This page includes a list of research studies currently supported by the CRC. Please note that some studies may not be open to enrollment. Call the study contact for more information.
Volunteers are also encouraged to visit the Information for Volunteers page for information about participating in clinical research. Information about other research studies at UConn Health may be found on the Clinical Trials page.
For volunteers currently participating in CRC research, the CRC Clinic Office phone number is 860.679.3666.
Addiction/Substance Abuse | Muscle, Bone and Cartilage | Cancer | Cardiology | Diabetes | Pulmonary | Dental Clinical Research | Infectious Disease | Psychiatry/Mental Health | Neurology | Senior Health/Aging | Women’s Health | Genetic | Other
This page was last updated 4/11/2022
Addiction / Substance Abuse
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 51 |
089-89-1 |
Hesselbrock, Victor |
Collaborative Study on the Genetics of Alcoholism |
| 751 |
17-180H6.2 |
Mead, Erin |
Electronic Cigarette Use During Pregnancy |
| 10118 |
16-221-2 |
Litt, Mark |
Individualized Assessment and Treatment Program for Alcoholism: Treatment and Mechanisms |
| 10162 |
19-202-2 |
Mead, Erin |
Impact of Cigar Flavor on Tobacco Use Behaviors and Addiction in Dual Users |
Muscle, Bone, and Cartilage
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 10203 |
W21-077-2 |
Moss, Isaac |
An Assessment of P-15L Bone Graft in Transforaminal Lumbar Interbody Fusion with Instrumentation |
Cancer
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 720 |
01-127-2 |
Machida, Kazuya |
Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies |
| 10195 |
W21-054-2 |
Brewer, Molly |
A Phase 3, Double-Blind, Placebo-Controlled, Multicenter Clinical Study comparing Chemo-Immunotherapy (Paclitaxel-Carboplatin-Oregovomab) versus Chemotherapy (Paclitaxel-Carboplatin-Placebo) in Patients with Advanced Epithelial Ovarian, Fallopian Tube or Peritoneal Carcinoma |
| 10206 |
O21-173-1 |
Ibrahim, Omar |
GMCI plus Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC Patients |
| 10210 |
21-167JSO-1 |
Rosenberg, Daniel |
Microbiota, Metabolites and Colon Neoplasia |
| 10231 |
W22-268-1 |
Tannenbaum, Susan |
Safety, Pharmacokinetics (PK), and Efficacy of ONC-392 as a Single Agent and in Combination with Pembrolizumab in Advanced Solid Tumors and NSCLC: An Open-label Phase IA/IB Study |
Cardiology
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 10220 |
22-145-2 |
Pickett, Christopher |
Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients with Heart Failure with Preserved Ejection Fraction |
Diabetes
Pulmonary
CRC#
|
IRB#
|
Principal Investigator
|
Name of Study
|
| 749 |
17-045-2 |
Perez, Mario |
Airway Inflammatory Profile in E-Cigarette Users |
| 10045 |
12-009-2 |
Metersky, Mark |
Bronchiectasis Research Registry: A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions |
| 10238 |
U23-047-1 |
Metersky, Mark |
A Phase 2, Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Phage Kinetics, and Efficacy of Inhaled AP-PA02 Multi-Phage
Therapeutic in Subjects with Non-Cystic Fibrosis Bronchiectasis and Chronic
Pulmonary Pseudomonas aeruginosa Infection |
Dental Clinical Research
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 526 |
02-288-2 |
Dongari-Bagtzoglou, Anna |
Oral Epithelial Cells, Candida and PMN Activation |
| 638 |
07-016-1 |
Freilich, Martin |
Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study |
| 680 |
09-010-1 |
Lalla, Rajesh |
Oral Mucositis Research Registry/Repository |
| 10080 |
14-221-3 |
Freilich, Martin |
A prospective cohort study on 2-implant maxillary overdentures |
| 10148 |
19-056-2 |
Yadav, Sumit |
A Randomized Clinical Trial Evaluating the Efficacy of OrthoPulse device- a Molecular Level Study |
| 10171 |
20-137-1 |
Thacker, Sejal |
An pilot RCT comparing dimensional alteration after socket grafting with xenograft versus allograft |
| 10173 |
20-045-2 |
Litt, Mark |
Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism |
| 10179 |
20-043-1 |
Chen, I-Ping |
Quantitative assessment of dental pain by measuring the electrodermal activity |
| 10218 |
U22-235-1 |
Lalla, Rajesh |
Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients (ORARAD II) |
| 10232 |
22-314-2 |
Uribe, Flavio |
A Randomized Clinical Trial Comparing the Effect of Force Magnitude on the Rate of Canine Retraction and Gingival Crevicular Fluid Proteome Profile |
Infectious Disease
CRC#
|
IRB
|
Principal Investigator
|
Name of Study
|
| 10182 |
20-186-1 |
Liang, Bruce |
SARS-CoV-2 SeroSurvelliance in Health Care Workers on COVID-19 Patients |
| 10224 |
22-232-2 |
Salazar, Juan |
Elucidation of Treponema pallidum-specific antibodies in human syphilitic serum |
Psychiatry / Mental Health
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 736 |
IE-13-048H-6.1 |
Steffens, David |
Neurobiology and Acute Treatment Outcomes of Late Life Depression |
| 10102 |
16-055-2 |
Steffens, David |
Department of Psychiatry: Adult Repository |
| 10155 |
19-147-2 |
Covault, Jonathan |
Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy |
| 10175 |
U20-082-2 |
Kamath, Jayesh |
A Phase 3, Multicenter, Randomized, Double-blind Trial of Brexpiprazole as Combination Therapy with Sertraline in the Treatment of Adults with Post-traumatic Stress Disorder. Protocol #331-201-00071 |
| 10176 |
19-214-1 |
Manning, Kevin/ Steffens, David |
Apathy and Reward Systems in Late-Life Major Depression |
| 10194 |
O21-071-2 |
Kamath Jayesh |
A Randomized, Double-blind, Multicenter, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants with Treatment-resistant Depression Protocol 54135419TRD4005 |
| 10197 |
W21-027-2 |
Kamath, Jayesh |
A Multicenter, Double-Blind, Randomized, Parallel-Group, Placebo-Controlled, Study to Evaluate the Efficacy and Safety of Seltorexant 20 mg as Adjunctive Therapy to Antidepressants in Adult and Elderly Patients with Major Depressive Disorder with Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy and an Open-labeled Long-term Safety Extension Treatment with Seltorexant |
| 10214 |
20-105-2 |
Manning, Kevin |
Apathy and Biomarkers of Cognitive Decline in Depression (ABCD) |
| 10215 |
U21-224-2 |
Kamath, Jayesh |
A double-blind, placebo-controlled, randomized dose-ranging trial to investigate efficacy and safety of intravenous MIJ821 infusion in addition to comprehensive standard of care on the rapid reduction of symptoms of Major Depressive Disorder in subjects who have suicidal ideation with intent |
| 10229 |
21-143OSC-1 |
Grasso, Damion |
Impact of Perinatal Pandemic-Related Stress on the Early Caregiving Environment, Infant Functioning, DNA Methylation, and Telomere Length |
| 10244 |
20-122-2 |
Wang, Lihong |
A Neural Study of the Maturational Shift in Emotion Regulation in Healthy Aging and Depression (AMSER) |
Neurology
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
| 10212 |
22-122-1 |
Bulsara, Ketan |
The Intra-arterial Vasospasm Trial |
| 10223 |
WCG IRB Approval |
Prakash, Neha |
TOPAZ Study: Trial of Parkinson’s and Zoledronic Acid — A Randomized Placebo-controlled Trial of Zoledronic Acid for Prevention of Fractures in Patients with Parkinson’s Disease |
Senior Health / Aging
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
Women’s Health
| CRC# |
IRB# |
Principal Investigator |
Name of Study |
Genetic
| CRC# |
IRB#
|
Principal Investigator
|
Name of Study
|
| 492 |
03-007-1 |
Reichenberger, Ernst |
Genetic Analysis of Human Disorders: Keloid Formation |
| 518 |
03-008-1 |
Reichenberger, Ernst |
Genetic analysis of Human disorders: Skeletal Disorders |
| 10163 |
W19-209-1 |
Riba-Wolman, Rebecca |
A Long-Term Follow-up Study to Evaluate the Safety and Efficacy of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)-Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults with Glycogen Storage Disease Type Ia (GSDIa) |
| 10217 |
U21-192-1 |
Riba-Wolman, Rebecca |
A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Adeno-associated Virus Serotype 8-mediated Gene Transfer of Glucose-6-phosphatase in Patients With Glycogen Storage Disease Type Ia |
| 10219 |
U22-131-2 |
Loechner, Karen |
An Open-Label Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-3745 in Participants with Glycogen Storage Disease Type 1a (GSD1a) |
Other
| CRC# |
IRB#
|
Principal Investigator
|
Name of Study
|
| 596 |
01-262-1 |
Frank, Marion |
Human Salty and Bitter Taste Mechanisms |
| 10030 |
10-273SFS-2 |
Clark, Robert |
The Role of Unique Lipids Derived From Common Human Bacteria in Multiple Sclerosis |
| 10093 |
13-132-2 |
Khan, Shakaib |
Enroll HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort |
| 10172 |
20-084-2 |
Fan, Zhichao |
Molecular mechanism and preclinical translation of beta2 integrin auto-inhibition on neutrophil arrest and inflammation |
| 10200 |
22-255-2 |
Fan, Zhichao |
Mechanisms and Roles of Integrin Activation of Cystic Fibrosis Leukocytes |
| 10201 |
22X-137-2 |
Shields, Andrea |
Advances in Patient Safety Through Simulation Research |
| 10211 |
U21-249-1 |
Andemariam, Biree |
An Adaptive, Randomized, Placebo-controlled, Double-blind, Multi-center Study of Oral FT-4202, a Pyruvate Kinase Agonist in Subjects with Sickle Cell Disease (PRAISE) |
| 10221 |
22-229-1 |
Bermudez-Millan, Angela |
Barriers to WIC Farmers Market Vouchers Redemption among Hartford WIC Participants:
A Community-Based Pilot Study to Strengthen WIC Benefits Use and to Develop a Childhood Obesity
Intervention |
| 10222 |
22-174-2 |
Fan, Zhichao |
Investigating Mechanisms and Roles of Integrin Activation of Human Blood Leukocytes in Mitofusin (MFN2) Disease Condition; Charcot-Marie-Tooth Neuropathy (CMT2A) |
| 10233 |
22-320J-2 |
Ucar, Duygu |
Next-Generation Sequencing Analysis of Healthy Human Cells |
| 10253 |
22-327-1 |
Andemariam, Biree |
Bone Loss, Physical Function and Frailty in Older Women with Sickle Cell Trait |