The Center for Mouse Genome Modification (CMGM) at UConn Health provides design and generation of genetically modified mice and other services.
A rare mutation in a gene causes weak bones in mice and people – but not for the reasons you might expect. UConn researchers report in the September 7, 2018 issue of the Journal of Biological Chemistry how this mutation creates more bone-making cells but results in less bone, and find intriguing hints as to how the gene might affect other conditions as diverse as breast cancer and dementia. See full story from UConn Today.
We now currently offer PiggyBac-on-BAC for single copy integration of transgenes. This offers reliable and consistent expression of large constructs.