Current Research Listing

This page includes a list of research studies currently supported by the CRCPlease note that some studies may not be open to enrollment. Call the study contact for more information.

Volunteers are also encouraged to visit the Information for Volunteers and Research Subject Advocate Core pages for information about participating in clinical research. Information about other research studies at UConn Health may be found on the Clinical Trials page.

For volunteers currently participating in CRC research, the CRC Clinic Office phone number is 860.679.3666.


Addiction/Substance Abuse  |  Muscle, Bone and Cartilage  |  Cancer  |  Cardiology  |  Diabetes  |  Pulmonary  |  Dental Clinical Research | Infectious Disease  |  Psychiatry/Mental Health  |  Neurology | Senior Health/Aging  |  Women’s Health  |  Genetic  |  Other


This page was last updated 10/17/2019

Addiction / Substance Abuse

CRC#

IRB#

Principal Investigator

Name of Study

51 089-89-1 Hesselbrock, Victor Collaborative Study on the Genetics of Alcoholism
751 17-180H6.2 Oncken, Cheryl Electronic Cigarette Use During Pregnancy
10071 H14-120-1 Oncken, Cheryl Manipulating Tobacco Constituents in Female Menthol Smokers
10107 16-148-3 Covault, Jonathan Zonisamide Treatment of Alcohol Use Disorder: An Evaluation of Efficacy and Mechanism of Action
10136 18-091-1 Mead, Erin Addictive Potential of Little Cigars/Cigarillos in Dual Users: Effects by Flavor and Gender
10162 19-202-2 Mead, Erin Impact of Cigar Flavor on Tobacco Use Behaviors and Addiction in Dual Users

Muscle, Bone, and Cartilage

CRC#

IRB#

Principal Investigator

Name of Study

Cancer

CRC#

IRB#

Principal Investigator

Name of Study

700 09-185-2 Hegde, Upendra TCR Engineered DC4 Cells as Helpers in Tumors Immunity
720 01-127-2 Machida, Kazuya Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies
10157 W19-144-2 Brewer, Molly A Randomized, Double-Blind, Phase 3 Comparison Of Platinum-Based Therapy With TSR-042 and Niraparib Versus Standard Of Care Platinum-Based Therapy As First-Line Treatment Of Stage III OR IV Nonmucinous Epithelial Ovarian Cancer
10159 W19-194-2 Andemariam, Biree A Prospective Phase II, Open-Label, Single-arm, Multicenter, Study to Assess Efficacy and Safety of SEG101 (crizanlizumab), in Sickle Cell Disease Patients with Priapism (SPARTAN)
10166 W19-251-1 Hegde, Upendra A Phase II, Open-Label, Multicenter, Randomized Study of the Efficacy and Safety of RO7198457 in Combination with Pembrolizumab Versus Pembrolizumab in Patients with Previously Untreated Advanced Melanoma

Cardiology

CRC#

IRB

Principal Investigator

Name of Study

Diabetes

CRC#

IRB#

Principal Investigator

Name of Study

10095 15-164S-3 Wagner, Julie Lifestyle and Medication Management to Lower Diabetes Risk in Severe Mental Illness (DREAM)
10139 18-101-6 Laurencin, Cato Just Us Moving: Reducing Hemoglobin A1C Levels among African and Hispanic Americans with Type 2 Diabetes
10144 19-016S-1 Chon, Ki Diabetic Cardiovascular Autonomic Neuropathy Detection Using Principal Dynamic Mode and Electrodermal Activity
10164 19-206S-1 Laurencin, Cato Just Us Moving Program in the State of Connecticut (JUMP-CT)

Pulmonary

CRC#

IRB#

Principal Investigator

Name of Study

12-009-3 Metersky, Mark Bronchiectasis Research Registry: A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions
INS1007-201 Metersky, Mark The Willow Study: A Phase II Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multi-Center Study to Assess the Efficacy, Safety and Tolerability, and Pharmacokinetics of INS1007 for Subjects with Non Cystic Fibrosis Bronchiectasis
10115 17-045-2 Perez, Mario Airway Inflammatory Profile in E-Cigarette Users

Dental Clinical Research

CRC#

IRB#

Principal Investigator

Name of Study

638 07-016-1 Freilich, Martin Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study
680 09-010-1 Lalla, Rajesh Oral Mucositis Research Registry/Repository
10083 14-188O-6.1 Reisine, Susan Good Oral Health – A Bi-level Intervention to Improve Older Adult Oral Health
10031 10-051-3 Taylor, Thomas Short-implants – An Alternative To Bone Grafting
10080 14-221-3 Freilich, Martin A prospective cohort study on 2-implant maxillary overdentures
10108 16-111-1 Ioannidou, Efthimia Novel Paradigm to Improve Inflammatory Burden in ESRD
10148 19-056-2 Yadav, Sumit A Randomized Clinical Trial Evaluating the Efficacy of OrthoPulse device- a Molecular Level Study
10153 W19-099-1 Lalla, Rajesh ROMAN: Reduction in Oral Mucositis with Avasopasem Manganese (GC4419) – Phase 3 Trial in Patients
Receiving Chemoradiotherapy for Locally-Advanced, Non-Metastatic Head and Neck Cancer.
10168 20-03IJ-2 Ioannidou, Efthimia Treat-to-target and personalized periodontal therapyTreat-to-target and personalized periodontal therapy
10171 20-137-1 Thacker, Sejal An pilot RCT comparing dimensional alteration after socket grafting with xenograft versus allograft
10173 20-045-2 Litt, Mark Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism
10179 20-043-1 Chen, I-Ping Quantitative assessment of dental pain by measuring the electrodermal activity
10181 20X-181-2 Lottinger, Christy Dental Implant Abutments in a Clinical Setting – Retrospective Outcomes.

 

Infectious Disease

CRC#

IRB

Principal Investigator

Name of Study

292 99-226-1 Salazar, Juan Cutaneous Immune Response in Secondary Syphilis and Lyme Disease
10182 20-186-1 Liang, Bruce SARS-CoV-2 SeroSurvelliance in Health Care Workers on COVID-19 Patients
10183 W20-218-2 Elali, Ibrahim Evaluating the use of Polymyxin B cartridge hemoperfusion for patients with septic shock and COVID-19

 

Psychiatry / Mental Health

CRC#

IRB#

Principal Investigator

Name of Study

07-131-1 Covault, Jonathan Behavioral Gene Bank
13-048-6 Steffens, David Neurobiology and Acute Treatment Outcomes of Late Life Depression
16-055-2 Steffens, David Department of Psychiatry: Adult Repository
18-038-1 Grasso, Damion Intergenerational Transmission of Trauma-Related Risk

Neurology

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IRB#

Principal Investigator

Name of Study

10177 W20-159-2 Wajnsztajn, Fernanda A phase 4 multicenter Observational study to evaluate the effectiveness of Patisiran in Patients with Polyneuropathy of Heredirary Transthyretin Mediated (hATTR) Amyloidosis with V122I or T60A mutation

Senior Health / Aging

CRC#

IRB

Principal Investigator

Name of Study

10145 O18-075-2 Kuchel, George Combining Testosterone Therapy and Exercise to Improve Function Post Hip
Fracture

Women’s Health

CRC#

IRB

Principal Investigator

Name of Study

687 09-097-2 Oncken, Cheryl Exercise for Smoking Cessation in Postmenopasual Women
10169 19-140H-1 Cooper, Shontreal/Zhou, Yanjiao Tracking the Microbiome Origin of Inflammation from Mouth to Placenta in Preeclampsia

Genetic

CRC#

IRB#

Principal Investigator

Name of Study

492 03-007-1 Reichenberger, Ernst Genetic Analysis of Human Disorders: Keloid Formation
518 03-008-1 Reichenberger, Ernst Genetic analysis of Human disorders: Skeletal Disorders
10097 15-174-1 Chamberlain, Stormy Induced Pluripotent Stem Cells (iPSCs) to study chromosome 15q neurodevelopmental and behavioral disorders
10133 08-310-1 Sanders, Melinda UCONN Health Center Research Tissue Registry/Repository (COHORT 2)
10142 W18-164-1 Riba-Wolman, Rebecca A Phase 1/2, Open-Label Safety and Dose-Finding Study of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)- Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults
with Glycogen Storage Disease Type Ia (GSDIa)
10163 W19-209-1 Riba-Wolman, Rebecca A Long-Term Follow-up Study to Evaluate the Safety and Efficacy of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)-Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults with Glycogen Storage Disease Type Ia (GSDIa)

Other

CRC#

IRB#

Principal Investigator

Name of Study

14-136-6 Andemarian, Biree Hemoglobinopathies and Bone Health
10-273SFS-2 Clark, Robert The Role of Unique Lipids Derived From Common Human Bacteria in Multiple Sclerosis
16-220-1 Kamath, Jayesh A Phase I Study of the Biomarker Response and Pharmacokinetic Profile of Thyrotropin-Releasing Hormone (TRH) Administered as a Sublingual Tablet
13-132-2 Konopaske, Glenn T. Enroll HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort