophils during sepsis. Journal of Experimental Medicine. 2021 Mar 1;218(3):e20200551.

Wen L, Marki A, Roy P, McArdle S, Sun H, Fan Z, Gingras A, Ginsberg M, Ley K. Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling. Blood. 2020, blood.2019003446. doi: 10.1182/blood.2019003446. Online ahead of print

Zhang S, Liu Y, Wang X, Yang L, Li H, Wang Y, Liu M, Zhao X, Xie Y, Yang Y, Zhang S, Fan Z, Dong J, Yuan Z, Ding Z, Zhang Y, Hu L. SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19. Journal of Hematology & Oncology. 2020; 13: 120.

Wen L, Fan Z, Mikulski Z, Ley, K. Imaging of the immune system - towards a subcellular and molecular understanding. Journal of Cell Science. 2020; 133, jcs234922.

Aspland AM, Douagi I, Filby A, Jellison ER, Martinez L, Shinko D, Smith AL, Tang VA, Thornton S. Rising to the challenge: Overcoming Shared Resource Laboratory biosafety challenges during a pandemic. Cytometry A. 2020 Dec 2. doi: 10.1002/cyto.a.24280. Online ahead of print. PMID: 33289290

https://www.frontiersin.org/articles/10.3389/fimmu.2020.575967/full. Mucosal CD8 T cell responses are shaped by Batf3-DC after foodborne Listeria monoctyogenes infection, by Jessica Nancy Imperato, Daqi Xu, Pablo A. Romagnoli, Zhijuan Qiu, Pedro Perez, Camille Khairallah, Quynh-Mai Pham, Anna Andrusaite, Alberto Bravo-Blas, Simon W.F. Milling, Leo Lefrancois, Kamal Khanna, Lynn Puddington, Brian S. Sheridan, published in Frontiers in Immunology, section Mucosal Immunity.

A Cytometrist's Guide to Coordinating and Performing Effective COVID-19 Research. Chattopadhyay PK, Filby A, Jellison ER, Ferrari G, Green C, Cherian S, Irish J, Litwin V; other members of the ISAC COVID‐19 Work Group. Cytometry A. 2020 Aug 16. doi: 10.1002/cyto.a.24210. Online ahead of print. PMID: 32881296 Free PMC article. https://pubmed.ncbi.nlm.nih.gov/32881296/

Adler AJ, Mittal P, Hagymasi AT, Menoret A, Shen C, Agliano F, Wright KT, Grady JJ, Kuo CL, Ballesteros E, Claffey KP, Vella AT, 2020. GRK2 enforces androgen receptor dependence in the prostate and prostate tumors. Oncogene 39:2424-2436. PMC7072002

Functional polymeric nerve guidance conduits and drug delivery strategies for peripheral nerve repair and regeneration. Manoukian OS, Baker JT, Rudraiah S, Arul MR, Vella AT, Domb AJ, Kumbar SG.J Control Release. 2020 Jan 10;317:78-95. doi: 10.1016/j.jconrel.2019.11.021. Epub 2019 Nov 19.PMID: 31756394 Review.

GRK2 enforces androgen receptor dependence in the prostate and prostate tumors. Adler AJ, Mittal P, Hagymasi AT, Menoret A, Shen C, Agliano F, Wright KT, Grady JJ, Kuo CL, Ballesteros E, Claffey KP, Vella AT.Oncogene. 2020 Mar;39(11):2424-2436. doi: 10.1038/s41388-020-1159-x. Epub 2020 Jan 20.PMID: 31959897

Evaluation of a bioengineered ACL matrix's osteointegration with BMP-2 supplementation. Mengsteab PY, Conroy P, Badon M, Otsuka T, Kan HM, Vella AT, Nair LS, Laurencin CT.PLoS One. 2020 Jan 7;15(1):e0227181. doi: 10.1371/journal.pone.0227181. eCollection 2020.PMID: 31910231

Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age. Willis CM, Nicaise AM, Bongarzone ER, Givogri M, Reiter CR, Heintz O, Jellison ER, Sutter PA, TeHennepe G, Ananda G, Vella AT, Crocker SJ.Sci Rep. 2020 Jan 21;10(1):828. doi: 10.1038/s41598-020-57663-x.PMID: 31964978

Replens prevents preterm birth by decreasing type I interferon strengthening the cervical epithelial barrier. Nold C, Jensen T, O'Hara K, Stone J, Yellon SM, Vella AT.Am J Reprod Immunol. 2020 Jan;83(1):e13192. doi: 10.1111/aji.13192. Epub 2019 Oct 14.PMID: 31549469

Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration. Ferrigno B, Bordett R, Duraisamy N, Moskow J, Arul MR, Rudraiah S, Nukavarapu SP, Vella AT, Kumbar SG.Bioact Mater. 2020 Apr 7;5(3):468-485. doi: 10.1016/j.bioactmat.2020.03.010. eCollection 2020 Sep.PMID: 32280836

Long Non-coding RNA LincRNA-EPS Inhibits Host Defense Against Listeria monocytogenes Infection. Agliano F, Fitzgerald KA, Vella AT, Rathinam VA, Medvedev AE.Front Cell Infect Microbiol. 2020 Jan 22;9:481. doi: 10.3389/fcimb.2019.00481. eCollection 2019.PMID: 32039056

Cookenham, T., Lanzer, K.G., Gage, E., Lorenzo, E.C., Carter, D., Coler, R.N., Baldwin, S.L., Haynes, L., Reily, W.W., Blackman, M.A. (2020) Vaccination of aged mice with adjuvanted recombinant influenza nucleoprotein enhances protective immunity. Vaccine in press.

Keilich, S.R., Lorenzo, E.C., Torrance, B.L., Harrison, A.G., Bartley, J.M., Haynes, L. (2020) Vaccination mitigates influenza-induced muscular declines in aged mice. Geroscience May 29. doi: 10.1007/s11357-020-00206-z.

Frasca, D., Blomberg, B.B., Garcia, D., Keilich, S.R., Haynes, L. (2020) Age-related factors that affect B cell responses to vaccination in mice and humans. Imm. Rev. Jun 2. doi: 10.1111/imr.12864.

Straight, C.R., Ringham, O.R., Bartley, J.M., Keilich, S.R., Kuchel, G.A., Haynes, L., Miller, M.S. (2020) Influenza infection has fiber type-specific effects on cellular and molecular skeletal muscle function in aged mice. J. Gerontol. A Biol. Sci. Med. Sci. in press.

McElhaney, J.E., Verschoor, C.P., Andrew, M.K., Haynes, L., Kuchel, G.A., Pawelec, G. (2020) The immune response to influenza in older humans: beyond immune senescence. Immun. Ageing 7;17:10.

McElhaney, J.E., Andrew, M.K., Haynes, L., Kuchel, G.A., McNeil, S.A., Pawelec, G. (2020) Influenza Vaccination: Accelerating the Process for New Vaccine Development in Older Adults. Interdiscip. Top. Gerontol. Geriatr. 43:98-112.

Loeb, N., Andrew, M.K., Loeb, M., Kuchel, G.A., Haynes, L., McElhaney, J.E., Verschoor, C.P. (2020) Frailty is associated with increased hemagglutination-inhibition titres in a 4-year randomized trial comparing standard and high dose influenza vaccination. Open Forum Infect Dis ofaa148, https://doi.org/10.1093/ofid/ofaa148

Wen L, Fan Z, Mikulski Z, Ley, K. Imaging of the immune system - towards a subcellular and molecular understanding. Journal of Cell Science. 2020; 133, jcs234922.

Fan Z, Mikulski Z, McArdle S, Sundd P, Ley K. Super-STORM: Molecular Modeling to Achieve Single-molecule Localization with STORM Microscopy. STARprotocol. 2020; 100012.

Procedures for Flow Cytometry-Based Sorting of Unfixed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infected Cells and Other Infectious Agents. Reifel KM, Swan BK, Jellison ER, Ambrozak D, Baijer J, Nguyen R, Monard S, Lyon G, Fontes B, Perfetto SP. Cytometry A. 2020 Jun 3. doi: 10.1002/cyto.a.24040. Online ahead of print. PMID: 32488957 https://pubmed.ncbi.nlm.nih.gov/32488957/

Chimera RNA interference knockdown of γ-synuclein in human cortical astrocytes results in mitotic catastrophe. Le T, Winham CL, Andromidas F, Silver AC, Jellison ER, Levesque AA, Koob AO. Neural Regen Res. 2020 Oct;15(10):1894-1902. doi: 10.4103/1673-5374.280329. PMID: 32246638 https://pubmed.ncbi.nlm.nih.gov/32246638/

Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age. Willis CM, Nicaise AM, Bongarzone ER, Givogri M, Reiter CR, Heintz O, Jellison ER, Sutter PA, TeHennepe G, Ananda G, Vella AT, Crocker SJ. Sci Rep. 2020 Jan 21;10(1):828. doi: 10.1038/s41598-020-57663-x. PMID: 31964978 https://pubmed.ncbi.nlm.nih.gov/31964978/

Nichols FC, Clark RB, Liu Y, Provatas AA, Dietz CJ, Zhu Q, Wang YH, Smith MB. Glycine Lipids of Porphyromonas gingivalis Are Agonists for Toll-Like Receptor 2. Infect Immun. 2020 Mar 23;88(4). doi: 10.1128/IAI.00877-19. Print 2020 Mar 23. PubMed PMID: 31932327; PubMed Central PMCID: PMC7093120.

Wasko NJ, Nichols F, Clark RB. Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis. Autoimmun Rev. 2020 Jan;19(1):102430. doi: 10.1016/j.autrev.2019.102430. Epub 2019 Nov 15. Review. PubMed PMID: 31734400.​

Ge, S., Jiang, X., Paul, D., Song, L., Wang, X. and Pachter, J.S. Human ES-derived MSCs correct TNF-a-mediated alterations in a blood-brain barrier model. Fluids Barriers CNS. In press.

Morales Del Valle C, Maxwell JR, Xu MM, Menoret A, Mittal P, Tsurutani N, Adler AJ and Vella AT, 2019. Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-Like Mechanism. Cell Rep. 27:1434-1445.

Ebrahimi-Nik H, Michaux J, Corwin WL, Keller G, Shcheglova, Pak H, Coukos G, Baker B, Mandoiu II Bassani-Sternberg M, Srivastava PK. Mass spectrometry driven exploration reveals nuances of neoepitope-driven tumor rejection. JCI Insight. 2019 June 20, https://doi.org/10.1172/jci.insight.129152

Karandikar SH, Zhang C, Meiyappan A, Barman I, Finck C, Srivastava PK, Pandey R. Reagent-Free and Rapid Assessment of T Cell Activation State Using Diffraction Phase Microscopy and Deep Learning. Anal Chem. 2019 Mar 5;91(5):3405-3411. doi: 10.1021/acs.analchem.8b04895. Epub 2019 Feb 22. PMCID:PMC6423970

Karandikar SH, Sidney J, Sette A, Selby MJ, Korman AJ, Srivastava PK. Identification of epitopes in ovalbumin provide insights for cancer neoepitopes. JCI Insight. 2019 Apr 18; 4(8): e127882 doi: 10.1172/jci.insight.127882 PMID: 30869653

Sun H*, Fan Z*, Gingras AR, Lopez-Ramirez MA, Ginsberg MH, Ley K. A flexible kink in the transmembrane domain impairs β2 integrin extension and cell arrest from rolling. Journal of Leukocyte Biology. 2019; Epub ahead of print. (*co-first authors

Fan Z, Mikulski Z, McArdle S, Sundd P, Ley K. Super-STORM: using molecular structure modeling to sharp images of single molecule localization microscopy. STARprotocol. 2019; in press.

Konstorum A, Vella AT, Adler AJ and Laubenbacher RC. A mathematical model of combined CD8 T cell costimulation by 4-1BB (CD137) and OX40 (CD134) receptors, 2019. Sci Rep. 9:10862. PMC6659676  (https://www.ncbi.nlm.nih.gov/pubmed/31350431)

Suarez-Ramirez, J.E. Chandiran, K. Brocke, S. and Cauley. L.S.*. (2019). Immunity to respiratory infection is reinforced through early proliferation of lymphoid T_RM cells and prompt arrival of effector CD8 T cells in the lungs. Frontiers in Immunology 10:1370. PMID: 31258537​

Systemic TLR2 tolerance enhances central nervous system remyelination. Wasko NJ, Kulak MH, Paul D, Nicaise AM, Yeung ST, Nichols FC, Khanna KM, Crocker S, Pachter JS, Clark RB. J Neuroinflammation.  2019 Jul 27;16(1):158. doi: 10.1186/s12974-019-1540-2. PMID:31351476

Multiple Sclerosis, the Microbiome, TLR2, and the Hygiene Hypothesis. Nicholas J Wasko, Frank Nichols, Robert B Clark. Autoimmunity Reviews. 2019 Nov 15 [Online ahead of print]  (Publish date: Jan. 2020).  PMID: 31734400 DOI: 10.1016/j.autrev.2019.102430

Yu X, Zhu Y, Xiao X, Wang P, Cheng G. Progress towards Understanding the Mosquito-Borne Virus Life Cycle. Trends Parasitol. 2019 Dec;35(12):1009-1017. doi: 10.1016/j.pt.2019.09.006. Epub 2019 Oct 25. Review. PubMed PMID: 31669148.

Wang P, Li S, Zhao Y, Zhang B, Li Y, Liu S, Du H, Cao L, Ou M, Ye X, Li P, Gao X, Wang P, Jing C, Shao F, Yang G, You F. The GRA15 protein from Toxoplasma gondii enhances host defense responses by activating the interferon stimulator STING. J Biol Chem. 2019 Nov 8;294(45):16494-16508. doi: 10.1074/jbc.RA119.009172. Epub 2019 Aug 15. PubMed PMID: 31416833; PubMed Central PMCID: PMC6851339.

Zhu Y, Tong L, Nie K, Wiwatanaratanabutr I, Sun P, Li Q, Yu X, Wu P, Wu T, Yu C, Liu Q, Bian Z, Wang P, Cheng G. Host serum iron modulates dengue virus acquisition by mosquitoes. Nat Microbiol. 2019 Sep 16;. doi: 10.1038/s41564-019-0555-x. [Epub ahead of print] PubMed PMID: 31527795.

Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F. The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host Microbe. 2019 Sep 11;26(3):369-384.e8. doi: 10.1016/j.chom.2019.08.010. PubMed PMID: 31513772.

Liu Y, Liu H, Xie Y, Zhang B, Zou X, Ou M, Ye X, Han Y, Wu J, Chen X, Dong S, Zhu K, Guo C, Wang P, Zhai H, Jing C, Yang G. Identification of genetic variations in Necator americanus through resequencing by whole genome amplification. J Int Med Res. 2019 Sep;47(9):4353-4364. doi: 10.1177/0300060519862069. Epub 2019 Jul 23. PubMed PMID: 31331217; PubMed Central PMCID: PMC6753555.

Ketkar H, Yang L, Wormser GP, Wang P. Lack of efficacy of ivermectin for prevention of a lethal Zika virus infection in a murine system. Diagn Microbiol Infect Dis. 2019 Sep;95(1):38-40. doi: 10.1016/j.diagmicrobio.2019.03.012. Epub 2019 Mar 29. PubMed PMID: 31097261; PubMed Central PMCID: PMC6697611.

Wang P, Zhang R. Chikungunya Virus and (Re-) Emerging Alphaviruses. Viruses. 2019 Aug 24;11(9). doi: 10.3390/v11090779. PubMed PMID: 31450552; PubMed Central PMCID: PMC6784149.

Zhou B, Qi F, Wu F, Nie H, Song Y, Shao L, Han J, Wu Z, Saiyin H, Wei G, Wang P, Ni T, Qian F. Endogenous Retrovirus-Derived Long Noncoding RNA Enhances Innate Immune Responses via Derepressing RELA Expression. MBio. 2019 Jul 30;10(4). doi: 10.1128/mBio.00937-19. PubMed PMID: 31363026; PubMed Central PMCID: PMC6667616.

Systemic TLR2 tolerance enhances central nervous system remyelination. Wasko NJ, Kulak MH, Paul D, Nicaise AM, Yeung ST, Nichols FC, Khanna KM, Crocker S, Pachter JS, Clark RB. J Neuroinflammation. 2019 Jul 27;16(1):158. doi: 10.1186/s12974-019-1540-2. PMID: 31351476

Human ES-derived MSCs correct TNF-α-mediated alterations in a blood-brain barrier model. Ge S, Jiang X, Paul D, Song L, Wang X, Pachter JS. Fluids Barriers CNS. 2019 Jul 1;16(1):18. doi: 10.1186/s12987-019-0138-5. PMID: 31256757

Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism. Jastrzebski S, Kalinowski J, Mun S, Shin B, Adapala NS, Jacome-Galarza CE, Mirza F, Aguila HL, Drissi H, Sanjay A, Canalis E, Lee SK, Lorenzo JA. J Immunol. 2019 Jul 1;203(1):105-116. doi: 10.4049/jimmunol.1801032. Epub 2019 May 20. PMID:31109956​

PI3K activation increases SDF-1 production and number of osteoclast precursors, and enhances SDF-1-mediated osteoclast precursor migration. Adapala NS, Root S, Lorenzo J, Aguila H, Sanjay A. Bone Rep. 2019 Mar 22;10:100203. doi: 10.1016/j.bonr.2019.100203. eCollection 2019 Jun. PMID:30989092​

γ-Synuclein Induces Human Cortical Astrocyte Proliferation and Subsequent BDNF Expression and Release. Winham CL, Le T, Jellison ER, Silver AC, Levesque AA, Koob AO. Neuroscience. 2019 Jul 1;410:41-54. doi:10.1016/j.neuroscience.2019.04.057. Epub 2019 May 10. PubMed PMID: 31078687. https://www.ncbi.nlm.nih.gov/pubmed/31078687

Xu MM, Ménoret A, Nicholas SE, Günther S, Sundberg EJ, Zhou B, Rodriguez A, Murphy PA, Vella AT. Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci. Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1480-H1494. doi: 10.1152/ajpheart.00088.2019. Epub 2019 Apr 12. PubMed PMID: 30978132.

Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ. Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10488-10493. doi: 10.1073/pnas.1816911116. Epub 2019 May 8. PubMed PMID: 31068461; PubMed Central PMCID: PMC6535008.

Morales Del Valle C, Maxwell JR, Xu MM, Menoret A, Mittal P, Tsurutani N, Adler AJ, Vella AT. Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-like Mechanism. Cell Rep. 2019 Apr 30;27(5):1434-1445.e3. doi: 10.1016/j.celrep.2019.04.016. PubMed PMID: 31042471; PubMed Central PMCID: PMC6508096.

Li C, Menoret A, Farragher C, Ouyang Z, Bonin C, Holvoet P, Vella AT, Zhou B. Single cell transcriptomics based-MacSpectrum reveals novel macrophage activation signatures in diseases. JCI Insight. 2019 Apr 16;5. doi: 10.1172/jci.insight.126453. PubMed PMID: 30990466; PubMed Central PMCID: PMC6542613.

Ketkar H, Yang L, Wormser GP, Wang P. Lack of efficacy of ivermectin for prevention of a lethal Zika virus infection in a murine system. Diagn Microbiol Infect Dis. 2019 Mar 29;. doi: 10.1016/j.diagmicrobio.2019.03.012. [Epub ahead of print] PubMed PMID: 31097261.

Du S, Liu Y, Liu J, Zhao J, Champagne C, Tong L, Zhang R, Zhang F, Qin CF, Ma P, Chen CH, Liang G, Liu Q, Shi PY, Cazelles B, Wang P, Tian H, Cheng G. Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments. Nat Commun. 2019 Mar 22;10(1):1324. doi: 10.1038/s41467-019-09256-0. PubMed PMID: 30902991; PubMed Central PMCID: PMC6430813.

Cao L, Yang G, Gao S, Jing C, Montgomery RR, Yin Y, Wang P, Fikrig E, You F. HIPK2 is necessary for type I interferon-mediated antiviral immunity. Sci Signal. 2019 Mar 19;12(573). doi: 10.1126/scisignal.aau4604. PubMed PMID: 30890658.

Wu P, Yu X, Wang P, Cheng G. Arbovirus lifecycle in mosquito: acquisition, propagation and transmission. Expert Rev Mol Med. 2019 Mar 13;21:e1. doi: 10.1017/erm.2018.6. Review. PubMed PMID: 30862324.

Ketkar H, Herman D, Wang P. Genetic Determinants of the Re-Emergence of Arboviral Diseases. Viruses. 2019 Feb 12;11(2). doi: 10.3390/v11020150. Review. PubMed PMID: 30759739; PubMed Central PMCID: PMC6410223.

Wu P, Sun P, Nie K, Zhu Y, Shi M, Xiao C, Liu H, Liu Q, Zhao T, Chen X, Zhou H, Wang P, Cheng G. A Gut Commensal Bacterium Promotes Mosquito Permissiveness to Arboviruses. Cell Host Microbe. 2019 Jan 9;25(1):101-112.e5. doi: 10.1016/j.chom.2018.11.004. Epub 2018 Dec 27. PubMed PMID: 30595552.

Morales Del Valle C, Maxwell JR, Xu MM, Menoret A, Mittal P, Tsurutani N, Adler AJ, Vella AT. 2019 Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-like Mechanism. Cell Rep. Apr 30;27(5):1434-1445.e3. doi: 10.1016/j.celrep.2019.04.016. PMC6508096

Agliano F, Rathinam VA, Medvedev AE, Vanaja SK, Vella AT. 2019. Long Noncoding RNAs in Host-Pathogen Interactions. Trends Immunol. Apr 30. pii: S1471-4906(19)30075-4. PMC in Progress.

Li C, Menoret A, Farragher C, Ouyang Z, Bonin C, Holvoet P, Vella AT, Zhou B. 2019. Single cell transcriptomics based-MacSpectrum reveals novel macrophage activation signatures in diseases. Journal of Clinical Investigation-Insight. Apr 16;5. pii: 126453. PMC in progress.

Willis CM, Nicaise AM, Menoret A, Ryu JK, Mendiola AS, Jellison ER, Givogri MI, Han DK, Bongarzone ER, Akassoglou K, Vella AT, Crocker SJ. 2019. Extracellular vesicle fibrinogen induces encephalitogenic CD8+ T cells in a mouse model of multiple sclerosis. Proc Natl Acad Sci U S A. May 8. pii: 201816911. Doi: PMC in progress.

Xu MM, Ménoret A, Nicholas SE, Günther S, Sundberg EJ, Zhou B, Rodriguez A, Murphy PA, Vella AT. 2019. Direct CD137 costimulation of CD8 T cells promotes retention and innate-like function within nascent atherogenic foci. Am J Physiol Heart Circ Physiol. Apr 12. doi: 10.1152/ajpheart.00088.2019. PMC in Progress.

Xu MM, Murphy PA, Vella AT. 2019. Activated T effector seeds: Cultivating atherosclerotic plaque through alternative activation. Am J Physiol Heart Circ Physiol. Mar 29. doi: 10.1152/ajpheart.00148.2019. PMC in Progress.

Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism. Jastrzebski S, Kalinowski J, Mun S, Shin B, Adapala NS, Jacome-Galarza CE, Mirza F, Aguila HL, Drissi H, Sanjay A, Canalis E, Lee SK, Lorenzo JA. J Immunol. 2019 Jul 1;203(1):105-116. doi: 10.4049/jimmunol.1801032. Epub 2019 May 20. PMID:31109956​

Shinde P, Bharat V, Rodriguez-Oquendo A, Zhou B, Vella AT. 2018. Understanding how combinatorial targeting of TLRs and TNFR family costimulatory members promote enhanced T cell responses. Expert Opin Biol Ther. Oct;18(10):1073-1083. PMC in progress.

Nold C, Stone J, O'Hara K, Davis P, Kiveliyk V, Blanchard V, Yellon SM, Vella AT. 2018. Block of Granulocyte-Macrophage Colony-Stimulating Factor Prevents Inflammation-Induced Preterm Birth in a Mouse Model for Parturition. Reprod Sci. 2019 Apr;26(4):551-559. PMC6421621.

Ménoret A, Buturla JA, Xu MM, Svedova J, Kumar S, Rathinam VAK, Vella AT. 2018. T cell-directed IL-17 production by lung granular γδ T cells is coordinated by a novel IL-2 and IL-1β circuit. Mucosal Immunol. 2018. Sep;11(5):1398-1407.

Ryan JM, Mittal P, Menoret A, Svedova J, Wasser JS, Adler AJ, Vella AT. 2018. A novel biologic platform elicits profound T cell costimulatory activity and antitumor immunity in mice. Cancer Immunol Immunother. 2018 Jan 11. PMC5862768

Mittal P, Abblett R, Ryan JM, Hagymasi AT, Agyekum-Yamoah A, Svedova J, Reiner SL, St Rose MC, Hanley MP, Vella AT, and Adler AJ. 2018. An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells. J Immunol. 2018 Jan 5. PMC5809300.

Li C, Xu MM, Wang K, Adler AJ, Vella AT, and Zhou B. 2018. Macrophage polarization and meta-inflammation. Transl Res. Jan;191:29-44. PMC5776711.

Benoun JM, Peres NG, Wang N, Pham OH, Rudisill VL, Fogassy ZN, Whitney PG, Fernandez-Ruiz D, Gebhardt T, Pham QM, Puddington L, Bedoui S, Strugnell RA, McSorley SJ. Optimal protection against Salmonella infection requires noncirculating memory. Proc Natl Acad Sci U S A. 115:10416-10421, 2018. PMC6187142.

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis. Banerjee I, Behl B, Mendonca M, Shrivastava G, Russo AJ, Menoret A, Ghosh A, Vella AT, Vanaja SK, Sarkar SN, Fitzgerald KA, Rathinam VAK. Immunity. 2018 Aug 14. pii: S1074-7613(18)30326-1. doi: 10.1016/j.immuni.2018.07.006. [Epub ahead of print]

An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells. Mittal P, Abblett R, Ryan JM, Hagymasi AT, Agyekum-Yamoah A, Svedova J, Reiner SL, St. Rose M-C, Hanley MP, Vella AT and Adler AJ, 2018. J. Immunol. 200:1513-1526. PMID29305435, PMC5809300.

A novel biologic platform elicits profound T cell costimulatory activity and antitumor immunity in mice. Ryan JM, Mittal P, Menoret A, Svedova J, Wasser JS, Adler AJ and Vella AT, 2018. Cancer Immunol. Immunother. 67:605-613. PMID29327109 PMC5862768.

Masters, A.R., Jellison, E.R., Puddington, L., Khanna, K.M., Haynes, L. (2018) Attrition of T cell zone fibroblastic reticular cell number and function in aged spleens. Immunohorizons 2:155-163.

Lorenzo, E.C., Bartley, J.M., Haynes, L. (2018) The impact of aging on CD4+ T cell responses to influenza infection. Biogerontology doi: 10.1007/s10522-018-9754-8. PMID:29616390.

Baldwin, S.L., Hsu, F-C, VanHoeven, N, Gage, E., Granger, B., Guderian, J.A., Larsen, S.E., Lorenzo, E.C., Haynes, L., Reed, S.G., Coler, R.N. (2018) Improved immune responses in young and aged mice with adjuvanted vaccines against H1N1 influenza infection. Front. Immunol. 9; article 295. PMID:29515589.

Parham, K., Kuchel, G.A., McElhaney, J.E., Haynes, L. (2018) A relationship between blood levels of otolin-1 and vitamin D. Otol. Neurotol. 2018 Apr;39(4):e269-e273. PMID:29533337.

Ritzel RM, Lai YJ, Crapser JD, Patel AR, Schrecengost A, Grenier JM, Mancini NS, Patrizz A, Jellison ER, Morales-Scheihing D, Venna VR, Kofler JK, Liu F, Verma R, McCullough LD. Aging alters the immunological response to ischemic stroke. Acta Neuropathol. 2018 May 11. doi: 10.1007/s00401-018-1859-2. [Epub ahead of print] PubMed PMID: 29752550; PubMed Central PMCID: PMC6015099.

Grenier JM, Yeung ST, Qiu Z, Jellison ER, Khanna KM. Combining Adoptive Cell Therapy with Cytomegalovirus-Based Vaccine Is Protective Against Solid Skin Tumors. Front Immunol. 2018 Jan 16;8:1993. doi: 10.3389/fimmu.2017.01993. eCollection 2017. PubMed PMID: 29387061; PubMed Central PMCID: PMC5775971.

Yu J, Zanotti S, Walia B, Jellison E, Sanjay A, Canalis E. The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone. Am J Pathol. 2018 Jan;188(1):149-159. doi: 10.1016/j.ajpath.2017.09.010. Epub 2017 Oct PubMed PMID: 29037852; PubMed Central PMCID: PMC5745525.

Pattabiraman G, Murphy M, Agliano F, Karlinsey K, Medvedev AE. IRAK4 activity controls immune responses to intracellular bacteria Listeria monocytogenes and Mycobacterium smegmatis. J Leukoc Biol. 2018 May 11. doi: 10.1002/JLB.2A1117-449R. [Epub ahead of print] PMID: 29749650.

Ménoret A, Buturla J.A, Xu M.M, Svedova J, Kumar S, Rathinam V.A., Vella A.T. T cell-Directed IL-17 Production by Lung Granular gd T cells is Coordinated by a Novel IL-2 and IL-1β Circuit. Mucosal Immunology. 2018 June 15. doi: 10.1038/s41385-018-0037-0. [Epub ahead of print] PMID: 29907868.

Li, C., Xu, M.M., Wang, K., Adler, A.J., Vella, A.T., and Zhou, B. Macrophage polarization and meta-inflammation. Transl Res, 2018. 191: p. 29-44. PMID: 29154757.

Ma J, Ketkar H, Geng T, Lo E, Wang L, Xi J, Sun Q, Zhu Z, Cui Y, Yang L, Wang P. Zika Virus Non-structural Protein 4A Blocks the RLR-MAVS Signaling. Front Microbiol. 2018 Jun 25;9:1350. doi: 10.3389/fmicb.2018.01350. eCollection 2018. PubMed PMID: 29988497; PubMed Central PMCID: PMC6026624.

Yang L, Wang L, Ketkar H, Ma J, Yang G, Cui S, Geng T, Mordue DG, Fujimoto T, Cheng G, You F, Lin R, Fikrig E, Wang P. UBXN3B positively regulates STING-mediated antiviral immune responses. Nature communications. 2018; 9(1):2329. PubMed [journal] PMID: 29899553, PMCID: PMC5998066.

Zou J, Chen Z, Liang C, Fu Y, Wei X, Lu J, Pan M, Guo Y, Liao X, Xie H, Wu D, Li  M, Liang L, Wang P, Wang Q. Trefoil Factor 3, Cholinesterase and Homocysteine: Potential Predictors for Parkinson's Disease Dementia and Vascular Parkinsonism Dementia in Advanced Stage. Aging and disease. 2018; 9(1):51-65. PubMed [journal] PMID: 29392081, PMCID: PMC5772858.

Sun P, Zhang S, Qin X, Chang X, Cui X, Li H, Zhang S, Gao H, Wang P, Zhang Z, Luo J, Li Z. Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1. Autophagy. 2018; 14(2):336-346. PubMed [journal] PMID: 29166823, PMCID: PMC5902195.

Addressing current challenges in cancer immunotherapy with mathematical and computational modelling. Konstorum A, Vella AT, Adler AJ, Laubenbacher RL, 2017. J. R. Soc. Interface 14:20170150. PMID28659410 PMC5493798.

Basole, C., Nguyen, R. K., Lamothe, K., Vang, A., Clark, R. B., Epstein, P. M., Baillie, G.S. and Brocke, S. (2017) PDE8 controls CD4⁺ T cell motility through the PDE8A-Raf-1 kinase signaling complex. Cell Sign 40, 62 PMID: 28851628 DOI: 10.1016/j.cellsig.2017.08.007.

Bartley, J.M., Zhou, X., Kuchel, G.A., Weinstock, G.M., Haynes, L. (2017) Impact of age, caloric restriction, and influenza infection on mouse gut microbiome: an exploratory study of the role of age-related microbiome changes on influenza responses. Front. Immunol. 8; article 1164. PMID:28979265.

Tabtabai, R., Haynes, L., Kuchel, G.A., Parham, K. (2017) Age-Related Increase in Blood Levels of Otolin-1 in Humans. Otol. Neurotol. 38(6):865-869. PMID:28498270.

Liu W, Ménoret A, Vella AT. Responses to LPS boost effector CD8 T-cell accumulation outside of signals 1 and 2. Cell Mol Immunol. 14(3):254-253 (2017). PMID: 26189366.

Programmed cell death-1, PD-1, is dysregulated in T cells from children with new onset type 1 diabetes. Granados HM, Draghi A 2nd, Tsurutani N, Wright K, Fernandez ML, Sylvester FA, Vella AT. PLoS One. 2017 Sep 6;12(9):e0183887. doi: 10.1371/journal.pone.0183887. eCollection 2017.

Chen, J., Pitmon, E., and Wang, K. Microbiome, inflammation and colorectal cancer. Semin Immunol, 2017. 32: p. 43-53. PMID: 28982615.

Zhu Y, Zhang R, Zhang B, Zhao T, Wang P, Liang G, Cheng G. Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system. Nature communications. 2017; 8(1):1262. PubMed [journal] PMID: 29093445,PMCID: PMC5665997.

Sze A, Olagnier D, Hadj SB, Han X, Tian XH, Xu HT, Yang L, Shi Q, Wang P, Wainberg MA, Wu JH, Lin R. Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference. Viruses. 2017; 9(10). PubMed [journal] PMID: 28972551, PMCID: PMC5691638.

Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017;546(7660):667-670. NIHMSID: NIHMS932104 PubMed [journal] PMID: 28636595, PMCID:PMC5787375.

Wang L, Yang L, Fikrig E, Wang P. An essential role of PI3K in the control of West Nile virus infection. Scientific reports. 2017; 7(1):3724. PubMed [journal] PMID: 28623344, PMCID: PMC5473900.

Liu Y, Liu J, Du S, Shan C, Nie K, Zhang R, Li XF, Zhang R, Wang T, Qin CF, Wang P, Shi PY, Cheng G. Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes. Nature. 2017; 545(7655):482-486. NIHMSID: NIHMS867392 PubMed [journal] PMID: 28514450, PMCID: PMC5885636.

Xiao X, Yang L, Pang X, Zhang R, Zhu Y, Wang P, Gao G, Cheng G. A Mesh-Duox pathway regulates homeostasis in the insect gut. Nature microbiology. 2017; 2:17020. NIHMSID: NIHMS846205 PubMed [journal] PMID: 28248301, PMCID: PMC5332881.

Hu Y, O'Boyle K, Auer J, Raju S, You F, Wang P, Fikrig E, Sutton RE. Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα. PLoS pathogens. 2017; 13(2):e1006187. PubMed [journal] PMID: 28152074, PMCID: PMC5308826.

Acharya D, Wang P, Paul AM, Dai J, Gate D, Lowery JE, Stokic DS, Leis AA, Flavell RA, Town T, Fikrig E, Bai F. Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance. Journal of virology. 2017; 91(1). PubMed [journal] PMID: 27795421, PMCID: PMC5165211.

IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages. Li C, Ying W, Huang Z, Brehm T, Morin A, Vella AT, Zhou B. Endocrinology. 2017 Sep 1;158(9):2837-2847. doi: 10.1210/en.2017-00053. PMID: 28645193.

Nano-curcumin safely prevents streptozotocin-induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus. Ganugula R, Arora M, Jaisamut P, Wiwattanapatapee R, Jørgensen HG, Venkatpurwar VP, Zhou B, Rodrigues Hoffmann A, Basu R, Guo S, Majeti NVRK. Br J Pharmacol. 2017 Jul;174(13):2074-2084. doi: 10.1111/bph.13816. Epub 2017 May 30. PMID: 28409821, PMCID: PMC5466524.

Assessment of histone tail modifications and transcriptional profiling during colon cancer progression reveals a global decrease in H3K4me3 activity. Triff K, McLean MW, Konganti K, Pang J, Callaway E, Zhou B, Ivanov I, Chapkin RS. Biochim Biophys Acta. 2017 Jun;1863(6):1392-1402. doi: 10.1016/j.bbadis.2017.03.009. Epub 2017 Mar 16. PMID: 28315775, PMCID: PMC5474136.

Bardoxolone Methyl and a Related Triterpenoid Downregulate cMyc Expression in Leukemia Cells. Jin UH, Cheng Y, Zhou B, Safe S. Mol Pharmacol. 2017 May;91(5):438-450. doi: 10.1124/mol.116.106245. Epub 2017 Mar 8. PMID: 28275049, PMCID: PMC5399643.

Epistasis and destabilizing mutations shape gene expression variability in humans via distinct modes of action. Yang E, Wang G, Yang J, Zhou B, Tian Y, Cai JJ. Hum Mol Genet. 2016 Nov 15;25(22):4911-4919. doi: 10.1093/hmg/ddw314. PMID: 28171656.

Nutrition, microRNAs, and Human Health. Cui J, Zhou B, Ross SA, Zempleni J. Adv Nutr. 2017 Jan 17;8(1):105-112. doi: 10.3945/an.116.013839. Print 2017 Jan. Review. PMID: 28096131, PMCID: PMC5227982.

Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy. Adler AJ, Mittal P, Ryan JM, Zhou B, Wasser JS, Vella AT. Immunotherapy. 2017 Jan;9(1):71-82. doi: 10.2217/imt-2016-0097. Review. PMID: 28000531, PMCID: PMC5619014​.

Acharya N, Penukonda S, Shcheglova T, Hagymasi AT, Basu S, Srivastava PK. Endocannabinoid system acts as a regulator of immune homeostasis in the gut. Proc Natl Acad Sci USA. 2017 May 9;114(19):5005-5010. doi: 10.1073 PMID: 28439004.

Srivastava PK. George Klein  (1925-2016) A Prescient, Luminous Voice. Cancer Immunol Res. 2017 Apr;5(4):272. doi: 10.1158/2326-6066.CIR-17-0105. Review. PMID: 28373213.

Corwin WL, Ebrahimi-Nik H, Floyd SM, Tavousi P, Mandoiu II, Srivastava PK. Tumor Control Index as a new tool to assess tumor growth in experimental animals. J Immunol Methods. 2017 Jun;445:71-76. doi: 10.1016/j.jim.2017.03.013. Epub 2017 Mar 20. PMID: 28336396.

Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination. Kim S, Bielawski J, Yang H, Kong Y, Zhou B, Li J. Glia. 2018 Mar;66(3):654-669. doi: 10.1002/glia.23272. Epub 2017 Nov 29. PMID: 29193293.

Deficiency in IRAK4 activity attenuates manifestations of murine lupus. Murphy, M., Pattabiraman, G., Manavalan, T. T., and Medvedev, A. E. Eur J Immunol. 2017 47:880-891. PMCID: PMC5575829.

The R753Q polymorphism in Toll-like receptor 2 (TLR2) attenuates innate immune responses to mycobacteria and impairs MyD88 adapter recruitment to TLR2. Pattabiraman, G., Panchal, R., and Medvedev, A. E. J Biol Chem. 2017 292(25):10685-10695. PMCID: PMC5481573.

Therapeutic blockade of CD54 attenuates pulmonary barrier damage in T cell-induced acute lung injury. Svedova J, Ménoret A, Mittal P, Ryan JM, Buturla JA, Vella AT. Am J Physiol Lung Cell Mol Physiol. 2017 May 4 (2017) [Epub ahead of print]. PMID: 28473322.

Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Chen S1, Lu W2, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1432-E1440. doi: 10.1073/pnas.1700232114. Epub 2017 Feb 6. PMID 28167773.

YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Taniguchi K1,2,3,4,5, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, Farin HF, Guan KL, Haybaeck J, Datz C, Zhang K, Karin M. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1643-1648. doi: 10.1073/pnas.1620290114. Epub 2017 Jan 27. PMID: 28130546.

Splenomegaly, myeloid lineage expansion and increased osteoclastogenesis in osteogenesis imperfecta murine. Matthews BG, Roeder E, Wang X, Aguila HL, Lee SK, Grcevic D, Kalajzic I. Bone. 2017 Oct;103:1-11. doi: 10.1016/j.bone.2017.06.004. Epub 2017 Jun 7. PMID: 28600151.

IL-15-deficient mice develop enhanced allergic responses to airway allergen exposure. Mathias CB, Schramm CM, Guernsey LA, Wu CA, Polukort SH, Rovatti J, Ser-Dolansky J, Secor E, Schneider SS, Thrall RS, Aguila HL. Clin Exp Allergy. 2017 May;47(5):639-655. doi: 10.1111/cea.12886. Epub 2017 Feb 7. PMID: 28093832.

A Refined Bead-Free Method to Identify Astrocytic Exosomes in Primary Glial Cultures and Blood Plasma. Willis CM, Ménoret A, Jellison ER, Nicaise AM, Vella AT, Crocker SJ.  Front Neurosci. 2017 Jun 15;11:335. doi: 10.3389/fnins.2017.00335. eCollection 2017. PMID: 28663721.

Multiparity improves outcomes after cerebral ischemia in female mice despite features of increased metabovascular risk. Ritzel RM, Patel AR, Spychala M, Verma R, Crapser J, Koellhoffer EC, Schrecengost A, Jellison ER, Zhu L, Venna VR, McCullough LD. Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5673-E5682. doi: 10.1073/pnas.1607002114. Epub 2017 Jun 23.

Dual Immunization with SseB/Flagellin Provides Enhanced Protection against <i>Salmonella</i> Infection Mediated by Circulating Memory Cells. Lee SJ, Benoun J, Sheridan BS, Fogassy Z, Pham O, Pham QM, Puddington L, McSorley SJ. J Immunol. 2017 Aug 15;199(4):1353-1361. doi: 10.4049/jimmunol.1601357. Epub 2017 Jul 14. PMID: 28710253 [PubMed - in process] Similar articles.

CD169₊ macrophages orchestrate innate immune responses by regulating bacterial localization in the spleen. Perez OA, Yeung ST, Vera-Licona P, Romagnoli PA, Samji T, Ural BB, Maher L, Tanaka M, Khanna KM. Sci Immunol. 2017 Oct 6;2(16). pii: eaah5520. doi: 10.1126/sciimmunol.aah5520. PMID: 28986418.

Vang, A. G., Basole, C., Dong, H., Nguyen, R. K., Housley, W., Guernsey, L., Adami, A. J., Thrall, R. S., Clark, R. B., Epstein, P. M. and Brocke, S. (2016) Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation. Front Pharmacol. 7, 259 PMID: 27601994 DOI: 10.3389/fphar.2016.00259.

McElhaney JE, Kuchel GA, Zhou X, Swain SL, Haynes L. (2016) T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines. Front. Immunol Feb 25;7:41. PMID:26941738.

Leifer CA, Medvedev AE. Molecular mechanisms of regulation of Toll-like receptor signaling. J Leukoc Biol. 2016 Nov;100(5):927-941. Epub 2016 Jun 24. PMID: 27343013; PMCID: PMC5069093.

Sayej WN, Ménoret A, Maharjan AS, Fernandez M, Wang Z, Balarezo F, Hyams JS, Sylvester FA, Vella AT. Characterizing the inflammatory response in esophageal mucosal biopsies in children with eosinophilic esophagitis. Clin Transl Immunology. 2016 Jul 1;5(7):e88. doi: 10.1038/cti.2016.30. eCollection 2016 Jul. PubMed PMID: 27525061; PubMed Central PMCID: PMC4973319.

Paul AM, Acharya D, Le L, Wang P, Stokic DS, Leis AA, Alexopoulou L, Town T, Flavell RA, Fikrig E, Bai F. TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice. Journal of immunology (Baltimore, Md. : 1950). 2016; 197(11):4425-4435. NIHMSID: NIHMS820852 PubMed [journal] PMID: 27798161, PMCID: PMC5123688.

Liu J, Liu Y, Nie K, Du S, Qiu J, Pang X, Wang P, Cheng G. Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes. Nature microbiology. 2016; 1(9):16087. NIHMSID: NIHMS784820 PubMed [journal] PMID: 27562253, PMCID: PMC5003325.

Wang K, Wang J, Sun T, Bian G, Pan W, Feng T, Wang P, Li Y, Dai J. Glycosphingolipid GM3 is Indispensable for Dengue Virus Genome Replication. International journal of biological sciences. 2016; 12(7):872-83. PubMed [journal] PMID: 27313500, PMCID: PMC4910605.

Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature microbiology. 2016; 1. NIHMSID: NIHMS781987 PubMed [journal] PMID: 27170846, PMCID: PMC4861079.

Pang X, Xiao X, Liu Y, Zhang R, Liu J, Liu Q, Wang P, Cheng G. Mosquito C-type lectins maintain gut microbiome homeostasis. Nature microbiology. 2016; 1:16023. PubMed [journal] PMID: 27572642.

Cheng G, Liu Y, Wang P, Xiao X. Mosquito Defense Strategies against Viral Infection. Trends in parasitology. 2016; 32(3):177-186. NIHMSID: NIHMS728587 PubMed [journal] PMID: 26626596, PMCID: PMC4767563.

Wang P. Exploration of West Nile Virus Infection in Mouse Models. Methods in molecular biology (Clifton, N.J.). 2016; 1435:71-81. PubMed [journal] PMID: 27188551.

Regulatory T Cells and Cancer: A Two-Sided Story. Wang K, Vella AT. Immunol Invest. 2016 Nov;45(8):797-812. Epub 2016 Sep 7. PMID: 27603750.

Long noncoding RNAs as regulators of Toll-like receptor signaling and innate immunity. Murphy MB, Medvedev AE. J Leukoc Biol. 2016 99:839-50. PMID: 26965636.

Endotoxin Tolerance Inhibits Lyn and c-Src Phosphorylation and Association with Toll-Like Receptor 4 but Increases Expression and Activity of Protein Phosphatases. Xiong Y, Murphy M, Manavalan TT, Pattabiraman G, Qiu F, Chang HH, Ho IC, Medvedev AE. J Innate Immun. 2016;8:171-184. PMCID: PMC4801746.

Appearance of claudin-5+ leukocytes in the central nervous system during neuroinflammation: a novel role for endothelial-derived extracellular vesicles. Paul D, Baena V, Ge S, Jiang X Jellison ER, Kiprono T, Agalliu D5, Pachter JS. J Neuroinflammation. 2016 Nov 16;13(1):292.

Age-Associated Resident Memory CD8 T Cells in the Central Nervous System Are Primed To Potentiate Inflammation after Ischemic Brain Injury. Ritzel RM, Crapser J, Patel AR, Verma R1, Grenier JM, Chauhan A, Jellison ER, McCullough LD. J Immunol. 2016 Apr 15;196(8):3318-30. doi: 10.4049/jimmunol.1502021. Epub 2016 Mar 9.

Differentiation of distinct long-lived memory CD4 T cells in intestinal tissues after oral Listeria monocytogenes infection. Romagnoli PA, Fu HH, Qiu Z, Khairallah C, Pham QM, Puddington L, Khanna KM, Lefrançois L, Sheridan BS. Mucosal Immunol. 2017 Mar;10(2):520-530. doi: 10.1038/mi.2016.66. Epub 2016 Jul 27. PMID: 27461178 [PubMed - in process] Free PMC Article.
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Ménoret A, Crocker SJ, Rodriguez A, Rathinam VA, Clark RB, and Vella AT. 2016. Transition from identity to bioactivity-guided proteomics for biomarker discovery with focus on the PF2D platform. Proteomics Clin Appl. Jan;10(1):8-24.

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Sharma N, Benechet AP, Lefrancois L, Khanna KM. 2015. CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, but the Subsequent Expansion and Trafficking Patterns of Effector T Cells after Infection Are Dysregulated in the Absence of CCR7 Migratory Cues. J. Immunol. 2015 Dec 1: 195(11):5226-36.

Ménoret A, Svedova J, Behl B, and Vella AT. 2015. Trace Levels of Staphylococcal Enterotoxin Bioactivity Are Concealed in a Mucosal Niche during Pulmonary Inflammation. PLoS One. 2015 Oct 28;10(10):e0141548.

Mittal P, St Rose MC, Wang X, Ryan JM, Wasser JS, Vella AT, Adler AJ. 2015. Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy. J of Immunol. 195:5816-26.

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Liu W, Menoret A, Vella AT. 2015. Responses to LPS boost effector CD8 T-cell accumulation outside of signals 1 and 2. Cell. Mol. Immunol. 2015 Jul 20. doi: 10.1038/cmi.2015.69. [Epub ahead of print]

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Qiu Z, Huang H, Grenier JM, Perez OA, Smilowitz HM, Adler B, Khanna KM. 2015. Cytomegalovirus-Based Vaccine Expressing a Modified Tumor Antigen Induces Potent Tumor-Specific CD8(+) T-cell Response and Protects Mice from Melanoma. Cancer Immunol Res. 2015 May; 3(5): 536-46.

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Sheridan BS, Pham QM, Lee YT, Cauley LS, Puddington L, and L Lefrançois. 2014. Immunity. 40: 747-757.

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Swede H1, Hajduk AM, Sharma J, Rawal S, Rasool H, Vella AT, Tobet RE, Stevens RG. Int J Cancer. 2014 Apr 15;134(8):1862-70. doi: 10.1002/ijc.28504. Epub 2013 Oct 31.

Pro-inflammatory role of natural killer cells in the development of allergic airway disease.
Mathias CB, Guernsey LA, Zammit D, Brammer C, Wu CA, Thrall RS, Aguila HL. Clin Exp Allergy. 2014 Apr;44(4):589-601. doi: 10.1111/cea.12271.

CCR2+ Ly6C(hi) inflammatory monocyte recruitment exacerbates acute disability following intracerebral hemorrhage.
Hammond MD, Taylor RA, Mullen MT, Ai Y, Aguila HL, Mack M, Kasner SE, McCullough LD, Sansing LH. J Neurosci. 2014 Mar 12;34(11):3901-9. doi: 10.1523/JNEUROSCI.4070-13.2014.

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Shoji KF, Sáez PJ, Harcha P, Aguila HL, Sáez JC. Channels (Austin). 2014 Mar 3;8(2). [Epub ahead of print]

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Wu T, Hu Y, Lee YT, Bouchard KR, Benechet A, Khanna K, Cauley LS. J Leukoc Biol. 2014 Feb;95(2):215-24. doi: 10.1189/jlb.0313180. Epub 2013 Sep 4.

Pillars article: preferential localization of effector memory cells in nonlymphoid tissue.
Science. 2001. 291: 2413-2417.Masopust D, Vezys V, Marzo AL, Lefrançois L. J Immunol. 2014 Feb 1;192(3):845-9. PMID: 24443507.

Cell-selective knockout and 3D confocal image analysis reveals separate roles for astrocyte-and endothelial-derived CCL2 in neuroinflammation.
Paul D, Ge S, Lemire Y, Jellison ER, Serwanski DR, Ruddle NH, Pachter JS. J Neuroinflammation. 2014 Jan 21;11:10. doi: 10.1186/1742-2094-11-10.

Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodium-derived hemozoin and DNA during malaria.
Kalantari, Parisa; DeOliveira, Rosane B; Chan, Jennie; Corbett, Yolanda; Rathinam, Vijay; Stutz, Andrea; Latz, Eicke; Gazzinelli, Ricardo T; Golenbock, Douglas T; Fitzgerald, Katherine A (2014 Jan.) Cell reports 1 (6) 196-210.

Sex and genetic factors determine osteoblastic differentiation potential of murine bone marrow stromal cells.
Zanotti S, Kalajzic I, Aguila HL, Canalis E. PLoS One. 2014 Jan 28;9(1):e86757. doi: 10.1371/journal.pone.0086757. eCollection 2014.

 

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Adler AJ, Vella AT. Immunotherapy. 2013 Dec;5(12):1271-3. doi: 10.2217/imt.13.129. No abstract available.

Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac.
Vang AG, Housley W, Dong H, Basole C, Ben-Sasson SZ, Kream BE, Epstein PM, Clark RB, Brocke S. Biochem J. 2013 Dec 15;456(3):463-73. doi: 10.1042/BJ20130064.

Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells.
Dong H, Claffey KP, Brocke S, Epstein PM. Springerplus. 2013 Dec 18;2:680. doi: 10.1186/2193-1801-2-680. eCollection 2013.

Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells.
Secor ER Jr, Szczepanek SM, Castater CA, Adami AJ, Matson AP, Rafti ET, Guernsey L, Natarajan P, McNamara JT, Schramm CM, Thrall RS, Silbart LK. Evid Based Complement Alternat Med. 2013;2013:702196. doi: 10.1155/2013/702196. Epub 2013 Dec 5.

Bacterial lipodipeptide, Lipid 654, is a microbiome-associated biomarker for multiple sclerosis.
V. Farrokhi, R. Nemati, F. Nichols, X. Yao, E. Anstadt, M. Fujiwara, J.Grady, D. Wakefield, W. Castro, J. Donaldson, R. Clark. Clinical & Translational Immunology (2013) 2, e8; doi:10.1038/cti.2013.11 Published online 15 November 2013.

Immune response to mutant neo-antigens: Cancer’s lessons for aging.
Geyer RJ, Tobet R, Berlin RD, Srivastava PK. Oncoimmunology. 2013 Nov 1;2(11):e26382. Epub 2013 Oct 15.

Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system.
Shah S, Bohsali A, Ahlbrand SE, Srinivasan L, Rathinam VA, Vogel SN, Fitzgerald KA, Sutterwala FS, Briken V. J Immunol. 2013 Oct 1;191(7):3514-8. doi: 10.4049/jimmunol.1301331. Epub 2013 Aug 30.

Transcriptional regulation of IL-15 expression during hematopoiesis.
Colpitts SL, Stonier SW, Stoklasek TA, Root SH, Aguila HL, Schluns KS, Lefrançois L. J Immunol. 2013 Sep 15;191(6):3017-24. doi: 10.4049/jimmunol.1301389. Epub 2013 Aug 21.

Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.
Bossaller L, Rathinam VA, Bonegio R, Chiang PI, Busto P, Wespiser AR, Caffrey DR, Li QZ, Mohan C, Fitzgerald KA, Latz E, Marshak-Rothstein A. J Immunol. 2013 Sep 1;191(5):2104-14. doi: 10.4049/jimmunol.1300341. Epub 2013 Aug 5.

Rapid αβ T-cell responses orchestrate innate immunity in response to Staphylococcal enterotoxin A.
Kumar S, Colpitts SL, Ménoret A, Budelsky AL, Lefrancois L, Vella AT. Mucosal Immunol. 2013 Sep;6(5):1006-15. doi: 10.1038/mi.2012.138. Epub 2013 Jan 16.

Serine lipids of Porphyromonas gingivalis are human and mouse Toll-like receptor 2 ligands.
Clark RB, Cervantes JL, Maciejewski MW, Farrokhi V, Nemati R, Yao X, Anstadt E, Fujiwara M, Wright KT, Riddle C, La Vake CJ, Salazar JC, Finegold S, Nichols FC. Infect Immun. 2013 Sep;81(9):3479-89. doi: 10.1128/IAI.00803-13. Epub 2013 Jul 8.

Maternal allergy is associated with surface-bound IgE on cord blood basophils.
Matson AP, Cloutier MM, Dhongade A, Puddington L, Rafti E. Pediatr Allergy Immunol. 2013 Sep;24(6):614-21. doi: 10.1111/pai.12113.

Toll-like receptor polymorphisms, inflammatory and infectious diseases, allergies, and cancer.
Medvedev AE. J Interferon Cytokine Res. 2013 Sep;33(9):467-84. doi: 10.1089/jir.2012.0140. Epub 2013 May 15. Review.

IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance.
Xiong Y, Pennini M, Vogel SN, Medvedev AE. J Leukoc Biol. 2013 Aug;94(2):291-300. doi: 10.1189/jlb.0812401. Epub 2013 May 21.

Antigen and transforming growth factor Beta receptors contribute to long term functional and phenotypic heterogeneity of memory CD8 T cells.
Hu Y, Cauley L. Front Immunol. 2013 Aug 12;4:227. doi: 10.3389/fimmu.2013.00227. eCollection 2013.

IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance.
Xiong Y, Pennini M, Vogel SN, Medvedev AE. J Leukoc Biol. 2013 Aug;94(2):291-300. doi: 10.1189/jlb.0812401. Epub 2013 May 21.

Transgenic sickle cell disease mice have high mortality and dysregulated immune responses after vaccination.
Szczepanek SM, Secor ER Jr, Bracken SJ, Guernsey L, Rafti E, Matson A, Thrall RS, Andemariam B. Pediatr Res. 2013 Aug;74(2):141-7. doi: 10.1038/pr.2013.85. Epub 2013 May 31.

Environmental Cues Dictate the Fate of Individual CD8+ T Cells Responding to Infection.
Plumlee CR, Sheridan BS, Cicek BB, Lefrançois L. Immunity. 2013 Aug 7. doi:pii: S1074-7613(13)00322-1. 10.1016/j.immuni.2013.07.014]

RKIP contributes to IFN-γ synthesis by CD8+ T cells after serial TCR triggering in systemic inflammatory response syndrome.
Wright KT, Vella AT. J Immunol. 2013 Jul 15;191(2):708-16. doi: 10.4049/jimmunol.1203486. Epub 2013 Jun 12.

γδ T cells exhibit multifunctional and protective memory in intestinal tissues.
Sheridan BS, Romagnoli PA, Pham QM, Fu HH, Alonzo F 3rd, Schubert WD, Freitag NE, Lefrançois L. Immunity. 2013 Jul 25;39(1):184-95. doi: 10.1016/j.immuni.2013.06.015.

Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function.
Sokolovska A, Becker CE, Ip WK, Rathinam VA, Brudner M, Paquette N, Tanne A, Vanaja SK, Moore KJ, Fitzgerald KA, Lacy-Hulbert A, Stuart LM. Nat Immunol. 2013 Jun;14(6):543-53. doi: 10.1038/ni.2595. Epub 2013 May 5.

Harnessing the antigenic fingerprint of each individual cancer for immunotherapy of human cancer: genomics shows a new way and its challenges.
Srivastava PK, Duan F. Cancer Immunol Immunother. 2013 May;62(5):967-74. doi: 10.1007/s00262-013-1422-x. Epub 2013 Apr 19. Review.

Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery.
Jacome-Galarza CE, Lee SK, Lorenzo JA, Aguila HL. J Bone Miner Res. 2013 May;28(5):1203-13. doi: 10.1002/jbmr.1822.

Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.
Conlon J, Burdette DL, Sharma S, Bhat N, Thompson M, Jiang Z, Rathinam VA, Monks B, Jin T, Xiao TS, Vogel SN, Vance RE, Fitzgerald KA. J Immunol. 2013 May 15;190(10):5216-25. doi: 10.4049/jimmunol.1300097. Epub 2013 Apr 12.

CD11a regulates effector CD8 T cell differentiation and central memory development in response to infection with Listeria monocytogenes.
Bose TO, Pham QM, Jellison ER, Mouries J, Ballantyne CM, Lefrançois L. Infect Immun. 2013 Apr;81(4):1140-51. doi: 10.1128/IAI.00749-12. Epub 2013 Jan 28.

Vaccines against advanced melanoma.
Blanchard T, Srivastava PK, Duan F. Clin Dermatol. 2013 Mar-Apr;31(2):179-90. doi: 10.1016/j.clindermatol.2012.08.005. Review.

A potential new pathway for PD-L1 costimulation of the CD8-T cell response to Listeria monocytogenes infection.
Xu D, Fu HH, Obar JJ, Park JJ, Tamada K, Yagita H, Lefrançois L. PLoS One. 2013;8(2):e56539. doi: 10.1371/journal.pone.0056539. Epub 2013 Feb 11. PMID: 23409193.

Splenic priming of virus-specific CD8 T cells following influenza virus infection.
Turner DL, Bickham KL, Farber DL, Lefrançois L. J Virol. 2013 Apr;87(8):4496-506. doi: 10.1128/JVI.03413-12. Epub 2013 Feb 6. PMID: 23388712.

Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.
Wang D, Höing S, Patterson HC, Ahmad UM, Rathinam VA, Rajewsky K, Fitzgerald KA, Golenbock DT. J Biol Chem. 2013 Feb 15;288(7):4594-601. doi: 10.1074/jbc.M112.443077. Epub 2013 Jan 4.

CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion.
St Rose MC, Taylor RA, Bandyopadhyay S, Qui HZ, Hagymasi AT, Vella AT, Adler AJ. Immunol Cell Biol. 2013 Feb;91(2):173-83. doi: 10.1038/icb.2012.74. Epub 2013 Jan 8.