Myoclonus is a sudden, brief, involuntary twitch-like movement. Myoclonic twitches can be present in normal persons, as with the sudden jerk that may happen just before falling asleep, but can also be a symptom of a neurological condition. Medications, stress and anxiety are also associated with myoclonic jerks. Myoclonus is seen with many neurological conditions including multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, muscle dystrophies, Creutzfeldt-Jakob disease, Wilson’s disease, Huntington’s disease and epilepsy, among others. Your neurologist will review your history and medications and order tests to rule out structural lesions, seizures and other neurologic conditions. Good control can be achieved with symptomatic treatment, often using anti-epileptic drugs. You can find out more about myoclonus on NIH's Myoclonus Fact Sheet.