Postdoctoral Job Postings

UCH Postdoc 4

Postdoctoral Fellow Positions

A postdoctoral position is available in a NIH funded laboratory with interest in elucidating pathogenic mechanisms of rare bone disorders by multiple molecular and functional analyses in mouse models as well as patient-specific induced pluripotent stem cells (iPSCs).
Candidates must have PhD, MD/PhD, or MD and must be highly motivated.

The successful applicant will have strong background in BONE RESEARCH with technical expertise in molecular biology, cell biology, stem cell biology and/or signal transduction.

Our newly renovated laboratory is embedded in the Center for Regenerative Medicine and Skeletal Development at University of Connecticut Health within a vibrant research environment. We study molecular mechanisms of disease-related mutated genes with a current focus on osteoclast biology. We further test findings from mouse models in patient-specific iPS cell culture systems.
Candidates must be innovative, enthusiastic and have a solid background in at least one of the identified areas (bone biology, molecular biology, cell biology, stem cell biology or signal transduction) and must be motivated and capable to engage in other areas of expertise as required by the project. The dynamics of this research project requires the ability for multitasking, to work independently as well as collaboratively with other lab members and external collaborators. The candidate should be proficient in basic molecular biology techniques, including RT-PCR, qPCR, histology, immunostaining, Western blots, immunoprecipitation, sequencing, cloning and cell cultures etc.
Please send CV, statement of research interests and research accomplishments, and contact information for 3 references to:
I-Ping Chen, D.D.S, Ph.D.
(Associate Professor)

University of Connecticut Health (UConn Health)
Department of Oral Health and Diagnostic Sciences
263 Farmington Avenue
Farmington, CT 06030-3705

Tel: 860-679-1030
email: ipchen@uchc.edu

The Laboratory of Microbiome Science at University of Connecticut Health Center is a new laboratory that is interested in developing microbiome-based diagnosis and therapeutics for human diseases. We are looking for a dedicated postdoctoral candidate to study host-gut microbiome interaction in multiple sclerosis, an autoimmune disease affecting central nervous system. By integrating experimental and multi-OMICS approaches, the postdoc associate will investigate how the gut microbiome modulates local gut immune response and affects neuroinflammations in an animal model of multiple sclerosis. The postdoc associate will have the opportunity to perform microbiome manipulation including fecal transplantation and anaerobic culturing, immune assays and bioinformatics.

An NIH funded postdoctoral research position is available immediately in the Weller lab in the Department of Molecular Biology and Biophysics at the University of Connecticut School of Medicine in Farmington CT. The Weller lab uses biochemical, biophysical and molecular genetic approaches to study the mechanisms and enzymology of DNA replication in Herpes Simplex Virus. HSV infects almost 70% of the world’s population, and we have discovered that this important viral pathogen has evolved an unusual replication strategy that uses recombination-dependent replication to produce progeny genomes. Our newly funded R01 focuses on a virally-encoded ssDNA binding protein that plays many roles during viral DNA replication, participating protein-protein interactions necessary for the initiation of DNA synthesis, the cooperative binding to ssDNA, filament formation and the annealing of complementary ssDNA (Weerasooriya et al. 2018l PNAS. doi: 10.1073/pnas.1817642116). We also use our structural and mechanistic insights to drive development of novel antiviral drugs in collaboration with Dr. Dennis Wright Professor of Medicinal Chemistry in the School of Pharmacy at UConn Storrs. We are looking for curious and mechanistically minded scientists interested in DNA replication mechanisms and translational biochemistry. Please see some of our recent publications listed below for more information: https://www.ncbi.nlm.nih.gov/myncbi/sandra.weller.1/bibliography/public/

Applicants should be recent Ph.D. graduates in the Life Sciences or Physical Sciences and have experience working with nucleic acids, proteins, enzyme assays and biophysical characterization of biomolecules. The ideal candidate will have technical expertise in protein expression and purification using bacterial, mammalian or insect systems as well as basic molecular biology techniques. Experience with biophysical methods and the ability to relate biochemical mechanisms to biological processes are highly desirable.
MBB has a vibrant, active collaborative faculty working in diverse areas, including DNA replication/repair, protein homeostasis, microbiology/infectious diseases, structural biology (X-ray crystallography and NMR), computational biology, and drug discovery. The MBB department hosts outstanding core facilities for structural biology (NMR and X-ray Crystallography), biophysical analysis and EM. Postdoctoral fellows are employees of UConn School of Medicine and receive a generous benefits package including health insurance, retirement contributions, paid vacation and up to 12 days of paid sick leave per year.

Interested applicants should send a single PDF file that includes a cover letter summarizing their research training and accomplishments, a personal statement of scientific interests and goals, current CV with recent publications, and contact information for three references to Dr. Sandra Weller at Weller@uchc.edu.

A Postdoctoral Associate is available in the Division of Nephrology of the Department of Medicine at University of Connecticut Health Center to investigate the role of macrophages, immune cells, and fibroblasts in the pathogenesis of kidney injury and fibrosis. The ideal candidate will be expected to design and perform experiments, and prepare and publish manuscripts under the direction of the Principal Investigator. The candidate will work with animal models relevant to a human disease, using multiple scientific techniques including cell culture, flow cytometry, confocal microscope, single cell transcriptome analysis, RNA-seq, ChIP-PCR assays, histological and morphometric analysis, immunohistochemistry and bone marrow cell transfer. Candidates must have a PhD degree and a strong background in Molecular and Cell Biology. Working experience with small animal models is preferred. Interested applicants, please email curriculum vitae and contact information of three references to Dr. Yanlin Wang (yanlwang@uchc.edu).

The main research focus of Dr. Kalajzic laboratory is stem cell biology and biology of bone repair. The main goal of the project is regulation of osteogenic differentiation of mesenchymal stem cells during fracture healing with the particular focus on neuronal regulation of bone healing.

Responsibilities will include discussion and planning of experimental designs, completion of experiments using established in vitro and in vivo models, presentation of data within institution and at international conferences and preparation of manuscripts.

Applicants must have a Ph.D., good command of the English language and good interpersonal skills. Experience in a bone or orthopedic-related field would be advantageous, but is not critical. USA citizens/permanent residents will have an opportunity to compete for a T90 training position funded by NIDCR.
The University of Connecticut Health is an affirmative action employer, in addition to an EEO and M/F/V/PWD/PV employer.

Please send curriculum vitae including qualifications, bibliography, summary of past accomplishments, and names of three references to:
Dr. Ivo Kalajzic | Professor, Reconstructive Sciences
Center for Regenerative Medicine and Skeletal Development
School of Dental Medicine | UConn Health
263 Farmington Avenue, Farmington, CT 06030-3705
Office: 860.679.6051
ikalaj@uchc.edu

The postdoctoral fellow will work on an NIH-funded project that develops the widely used simulation software COPASI. This project is focused on parallel optimization algorithms for high-performance computing to accelerate parameter estimation of biochemical models. The postdoc will contribute to the C++ source code of COPASI and the python code of Cloud-COPASI. The postdoc will join the International team that are developing COPASI with collaborators in the University of Virginia and University of Heidelberg, Germany.

The environment at UConn Health is particularly rich in the area of computational biology and the successful candidate will be able to interact with other teams working in systems biology, computational biology and bioinformatics, including related computational biology projects (VCell, BioNetGen, etc.).

Requirements: A PhD or equivalent in computational biology, computer science, mathematics, physics, or related areas. Experience of programming in C++ or python are essential. Previous experience of using COPASI or other systems biology simulation software is desirable but not essential.

Availability: this position is available immediately and open until filled. Contact Pedro Mendes pmendes@uchc.edu for further details.

The post-doctoral fellow will work on an NIH-funded project studying the interactions of Candida albicans with lactic acid bacteria in polymicrobial biofilms. The project is multidisciplinary and involves the study of polymicrobial biofilms using advanced biofilm imaging and image analysis techniques, as well as mathematical modeling of factors controlling biofilm growth using agent-based simulations. The post-doc will be trained to work with experimental polymicrobial systems/models in the laboratory of Dr Dongari-Bagtzoglou and will work closely with a modeling post-doc from the Quantitative Medicine Center to apply experimental data in mathematical model calibration and validation. The post-doc will be mentored in grant writing.

Requirements: PhD in Microbiology with experience in basic microbiology-related cell and molecular biology assays. Alternatively, PhD in Environmental Engineering or Biomedical Engineering with a background/interest in Microbiology and biofilm control methods.

Positon available immediately and open until filled.

Contact Person: Anna Dongari-Bagtzoglou, PhD, adongari@uchc.edu, 860-679-4543

Always be sure to check the UConn Health Find Jobs page for more listings.


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