Current Research Listing

This page includes a list of research studies currently supported by the CRC. Please note that some studies may not be open to enrollment. Call the study contact for more information.

Volunteers are also encouraged to visit the Information for Volunteers page for information about participating in clinical research. Information about other research studies at UConn Health may be found on the Clinical Trials page.

For volunteers currently participating in CRC research, the CRC Clinic Office phone number is 860.679.3666.


Addiction/Substance Abuse | Muscle, Bone and Cartilage | Hematology/Oncology | Cardiology | Diabetes | Pulmonary | Dental Clinical Research | Infectious Disease | Psychiatry/Mental Health | Neurology | Senior Health/Aging | Women’s Health | Genetic | Other | Healthy Volunteer Studies


This page was last updated 6/20/2023

Addiction / Substance Abuse

CRC# IRB# Principal Investigator Name of Study
51 089-89-1 Hesselbrock, Victor Collaborative Study on the Genetics of Alcoholism
751 17-180H6.2 Mead-Morse, Erin Electronic Cigarette Use During Pregnancy
10162 19-202-2 Mead-Morse, Erin Impact of Cigar Flavor on Tobacco Use Behaviors and Addiction in Dual Users

Muscle, Bone, and Cartilage

CRC# IRB# Principal Investigator Name of Study
10203 W21-077-2 Moss, Isaac An Assessment of P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion with Instrumentation

Hematology/Oncology

CRC# IRB# Principal Investigator Name of Study
720 01-127-2 Machida, Kazuya Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies
10195 W21-054-2 Brewer, Molly A Phase 3, Double-Blind, Placebo-Controlled, Multicenter Clinical Study comparing Chemo-Immunotherapy (Paclitaxel-Carboplatin-Oregovomab) versus Chemotherapy (Paclitaxel-Carboplatin-Placebo) in Patients with Advanced Epithelial Ovarian, Fallopian Tube or Peritoneal Carcinoma
10206 O21-173-1 Ibrahim, Omar GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients
10210 21-167JSO-1 Rosenberg, Daniel Microbiota, Metabolites and Colon Neoplasia
10211 U21-249-1 Andemariam, Biree An Adaptive, Randomized, Placebo-controlled, Double-blind, Multi-center Study of Oral FT-4202, a Pyruvate Kinase Agonist in Subjects with Sickle Cell Disease (PRAISE)
10231 W22-268-1 Tannenbaum, Susan Safety, Pharmacokinetics (PK), and Efficacy of ONC-392 as a Single Agent and in Combination with Pembrolizumab in Advanced Solid Tumors and NSCLC: An Open-label Phase IA/IB Study
10236 U22-299-2 Andemariam, Biree A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Safety and Efficacy of Inclacumab in Participants with Sickle Cell Disease Experiencing Vaso occlusive Crises
10253 22-327-1 Andemariam, Biree Bone Loss, Physical Function and Frailty in Older Women with Sickle Cell Trait

Cardiology

CRC# IRB# Principal Investigator Name of Study
10220 22-145-2 Pickett, Christopher Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients with Heart Failure with Preserved Ejection Fraction

Diabetes

CRC# IRB# Principal Investigator Name of Study
755 21-045O-1 Bermudez-Millan, Angela The Monthly Cycling of Food Insecurity and Diabetes Risk
10144 19-016S-1 Chon, Ki Diabetic Cardiovascular Autonomic Neuropathy Detection Using Principal Dynamic Mode and Electrodermal Activity

Pulmonary

CRC# IRB# Principal Investigator Name of Study
749 17-045-2 Perez, Mario Airway Inflammatory Profile in E-Cigarette Users
10045 12-009-2 Metersky, Mark Bronchiectasis Research Registry: A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions
10187 U21-098-1 Metersky, Mark A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib Administered Once Daily for 52 Weeks in Subjects with Non-Cystic Fibrosis Bronchiectasis – The ASPEN Study
10238 U23-047-1 Metersky, Mark A Phase 2, Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Phage Kinetics, and Efficacy of Inhaled AP-PA02 Multi-Phage Therapeutic in Subjects with Non-Cystic Fibrosis Bronchiectasis and Chronic Pulmonary Pseudomonas Aeruginosa Infection

Dental Clinical Research

CRC# IRB# Principal Investigator Name of Study
526 02-288-2 Dongari-Bagtzoglou Oral Epithelial Cells, Candida and PMN Activation
638 07-016-1 Freilich, Martin Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study
680 09-010-1 Lalla, Rajesh Oral Mucositis Research Registry/Repository
10173 20-045-2 Litt, Mark Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism
10179 20-043-1 Chen, I-Ping Quantitative assessment of dental pain by measuring the electrodermal activity
10218 U22-235-1 Lalla, Rajesh Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients (ORARAD II)
10232 22-314-2 Uribe, Flavio A Randomized Clinical Trial Comparing the Effect of Force Magnitude on the Rate of Canine Retraction and Gingival Crevicular Fluid Proteome Profile

Infectious Disease

CRC# IRB# Principal Investigator Name of Study
10182 22-232- Liang, Bruce SARS-CoV-2 SeroSurvelliance in Health Care Workers on COVID-19 Patients
10224 20-186-1 Salazar, Juan Elucidation of Treponema pallidum-specific antibodies in human syphilitic serum

Psychiatry / Mental Health

CRC# IRB# Principal Investigator Name of Study
736 IE-13-048H-6.1 Steffens, David Neurobiology and Acute Treatment Outcomes of Late Life Depression
10155 19-147-2 Covault, Jonathan Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy
10176 19-214-1 Manning, Kevin/ Steffens, David Apathy and Reward Systems in Late-Life Major Depression
10194 O21-071-2 Kamath Jayesh A Randomized, Double-blind, Multicenter, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants with Treatment-resistant Depression Protocol 54135419TRD4005
10229 21-143OSC-1 Grasso, Damion Impact of Perinatal Pandemic-Related Stress on the Early Caregiving Environment, Infant Functioning, DNA Methylation, and Telomere Length
10242 W23-092-1 Kamath, Jayesh A Randomized, Double-blind, Multicenter, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants with Major Depressive Disorder (MDD) with Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
10247 21-257-2 Diniz, Breno The SenDep Study: Linking Molecular Senescence Changes to Depression and Cognitive impairment in Late Life
10175 U20-082-2 Kamath, Jayesh A Phase 3, Multicenter, Randomized, Double-blind Trial of Brexpiprazole as Combination Therapy with Sertraline in the Treatment of Adults with Post-traumatic Stress Disorder. Protocol #331-201-00071

Neurology

CRC# IRB# Principal Investigator Name of Study
10212 22-122-1 Bulsara, Ketan The Intra-arterial Vasospasm Trial
10223 n/a Prakash, Neha A Randomized Placebo-controlled Trial of Zolendronic Acid for Prevention of Fractures in Patients with Parkinson’s Disease (TOPAZ)
10228 U22-283-2 Prakash, Neha A Double-Blind, Placebo-Controlled, Randomized, 18-Month Phase 2A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Oral UCB0599 in Study Participants with Early Parkinson’s Disease

Senior Health / Aging

CRC# IRB# Principal Investigator Name of Study

Women’s Health

CRC# IRB# Principal Investigator Name of Study

Genetic

CRC# IRB# Principal Investigator Name of Study
492 03-007-1 Reichenberger, Ernst Genetic Analysis of Human Disorders: Keloid Formation
518 03-008-1 Reichenberger, Ernst Genetic analysis of Human disorders: Skeletal Disorders
10163 W19-209-1 Riba-Wolman, Rebecca A Long-Term Follow-up Study to Evaluate the Safety and Efficacy of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)-Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults with Glycogen Storage Disease Type Ia (GSDIa)
10217 U21-192-1 Riba-Wolman, Rebecca A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Adeno-associated Virus Serotype 8-mediated Gene Transfer of Glucose-6-phosphatase in Patients With Glycogen Storage Disease Type Ia
10219 U22-131-2 Loechner, Karen An Open-Label Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-3745 in Participants with Glycogen Storage Disease Type 1a (GSD1a)

Other

CRC# IRB# Principal Investigator Name of Study
10093 13-132-2 Khan, Shakaib Enroll HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort
10172 20-084-2 Fan, Zhichao Molecular mechanism and preclinical translation of beta2 integrin auto-inhibition on neutrophil arrest and inflammation
10200 22-255-2 Fan, Zhichao Mechanisms and Roles of Integrin Activation of Cystic Fibrosis Leukocytes
10221 22-229-1 Bermudez-Millan, Angela Barriers to WIC Farmers Market Vouchers Redemption among Hartford WIC Participants:
A Community-Based Pilot Study to Strengthen WIC Benefits Use and to Develop a Childhood Obesity
Intervention
10222 22-174-2 Fan, Zhichao Investigating Mechanisms and Roles of Integrin Activation of Human Blood Leukocytes in Mitofusin (MFN2) Disease Condition; Charcot-Marie-Tooth Neuropathy (CMT2A)
10233 22-320J-2 Ucar, Duygu Next-Generation Sequencing Analysis of Healthy Human Cells

Healthy Volunteer Studies

CRC# IRB# Principal Investigator Name of Study
10254 23-193J-1 Wang, Eric Healthy Control Blood Collection to Investigate Mechanisms of Therapy Resistance in Hematologic Malignancies
10265 N/A Adams, Mark Collection of Human Specimens for Validation of Assays in the JAX Advanced Precision Medicine Lab (This is a non-research study)