Additional seminar information – 3D printing or additive manufacturing (AM) is becoming important in clinical needs for on demand patient matched implants due to better functionalities, lower cost and shorter lead time to manufacture. Establishing process property relationships for different AM techniques are vital towards successful implementation of these manufacturing practices in biomedical devices. Additive manufacturing of multiple materials in single operation is also an exciting innovation. Hard biomaterials, e.g., calcium phosphate (CaP) ceramics being compositionally similar to the inorganic part of bone, are often used in bone implant applications, as both 3D printed tissue engineering scaffolds and surface modified hip and knee implant devices. We have used CaP scaffolds, fabricated using 3-D printing technology, for bone tissue engineering. Dopant chemistry in CaP plays a vital role in controlling their resorption or degradation kinetics as scaffolds, mechanical strength, and biological properties of resorbable CaPs. 3D interconnected channels in CaP scaffolds provide pathways for micronutrients, improved cell-material interactions, and increased surface area allows improved mechanical interlocking between scaffolds and surrounding bone. Use of polymer helps in controlling drug release kinetics. In vivo studies show improved osteogenesis, angiogenesis and controlled drug delivery using natural medicinal compounds (NMCs) in these 3D printed scaffolds and coatings. These systems show promise for use in orthopedic and dental devices while eliminating the need for the autografts and the second site surgery for harvesting, as well as improving current hip / knee implant lifetime. The presentation will address design of next generation bone tissue engineering scaffolds and hip / knee devices based on clinical needs in fixation of bone disorders and scientific challenges
Susmita Bose, Ph.D. – Susmita Bose is the Herman and Brita Lindholm Endowed Chair Professor at the School of Mechanical and Materials Engineering, affiliate faculty of Department of Chemistry and Elson Floyd College of Medicine at Washington State University. Prof. Bose’s interdisciplinary research interest lies at the interface of Chemistry, Materials Science, Mechanical Engineering, Bioengineering and Biology, focusing on 3D printed bone scaffolds, implant materials and drug delivery vehicles. Prof. Bose received the CAREER award and the prestigious Presidential Early Career Award for Scientist and Engineers (PECASE) from the National Science Foundation. She has advised over 40 graduate students for their MS and PhD, published over 250 technical articles including over 200 journal articles, 15 book chapters, 7 edited books, 12 patents. Her research papers have been cited ~ 15,000 times (‘h” index 67, Google scholar). She was invited as “Kavli fellow” by the National Academy of Sciences, received the PACE and Fulrath Awards from the American Ceramic Society. In 2015, Prof. Bose was named as Life Science Innovation Northwest Women to Watch Honoree, by the Washington Biotechnology and Biomedical Association. In 2016, she received the International Society for Ceramics in Medicine research excellence award. She is a fellow of the American Association for the Advancement of Science (AAAS), National Academy of Inventors (NAI), Materials Research Society (MRS), ASM International, American Institute for Medical and Biological Engineering (AIMBE), the American Ceramic Society (ACerS) and the Royal Society of Chemistry (RSC). In 2017 she has been elected to the Washington State Academy of Sciences, in 2018 she received WSU distinguished faculty address award and in 2019 WSU Sahlin faculty excellence award for research scholarships and art. Prof. Bose’s group research on 3D printed bone tissue engineering scaffolds with controlled chemistry has been featured by the AP, BBC, NPR, CBS, MSNBC, ABC, and many other TV, radio stations, magazines and news sites all over the world