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    NIH Data Acquisition

    The NIH makes the results of the research it supports and conducts available to the public enabling data reuse, increasing transparency, and the facilitation of reproducibility of research results.

    While open-access data can be browsed online or downloaded without prior permission, controlled-access data can only be obtained after the requestor has been authorized and IRB approval is required for some.

    Specific information about the more commonly used repositories can be found below.

    The database of Genotypes and Phenotypes (dbGaP)

    The database of Genotypes and Phenotypes (dbGaP) was developed by NIH’s National Center for Biotechnology Information (NCBI) to archive and distribute the data results from studies that have investigated the interaction of genotype and phenotype in humans. The high-level workflow is below:
    1. The PI will:
    2. NCBI will notify the SPS Signing Official (SO) of the request.
    3. SPS will secure NCBI application and Data Use Certification Agreement (DUC) signature(s).
    4. The SO will approve the request in the NCBI system.
    Use of the data set is authorized for one year and must be renewed annually. Renewals also follow the above process. The detailed process document can be found here: LINK  

    NIDDK Specimen and Data Repository

    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Central Repository

    The NIDDK Central Repository enables scientists to test new hypotheses without the need to collect any new data or biospecimens and provides the opportunity to pool data across several studies to increase the power of statistical analyses. In addition, most NIDDK-funded studies are collecting genetic biospecimens and carrying out high-throughput genotyping making it possible for other scientists to use Central Repository resources to match genotypes to phenotypes and to perform informative genetic analyses. Data Access is Controlled:

    Summary level data is open.

    Credentialed user must apply for access to individual level data.

    Data Request Instructions

    National Institute of Mental Health Data Archive (NDA)

    National Institute of Mental Health Data Archive (NDA)

    The National Institute of Mental Health Data Archive (NDA) makes available human subjects data collected from hundreds of research projects across many scientific domains. NDA provides infrastructure for sharing research data, tools, methods, and analyses enabling collaborative science and discovery. De-identified human subjects’ data, harmonized to a common standard, are available to qualified researchers. Summary data are available to all. Data Access is Mixed.
    NDA access portal
    The NIH also provides a searchable list of more than 100 affiliated repositories containing scientific data that can be accessed by researchers, and more than 25 containing genomic data. The list provides links to information about how to request access to the datasets.