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The Center for Mouse Genome Modification (CMGM) at UConn Health provides design and generation of genetically modified mice and other services.

CMGM Mice on Cover of Journal of Biological Chemistry

Posted on by Deborah M Kaback

A rare mutation in a gene causes weak bones in mice and people – but not for the reasons you might expect. UConn researchers report in the September 7, 2018 issue of the Journal of Biological Chemistry how this mutation creates more bone-making cells but results in less bone, and find intriguing hints as to how the gene might affect other conditions as diverse as breast cancer and dementia. See full story from UConn Today.

CMGM Mice on Lead Story of UConn Today

Posted on by Deborah M Kaback
Bone-forming cells inside a living bone from a newborn mouse
Bone-forming cells inside a living bone from a newborn mouse. In a recently published study in eLife, Leia Shuhaibar and others at UConn Health showed that these cells produce less cyclic GMP under conditions that resemble those in people with achondroplasia (dwarfism). Understanding how cyclic GMP production is regulated could contribute to improved therapies for achondroplasia. Read full story.

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