2021-2022
Mondays at Noon, Remote via Blackboard Collaborate
Link: https://uconn-edu.zoom.us/j/94261684744?pwd=YkZBVW4weUtzZy8xY2dHWHhHZmFjZz09
MBB Conference Room E2036 (when conditions allow)
| Date | Presenter | Title |
| 8/30 | Graduate Student Meeting | |
| 9/6 | LABOR DAY | |
| 9/13 | JC – Kerry Silva McPherson | Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site |
| 9/20 | JC – Kirby Madden-Hennessey | Cycling cancer persister cells arise from lineages with distinct programs |
| 9/27 | JC – Thomas Bregnard | Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis |
| 10/4 | WIP – Socheata Lim | The Opening Dynamics of the β-clamp |
| 10/11 | JC – Emilie Korchak | Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity |
| 10/18 | JC – Angela DeMarco | Metabolic differentiation and intercellular nurturing underpin bacterial endospore formation |
| 10/25 | WIP – Patricia Hare | The Anti-Persister Playbook: Defensive and Offensive Strategies Against Antibiotic Treatment Failure |
| 11/1 | WIP – Brandon Byrd | Investigating the Survival Strategies of Bacterial Phenotypic Variance |
| 11/8 | JC – Travis LaGree | Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes |
| 11/15 | JC – Darien Levi Craft | NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission |
| 11/22 | THANKSGIVING WEEK | |
| 11/29 | JC – Margaret Vos | Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase |
| 12/6 | WIP – Kerry Silva McPherson | Assembly of S. cerevisiae Polymerase ζ |
| 12/13* | JC – Dr. Elizabeth Szabo | EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart |
| 12/20* | JC – Dr. Paul Ross Wilderman | CANCELED |
| 12/27 | CHRISTMAS – NEW YEAR | |
| 1/3* | JC – Dr. Peter Setlow | A combination of Class-I fumarases and metabolites (α-ketoglutarate and fumarate) signal the DNA damage response in Escherichia coli |
| 1/10* | JC – Dr. Steve King | CANCELED |
| 1/17 | MARTIN LUTHER KING DAY | |
| 1/24 | JC – Sam Mahdi | Illumination of serotonin transporter mechanism and role of the allosteric site |
| 1/31 | JC – Gianluca Arianna | Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis |
| 2/7 | JC – Victor Yu | A dual role in regulation and toxicity for the disordered N-terminus of the toxin GraT |
| 2/14 | WIP – Emilie Korchak | Mutations in USP7 gene leading to the Hao-Fountain syndrome |
| 2/22 | WIP – Angela DeMarco | Alone and Together: Investigating How Bacteria Survive Stress in Isolation and Communities |
| 2/28 | WIP – Travis LaGree | Strategies for the potentiation of existing antibiotics against slow/non-growing Escherichia coli |
| 3/7 | WIP – Thomas Bregnard | Conformational exchange at a C2H2 zinc-binding site facilitates redox sensing by the PML protein |
| 3/14 | SPRING BREAK | |
| 3/21 | WIP – Elizabeth Szabo | Functional analysis of variants of uncertain significance in the MSH6 mismatch repair gene |
| 3/28 | WIP – Victor Yu | Mechanism of action of MqsR, a noncanonical bacterial RNase toxin |
| 4/4 | WIP – Darien Levi Craft | – CANCELED |
| 4/11 | WIP – Margaret Vos | Using NMR spectroscopy to define the binding elements between PP2A-B55 and its endogenous inhibitors |
| 4/18 | WIP – Sam Mahdi | Structure and Dynamics of the E. coli Clamp Loader |
| 4/25 | JC – Patricia Hare | Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis |
| 5/2 | WIP- Gianluca Arianna | Studying Protein Interaction Mechanisms in Translesion Synthesis |
| 5/3 | WIP- Darien Levi Craft | “Workflows and Quantitative Tools: Striving for an Automated Approach to NMR” |
| 5/9* | JC – Dr. Suzy Torti | Ferroptotic damage promotes pancreatic tumorigenesis through a TMEM173/STING dependent DNA sensor pathway |
| 5/16* | JC – Everton (Tim) Bettin | An ancient divide in outer membrane tethering systems in bacteria suggests a mechanism for the diderm-to-monoderm transition |
| 5/23* | JC – Dr. Ann Cowan | – CANCELED |
| 5/30 | MEMORIAL DAY | |
| 6/6* | JC – Ann Cowan | – CANCELED |
| 6/13* | WIP – Dr. Wolfgang Peti | |
| 6/20* | JUNETEENTH | |
| 6/27* | JC – Dr. Bing Hao |
* These dates are outside of the academic calendar