Postdoctoral Research Opportunity in Biochemistry of Herpesvirus DNA replication
An NIH funded postdoctoral research position is available immediately in the Weller lab in the Department of Molecular Biology and Biophysics at the University of Connecticut School of Medicine in Farmington CT. The Weller lab uses biochemical, biophysical and molecular genetic approaches to study the mechanisms and enzymology of DNA replication in Herpes Simplex Virus. HSV infects almost 70% of the world’s population, and we have discovered that this important viral pathogen has evolved an unusual replication strategy that uses recombination-dependent replication to produce progeny genomes. Our newly funded R01 focuses on a virally-encoded ssDNA binding protein that plays many roles during viral DNA replication, participating protein-protein interactions necessary for the initiation of DNA synthesis, the cooperative binding to ssDNA, filament formation and the annealing of complementary ssDNA (Weerasooriya et al. 2018 PNAS https://www.pnas.org/content/116/3/1033). We also use our structural and mechanistic insights to drive development of novel antiviral drugs in collaboration with Dr. Dennis Wright Professor of Medicinal Chemistry in the School of Pharmacy at UConn Storrs. We are looking for curious and mechanistically minded scientists interested in DNA replication mechanisms and translational biochemistry.
Please see some of our recent publications listed below for more information: https://www.ncbi.nlm.nih.gov/myncbi/sandra.weller.1/bibliography/public/
Applicants should be recent Ph.D. graduates in the Life Sciences or Physical Sciences and have experience working with nucleic acids, proteins, enzyme assays and biophysical characterization of biomolecules. The ideal candidate will have technical expertise in protein expression and purification using bacterial, mammalian or insect systems as well as basic molecular biology techniques. Experience with biophysical methods and the ability to relate biochemical mechanisms to biological processes are highly desirable.
MBB has a vibrant, active collaborative faculty working in diverse areas, including DNA replication/repair, protein homeostasis, microbiology/infectious diseases, structural biology (X-ray crystallography and NMR), computational biology, and drug discovery. The MBB department hosts outstanding core facilities for structural biology (NMR and X-ray Crystallography), biophysical analysis and EM. Postdoctoral fellows are employees of UConn School of Medicine and receive a generous benefits package including health insurance, retirement contributions, paid vacation and up to 12 days of paid sick leave per year.
Interested applicants should send a single PDF file that includes a cover letter summarizing their research training and accomplishments, a personal statement of scientific interests and goals, current CV with recent publications, and contact information for three references to Dr. Sandra Weller at firstname.lastname@example.org.
The School of Medicine (SOM) at University of Connecticut seeks an outstanding investigator with demonstrated leadership skills to serve as Chair for the Department of Molecular Biology and Biophysics (MBB) (position #2019-808). MBB has a vibrant and active faculty working in diverse areas, including DNA replication/repair, protein homeostasis, structural biology (X-ray crystallography and NMR), microbiology/infectious diseases, computational biology, and drug discovery, that has been very successful in garnering external grant support. MBB faculty also provide outstanding education and training to medical and graduate students. It is anticipated that the incoming chair will utilize approaches including but are not limited to biochemical, biophysical, structural and molecular biology to study molecular mechanisms of various disorders such as cancer, heart disease, infectious and inflammatory diseases, metabolic syndromes or neurodegeneration. The chair will not only have the opportunity to strengthen the existing research areas, but also to develop innovative new research initiatives within the department and to foster research collaboration in SOM and across the University. The Chair, reporting to the dean of SOM, is also responsible for facilitating and advancing departmental education of graduate and medical students at the SOM.
The search committee invites nominations or applications for this open position, expected to be appointed at the Associate or Full professor level with tenure. The candidate must currently lead distinguished and active NIH funded research programs that are recognized at the national and international level in the field. A record of successful mentorship of graduate students and post-doctoral fellows and junior faculty is expected.
The University of Connecticut School of Medicine has strong commitment to excellence in research and education with diverse research and education portfolios. The Bioscience Connecticut initiative has expanded the University of Connecticut Health Center health care offerings and research capabilities. Researchers at the Jackson Laboratory for Genomic Medicine, which is located on the University’s Health Center campus, are easily accessible for collaboration. The applicant will gain access to growing translational research programs in Connecticut and be able to facilitate inter-disciplinary collaborative researches.
UConn is an Equal Opportunity Employer, and we consider applicants from all ethnic and diversity backgrounds. Applicants may apply through Career Opportunities at UConn Health by uploading their CV, cover letter and a concise statement of their research, teaching interests and leadership experiences.
Employment opportunities in the Department of Molecular Biology and Biophysics (MBB) include those in the following categories:
- Postdoctoral Fellows
- Research/Staff Positions
- Summer Jobs
The list of available research and staff positions is available through the Department of Human Resources.
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