Publications Using CMGM Mice

Hiu W. Cheung, Alexander D. Schouw, Zeynep M. Altunay, J. Wesley Maddox, Lyndsay C. Kresic, Brenna C. McAllister, Keaven Caro, Shahnawaz Alam, Angie Huang, Robert S. Pijewski, Amy Lee, David C. Martinelli. (2024) Creation of a novel CRISPR-generated allele to express HA epitope-tagged C1QL1 and improved methods for its detecion at synapses. FEBS PRESS 10 June 2024 doi:10.1002/1873-3468.14946

Corie M Owen, Laurinda A Jaffe. (2024) Luteinizing hormone stimulates ingression of mural granulosa cells within the mouse preovulatory follicle. Biol Reprod. Feb 10;110(2):288-299. doi:10.1093/biolre/ioad142.

Rachael P Norris, Laurinda A Jaffe. (2024) Granulosa Cells Alone, Without Theca Cells, Can Mediate LH-induced Oocyte Meiotic Resumption. Endocrinology. Jan 16;165(3):bqad200. doi:10.1210/endocr/bqad200.

Nicholes R. Candelaria, JoAnne S Richards. (2024) Targeted deletion of NR2F2 and VCAM1 in theca cells imacts ovarian follicular development: insights into PCOS? Biol Reprod. Jan 15:ioae010. doi:10.1093/biolre/ioae010.

Egbert JR, Silbern I, Uliasz TF, Lowther KM, Yee SP, Urlaub H, Jaffe LA.(2023) Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase Biol Reprod. 2023 Sep 29:ioad130. doi: 10.1093/biolre/ioad130. Online ahead of print. PMID: 37774352

Seetur R. PradeepMahesh Thirunavukkarasu, Diego Accorsi, Santosh Swaminathan, Sue Ting Lim, Bryan Cernuda, Andrew Kemerley, Jennifer Hubbard, Jacob Campbell, Rickesha L. Wilson, Vladimir Coca-Soliz, Leondidas Tapias, Vaithinathan Selvaraju, Evan R. Jellison, Siu-Pok Yee, J. Alexander Palesty, Nilanjana Maulik  (2023) Novel approaches to determine the functional role of cardiomyocyte specific E3 ligase, Pellino-1 following myocardial infarction. 2023 Sep 29:166899. doi: 10.1016/j.bbadis.2023.166899. Online ahead of print.

Yi Tian YapWei Li Qian Huang Qi Zhou David Zhang Yi ShengLjljiana Mladenovic-Lucas Siu-Pok Yee Kyle E Orwig James G Granneman David C Williams Jr Rex Hess Aminata Toure Zhibing Zhang (2023) DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice. Apr 21, 2023.

Yonghong Man, Wei Li, Yi Tian Yap, Alivia Kearney, Siu-Pok Yee, Jerome F. Strauss III, Pamela Harding, Shizheng Song, Ling Zhang, Zhibing Zhang (2023) Generation of floxed Spag6l mice and disruption of the gene by crossing to a Hprt-Cre line. 2023 Apr 14;e23512. doi: 10.1002/dvg.23512. Online ahead of print.

Masakazu Yamamoto, Sean J Stoessel, Shoko Yamamoto, and David J Goldhamer (2022) Overexpression of Wild-Type ACVR1 in Fibrodysplasia Ossificans Progressive Mice Rescues Perinatal Lethality and Inhibits Heterotopic Ossification. J Bone Miner Res. 2022 Nov; 37(11):2077-2093.

Jeremy R. Egbert, Tracy F. Uliasz, Katie M. Lowther, Deborah Kaback, Brandon M. Wagner, Chastity L. Healy, Timothy D. O'Connell, Lincoln R. Potter, Laurinda A. Jaffe and Siu-Pok Yee (2022) Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases. Front Mol Neurosci. 2022 Oct 19;15:1007026. doin: 10.3389/fnmol.2022.100726. eCollection 2022.

E. Canalis, S.P. Yee, A.N. Economdies, L. Schilling, J. Yu. Induction of a NOTCH3 Lehman syndrome mutation in osteocytes causes osteopenia in male C57BL/6J mice. (2022) Bone Volume 162, September 2022, 116476 doi 10.1016/j.bone/2022.116476

John R SinnamonMichael E JacobsonJohn F YungJenna R FiskSophia JengShannon K McWeeneyLindsay K ParmeleeChi Ngai ChanSiu-Pok YeeGail Mandel (2022). Targeted RNA editing in brainstem alleviates respiratory dysfunction in a mouse model of Rett syndrome. Proc Natl Acad Sci USA. 2022 Aug 16;119(33):e2206053119. doi: 10.1073/pnas.2206053119. Epub 2022 Aug 8.

Brandon M Wagner, Jerid W Robinson, Chastity L Healy, Madeline Gauthier, Deborah M Dickey, Siu-Pok Yee, John W Osborn, Timothy D O'Connell, Lincoln R Potter (2022). Guanylyl cyclase-A phosphorylation decreases cardiac hypertrophy and improves systolic function in male, but not female, mice. FASEB J. Jan;36(1):e22069.PMID: 34859913.

Jeremy R Egbert, Jerid W Robinson, Tracy F Uliasz, Lincoln R Potter, Laurinda A Jaffe (2021). Cyclic AMP links luteinizing hormone signaling to dephosphorylation and inactivation of the NPR2 guanylyl cyclase in ovarian folliclesBiol Reprod. May 7;104(5):939-941.

Shuhaibar, L.C.,  Kaci, N., Egbert, J.R., Horville, T., Loisay, L., Vigone, G., Uliasz, T.F., Dambroise,E., Swingle, M.R.,  Honkanen, R.E., Duplan, M.B., Jaffe, L.A., Legeai-Mallet, L. (2021) Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth JCI insight. 6 (9):141426.

Mallika Ghosh, Tomislav Kelava, Ivana Vrhovac Madunic, Ivo Kalajzic, Linda H Shapiro CD13 is a critical regulator of cell-cell fusion in osteoclastogenesis. Sci Rep. 2021 May 24;11(1):10736. doi10.1038/s41598-021-90271-x.

JungeunYu12LaurenSchilling2TabithaEller2ErnestoCanalis123(2021). Hairy and enhancer of split 1 is a primary effector of NOTCH2 signaling and induces osteoclast differentiation and function. J Biol Chem. Volume 297, Issue 6,doi: 10.1016/j.jbc.2021.101376. Epub 2021 Nov 3.

Yue Su Ling Wang, Zhiqiang Fan, Ying Liu, Jiaqi Zhu, Deborah Kaback, Julia Oudiz, Tayler Patrick, Siu Pok Yee, Xiuchun Cindy TianIrina Polejaeva, Young Tang. (2021) Establishment of Bovine-Induced Pluripotent Stem Cells. Int. J. Mol. Sci., 22(19), 10489;

Jessica Costa-Guda, Kristin Corrado, Justin Bellizzi, Robert Romano, Elizabeth Saria, Kirsten Saucier, Madison Rose, Samip Shah, Cynthia Alander, Sanjay Mallya, and Andrew Arnold. (2020) CDK4/6 Dependence of Cyclin D1-Driven Parathyroid Neoplasia in Transgenic Mice. Endocrinology, 2020 Oct; 161 (10): bpqaa159. doi: 10.1210/endocr/bqaa159.

Qu W, Yuan S, Quan C, Huang Q, Zhou Q, Yap Y, Shi L, Zhang D, Guest T, Li W, Yee SP, Zhang L, Cazin C, Hess RA, Ray PF, Kherraf ZE, Zhang Z. (2020) The essential role of intraflagellar transport protein IFT81 in male mice spermiogenesis and fertility. Am J Physiol Cell Physiol. 318(6):C1092-C1106. doi: 10.1152/ajpcell.00450.2019. Epub 2020 Apr 1.PMID: 32233951

Hrdlicka HC, Pereira RC, Shin B, Yee SP, Deymier AC, Lee SK, Delany (2021) Inhibition of miR-29-3p isoforms via tough decoy suppresses osteoblast function in homeostasis but promotes intermittent parathyroid hormone-induced bone anabolism. AM.Bone. 143:115779. doi: 10.1016/j.bone.2020.115779. Epub 2020 Nov 28.PMID: 33253931

Li J, Liang CC, Pappas SS, Dauer WT. (2020) TorsinB overexpression prevents abnormal twisting in DYT1 dystonia mouse models. Elife. 23;9:e54285. doi: 10.7554/eLife.54285.PMID: 32202496 

Selvaraju, V., Thirunavukkarasu, M., Joshi, M., Oriowo, B., Shaikh, I.A., Rishi, M.T., Tapias, L., Coca-Soliz, V., Saad, I., Campbell, J., Pradeep, S.R., Swaminathan, S., Yee, S.P., McFadden, D., Alexander Palesty, J., Maulik, N.  (2020) Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-kB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models. Basic Res. Cardiol. 115(4):45.

Baena, V., Owen, C.M., Uliasz, T.F., Lowther, K.M., Yee, S.-P., Terasaski, M., Egbert, J.E., and Jaffe, L.A. (2020). Cellular heterogeneity of the LH receptor and its significance for cyclic GMP signaling in mouse preovulatory follicles. Endocrinology 161(7):bqaa074. Crispr/CAS approach.

Wei QuShuo YuanChao QuanQian HuangQi ZhouYitian YapLin ShiDavid ZhangTamia GuestWei LiSiu-Pok YeeLing ZhangCaroline CazinRex A HessPierre F RayZine-Eddine Kherraf Zhibing Zhang. (2020) The essential role of intraflagellar transport protein IFT81 in male mice spermiogenesis and fertility. Am J Physiol Cell Physiol. 318(6):C1092-C1106.

Robinson JWBlixt NCNorton AMansky KCYe ZAparicio CWagner BMBenton AMWarren GLKhosla SGaddy DSuva LJPotter LR. (2020) Male mice with elevated C-type natriuretic peptide-dependent guanylyl cyclase-B activity have increased osteoblasts, bone mass and bone strengthBone. 135:115320. 

Uyhazi KEYang YLiu NQi HHuang XAMak WWeatherbee SDde Prisco NGennarino VASong XLin H. (2020) Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis. Proc Natl Acad Sci U S A. 117(14):7851-7862.

Galmozzi AKok BPKim ASMontenegro-Burke JRLee JYSpreafico RMosure SAlbert VCintron-Colon RGodio CWebb WRConti BSolt LAKojetin DParker CGPeluso JJPru JKSiuzdak GCravatt B, Saez E. (2019) PGRMC2 is an intracellular haem chaperone critical for adipocyte function. Nature. 576(7785):138-142.

Oakie A, Feng ZC, Li J, Silverstein J, Yee SP, Wang R. (2019) Long-term c-Kit overexpression in beta cells compromises their function in ageing mice. Diabetologia. 62:1430-1444.

Zhou Y, Dhaher R, Parent M, Hu QX, Hassel B, Yee SP, Hyder F, Gruenbaum SE, Eid T, Danbolt NC. (2019) Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration.  Neurochem Int. 123:22-33.

Jiang DY, Wu Z, Forsyth CT, Hu Y, Yee SP, Chen G. (2018) GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation. Mol Brain. 11:31.

Canalis E, Yu J, Schilling L, Yee SP, Zanotti S. (2018) The lateral meningocele syndrome mutation causes marked osteopenia in mice.  J Biol Chem. 293:14165-14177. CRISPR/Cas9 approach.

Thirunavukkarasu M, Selvaraju V, Joshi M, Coca-Soliz V, Tapias L, Saad I, Fournier C, Husain A, Campbell J, Yee SP, Sanchez JA, Palesty JA, McFadden DW, Maulik N. (2018) Disruption of VEGF Mediated Flk-1 Signaling Leads to a Gradual Loss of Vessel Health and Cardiac Function During Myocardial Infarction: Potential Therapy With Pellino-1. J Am Heart Assoc. Sep 18;7(18):e007601.

Schmidt H, Dickey DM, Dumoulin A, Octave M, Robinson JW, Kühn R, Feil R, Potter LR, Rathjen FG. (2018) Regulation of the natriuretic peptide receptor 2 (Npr2) by phosphorylation of juxtamembrane serine and threonine residues is essential for bifurcation of sensory axons. J. Neurosci., 38:9768-9780.

Yu J, Zanotti S, Schilling L, Schoenherr C, Economides AN, Sanjay A, Canalis E. (2018) Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal HomeostasisAm J Pathol. 188:1430-1446.

Yu J, Zanotti S, Walia B, Jellison E, Sanjay A, Canalis E. (2018) The Hajdu Cheney Mutation Is a Determinant of B-Cell Allocation of the Splenic Marginal Zone. Am J Pathol. 188:149-159.

Choudhary S, Santone E, Yee SP, Lorenzo J, Adams DJ, Goetjen A, McCarthy MB, Mazzocca AD, Pilbeam C. (2018) Continuous PTH in Male Mice Causes Bone Loss Because It Induces Serum Amyloid A (SAA)EndocrinologyJul;159(7):2759-2776. CRISPR/Cas9 approach.

Egbert JR, Yee SP and Jaffe LA. (2018) Luteinizing hormone signaling phosphorylates and activates the cyclic GMP phosphodiesterase PDE5 in mouse ovarian follicles, contributing an additional component to the hormonally induced decrease in cyclic GMP that reinitiates meiosis. Dev. Biol.,  435:6-14. CRISPR/Cas9 approach.

Park JW, Yan L, Stoddard C, Wang X, Yue Z, Crandall L, Robinson T, Chang Y, Denton K, Li E, Jiang B, Zhang Z, Martins-Taylor K, Yee S, Nie H, Gu F, Si W, Xie T, Yue L, and Xu R. (2017) Recapitulating and Correcting Marfan Syndrome in a Cellular Model. Int. J. Biol. Sci. 13:588-603. Talen approach.

Smith SA, Samokhin AO, Alfadi M, Murphy EC, Rhodes D, Holcombe WML, Kiss-Toth E, Storey RF, Yee SP, Francis SE, and Qwarnstrom EE. (2017)  The IL-1RI Co-Receptor TILRR (FREM1 Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease. J Am Coll Cardiol Basic Trans Sci. 2:398–414.

Shuhaibar LC, Robinson JW, Vigone G, Shuhaibar NP, Egbert JR, Baena V, Uliasz TF, Kaback D, Yee SP, Feil R, Fisher MC, Dealy CN, Potter LR, Jaffe, L.A. (2017) Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor. eLife; 6: e31343.

Clark NC, Pru CA, Yee SP, Lydon JP, Peluso JJ, Pru JK.(2017) Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence. Endocrinology. 158(3):640-651.

McCallum ML, Pru CA, Niikura Y, Yee SP, Lydon JP, Peluso JJ, Pru JK. (2016) Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial CystsEndocrinology. 157(9):3309-19.

Enkhmandakh B, Stoddard C, Mack K, He W, Kaback D, Yee SP, Bayarsaihan D. (2016) Generation of a Mouse Model for a Conditional Inactivation of Gtf2i Allele. Genesis. 54:407-12.

Canalis E, Schilling L, Yee SP, Lee SK, Zanotti S. (2016) Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis and Bone ResorptionJ Biol Chem. 291:1538-51.

Shuhaibar LC, Egbert JR, Edmund AB, Uliasz TF, Dickey DM, Yee SP, Potter LR, Jaffe LA. (2016) Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone. Dev Biol. 409(1):194-201.

Jing-Qiong Kang, Wangzhen Shen, Chengwen Zhou, Dong Xu, Robert L Macdonald. (2015) The Human Epilepsy Mutation GABRG2(Q390X) Causes Chronic Subunit Accumulation and Neurodegeneration. Nat Neurosci. Jul: 18(7): 988-996.

Dey S, Chamero P, Pru JK, Chien MS, Ibarra-Soria X, Spencer KR, Logan DW, Matsunami H, Peluso JJ, Stowers L(2015) Cyclic Regulation of Sensory Perception by a Female Hormone Alters BehaviorCell. 161(6):1334-44.

Feng ZC, Popell A, Li J, Silverstein J, Oakie A, Yee SP, Wang R. (2015) c-Kit Receptor Signaling Regulates Islet Vasculature, b-Cell Survival, and Function In VivoDiabetes. 64(11):3852-66.

Nobuta H, Cilio MR, Danhaive O, Tsai HH, Tupal S, Chang SM, Murnen A, Kreitzer F, Bravo V, Czeisler C, Gokozan HN, Gygli P, Bush S, Weese-Mayer DE, Conklin B, Yee SP, Huang EJ, Gray PA, Rowitch D, Otero JJ. (2015) Dysregulation of locus coeruleus development in congenital central hypoventilation syndromeActa Neuropathol. 130(2):171-83.

Du EX, Wang XF, Yang WC, Kaback D, Yee SP, Qin CL, George A, Hao JJ. (2015) Characterization of Fam20C expression in odontogenesis and osteogenesis using transgenic mice. Int J Oral Sci. 7(2):89-94.

Dole NS, Kapinas K, Kessler CB, Yee SP, Adams DJ, Pereira RC, Delany AM. (2015) A Single Nucleotide Polymorphism in Osteonectin 3' Untranslated Region Regulates Bone Volume and Is Targeted by miR‐433J Bone Miner Res. 30(4):723-32.

Sakamaki J, Fu A, Reeks C, Baird S, Depatie C, Al Azzabi M, Bardeesy N, Gingras AC, Yee SP, Screaton RA. (2014) Role of the SIK2-p35-PJA2 complex in pancreatic beta cell functional compensation. Nat Cell Biol. 16(3):234-44. doi: 10.1038/ncb2919. Erratum in: Nat Cell Biol. 2014 Apr;16(4):382.

Feng ZC, Li J, Turco BA, Riopel M, Yee SP, Wang R. (2012) Critical role of c-Kit in beta cell function: increased insulin secretion and protection against diabetes in a mouse modelDiabetologia. 55(8):2214-25.

Starkey JD,Yamamoto M,Yamamoto S,Goldhamer DJ. (2011) Skeletal muscle satellite cells are committed to myogenesis and do not spontaneously adopt nonmyogenic fates. J Histochem Cytochem. 59(1):33-46.

Sunmonu NA, Li K, Guo Q, Li JY. (2011) Gbx2 and Fgf8 are sequentially required for formation of the midbrain-hindbrain compartment boundary. Development. 138(4):725-34.

Fantin A, Schwarz Q, Davidson K, Normando EM, Denti L, Ruhrberg C. (2011) The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins. Development. 138(19):4185-91.

Kurosaka S, Leu NA, Zhang F, Bunte R, Saha S, Wang J, Guo C, He W, and Kashina A. (2010) Arginylation-Dependent Neural Crest Cell Migration Is Essential for Mouse Development. PLOS Genetics 6: e1000878.

Ge, S, Murugesan, N, and Pachter, JS. (2009) Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation. J Mol Neurosci. 39(1-2): 269–283.

Chen L, Guo Q, Li JY. (2009) Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamus. Development 136 (8):1317-26.

Chen IP, Wang CJ, Strecker S, Koczon-Jaremko B, Boskey A, Reichenberger EJ. (2009) Introduction of a Phe377del mutation in ANK creates a mouse model for craniometaphyseal dysplasia. J Bone Miner Res.(7):1206-15.

Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D. (2009) Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. J Biol Chem. 284(42):28599-606.

Shen J, Yu WM, Brotto M, Scherman JA, Guo C, Stoddard C, Nosek TM,  Valdivia HH, and Qu CK. (2009) Deficiency of MIP phosphatase induces a muscle disorder by disrupting Ca2+homeostasis. Nat Cell Biol. 11(6): 769–776.

Ma, XM, Kiraly, DD, Gaier, ED, Wang, Y, Kim, EJ, Levine, ES, Eipper, BA and Mains, RA. (2008) Kalirin-7 Is Required for Synaptic Structure and Function. Journal of Neuroscience, 28 (47) 12368-12382.

Li X, Liu P, Liu W, Maye P, Zhang J, Zhang Y, Hurley M, Guo C, Boskey A, Sun L, Harris SE, Rowe DW, Ke HZ, Wu D. (2005) Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet. 37(9):945-52.