CCAM Events are typically held in the CCAM Conference Room, R1673
Cell & Genome Sciences Building (CGSB)
400 Farmington Avenue
Farmington, CT 06030
CCAM Seminars - Thursdays, 12 p.m., September - June.
(Please note calendar for possible time changes.)
CCAM Lab Meetings - Fridays, 12 p.m., year round.
Upcoming Events
-
Feb
5
CCAM Seminar Series - Dr. Ankita Jha 4:00pm
CCAM Seminar Series - Dr. Ankita Jha
Thursday, February 5th, 2026
04:00 PM
Grossman Auditorium (UConn Health)
Guest Speaker: Ankita Jha, Ph.D., Research Fellow, Laboratory of Cell & Tissue Morphodynamics, Cell Biology & Research Center, NIH/NHLBI
Title: “Blebs in Cell Signaling and Cancer Disease Progression”
Abstract: Blebs are dynamic membrane protrusions increasingly recognized as active regulators of signaling and cell behavior. In this talk, I will present how bleb morphology organizes intracellular signaling to drive migration in metastatic melanoma, particularly under confined, low-adhesion environments. Unlike mesenchymal migration, bleb-based motility relies on large, pressure-driven leader blebs that define cell polarity. Using high-resolution live imaging, molecular perturbations, and optogenetics, we show that growth factor receptor-PI3K signaling is essential for maintaining a stable, polarized bleb. We further identify that CD44 and membrane-cortex linkers restrict receptor mobility on the plasma membrane at the bleb rear, supporting a spatial signaling gradient crucial for persistent migration. Our combined experimental and modeling approaches reveal a feedback loop between cortical architecture and signaling, establishing a novel polarity axis. These findings highlight how membrane organization enables migratory plasticity, allowing tumor cells to adapt to physical constraints during metastasis. This work also underscores how distinct spatial arrangements of conserved signaling modules on the membrane enable plasticity in migration strategies, allowing metastatic cells to adapt to biophysical constraints of the tumor microenvironment.
Guest Host: Dr. Abhijit Deb Roy
Contact Information:
More -
Feb
6
CAM Research in Progress: Tasnif Rahman 12:00pm
CAM Research in Progress: Tasnif Rahman
Friday, February 6th, 2026
12:00 PM
CGSB, 400 Farmington Ave.
Speaker: Tasnif Rahman
Title: “A Schema-First Approach to Multi-Scale, Multicellular Simulations with Tyssue”
Via Webex: https://uconnhealth.webex.com/uconnhealth/j.php?MTID=mdacf393cf6a2ee5314a3b76525ea5e57
Contact Information:
More -
Feb
13
CAM Presentation: Siyu Sun 12:00pm
CAM Presentation: Siyu Sun
Friday, February 13th, 2026
12:00 PM
CGSB, 400 Farmington Ave.
Speaker: Siyu Sun
Title: TBD
Via Webex: https://uconnhealth.webex.com/uconnhealth/j.php?MTID=mdacf393cf6a2ee5314a3b76525ea5e57
Contact Information:
More -
Feb
20
CAM Presentation: Rudradeep Mukherjee 12:00pm
CAM Presentation: Rudradeep Mukherjee
Friday, February 20th, 2026
12:00 PM
CGSB, 400 Farmington Ave.
Speaker: Rudradeep Mukherjee
Title: TBD
Via Webex: https://uconnhealth.webex.com/uconnhealth/j.php?MTID=mdacf393cf6a2ee5314a3b76525ea5e57
Contact Information:
More -
Feb
27
CAM Presentation: Rotation Students 12:00pm
CAM Presentation: Rotation Students
Friday, February 27th, 2026
12:00 PM
CGSB, 400 Farmington Ave.
Speaker:
Title: TBD
Via Webex: https://uconnhealth.webex.com/uconnhealth/j.php?MTID=mdacf393cf6a2ee5314a3b76525ea5e57
Contact Information:
More