This page includes a list of research studies currently supported by the CRC. Please note that some studies may not be open to enrollment. Call the study contact for more information.
Volunteers are also encouraged to visit the Information for Volunteers and Research Subject Advocate Core pages for information about participating in clinical research. Information about other research studies at UConn Health may be found on the Clinical Trials page.
For volunteers currently participating in CRC research, the CRC Clinic Office phone number is 860.679.3666.
Addiction/Substance Abuse | Muscle, Bone and Cartilage | Cancer | Cardiology | Diabetes | Pulmonary | Dental Clinical Research | Infectious Disease | Psychiatry/Mental Health | Neurology | Senior Health/Aging | Women’s Health | Genetic | Other
This page was last updated 03/27/2018
Addiction / Substance Abuse
IRB
|
Principal Investigator
|
Name of Study
|
| 16-148-3 |
Covault, Jonathan |
Zonisamide Treatment of Alcohol Use Disorder: An Evaluation of Efficacy and Mechanism of Action |
| 089-89-1 |
Hesselbrock, Victor |
Collaborative Study on the Genetics of Alcoholism |
| H14-120-1 |
Oncken, Cheryl |
Manipulating Tobacco Constituents in Female Menthol Smokers |
| 13-066-3 |
Tennen, Howard |
Vulnerabilities for Coping-Related Drinking among Post-College Young Adults |
| 18-091-1 |
Mead, Erin |
Addictive Potential of Little Cigars/Cigarillos in Dual Users: Effects by Flavor and Gender |
Muscle, Bone, and Cartilage
IRB
|
Principal Investigator
|
Name of Study
|
|
|
|
Cancer
IRB
|
Principal Investigator
|
Name of Study
|
| 14-162-2 |
Diaz, Patricia |
| The Prevalence of Culturable and Non-culturable Fungi Among Patients with Cancer Undergoing Chemotherapy Treatment Alone or in Combination with Head Neck Radiotherapy and Non-cancer Controls |
|
| 16-007-1 |
Hegde, Upendra |
A Phase 3 Clinical Trial of Pembrolizumab (MK-3475) in First Line Treatment of Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma |
| 01-127-2 |
Machida, Kazuya |
Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies |
| 09-185-2 |
Hegde, Upendra |
TCR Engineered DC4 Cells as Helpers in Tumors Immunity |
| 13-087-3 |
Tannenbaum, Susan |
Factors Influencing Fatigue in Breast Cancer Patients Undergoing Breast Irradiation |
| 15-077-1 |
Clement, Jessica |
A Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of MK-3475 in Combination with INCB024360 in Subjects with Selected Solid Tumors (Phase 1) Followed by a Randomized, Double-Blind, Placebo-Controlled Study in Subjects with Advanced Non-Small Cell Lung Cancer (Phase 2) |
| Q16-158-3 |
Tannenbaum, Susan |
Study of Oncoimmunone for the Treatment of Stage III/IV Ovarian Carcinoma |
| 16-227-3 |
Hegde, Upendra |
A Phase 1, Open-Label, Dose Escalation Study of PF-04518600 as a Single Agent and in Combination with PF-05082566 in Patients with Selected Locally Advanced or Metastatic Carcinomas, i.e. Melanoma, HNSCC, RCC, HCC, NSCLC, GI, cervical and bladder |
Cardiology
IRB
|
Principal Investigator
|
Name of Study
|
| 11-155S-2 |
White, William |
Intensive vs. Standard Blood Pressure Lowering to Prevent Functional Decline in Older People |
Diabetes
Pulmonary
IRB
|
Principal Investigator
|
Name of Study
|
| C10-268-3 |
Carroll, Christopher |
The Genetics of Severe Asthma in Children |
| 12-009-3 |
Metersky, Mark |
Bronchiectasis Research Registry: A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions |
| 17-045-2 |
Perez, Mario |
Airway Inflammatory Profile in E-Cigarette Users |
Dental Clinical Research
IRB
|
Principal Investigator
|
Name of Study
|
| 14-205-1 |
Dongari-Bagtzoglou, Anna |
Saliva Collection for In Vitro Laboratory Studies of Polymicrobial Infection |
| 07-016-1 |
Freilich, Martin |
Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study |
| 11-139-3 |
Ioannidou, Efthimia |
Microbial Profiles of Chronic Periodontitis Subjects Before and After Initial Periodontal Treatment |
| 16-111-1 |
Ioannidou, Efthimia |
Novel Paradigm to Improve Inflammatory Burden in ESRD |
| 14-041-1 |
Lalla, Rajesh |
Clinical Registry of Dental Outcomes in Head and Neck Cancer Patients (ORARAD) |
| 09-101-1 |
Lalla, Rajesh |
Oral Mucositis Research Registry/Repository |
| 14-179-1 |
Lalla, Rajesh |
Oral Microbiome in Head and Neck Cancer Patients |
| 14-188-6 |
Reisine, Susan |
Good Oral Health – A Bi-level Intervention to Improve Older Adult Oral Health |
| 10-051-3 |
Taylor, Thomas |
Short-implants – An Alternative To Bone Grafting |
| 14-221-3 |
Freilich, Martin |
A prospective cohort study on 2-implant maxillary overdentures |
Infectious Disease
IRB
|
Principal Investigator
|
Name of Study
|
| 99-226-1 |
Salazar, Juan |
Cutaneous Immune Response in Secondary Syphilis and Lyme Disease |
Psychiatry / Mental Health
IRB
|
Principal Investigator
|
Name of Study
|
| 07-131-1 |
Covault, Jonathan |
Behavioral Gene Bank |
| 13-048-6 |
Steffens, David |
Neurobiology and Acute Treatment Outcomes of Late Life Depression |
| 16-055-2 |
Steffens, David |
Department of Psychiatry: Adult Repository |
| 17-183-2 |
Kamath, Jayesh |
A Double- blind, Randomized, Placebo-controlled study to Evaluate the Safety of Intranasal Esketamine in Addiction to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Subjects Assessed to be at Imminent Risk for Suicide (ASPIRE-2) |
| 18-038-1 |
Grasso, Damion |
Intergenerational Transmission of Trauma-Related Risk |
Neurology
IRB
|
Principal Investigator
|
Name of Study
|
| 18-123-6 |
Eugene, Marie |
Effect of Chronic Levetiracetam Use on Bone Mineral Metabolism: Clinical Study |
| 7-1043477-1 |
Greenfield, Lazar John |
Efficacy and Safety of Eslicarbazepine Acetate as First Add-on to Levetiracetam or Lamotrigine Monotherapy or as Later Adjunctive Treatment for Subjects with Uncontrolled Partial-onset Seizures: A Multicenter, Open-label, Non-randomized Trial |
Senior Health / Aging
IRB
|
Principal Investigator
|
Name of Study
|
| 14-194J-3 |
Kuchel, George |
Impact on aging on gene expression and nRNA splice variants in peripheral blood cells |
Women’s Health
IRB
|
Principal Investigator
|
Name of Study
|
| 09-097-2 |
Oncken, Cheryl |
Exercise for Smoking Cessation in Postmenopasual Women |
| 17-180-6 |
Oncken, Cheryl |
Electronic Cigarette Use During Pregnancy |
Genetic
IRB
|
Principal Investigator
|
Name of Study
|
| 14-197-6 |
Grasso, Damion |
The Influence of Prenatal Exposure to Domestic Violence on the DNA Methylation Status of FKBP5 in Newborns |
| 15-174-1 |
Chamberlain, Stormy |
Induced Pluripotent Stem Cells (iPSCs) to study chromosome 15q neurodevelopmental and behavioral disorders |
| 03-007-1 |
Reichenberger, Ernst |
Genetic Analysis of Human Disorders: Keloid Formation |
| 03-008-1 |
Reichenberger, Ernst |
Genetic analysis of Human disorders: Skeletal Disorders |
Other
IRB
|
Principal Investigator
|
Name of Study
|
| 14-136-6 |
Andemarian, Biree |
Hemoglobinopathies and Bone Health |
| 10-273SFS-2 |
Clark, Robert |
The Role of Unique Lipids Derived From Common Human Bacteria in Multiple Sclerosis |
| 16-220-1 |
Kamath, Jayesh |
A Phase I Study of the Biomarker Response and Pharmacokinetic Profile of Thyrotropin-Releasing Hormone (TRH) Administered as a Sublingual Tablet |
| 13-132-2 |
Konopaske, Glenn T. |
Enroll HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort |