In this study we are using brain imaging to look for brain changes related to happiness in older adults and other changes that might predict worsening in depression over two years.

Recruiting adults 45 to 75 years old who:

• Have no history of depression

or

• Are in remission from a depressive disorder

Participation involves:

• 4 to 8 study appointments.
• Interviews and evaluations.
• Testing of thinking and memory.
• One-time MRI brain scan at UConn Health
• No cost for participation.
• All study appointments, except the MRI, can be done remotely

Payment to participants includes $100 at completion of the baseline assessments and $50 at completion of each of the follow-up assessments at 6 and 12 months for a total of up to $200 for the 1-year study.

Principal Investigator: Lihong Wang, M.D., Department of Psychiatry

IRB Number: 20-122-1

Enrollment end date: August 1, 2022