Current Research Listing

This page includes a list of research studies currently supported by the CRCPlease note that some studies may not be open to enrollment. Call the study contact for more information.

Volunteers are also encouraged to visit the Information for Volunteers page for information about participating in clinical research. Information about other research studies at UConn Health may be found on the Clinical Trials page.

For volunteers currently participating in CRC research, the CRC Clinic Office phone number is 860.679.3666.


Addiction/Substance Abuse  |  Muscle, Bone and Cartilage  |  Cancer  |  Cardiology  |  Diabetes  |  Pulmonary  |  Dental Clinical Research | Infectious Disease  |  Psychiatry/Mental Health  |  Neurology | Senior Health/Aging  |  Women’s Health  |  Genetic  |  Other


This page was last updated 11/30/2020

Addiction / Substance Abuse

CRC#

IRB#

Principal Investigator

Name of Study

51 089-89-1 Hesselbrock, Victor Collaborative Study on the Genetics of Alcoholism
751 17-180H6.2 Mead, Erin Electronic Cigarette Use During Pregnancy
10071 H14-120-1 Hesselbrock, Victor Manipulating Tobacco Constituents in Female Menthol Smokers
10107 16-148-3 Covault, Jonathan Zonisamide Treatment of Alcohol Use Disorder: An Evaluation of Efficacy and Mechanism of Action
10118 16-221-2 Litt, Mark Individualized Assessment and Treatment Program for Alcoholism: Treatment and Mechanisms
10136 18-091-1 Mead, Erin Addictive Potential of Little Cigars/Cigarillos in Dual Users: Effects by Flavor and Gender
10162 19-202-2 Mead, Erin Impact of Cigar Flavor on Tobacco Use Behaviors and Addiction in Dual Users

Muscle, Bone, and Cartilage

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IRB#

Principal Investigator

Name of Study

Cancer

CRC#

IRB#

Principal Investigator

Name of Study

700 09-185-2 Hegde, Upendra TCR Engineered DC4 Cells as Helpers in Tumors Immunity
720 01-127-2 Machida, Kazuya Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies
10157 W19-144-2 Brewer, Molly A Randomized, Double-Blind, Phase 3 Comparison Of Platinum-Based Therapy With TSR-042 and Niraparib Versus Standard Of Care Platinum-Based Therapy As First-Line Treatment Of Stage III OR IV Nonmucinous Epithelial Ovarian Cancer
10159 W19-194-2 Andemariam, Biree A Prospective Phase II, Open-Label, Single-arm, Multicenter, Study to Assess Efficacy and Safety of SEG101 (crizanlizumab), in Sickle Cell Disease Patients with Priapism (SPARTAN)
10166 W19-251-1 Hegde, Upendra A Phase II, Open-Label, Multicenter, Randomized Study of the Efficacy and Safety of RO7198457 in Combination with Pembrolizumab Versus Pembrolizumab in Patients with Previously Untreated Advanced Melanoma
10193 W21-062-1 Hegde, Upendra A Phase 3, randomized, placebo-controlled, double-blind clinical study of pembrolizumab (MK-3475) with or without lenvatinib (E7080/MK-7902) to evaluate the safety and efficacy of pembrolizumab and lenvatinib as 1L intervention in a PD-L1 selected population of participants with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) (LEAP-010).
10195 W21-054-2 Brewer, Molly A Phase 3, Double-Blind, Placebo-Controlled, Multicenter Clinical Study comparing Chemo-Immunotherapy (Paclitaxel-Carboplatin-Oregovomab) versus Chemotherapy (Paclitaxel-Carboplatin-Placebo) in Patients with Advanced Epithelial Ovarian, Fallopian Tube or Peritoneal Carcinoma

Cardiology

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IRB

Principal Investigator

Name of Study

Diabetes

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IRB#

Principal Investigator

Name of Study

755 21-045O-1 Bermudez-Millan, Angela The Monthly Cycling of Food Insecurity and Diabetes Risk
10095 15-164S-3 Wagner, Julie Lifestyle and Medication Management to Lower Diabetes Risk in Severe Mental Illness (DREAM)
10139 18-101-6 Laurencin, Cato Just Us Moving: Reducing Hemoglobin A1C Levels among African and Hispanic Americans with Type 2 Diabetes
10144 19-016S-1 Chon, Ki Diabetic Cardiovascular Autonomic Neuropathy Detection Using Principal Dynamic Mode and Electrodermal Activity
10164 19-206S-1 Laurencin, Cato Just Us Moving Program in the State of Connecticut (JUMP-CT)
10190 H19-093 Reagan, Louise Integrated Pain Self-Management for Comorbid Diabetes and Low Back Pain

Pulmonary

CRC#

IRB#

Principal Investigator

Name of Study

749 17-045-2 Perez, Mario Airway Inflammatory Profile in E-Cigarette Users
10045 12-009-2 Metersky, Mark Bronchiectasis Research Registry: A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions

Dental Clinical Research

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IRB#

Principal Investigator

Name of Study

526 02-288-2 Dongari-Bagtzoglou, Anna Oral Epithelial Cells, Candida and PMN Activation
638 07-016-1 Freilich, Martin Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study
680 09-010-1 Lalla, Rajesh Oral Mucositis Research Registry/Repository
10031 10-051-3 Taylor, Thomas Short-implants – An Alternative To Bone Grafting
10080 14-221-3 Freilich, Martin A prospective cohort study on 2-implant maxillary overdentures
10108 16-111-1 Ioannidou, Efthimia Novel Paradigm to Improve Inflammatory Burden in ESRD
10148 19-056-2 Yadav, Sumit A Randomized Clinical Trial Evaluating the Efficacy of OrthoPulse device- a Molecular Level Study
10153 W19-099-1 Lalla, Rajesh ROMAN: Reduction in Oral Mucositis with Avasopasem Manganese (GC4419) – Phase 3 Trial in Patients
Receiving Chemoradiotherapy for Locally-Advanced, Non-Metastatic Head and Neck Cancer.
10168 20-031J-2 Ioannidou, Efthimia Treat-to-target and personalized periodontal therapy Treat-to-target and personalized periodontal therapy
10171 20-137-1 Thacker, Sejal An pilot RCT comparing dimensional alteration after socket grafting with xenograft versus allograft
10173 20-045-2 Litt, Mark Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism
10179 20-043-1 Chen, I-Ping Quantitative assessment of dental pain by measuring the electrodermal activity
10181 20X-181-2 Lottinger, Christy Dental Implant Abutments in a Clinical Setting – Retrospective Outcomes.

 

Infectious Disease

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IRB

Principal Investigator

Name of Study

292 99-226-1 Salazar, Juan Cutaneous Immune Response in Secondary Syphilis and Lyme Disease
753 20-192-2.F Liang, Bruce A randomized, open-label study of the vascular and microbiologic efficacy of dipyridamole plus standard care vs. standard care in hospitalized COVID19 patients.
10182 20-186-1 Liang, Bruce SARS-CoV-2 SeroSurvelliance in Health Care Workers on COVID-19 Patients
10183 W20-218-2 Elali, Ibrahim A randomized, open-label study of the vascular and microbiologic efficacy of dipyridamole plus standard care vs. standard care in hospitalized COVID19 patients.

 

Psychiatry / Mental Health

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IRB#

Principal Investigator

Name of Study

736 IE-13-048H-6.1 Steffens, David Neurobiology and Acute Treatment Outcomes of Late Life Depression
752 18-156O-2 Powell, Wizdom Neighborhoods, daily stress, affect regulation, & Black male substance use: An Ecological Momentary Assessment (EMA) Study
10102 16-055-2 Steffens, David Department of Psychiatry: Adult Repository
10154 W19-052-2 Kamath, Jayesh A Double-Blind, Placebo-Controlled, Randomized Withdrawal, Multicenter Clinical Trial Evaluating The Efficacy, Safety, And Tolerability Of Cariprazine In A Dose-Reduction Paradigm In The Prevention Of Relapse In Patients With Schizophrenia
10155 19-147-2 Covault, Jonathan Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy
10174 U20-073-2 Kamath, Jayesh A Multicenter, Randomized, Flexible-dose, Double-blind Trial of Brexpiprazole Versus Placebo for the Treatment of Adults With Borderline Personality Disorder. Protocol 331-201-00242
10175 U20-082-2 Kamath, Jayesh A Phase 3, Multicenter, Randomized, Double-blind Trial of Brexpiprazole as Combination Therapy with Sertraline in the Treatment of Adults with Post-traumatic Stress Disorder.  Protocol #331-201-00071
10176 19-214-1 Manning, Kevin/ Steffens, David Apathy and Reward Systems in Late-Life Major Depression
10185 18-004-6.2 Ginsburg, Golda Teacher Anxiety Program for Elementary Students
10186 U20-197-1 Kamath, Jayesh A Multicenter, Open-label Trial to Evaluate the Safety and Tolerability of Brexpiprazole in the Treatment of Adult Subjects With Borderline Personality Disorder (Protocol: 331-201-00195)

Neurology

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Principal Investigator

Name of Study

10177 W20-159-2 Wajnsztajn, Fernanda A phase 4 multicenter Observational study to evaluate the effectiveness of Patisiran in Patients with Polyneuropathy of Heredirary Transthyretin Mediated (hATTR) Amyloidosis with V122I or T60A mutation

Senior Health / Aging

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Principal Investigator

Name of Study

10145 O18-075-2 Kuchel, George Combining Testosterone Therapy and Exercise to Improve Function Post Hip
Fracture

Women’s Health

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IRB

Principal Investigator

Name of Study

10169 19-140H-1 Cooper, Shontreal/ Zhou, Yanjiao Tracking the Microbiome Origin of Inflammation from Mouth to Placenta in Preeclampsia

Genetic

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IRB#

Principal Investigator

Name of Study

492 03-007-1 Reichenberger, Ernst Genetic Analysis of Human Disorders: Keloid Formation
518 03-008-1 Reichenberger, Ernst Genetic analysis of Human disorders: Skeletal Disorders
10097 15-174-1 Chamberlain, Stormy Induced Pluripotent Stem Cells (iPSCs) to study chromosome 15q neurodevelopmental and behavioral disorders
10133 08-310-1 Sanders, Melinda UCONN Health Center Research Tissue Registry/Repository (COHORT 2)
10142 W18-164-1 Riba-Wolman, Rebecca A Phase 1/2, Open-Label Safety and Dose-Finding Study of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)- Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults
with Glycogen Storage Disease Type Ia (GSDIa)
10163 W19-209-1 Riba-Wolman, Rebecca A Long-Term Follow-up Study to Evaluate the Safety and Efficacy of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)-Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults with Glycogen Storage Disease Type Ia (GSDIa)

Other

CRC#

IRB#

Principal Investigator

Name of Study

596 01-262-1 Frank, Marion Human Salty and Bitter Taste Mechanisms
10030 10-273SFS-2 Clark, Robert The Role of Unique Lipids Derived From Common Human Bacteria in Multiple Sclerosis
10093 13-132-2 Konopaske, Glenn T. Enroll HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort
10156 19-148-2 Andemariam, Biree An Open-label Extension Study of IMR-687 in Adult Patients with Sickle Cell Anemia (Homozygous HbSS or Sickle-β0 Thalassemia) Who Participated in Study IMR-SCD-102
10161 20-115J-1 Banchereau, Jacques Next-Generation Sequencing Analysis of Human Immune Cells
10167 W20-014-2 Merkulov,Alex Efficacy and safety of gadoPiclenol foR bOdy MagnetIc reSonancE imaging (MRI) Phase III Clinical Trial
10172 20-084-2 Fan, Zhichao Molecular mechanism and preclinical translation of beta2 integrin auto-inhibition on neutrophil arrest and inflammation
10196 U21-073-1 Andemariam, Biree A Phase 2b Study to Evaluate the Safety and Efficacy of IMR-687 in Subjects with Sickle Cell Disease