Current Research Listing

This page includes a list of research studies currently supported by the CRCPlease note that some studies may not be open to enrollment. Call the study contact for more information.

Volunteers are also encouraged to visit the Information for Volunteers and Research Subject Advocate Core pages for information about participating in clinical research. Information about other research studies at UConn Health may be found on the Clinical Trials page.

For volunteers currently participating in CRC research, the CRC Clinic Office phone number is 860.679.3666.


Addiction/Substance Abuse  |  Muscle, Bone and Cartilage  |  Cancer  |  Cardiology  |  Diabetes  |  Pulmonary  |  Dental Clinical Research
Infectious Disease  |  Psychiatry/Mental Health  |  Senior Health/Aging  |  Women’s Health  |  Genetic  |  Other


This page was last updated December 23, 2016

Addiction / Substance Abuse

IRB

Principal Investigator

Name of Study

13-056-2 Covault, Jonathan Dutasteride Treatment for the Reduction of Heavy Drinking
16-148-3 Covault, Jonathan Zonisamide Treatment of Alcohol Use Disorder: An Evaluation of Efficacy and Mechanism of Action
089-89-1 Hesselbrock, Victor Collaborative Study on the Genetics of Alcoholism
14-028S-3 Litt, Mark Taste, Preferences, and Behavior: Effects of Nicotine & Flavorings in Electronic Cigarettes
16-221-3 Litt, Mark Individualized Assessment and Treatment Program for Alcoholism: Treatment and Mechanisms
H14-120-1 Oncken, Cheryl Manipulating Tobacco Constituents in Female Menthol Smokers
13-066-3 Tennen, Howard Vulnerabilities for Coping-Related Drinking among Post-College Young Adults

Muscle, Bone, and Cartilage

IRB

Principal Investigator

Name of Study

13-060-3 Liang, Bruce A Novel Biomarker for Diagnosing and Quantifying Skeletal Muscle Injury
16-115-1 Mirza, Faryal Comparison of the Effects of the Direct Thrombin Inhibitor, Pradaxa, to that of Warfarin on Bone Mass and Bone Turnover Markers
H15-162 Starkweather, Angela Pain Sensitivity in Low Back Pain

Cancer

IRB

Principal Investigator

Name of Study

14-017-2 Chhabra, Arvind Generation of Customized Anti-Tumor T Cells From Human Pluripotent Stem Cells (hPS) Derived Embryoid Bodies (EB) For Immunotherapy of Human Melanoma.
14-162-2 Diaz, Patricia
The Prevalence of Culturable and Non-culturable Fungi Among Patients with Cancer Undergoing Chemotherapy Treatment Alone or in Combination with Head Neck Radiotherapy and Non-cancer Controls
16-007-1 Hegde, Upendra A Phase 3 Clinical Trial of Pembrolizumab (MK-3475) in First Line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma
15-143-3 Tannenbaum, Susan Trial of Vaginal Estrogen for Urogenital Symptom Relief in Women on Aromatase Inhibitors: Systemic Impact Versus Local Objective Benefits and Quality of Life
09-010-1 Lalla, Rajesh Oral Mucositis Research Registry/Repository
01-127-2 Machida, Kazuya Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies
09-185-2 Mukherji, Bijay TCR Engineered DC4 Cells as Helpers in Tumors Immunity
13-087-3 Tannenbaum, Susan Factors Influencing Fatigue in Breast Cancer Patients Undergoing Breast Irradiation
15-077-1 Wasser, Jeffrey A Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of MK-3475 in Combination with INCB024360 in Subjects with Selected Solid Tumors (Phase 1) Followed by a Randomized, Double-Blind, Placebo-Controlled Study in Subjects with Advanced Non-Small Cell Lung Cancer (Phase 2)

Cardiology

IRB

Principal Investigator

Name of Study

11-155S-2 White, William Intensive vs. Standard Blood Pressure Lowering to Prevent Functional Decline in Older People

Diabetes

IRB

Principal Investigator

Name of Study

15-164S-3 Wagner, Julie Lifestyle and Medication Management to Lower Diabetes Risk in Severe Mental Illness (DREAM)

Pulmonary

IRB

Principal Investigator

Name of Study

14-032-3 Burki, Nausherwan Enhancement of Corticosteroid Efficacy in COPD
C10-268-3 Carroll, Christopher The Genetics of Severe Asthma in Children
12-009-3 Metersky, Mark Bronchiectasis Research Registry: A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions

Dental Clinical Research

IRB

Principal Investigator

Name of Study

02-288-2 Dongari-Bagtzoglou, Anna Oral Epithelial Cells, Candida and PMN Activation
14-205-1 Dongari-Bagtzoglou, Anna Saliva Collection for In Vitro Laboratory Studies of Polymicrobial Infection
07-016-1 Freilich, Martin Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study
10-092-2 Ioannidou, Efthimia Periodontal Infection and Systemic Inflammation in Renal Patients
11-139-3 Ioannidou, Efthimia Microbial Profiles of Chronic Periodontitis Subjects Before and After Initial Periodontal Treatment
15-186-1 Ioannidou, Efthimia A Pilot Study to Investigate the Effect of Various CPC Concentrations on Gingivitis in a Split Mouth Design
16-111-1 Ioannidou, Efthimia Novel Paradigm to Improve Inflammatory Burden in ESRD
14-041-1 Lalla, Rajesh Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (ORARAD)
09-101-1 Lalla, Rajesh Oral Mucositis Research Registry/Repository
14-179-1 Lalla, Rajesh Oral Microbiome in Head and Neck Cancer Patients
14-188-6 Reisine, Susan Good Oral Health – A Bi-level Intervention to Improve Older Adult Oral Health
10-051-3 Taylor, Thomas Short-implants – An Alternative To Bone Grafting
14-221-3 Freilich, Martin A prospective cohort study on 2-implant maxillary overdentures

 

Infectious Disease

IRB

Principal Investigator

Name of Study

99-226-1 Salazar, Juan Cutaneous Immune Response in Secondary Syphilis and Lyme Disease

 

Psychiatry / Mental Health

IRB

Principal Investigator

Name of Study

07-131-1 Covault, Jonathan Behavioral Gene Bank
13-048-6 Steffens, David Neurobiology and Acute Treatment Outcomes of Late Life Depression
16-055-2 Steffens, David Department of Psychiatry: Adult Repository

Senior Health / Aging

IRB

Principal Investigator

Name of Study

12-188-2 Kuchel, George Impact of Aging T-Cell Responses to Influenza Vaccination
14-194J-3 Kuchel, George Impact on aging on gene expression and nRNA splice variants in peripheral blood cells

Women’s Health

IRB

Principal Investigator

Name of Study

09-097-2 Oncken, Cheryl Exercise for Smoking Cessation in Postmenopasual Women

Genetic

IRB

Principal Investigator

Name of Study

13-031-3 Bauer, Lance Alcohol Risk Genes and Obesity Risk
14-197-6 Grasso, Damion The Influence of Prenatal Exposure to Domestic Violence on the DNA Methylation Status of FKBP5 in Newborns
15-103-1 Kamath, Jayesh Wellness Clinic Repository
 15-174-1 Lalande, Marc Induced Pluripotent Stem Cells (iPSCs) to study chromosome 15q neurodevelopmental and behavioral disorders
03-007-1 Reichenberger, Ernst Genetic Analysis of Human Disorders: Keloid Formation
03-008-1 Reichenberger, Ernst Genetic analysis of Human disorders: Skeletal Disorders
13-112-2 Rodriguez-Oquendo, Annabelle Deficiency of the HDL Receptor, SR-BI, in Humans

Other

IRB

Principal Investigator

Name of Study

14-136-6 Andemarian, Biree Hemoglobinopathies and Bone Health
10-273SFS-2 Clark, Robert The Role of Unique Lipids Derived From Common Human Bacteria in Multiple Sclerosis
01-262-1 Frank, Marion Human Salty and Bitter Taste Mechanisms
16-220-1 Kamath, Jayesh A Phase I Study of the Biomarker Response and Pharmacokinetic Profile of Thyrotropin-Releasing Hormone (TRH) Administered as a Sublingual Tablet
13-132-2 Manning, Kevin Enroll HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort
15-038-6 Papasavas, Pavlos Weight Loss Success after Bariatric Surgery: Food Preference and Taste Sensation
16-003-1 Liang, Bruce A Pilot on Biobank UConn: The One Thousand Genotype-phenotype Study
H16-152 Cong, Xiaomei Precision Pain Self-Management in Young Adults with Irritable Bowel Syndrome