GTTF Mice on the Cover

Journal of Biological Chemistry

Mice harboring a gain-of-function Notch2 mutation recapitulate selected skeletal manifestations of Hajdu-Cheney syndrome. Image of a femoral cross-section (bone marrow cells in green, bone surface with osteoblasts in purple and red, osteoclasts in yellow) from a mutant mouse.

Canalis E, Schilling L, Yee SP, Lee SK, Zanotti S., (2016). Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis and Bone Resorption. J. Biol. Chem. 291: 1538-1551.