This page includes a list of research studies currently supported by the CRC. Please note that some studies may not be open to enrollment. Call the study contact for more information.
Volunteers are also encouraged to visit the Information for Volunteers page for information about participating in clinical research. Information about other research studies at UConn Health may be found on the Clinical Trials page.
For volunteers currently participating in CRC research, the CRC Clinic Office phone number is 860.679.3666.
Addiction/Substance Abuse | Muscle, Bone and Cartilage | Cancer | Cardiology | Diabetes | Pulmonary | Dental Clinical Research | Infectious Disease | Psychiatry/Mental Health | Neurology | Senior Health/Aging | Women’s Health | Genetic | Other
This page was last updated 11/30/2020
Addiction / Substance Abuse
CRC#
|
IRB#
|
Principal Investigator
|
Name of Study
|
| 51 |
089-89-1 |
Hesselbrock, Victor |
Collaborative Study on the Genetics of Alcoholism |
| 751 |
17-180H6.2 |
Mead, Erin |
Electronic Cigarette Use During Pregnancy |
| 10071 |
H14-120-1 |
Hesselbrock, Victor |
Manipulating Tobacco Constituents in Female Menthol Smokers |
| 10107 |
16-148-3 |
Covault, Jonathan |
Zonisamide Treatment of Alcohol Use Disorder: An Evaluation of Efficacy and Mechanism of Action |
| 10118 |
16-221-2 |
Litt, Mark |
Individualized Assessment and Treatment Program for Alcoholism: Treatment and Mechanisms |
| 10136 |
18-091-1 |
Mead, Erin |
Addictive Potential of Little Cigars/Cigarillos in Dual Users: Effects by Flavor and Gender |
| 10162 |
19-202-2 |
Mead, Erin |
Impact of Cigar Flavor on Tobacco Use Behaviors and Addiction in Dual Users |
Muscle, Bone, and Cartilage
CRC#
|
IRB#
|
Principal Investigator
|
Name of Study
|
Cancer
CRC#
|
IRB#
|
Principal Investigator
|
Name of Study
|
| 700 |
09-185-2 |
Hegde, Upendra |
TCR Engineered DC4 Cells as Helpers in Tumors Immunity |
| 720 |
01-127-2 |
Machida, Kazuya |
Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies |
| 10157 |
W19-144-2 |
Brewer, Molly |
A Randomized, Double-Blind, Phase 3 Comparison Of Platinum-Based Therapy With TSR-042 and Niraparib Versus Standard Of Care Platinum-Based Therapy As First-Line Treatment Of Stage III OR IV Nonmucinous Epithelial Ovarian Cancer |
| 10159 |
W19-194-2 |
Andemariam, Biree |
A Prospective Phase II, Open-Label, Single-arm, Multicenter, Study to Assess Efficacy and Safety of SEG101 (crizanlizumab), in Sickle Cell Disease Patients with Priapism (SPARTAN) |
| 10166 |
W19-251-1 |
Hegde, Upendra |
A Phase II, Open-Label, Multicenter, Randomized Study of the Efficacy and Safety of RO7198457 in Combination with Pembrolizumab Versus Pembrolizumab in Patients with Previously Untreated Advanced Melanoma |
| 10193 |
W21-062-1 |
Hegde, Upendra |
A Phase 3, randomized, placebo-controlled, double-blind clinical study of pembrolizumab (MK-3475) with or without lenvatinib (E7080/MK-7902) to evaluate the safety and efficacy of pembrolizumab and lenvatinib as 1L intervention in a PD-L1 selected population of participants with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) (LEAP-010). |
| 10195 |
W21-054-2 |
Brewer, Molly |
A Phase 3, Double-Blind, Placebo-Controlled, Multicenter Clinical Study comparing Chemo-Immunotherapy (Paclitaxel-Carboplatin-Oregovomab) versus Chemotherapy (Paclitaxel-Carboplatin-Placebo) in Patients with Advanced Epithelial Ovarian, Fallopian Tube or Peritoneal Carcinoma |
Cardiology
| CRC# |
IRB
|
Principal Investigator
|
Name of Study
|
Diabetes
CRC#
|
IRB#
|
Principal Investigator
|
Name of Study
|
| 755 |
21-045O-1 |
Bermudez-Millan, Angela |
The Monthly Cycling of Food Insecurity and Diabetes Risk |
| 10095 |
15-164S-3 |
Wagner, Julie |
Lifestyle and Medication Management to Lower Diabetes Risk in Severe Mental Illness (DREAM) |
| 10139 |
18-101-6 |
Laurencin, Cato |
Just Us Moving: Reducing Hemoglobin A1C Levels among African and Hispanic Americans with Type 2 Diabetes |
| 10144 |
19-016S-1 |
Chon, Ki |
Diabetic Cardiovascular Autonomic Neuropathy Detection Using Principal Dynamic Mode and Electrodermal Activity |
| 10164 |
19-206S-1 |
Laurencin, Cato |
Just Us Moving Program in the State of Connecticut (JUMP-CT) |
| 10190 |
H19-093 |
Reagan, Louise |
Integrated Pain Self-Management for Comorbid Diabetes and Low Back Pain |
Pulmonary
CRC#
|
IRB#
|
Principal Investigator
|
Name of Study
|
| 749 |
17-045-2 |
Perez, Mario |
Airway Inflammatory Profile in E-Cigarette Users |
| 10045 |
12-009-2 |
Metersky, Mark |
Bronchiectasis Research Registry: A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions |
Dental Clinical Research
| CRC# |
IRB#
|
Principal Investigator
|
Name of Study
|
| 526 |
02-288-2 |
Dongari-Bagtzoglou, Anna |
Oral Epithelial Cells, Candida and PMN Activation |
| 638 |
07-016-1 |
Freilich, Martin |
Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study |
| 680 |
09-010-1 |
Lalla, Rajesh |
Oral Mucositis Research Registry/Repository |
| 10031 |
10-051-3 |
Taylor, Thomas |
Short-implants – An Alternative To Bone Grafting |
| 10080 |
14-221-3 |
Freilich, Martin |
A prospective cohort study on 2-implant maxillary overdentures |
| 10108 |
16-111-1 |
Ioannidou, Efthimia |
Novel Paradigm to Improve Inflammatory Burden in ESRD |
| 10148 |
19-056-2 |
Yadav, Sumit |
A Randomized Clinical Trial Evaluating the Efficacy of OrthoPulse device- a Molecular Level Study |
| 10153 |
W19-099-1 |
Lalla, Rajesh |
ROMAN: Reduction in Oral Mucositis with Avasopasem Manganese (GC4419) – Phase 3 Trial in Patients
Receiving Chemoradiotherapy for Locally-Advanced, Non-Metastatic Head and Neck Cancer. |
| 10168 |
20-031J-2 |
Ioannidou, Efthimia |
Treat-to-target and personalized periodontal therapy Treat-to-target and personalized periodontal therapy |
| 10171 |
20-137-1 |
Thacker, Sejal |
An pilot RCT comparing dimensional alteration after socket grafting with xenograft versus allograft |
| 10173 |
20-045-2 |
Litt, Mark |
Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism |
| 10179 |
20-043-1 |
Chen, I-Ping |
Quantitative assessment of dental pain by measuring the electrodermal activity |
| 10181 |
20X-181-2 |
Lottinger, Christy |
Dental Implant Abutments in a Clinical Setting – Retrospective Outcomes. |
Infectious Disease
CRC#
|
IRB
|
Principal Investigator
|
Name of Study
|
| 292 |
99-226-1 |
Salazar, Juan |
Cutaneous Immune Response in Secondary Syphilis and Lyme Disease |
| 753 |
20-192-2.F |
Liang, Bruce |
A randomized, open-label study of the vascular and microbiologic efficacy of dipyridamole plus standard care vs. standard care in hospitalized COVID19 patients. |
| 10182 |
20-186-1 |
Liang, Bruce |
SARS-CoV-2 SeroSurvelliance in Health Care Workers on COVID-19 Patients |
| 10183 |
W20-218-2 |
Elali, Ibrahim |
A randomized, open-label study of the vascular and microbiologic efficacy of dipyridamole plus standard care vs. standard care in hospitalized COVID19 patients. |
Psychiatry / Mental Health
| CRC# |
IRB#
|
Principal Investigator
|
Name of Study
|
| 736 |
IE-13-048H-6.1 |
Steffens, David |
Neurobiology and Acute Treatment Outcomes of Late Life Depression |
| 752 |
18-156O-2 |
Powell, Wizdom |
Neighborhoods, daily stress, affect regulation, & Black male substance use: An Ecological Momentary Assessment (EMA) Study |
| 10102 |
16-055-2 |
Steffens, David |
Department of Psychiatry: Adult Repository |
| 10154 |
W19-052-2 |
Kamath, Jayesh |
A Double-Blind, Placebo-Controlled, Randomized Withdrawal, Multicenter Clinical Trial Evaluating The Efficacy, Safety, And Tolerability Of Cariprazine In A Dose-Reduction Paradigm In The Prevention Of Relapse In Patients With Schizophrenia |
| 10155 |
19-147-2 |
Covault, Jonathan |
Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy |
| 10174 |
U20-073-2 |
Kamath, Jayesh |
A Multicenter, Randomized, Flexible-dose, Double-blind Trial of Brexpiprazole Versus Placebo for the Treatment of Adults With Borderline Personality Disorder. Protocol 331-201-00242 |
| 10175 |
U20-082-2 |
Kamath, Jayesh |
A Phase 3, Multicenter, Randomized, Double-blind Trial of Brexpiprazole as Combination Therapy with Sertraline in the Treatment of Adults with Post-traumatic Stress Disorder. Protocol #331-201-00071 |
| 10176 |
19-214-1 |
Manning, Kevin/ Steffens, David |
Apathy and Reward Systems in Late-Life Major Depression |
| 10185 |
18-004-6.2 |
Ginsburg, Golda |
Teacher Anxiety Program for Elementary Students |
| 10186 |
U20-197-1 |
Kamath, Jayesh |
A Multicenter, Open-label Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Adult Subjects With Borderline Personality Disorder (Protocol: 331-201-00195) |
Neurology
| CRC# |
IRB#
|
Principal Investigator
|
Name of Study
|
| 10177 |
W20-159-2 |
Wajnsztajn, Fernanda |
A phase 4 multicenter Observational study to evaluate the effectiveness of Patisiran in Patients with Polyneuropathy of Heredirary Transthyretin Mediated (hATTR) Amyloidosis with V122I or T60A mutation |
Senior Health / Aging
| CRC# |
IRB
|
Principal Investigator
|
Name of Study
|
| 10145 |
O18-075-2 |
Kuchel, George |
Combining Testosterone Therapy and Exercise to Improve Function Post Hip
Fracture |
Women’s Health
| CRC# |
IRB
|
Principal Investigator
|
Name of Study
|
| 10169 |
19-140H-1 |
Cooper, Shontreal/ Zhou, Yanjiao |
Tracking the Microbiome Origin of Inflammation from Mouth to Placenta in Preeclampsia |
Genetic
| CRC# |
IRB#
|
Principal Investigator
|
Name of Study
|
| 492 |
03-007-1 |
Reichenberger, Ernst |
Genetic Analysis of Human Disorders: Keloid Formation |
| 518 |
03-008-1 |
Reichenberger, Ernst |
Genetic analysis of Human disorders: Skeletal Disorders |
| 10097 |
15-174-1 |
Chamberlain, Stormy |
Induced Pluripotent Stem Cells (iPSCs) to study chromosome 15q neurodevelopmental and behavioral disorders |
| 10133 |
08-310-1 |
Sanders, Melinda |
UCONN Health Center Research Tissue Registry/Repository (COHORT 2) |
| 10142 |
W18-164-1 |
Riba-Wolman, Rebecca |
A Phase 1/2, Open-Label Safety and Dose-Finding Study of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)- Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults
with Glycogen Storage Disease Type Ia (GSDIa) |
| 10163 |
W19-209-1 |
Riba-Wolman, Rebecca |
A Long-Term Follow-up Study to Evaluate the Safety and Efficacy of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)-Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults with Glycogen Storage Disease Type Ia (GSDIa) |
Other
| CRC# |
IRB#
|
Principal Investigator
|
Name of Study
|
| 596 |
01-262-1 |
Frank, Marion |
Human Salty and Bitter Taste Mechanisms |
| 10030 |
10-273SFS-2 |
Clark, Robert |
The Role of Unique Lipids Derived From Common Human Bacteria in Multiple Sclerosis |
| 10093 |
13-132-2 |
Konopaske, Glenn T. |
Enroll HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort |
| 10156 |
19-148-2 |
Andemariam, Biree |
An Open-label Extension Study of IMR-687 in Adult Patients with Sickle Cell Anemia (Homozygous HbSS or Sickle-β0 Thalassemia) Who Participated in Study IMR-SCD-102 |
| 10161 |
20-115J-1 |
Banchereau, Jacques |
Next-Generation Sequencing Analysis of Human Immune Cells |
| 10167 |
W20-014-2 |
Merkulov,Alex |
Efficacy and safety of gadoPiclenol foR bOdy MagnetIc reSonancE imaging (MRI) Phase III Clinical Trial |
| 10172 |
20-084-2 |
Fan, Zhichao |
Molecular mechanism and preclinical translation of beta2 integrin auto-inhibition on neutrophil arrest and inflammation |
| 10196 |
U21-073-1 |
Andemariam, Biree |
A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease |