This page includes a list of research studies currently supported by the CRC. Please note that some studies may not be open to enrollment. Call the study contact for more information.

Volunteers are also encouraged to visit the Information for Volunteers and Research Subject Advocate Core pages for information about participating in clinical research. Information about other research studies at UConn Health may be found on the Clinical Trials page.

For volunteers currently participating in CRC research, the CRC Clinic Office phone number is 860.679.3666.

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Addiction/Substance Abuse  |  Muscle, Bone and Cartilage  |  Cancer  |  Cardiology  |  Diabetes  |  Pulmonary  |  Dental Clinical Research | Infectious Disease  |  Psychiatry/Mental Health  |  Neurology | Senior Health/Aging  |  Women’s Health  |  Genetic  |  Other

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This page was last updated 03/27/2018

Addiction / Substance Abuse

IRB	Principal Investigator	Name of Study
13-056-2	Covault, Jonathan	Dutasteride Treatment for the Reduction of Heavy Drinking
16-148-3	Covault, Jonathan	Zonisamide Treatment of Alcohol Use Disorder: An Evaluation of Efficacy and Mechanism of Action
089-89-1	Hesselbrock, Victor	Collaborative Study on the Genetics of Alcoholism
14-028S-3	Litt, Mark	Taste, Preferences, and Behavior: Effects of Nicotine & Flavorings in Electronic Cigarettes
H14-120-1	Oncken, Cheryl	Manipulating Tobacco Constituents in Female Menthol Smokers
13-066-3	Tennen, Howard	Vulnerabilities for Coping-Related Drinking among Post-College Young Adults
18-091-1	Mead, Erin	Addictive Potential of Little Cigars/Cigarillos in Dual Users: Effects by Flavor and Gender

Muscle, Bone, and Cartilage

IRB	Principal Investigator	Name of Study

Cancer

IRB	Principal Investigator	Name of Study
14-162-2	Diaz, Patricia	The Prevalence of Culturable and Non-culturable Fungi Among Patients with Cancer Undergoing Chemotherapy Treatment Alone or in Combination with Head Neck Radiotherapy and Non-cancer Controls
16-007-1	Hegde, Upendra	A Phase 3 Clinical Trial of Pembrolizumab (MK-3475) in First Line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
01-127-2	Machida, Kazuya	Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies
09-185-2	Mukherji, Bijay	TCR Engineered DC4 Cells as Helpers in Tumors Immunity
13-087-3	Tannenbaum, Susan	Factors Influencing Fatigue in Breast Cancer Patients Undergoing Breast Irradiation
15-077-1	Clement, Jessica	A Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of MK-3475 in Combination with INCB024360 in Subjects with Selected Solid Tumors (Phase 1) Followed by a Randomized, Double-Blind, Placebo-Controlled Study in Subjects with Advanced Non-Small Cell Lung Cancer (Phase 2)
Q16-158-3	Tannenbaum, Susan	Study of Oncoimmunone for the Treatment of Stage III/IV Ovarian Carcinoma
16-227-3	Hegde, Upendra	A Phase 1, Open-Label, Dose Escalation Study of PF-04518600 as a Single Agent and in Combination with PF-05082566 in Patients with Selected Locally Advanced or Metastatic Carcinomas, i.e. Melanoma, HNSCC, RCC, HCC, NSCLC, GI, cervical and bladder

Cardiology

IRB	Principal Investigator	Name of Study
11-155S-2	White, William	Intensive vs. Standard Blood Pressure Lowering to Prevent Functional Decline in Older People

Diabetes

IRB	Principal Investigator	Name of Study
15-164S-3	Wagner, Julie	Lifestyle and Medication Management to Lower Diabetes Risk in Severe Mental Illness (DREAM)
18-101-6	Laurencin, Cato	Just Us Moving: Reducing Hemoglobin A1C Levels among African and Hispanic Americans with Type 2 Diabetes

Pulmonary

IRB	Principal Investigator	Name of Study
C10-268-3	Carroll, Christopher	The Genetics of Severe Asthma in Children
12-009-3	Metersky, Mark	Bronchiectasis Research Registry: A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions
17-045-2	Perez, Mario	Airway Inflammatory Profile in E-Cigarette Users

Dental Clinical Research

IRB	Principal Investigator	Name of Study
02-288-2	Dongari-Bagtzoglou, Anna	Oral Epithelial Cells, Candida and PMN Activation
14-205-1	Dongari-Bagtzoglou, Anna	Saliva Collection for In Vitro Laboratory Studies of Polymicrobial Infection
07-016-1	Freilich, Martin	Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study
11-139-3	Ioannidou, Efthimia	Microbial Profiles of Chronic Periodontitis Subjects Before and After Initial Periodontal Treatment
16-111-1	Ioannidou, Efthimia	Novel Paradigm to Improve Inflammatory Burden in ESRD
14-041-1	Lalla, Rajesh	Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (ORARAD)
09-101-1	Lalla, Rajesh	Oral Mucositis Research Registry/Repository
14-179-1	Lalla, Rajesh	Oral Microbiome in Head and Neck Cancer Patients
14-188-6	Reisine, Susan	Good Oral Health – A Bi-level Intervention to Improve Older Adult Oral Health
10-051-3	Taylor, Thomas	Short-implants – An Alternative To Bone Grafting
14-221-3	Freilich, Martin	A prospective cohort study on 2-implant maxillary overdentures

 

Infectious Disease

IRB	Principal Investigator	Name of Study
99-226-1	Salazar, Juan	Cutaneous Immune Response in Secondary Syphilis and Lyme Disease

 

Psychiatry / Mental Health

IRB	Principal Investigator	Name of Study
07-131-1	Covault, Jonathan	Behavioral Gene Bank
13-048-6	Steffens, David	Neurobiology and Acute Treatment Outcomes of Late Life Depression
16-055-2	Steffens, David	Department of Psychiatry: Adult Repository
17-183-2	Kamath, Jayesh	A Double- blind, Randomized, Placebo-controlled study to Evaluate the Safety of Intranasal Esketamine in Addiction to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Subjects Assessed to be at Imminent Risk for Suicide (ASPIRE-2)
18-038-1	Grasso, Damion	Intergenerational Transmission of Trauma-Related Risk

Neurology

IRB	Principal Investigator	Name of Study
18-123-6	Eugene, Marie	Impact on aging on gene expression and nRNA splice variants in peripheral blood cells
7-1043477-1	Greenfield, Lazar John	Efficacy and Safety of Eslicarbazepine Acetate as First Add-on to Levetiracetam or Lamotrigine Monotherapy or as Later Adjunctive Treatment for Subjects with Uncontrolled Partial-onset Seizures: A Multicenter, Open-label, Non-randomized Trial

Senior Health / Aging

IRB	Principal Investigator	Name of Study
14-194J-3	Kuchel, George	Impact on aging on gene expression and nRNA splice variants in peripheral blood cells

Women’s Health

IRB	Principal Investigator	Name of Study
09-097-2	Oncken, Cheryl	Exercise for Smoking Cessation in Postmenopasual Women
17-180-6	Oncken, Cheryl	Electronic Cigarette Use During Pregnancy

Genetic

IRB	Principal Investigator	Name of Study
14-197-6	Grasso, Damion	The Influence of Prenatal Exposure to Domestic Violence on the DNA Methylation Status of FKBP5 in Newborns
15-174-1	Chamberlain, Stormy	Induced Pluripotent Stem Cells (iPSCs) to study chromosome 15q neurodevelopmental and behavioral disorders
03-007-1	Reichenberger, Ernst	Genetic Analysis of Human Disorders: Keloid Formation
03-008-1	Reichenberger, Ernst	Genetic analysis of Human disorders: Skeletal Disorders

Other

IRB	Principal Investigator	Name of Study
14-136-6	Andemarian, Biree	Hemoglobinopathies and Bone Health
10-273SFS-2	Clark, Robert	The Role of Unique Lipids Derived From Common Human Bacteria in Multiple Sclerosis
01-262-1	Frank, Marion	Human Salty and Bitter Taste Mechanisms
16-220-1	Kamath, Jayesh	A Phase I Study of the Biomarker Response and Pharmacokinetic Profile of Thyrotropin-Releasing Hormone (TRH) Administered as a Sublingual Tablet
13-132-2	Manning, Kevin	Enroll HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort