Current Research Listing

This page includes a list of research studies currently supported by the CRCPlease note that some studies may not be open to enrollment. Call the study contact for more information.

Volunteers are also encouraged to visit the Information for Volunteers page for information about participating in clinical research. Information about other research studies at UConn Health may be found on the Clinical Trials page.

For volunteers currently participating in CRC research, the CRC Clinic Office phone number is 860.679.3666.


Addiction/Substance Abuse  |  Muscle, Bone and Cartilage  |  Cancer  |  Cardiology  |  Diabetes  |  Pulmonary  |  Dental Clinical Research | Infectious Disease  |  Psychiatry/Mental Health  |  Neurology | Senior Health/Aging  |  Women’s Health  |  Genetic  |  Other


This page was last updated 4/11/2022

Addiction / Substance Abuse

CRC# IRB# Principal Investigator Name of Study
51 089-89-1 Hesselbrock, Victor Collaborative Study on the Genetics of Alcoholism
751 17-180H6.2 Mead, Erin Electronic Cigarette Use During Pregnancy
10118 16-221-2 Litt, Mark Individualized Assessment and Treatment Program for Alcoholism: Treatment and Mechanisms
10162 19-202-2 Mead, Erin Impact of Cigar Flavor on Tobacco Use Behaviors and Addiction in Dual Users

Muscle, Bone, and Cartilage

CRC# IRB# Principal Investigator Name of Study
10203 W21-077-2 Moss, Isaac An Assessment of P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion with Instrumentation

Cancer

CRC# IRB# Principal Investigator Name of Study
720 01-127-2 Machida, Kazuya Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies
10195 W21-054-2 Brewer, Molly A Phase 3, Double-Blind, Placebo-Controlled, Multicenter Clinical Study comparing Chemo-Immunotherapy (Paclitaxel-Carboplatin-Oregovomab) versus Chemotherapy (Paclitaxel-Carboplatin-Placebo) in Patients with Advanced Epithelial Ovarian, Fallopian Tube or Peritoneal Carcinoma
10206 O21-173-1 Ibrahim, Omar GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients
10210 21-167JSO-1 Rosenberg, Daniel Microbiota, Metabolites and Colon Neoplasia
10231 W22-268-1 Tannenbaum, Susan Safety, Pharmacokinetics (PK), and Efficacy of ONC-392 as a Single Agent and in Combination with Pembrolizumab in Advanced Solid Tumors and NSCLC:  An Open-label Phase IA/IB Study

Cardiology

CRC# IRB# Principal Investigator Name of Study
10220 22-145-2 Pickett, Christopher Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients with Heart Failure with Preserved Ejection Fraction

Diabetes

CRC#

IRB#

Principal Investigator

Name of Study

755 21-045O-1 Bermudez-Millan, Angela The Monthly Cycling of Food Insecurity and Diabetes Risk
10139 18-101-6 Laurencin, Cato Just Us Moving: Reducing Hemoglobin A1C Levels among African and Hispanic Americans with Type 2 Diabetes
10144 19-016S-1 Chon, Ki Diabetic Cardiovascular Autonomic Neuropathy Detection Using Principal Dynamic Mode and Electrodermal Activity
10164 19-206S-1 Laurencin, Cato Just Us Moving Program in the State of Connecticut (JUMP-CT)

Pulmonary

CRC#

IRB#

Principal Investigator

Name of Study

749 17-045-2 Perez, Mario Airway Inflammatory Profile in E-Cigarette Users
10045 12-009-2 Metersky, Mark Bronchiectasis Research Registry: A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions
10238 U23-047-1 Metersky, Mark A Phase 2, Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Phage Kinetics, and Efficacy of Inhaled AP-PA02 Multi-Phage
Therapeutic in Subjects with Non-Cystic Fibrosis Bronchiectasis and Chronic
Pulmonary Pseudomonas aeruginosa Infection

Dental Clinical Research

CRC# IRB# Principal Investigator Name of Study
526 02-288-2 Dongari-Bagtzoglou, Anna Oral Epithelial Cells, Candida and PMN Activation
638 07-016-1 Freilich, Martin Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study
680 09-010-1 Lalla, Rajesh Oral Mucositis Research Registry/Repository
10080 14-221-3 Freilich, Martin A prospective cohort study on 2-implant maxillary overdentures
10148 19-056-2 Yadav, Sumit A Randomized Clinical Trial Evaluating the Efficacy of OrthoPulse device- a Molecular Level Study
10171 20-137-1 Thacker, Sejal An pilot RCT comparing dimensional alteration after socket grafting with xenograft versus allograft
10173 20-045-2 Litt, Mark Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism
10179 20-043-1 Chen, I-Ping Quantitative assessment of dental pain by measuring the electrodermal activity
10218 U22-235-1 Lalla, Rajesh Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients (ORARAD II)
10232 22-314-2 Uribe, Flavio A Randomized Clinical Trial Comparing the Effect of Force Magnitude on the Rate of Canine Retraction and Gingival Crevicular Fluid Proteome Profile

Infectious Disease

CRC#

IRB

Principal Investigator

Name of Study

10182 20-186-1 Liang, Bruce SARS-CoV-2 SeroSurvelliance in Health Care Workers on COVID-19 Patients
10224 22-232-2 Salazar, Juan Elucidation of Treponema pallidum-specific antibodies in human syphilitic serum

Psychiatry / Mental Health

CRC# IRB# Principal Investigator Name of Study
736 IE-13-048H-6.1 Steffens, David Neurobiology and Acute Treatment Outcomes of Late Life Depression
10102 16-055-2 Steffens, David Department of Psychiatry: Adult Repository
10155 19-147-2 Covault, Jonathan Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy
10175 U20-082-2 Kamath, Jayesh A Phase 3, Multicenter, Randomized, Double-blind Trial of Brexpiprazole as Combination Therapy with Sertraline in the Treatment of Adults with Post-traumatic Stress Disorder.  Protocol #331-201-00071
10176 19-214-1 Manning, Kevin/ Steffens, David Apathy and Reward Systems in Late-Life Major Depression
10194 O21-071-2 Kamath Jayesh A Randomized, Double-blind, Multicenter, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants with Treatment-resistant Depression Protocol 54135419TRD4005
10197 W21-027-2 Kamath, Jayesh A Multicenter, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Seltorexant 20 mg as Adjunctive Therapy to Antidepressants in Adult and Elderly Patients with Major Depressive Disorder with Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy and an Open-labeled Long-term Safety Extension Treatment with Seltorexant
10214 20-105-2 Manning, Kevin Apathy and Biomarkers of Cognitive Decline in Depression (ABCD)
10215 U21-224-2 Kamath, Jayesh A double-blind, placebo-controlled, randomized dose-ranging trial to investigate efficacy and safety of intravenous MIJ821 infusion in addition to comprehensive standard of care on the rapid reduction of symptoms of Major Depressive Disorder in subjects who have suicidal ideation with intent
10229 21-143OSC-1 Grasso, Damion Impact of Perinatal Pandemic-Related Stress on the Early Caregiving Environment, Infant Functioning, DNA Methylation, and Telomere Length
10244 20-122-2 Wang, Lihong A Neural Study of the Maturational Shift in Emotion Regulation in Healthy Aging and Depression (AMSER)

Neurology

CRC# IRB# Principal Investigator Name of Study
10212 22-122-1 Bulsara, Ketan The Intra-arterial Vasospasm Trial
10223 WCG IRB Approval Prakash, Neha TOPAZ Study: Trial of Parkinson’s and Zoledronic Acid — A Randomized Placebo-controlled Trial of Zoledronic Acid for Prevention of Fractures in Patients with Parkinson’s Disease

Senior Health / Aging

CRC# IRB# Principal Investigator Name of Study

Women’s Health

CRC# IRB# Principal Investigator Name of Study

Genetic

CRC#

IRB#

Principal Investigator

Name of Study

492 03-007-1 Reichenberger, Ernst Genetic Analysis of Human Disorders: Keloid Formation
518 03-008-1 Reichenberger, Ernst Genetic analysis of Human disorders: Skeletal Disorders
10163 W19-209-1 Riba-Wolman, Rebecca A Long-Term Follow-up Study to Evaluate the Safety and Efficacy of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)-Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults with Glycogen Storage Disease Type Ia (GSDIa)
10217 U21-192-1 Riba-Wolman, Rebecca A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Adeno-associated Virus Serotype 8-mediated Gene Transfer of Glucose-6-phosphatase in Patients With Glycogen Storage Disease Type Ia
10219 U22-131-2 Loechner, Karen An Open-Label Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-3745 in Participants with Glycogen Storage Disease Type 1a (GSD1a)

Other

CRC#

IRB#

Principal Investigator

Name of Study

596 01-262-1 Frank, Marion Human Salty and Bitter Taste Mechanisms
10030 10-273SFS-2 Clark, Robert The Role of Unique Lipids Derived From Common Human Bacteria in Multiple Sclerosis
10093 13-132-2 Khan, Shakaib Enroll HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort
10172 20-084-2 Fan, Zhichao Molecular mechanism and preclinical translation of beta2 integrin auto-inhibition on neutrophil arrest and inflammation
10200 22-255-2 Fan, Zhichao Mechanisms and Roles of Integrin Activation of Cystic Fibrosis Leukocytes
10201 22X-137-2 Shields, Andrea Advances in Patient Safety Through Simulation Research
10211 U21-249-1 Andemariam, Biree An Adaptive, Randomized, Placebo-controlled, Double-blind, Multi-center Study of Oral FT-4202, a Pyruvate Kinase Agonist in Subjects with Sickle Cell Disease (PRAISE)
10221 22-229-1 Bermudez-Millan, Angela Barriers to WIC Farmers Market Vouchers Redemption among Hartford WIC Participants:
A Community-Based Pilot Study to Strengthen WIC Benefits Use and to Develop a Childhood Obesity
Intervention
10222 22-174-2 Fan, Zhichao Investigating Mechanisms and Roles of Integrin Activation of Human Blood Leukocytes in Mitofusin (MFN2) Disease Condition; Charcot-Marie-Tooth Neuropathy (CMT2A)
10233 22-320J-2 Ucar, Duygu Next-Generation Sequencing Analysis of Healthy Human Cells
10253 22-327-1 Andemariam, Biree Bone Loss, Physical Function and Frailty in Older Women with Sickle Cell Trait