This page includes a list of research studies currently supported by the CRC. Please note that some studies may not be open to enrollment. Call the study contact for more information.
Volunteers are also encouraged to visit the Information for Volunteers and Research Subject Advocate Core pages for information about participating in clinical research. Information about other research studies at UConn Health may be found on the Clinical Trials page.
For volunteers currently participating in CRC research, the CRC Clinic Office phone number is 860.679.3666.
Addiction/Substance Abuse | Muscle, Bone and Cartilage | Cancer | Cardiology | Diabetes | Pulmonary | Dental Clinical Research | Infectious Disease | Psychiatry/Mental Health | Neurology | Senior Health/Aging | Women’s Health | Genetic | Other
This page was last updated 10/17/2019
Addiction / Substance Abuse
CRC#
|
IRB#
|
Principal Investigator
|
Name of Study
|
| 51 |
089-89-1 |
Hesselbrock, Victor |
Collaborative Study on the Genetics of Alcoholism |
| 751 |
17-180H6.2 |
Oncken, Cheryl |
Electronic Cigarette Use During Pregnancy |
| 10071 |
H14-120-1 |
Oncken, Cheryl |
Manipulating Tobacco Constituents in Female Menthol Smokers |
| 10107 |
16-148-3 |
Covault, Jonathan |
Zonisamide Treatment of Alcohol Use Disorder: An Evaluation of Efficacy and Mechanism of Action |
| 10136 |
18-091-1 |
Mead, Erin |
Addictive Potential of Little Cigars/Cigarillos in Dual Users: Effects by Flavor and Gender |
| 10162 |
19-202-2 |
Mead, Erin |
Impact of Cigar Flavor on Tobacco Use Behaviors and Addiction in Dual Users |
Muscle, Bone, and Cartilage
CRC#
|
IRB#
|
Principal Investigator
|
Name of Study
|
Cancer
CRC#
|
IRB#
|
Principal Investigator
|
Name of Study
|
| 700 |
09-185-2 |
Hegde, Upendra |
TCR Engineered DC4 Cells as Helpers in Tumors Immunity |
| 720 |
01-127-2 |
Machida, Kazuya |
Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies |
| 10157 |
W19-144-2 |
Brewer, Molly |
A Randomized, Double-Blind, Phase 3 Comparison Of Platinum-Based Therapy With TSR-042 and Niraparib Versus Standard Of Care Platinum-Based Therapy As First-Line Treatment Of Stage III OR IV Nonmucinous Epithelial Ovarian Cancer |
| 10159 |
W19-194-2 |
Andemariam, Biree |
A Prospective Phase II, Open-Label, Single-arm, Multicenter, Study to Assess Efficacy and Safety of SEG101 (crizanlizumab), in Sickle Cell Disease Patients with Priapism (SPARTAN) |
| 10166 |
W19-251-1 |
Hegde, Upendra |
A Phase II, Open-Label, Multicenter, Randomized Study of the Efficacy and Safety of RO7198457 in Combination with Pembrolizumab Versus Pembrolizumab in Patients with Previously Untreated Advanced Melanoma |
Cardiology
| CRC# |
IRB
|
Principal Investigator
|
Name of Study
|
Diabetes
Pulmonary
CRC#
|
IRB#
|
Principal Investigator
|
Name of Study
|
|
12-009-3 |
Metersky, Mark |
Bronchiectasis Research Registry: A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions |
|
INS1007-201 |
Metersky, Mark |
The Willow Study: A Phase II Randomized, Double-Blind, Placebo Controlled, Parallel-Group, Multi-Center Study to Assess the Efficacy, Safety and Tolerability, and Pharmacokinetics of INS1007 for Subjects with Non Cystic Fibrosis Bronchiectasis |
| 10115 |
17-045-2 |
Perez, Mario |
Airway Inflammatory Profile in E-Cigarette Users |
Dental Clinical Research
| CRC# |
IRB#
|
Principal Investigator
|
Name of Study
|
| 638 |
07-016-1 |
Freilich, Martin |
Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study |
| 680 |
09-010-1 |
Lalla, Rajesh |
Oral Mucositis Research Registry/Repository |
| 10083 |
14-188O-6.1 |
Reisine, Susan |
Good Oral Health – A Bi-level Intervention to Improve Older Adult Oral Health |
| 10031 |
10-051-3 |
Taylor, Thomas |
Short-implants – An Alternative To Bone Grafting |
| 10080 |
14-221-3 |
Freilich, Martin |
A prospective cohort study on 2-implant maxillary overdentures |
| 10108 |
16-111-1 |
Ioannidou, Efthimia |
Novel Paradigm to Improve Inflammatory Burden in ESRD |
| 10148 |
19-056-2 |
Yadav, Sumit |
A Randomized Clinical Trial Evaluating the Efficacy of OrthoPulse device- a Molecular Level Study |
| 10153 |
W19-099-1 |
Lalla, Rajesh |
ROMAN: Reduction in Oral Mucositis with Avasopasem Manganese (GC4419) – Phase 3 Trial in Patients
Receiving Chemoradiotherapy for Locally-Advanced, Non-Metastatic Head and Neck Cancer. |
| 10168 |
20-03IJ-2 |
Ioannidou, Efthimia |
Treat-to-target and personalized periodontal therapyTreat-to-target and personalized periodontal therapy |
| 10171 |
20-137-1 |
Thacker, Sejal |
An pilot RCT comparing dimensional alteration after socket grafting with xenograft versus allograft |
| 10173 |
20-045-2 |
Litt, Mark |
Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism |
| 10179 |
20-043-1 |
Chen, I-Ping |
Quantitative assessment of dental pain by measuring the electrodermal activity |
| 10181 |
20X-181-2 |
Lottinger, Christy |
Dental Implant Abutments in a Clinical Setting – Retrospective Outcomes. |
Infectious Disease
CRC#
|
IRB
|
Principal Investigator
|
Name of Study
|
| 292 |
99-226-1 |
Salazar, Juan |
Cutaneous Immune Response in Secondary Syphilis and Lyme Disease |
| 10182 |
20-186-1 |
Liang, Bruce |
SARS-CoV-2 SeroSurvelliance in Health Care Workers on COVID-19 Patients |
| 10183 |
W20-218-2 |
Elali, Ibrahim |
Evaluating the use of Polymyxin B cartridge hemoperfusion for patients with septic shock and COVID-19 |
Psychiatry / Mental Health
| CRC# |
IRB#
|
Principal Investigator
|
Name of Study
|
|
07-131-1 |
Covault, Jonathan |
Behavioral Gene Bank |
|
13-048-6 |
Steffens, David |
Neurobiology and Acute Treatment Outcomes of Late Life Depression |
|
16-055-2 |
Steffens, David |
Department of Psychiatry: Adult Repository |
|
18-038-1 |
Grasso, Damion |
Intergenerational Transmission of Trauma-Related Risk |
Neurology
| CRC# |
IRB#
|
Principal Investigator
|
Name of Study
|
| 10177 |
W20-159-2 |
Wajnsztajn, Fernanda |
A phase 4 multicenter Observational study to evaluate the effectiveness of Patisiran in Patients with Polyneuropathy of Heredirary Transthyretin Mediated (hATTR) Amyloidosis with V122I or T60A mutation |
Senior Health / Aging
| CRC# |
IRB
|
Principal Investigator
|
Name of Study
|
| 10145 |
O18-075-2 |
Kuchel, George |
Combining Testosterone Therapy and Exercise to Improve Function Post Hip
Fracture |
Women’s Health
| CRC# |
IRB
|
Principal Investigator
|
Name of Study
|
| 687 |
09-097-2 |
Oncken, Cheryl |
Exercise for Smoking Cessation in Postmenopasual Women |
| 10169 |
19-140H-1 |
Cooper, Shontreal/Zhou, Yanjiao |
Tracking the Microbiome Origin of Inflammation from Mouth to Placenta in Preeclampsia |
Genetic
| CRC# |
IRB#
|
Principal Investigator
|
Name of Study
|
| 492 |
03-007-1 |
Reichenberger, Ernst |
Genetic Analysis of Human Disorders: Keloid Formation |
| 518 |
03-008-1 |
Reichenberger, Ernst |
Genetic analysis of Human disorders: Skeletal Disorders |
| 10097 |
15-174-1 |
Chamberlain, Stormy |
Induced Pluripotent Stem Cells (iPSCs) to study chromosome 15q neurodevelopmental and behavioral disorders |
| 10133 |
08-310-1 |
Sanders, Melinda |
UCONN Health Center Research Tissue Registry/Repository (COHORT 2) |
| 10142 |
W18-164-1 |
Riba-Wolman, Rebecca |
A Phase 1/2, Open-Label Safety and Dose-Finding Study of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)- Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults
with Glycogen Storage Disease Type Ia (GSDIa) |
| 10163 |
W19-209-1 |
Riba-Wolman, Rebecca |
A Long-Term Follow-up Study to Evaluate the Safety and Efficacy of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)-Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults with Glycogen Storage Disease Type Ia (GSDIa) |
Other
| CRC# |
IRB#
|
Principal Investigator
|
Name of Study
|
|
14-136-6 |
Andemarian, Biree |
Hemoglobinopathies and Bone Health |
|
10-273SFS-2 |
Clark, Robert |
The Role of Unique Lipids Derived From Common Human Bacteria in Multiple Sclerosis |
|
16-220-1 |
Kamath, Jayesh |
A Phase I Study of the Biomarker Response and Pharmacokinetic Profile of Thyrotropin-Releasing Hormone (TRH) Administered as a Sublingual Tablet |
|
13-132-2 |
Konopaske, Glenn T. |
Enroll HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort |