This page includes a list of research studies currently supported by the CRC. Please note that some studies may not be open to enrollment. Call the study contact for more information.
Volunteers are also encouraged to visit the Information for Volunteers page for information about participating in clinical research. Information about other research studies at UConn Health may be found on the Clinical Trials page.
For volunteers currently participating in CRC research, the CRC Clinic Office phone number is 860.679.3666.
Addiction/Substance Abuse | Muscle, Bone and Cartilage | Hematology/Oncology | Cardiology | Diabetes | Pulmonary | Dental Clinical Research | Infectious Disease | Psychiatry/Mental Health | Neurology | Senior Health/Aging | Women’s Health | Genetic | Other | Healthy Volunteer Studies
This page was last updated 6/20/2023
Addiction / Substance Abuse
| CRC# | IRB# | Principal Investigator | Name of Study |
| 51 | 089-89-1 | Hesselbrock, Victor | Collaborative Study on the Genetics of Alcoholism |
| 10162 | 19-202-2 | Mead-Morse, Erin | Impact of Cigar Flavor on Tobacco Use Behaviors and Addiction in Dual Users |
Muscle, Bone, and Cartilage
| CRC# | IRB# | Principal Investigator | Name of Study |
Hematology/Oncology
| CRC# | IRB# | Principal Investigator | Name of Study |
| 720 | 01-127-2 | Machida, Kazuya | Signalosome-oriented Phosphotyrosine Profiling of B-cell Malignancies |
| 10210 | 21-167JSO-1 | Rosenberg, Daniel | Microbiota, Metabolites and Colon Neoplasia |
| 10211 | U21-249-1 | Andemariam, Biree | An Adaptive, Randomized, Placebo-controlled, Double-blind, Multi-center Study of Oral FT-4202, a Pyruvate Kinase Agonist in Subjects with Sickle Cell Disease (PRAISE) |
| 10245 | U23-049-2 | Andemariam, Biree | An Open-label Extension Study to Evaluate the Long-term Safety of Inclacumab Administered to Participants with Sickle Cell Disease Who Have Participated in an Inclacumab Clinical Trial |
| 10253 | 22-327-1 | Andemariam, Biree | Bone Loss, Physical Function and Frailty in Older Women with Sickle Cell Trait |
| 10258 | 24-193-1 | Andemariam, Biree | Hydroxyurea Pharmacokinetics and Pharmacodynamics in Adults with Sickle Cell Anemia |
| 10267 | W24-009-1 | Andemariam, Biree | An Open-label Mechanistic Study to Assess the Pharmacokinetics, Pharmacodynamics and Safety of Orally Administered Epeleuton in Patients with Sickle Cell Disease |
| 10277 | U24-118-2 | Andemariam, Biree | A Phase 2/3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Mitapivat in Subjects With Sickle Cell Disease |
| 10295 | U24-235-2 | Callahan, Margaret | A Phase 3 Randomized, Controlled Study of IMC-F106C Plus Nivolumab Versus Nivolumab Regimens in HLA-A*02:01-Positive Participants With Previously Untreated Advanced Melanoma (PRISM-MEL-301) |
| 10297 | W25-046-2 | Hegde, Upendra | A Randomized, Double-blind, Placebo-controlled Phase 3 Study to evaluate Dostalimab as Sequential Therapy after Chemoradiation in Participants with Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma |
Cardiology
| CRC# | IRB# | Principal Investigator | Name of Study |
| 10220 | 22-145-2 | Pickett, Christopher | Effect of Beta-blocker Discontinuation on Functional Capacity and Cardiac Hemodynamics in Patients with Heart Failure with Preserved Ejection Fraction |
Diabetes
| CRC# | IRB# | Principal Investigator | Name of Study |
| 755 | 21-045O-1 | Bermudez-Millan, Angela | The Monthly Cycling of Food Insecurity and Diabetes Risk |
Pulmonary
| CRC# | IRB# | Principal Investigator | Name of Study |
| 10045 | 12-009-2 | Metersky, Mark | Bronchiectasis Research Registry: A Consolidated Database of Non-Cystic Fibrosis Bronchiectasis Patients from Major Clinical and Research Institutions |
| 10238 | U23-047-1 | Metersky, Mark | A Phase 2, Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Phage Kinetics, and Efficacy of Inhaled AP-PA02 Multi-Phage Therapeutic in Subjects with Non-Cystic Fibrosis Bronchiectasis and Chronic Pulmonary Pseudomonas Aeruginosa Infection |
| 10266 | U24-022-1 | Foley, Raymond | A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Inhalation of Seralutinib for the Treatment of Pulmonary Arterial Hypertension (PROSERA) |
| 10268 | W23-053-2 | Metersky, Mark | Expanded Access Protocol: Brensocatib in Patients with Non-Cystic Fibrosis Bronchiectasis |
| 10275 | W24-073-2 | Rasheed, Ameer | A Randomized, Double-Blind, Four-Arm Active and Placebo-Controlled Dose-Finding Trial to Evaluate the Efficacy, Tolerability, Safety and Dose Response of LTY-100 in Patients with Idiopathic Pulmonary Fibrosis (IPF) |
| 10283 | W24-168-2 | Metersky, Mark | A Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Proof-of-Concept (PoC) Study to Assess the Efficacy, Safety and Tolerability of Itepekimab, in Participants with Non-Cystic Fibrosis bronchiectasis |
Dental Clinical Research
| CRC# | IRB# | Principal Investigator | Name of Study |
| 526 | 02-288-2 | Dongari-Bagtzoglou | Oral Epithelial Cells, Candida and PMN Activation |
| 638 | 07-016-1 | Freilich, Martin | Osteoporosis and Bone Augmentation/Implant Outcomes: An Observational Study |
| 680 | 09-010-1 | Lalla, Rajesh | Oral Mucositis Research Registry/Repository |
| 10173 | 20-045-2 | Litt, Mark | Individualized Assessment and Treatment Program for TMD: Coping as a Mechanism |
| 10179 | 20-043-1 | Chen, I-Ping | Quantitative assessment of dental pain by measuring the electrodermal activity |
| 10218 | U22-235-1 | Lalla, Rajesh | Clinical Registry of Long-Term Dental Outcomes in Head and Neck Cancer Patients (ORARAD II) |
| 10232 | 22-314-2 | Uribe, Flavio | A Randomized Clinical Trial Comparing the Effect of Force Magnitude on the Rate of Canine Retraction and Gingival Crevicular Fluid Proteome Profile |
| 10282 | 24-197-1 | Thacker, Sejal | Immediate Versus Delayed Loading of Mandibular Implant Retained Overdentures: A 10 Year Follow up of a Randomized Clinical Trial |
Infectious Disease
| CRC# | IRB# | Principal Investigator | Name of Study |
| 10182 | 20-186-1 | Liang, Bruce | SARS-CoV-2 SeroSurvelliance in Health Care Workers on COVID-19 Patients |
| 10224 | 22-232-2 | Salazar, Juan | Elucidation of Treponema pallidum-specific antibodies in human syphilitic serum |
Psychiatry / Mental Health
| CRC# | IRB# | Principal Investigator | Name of Study |
| 736 | IE-13-048H-6.1 | Steffens, David | Neurobiology and Acute Treatment Outcomes of Late Life Depression |
| 10155 | 19-147-2 | Covault, Jonathan | Dutasteride Treatment for Reducing Heavy Drinking in AUD: Predictors of Efficacy |
| 10176 | 19-214-1 | Manning, Kevin/ Steffens, David | Apathy and Reward Systems in Late-Life Major Depression |
| 10229 | 21-143OSC-1 | Grasso, Damion | Impact of Perinatal Pandemic-Related Stress on the Early Caregiving Environment, Infant Functioning, DNA Methylation, and Telomere Length |
| 10242 | W23-092-1 | Kamath, Jayesh | A Randomized, Double-blind, Multicenter, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants with Major Depressive Disorder (MDD) with Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy |
| 10247 | 21-257-2 | Diniz, Breno | The SenDep Study: Linking Molecular Senescence Changes to Depression and Cognitive impairment in Late Life |
| 10261 | W23-227-1 | Jain, Neha | A Study of Disease Characteristics and Real-life Standard of Care Effectiveness in Patients with Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including an SSRI or SNRI. Protocol 67953964MDD3004 VENTURA-RWE |
| 10262 | U23-210-2 | Kamath, Jayesh | A Randomized, Double-Blind, Placebo-controlled Multicenter Study to Assess the Efficacy and Safety of Lumateperone as Adjunctive Therapy in the Treatment of Patients with Major Depressive Disorder. Protocol ITI-007-505 |
| 10287 | O24-166-2 | Kamath, Jayesh | A Two-Part Multicenter, Double-Blind, Randomized Placebo-Controlled Study to Evaluate Efficacy and Safety and the Maintenance of Effect of 20-mg Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Patients with Major Depressive Disorder with Insomnia Symptoms. |
| 10288 | U24-209-1 | Kamath, Jayesh | A Phase 2, Multicenter, Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of BHV-7000 in Treatment of Major Depressive Disorder. (BHV7000-203) |
| 10289 | U24-208 | Kamath, Jayesh | A Phase 2 Multicenter, Randomized, Double-blind, Placebo-controlled, Study to Evaluate the Efficacy and Safety of BHV-7000 Monotherapy in Major Depressive Disorder (Protocol number BHV7000-305) |
Neurology
| CRC# | IRB# | Principal Investigator | Name of Study |
| 10228 | U22-283-2 | Prakash, Neha | A Double-Blind, Placebo-Controlled, Randomized, 18-Month Phase 2A Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Oral UCB0599 in Study Participants with Early Parkinson’s Disease |
| 10286 | U24-227-2 | Greenfield, L. John | A Phase 2/3 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Efficacy, Safety and Tolerability of BHV-7000 in Subjects with Refractory Focal Onset Epilepsy |
Senior Health / Aging
| CRC# | IRB# | Principal Investigator | Name of Study |
Women’s Health
| CRC# | IRB# | Principal Investigator | Name of Study |
Genetic
| CRC# | IRB# | Principal Investigator | Name of Study |
| 492 | 03-007-1 | Reichenberger, Ernst | Genetic Analysis of Human Disorders: Keloid Formation |
| 518 | 03-008-1 | Reichenberger, Ernst | Genetic analysis of Human disorders: Skeletal Disorders |
| 10163 | W19-209-1 | Riba-Wolman, Rebecca | A Long-Term Follow-up Study to Evaluate the Safety and Efficacy of Adeno-Associated Virus (AAV) Serotype 8 (AAV8)-Mediated Gene Transfer of Glucose-6-Phosphatase (G6Pase) in Adults with Glycogen Storage Disease Type Ia (GSDIa) |
| 10217 | U21-192-1 | Riba-Wolman, Rebecca | A Phase 3, Randomized, Double-blind, Placebo-controlled Study of Adeno-associated Virus Serotype 8-mediated Gene Transfer of Glucose-6-phosphatase in Patients With Glycogen Storage Disease Type Ia |
| 10219 | U22-131-2 | Loechner, Karen | An Open-Label Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-3745 in Participants with Glycogen Storage Disease Type 1a (GSD1a) |
Other
| CRC# | IRB# | Principal Investigator | Name of Study |
| 10093 | 13-132-2 | Khan, Shakaib | Enroll HD: A Prospective Registry Study in a Global Huntington’s Disease Cohort |
| 10172 | 20-084-2 | Fan, Zhichao | Molecular mechanism and preclinical translation of beta2 integrin auto-inhibition on neutrophil arrest and inflammation |
| 10200 | 22-255-2 | Fan, Zhichao | Mechanisms and Roles of Integrin Activation of Cystic Fibrosis Leukocytes |
| 10221 | 22-229-1 | Bermudez-Millan, Angela | Barriers to WIC Farmers Market Vouchers Redemption among Hartford WIC Participants: A Community-Based Pilot Study to Strengthen WIC Benefits Use and to Develop a Childhood Obesity Intervention |
| 10222 | 22-174-2 | Fan, Zhichao | Investigating Mechanisms and Roles of Integrin Activation of Human Blood Leukocytes in Mitofusin (MFN2) Disease Condition; Charcot-Marie-Tooth Neuropathy (CMT2A) |
| 10233 | 22-320J-2 | Ucar, Duygu | Next-Generation Sequencing Analysis of Healthy Human Cells |
| 10255 | W24-031-2 | Rezaizadeh, Houman | A Phase 2/3, Randomized, 3-Part Study to Investigate the Efficacy and Safety of Dupilumab in Adult and Adolescent Patients with Eosinophilic Gastritis with or without Eosinophilic Duodenitis (The “Engage” Study) |
| 10256 | U24-100-2 | Rezaizadeh, Houman | A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Barzolvolimab (CDX-0159) in Adults with Active Eosinophilic Esophagitis (The “EvolvE” Study) |
| 10264 | 24-023J-2 | Robson, Paul | An open resource of human induced pluripotent stem cells lines from diverse population groups. |
| 10269 | W24-115-1 | Vedere, Tarunya | A Randomized, Double-blind, Dose-Conversion Study to Evaluate the Safety and Efficacy of Hormone Replacement Therapy with North Star Desiccated Thyroid Extract Compared to Levothyroxine in Subjects with Primary Hypothyroidism who are Euthyroid on Levothyroxine Replacement Therapy |
Healthy Volunteer Studies
| CRC# | IRB# | Principal Investigator | Name of Study |
| 10254 | 23-193J-1 | Wang, Eric | Healthy Control Blood Collection to Investigate Mechanisms of Therapy Resistance in Hematologic Malignancies |
| 10265 | N/A | Adams, Mark | Collection of Human Specimens for Validation of Assays in the JAX Advanced Precision Medicine Lab (This is a non-research study) |
| 10290 | 25-018-2 | Covault, Jonathan | Healthy Volunteer Registry (HVR) https://redcap.link/fathqeur |