Welcome to the Center for Vascular Biology (CVB) at UConn Health, located in Farmington, Connecticut. Dr. Linda H. Shapiro, Director, oversees the Center which was formed in 1998. The University of Connecticut Board of Trustees chose vascular biology as one of the strategic areas of research in the UConn Health Strategic Plan and recruitment began in earnest in 1998. Currently, there are six primary faculty members in the Center. One other UConn Health faculty member is affiliated with the CVB and contributes to the research and education efforts of the Center.
Vascular biology is the study of the cells of the vascular system, which permeates every organ in the body. Blood vessels are dynamic structures made up of several cell types, including endothelial and smooth muscle cells. Abnormality of blood vessels is important in many serious diseases, including heart attacks, stroke, diabetic leg ulcers, cancer growth and metastasis, diabetic blindness, rheumatoid arthritis and neurodegeneration, among others.
CVB faculty participates in educational programs in the schools of medicine, dental medicine and graduate school. Active graduate and postdoctoral training programs exist in the laboratories of the CVB. Through cutting-edge research and education, we aim to contribute important new knowledge to the field of vascular biology.
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Golden D, Kolmakova A, Sura S, Vella AT, Manichaikul A, Wang XQ, Bielinski SJ, Taylor KD, Chen YI, Rich SS, Rodriguez A. Lymphocyte activation gene 3 and coronary artery disease. JCI Insight. 2016 Oct 20;1(17):e88628. PubMed PMID: 27777974.
Qendro V, Bugos GA, Lundgren DH, Glynn J, Han MH, Han DK. Integrative proteomics, genomics, and translational immunology approaches reveal mutated forms of Proteolipid Protein 1 (PLP1) and mutant-specific immune response in multiple sclerosis. Proteomics. 2017 Mar;17(6). doi: 10.1002/pmic.201600322. PubMed PMID: 28191734.
Kopsiaftis S, Hegde P, Taylor JA 3rd, Claffey KP. AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms. Transl Oncol. 2016 Dec;9(6):606-616. doi: 10.1016/j.tranon.2016.07.007. PubMed PMID: 27916296.
Kopsiaftis S, Sullivan KL, Garg I, Taylor JA 3rd, Claffey KP. AMPKα2 Regulates Bladder Cancer Growth through SKP2-Mediated Degradation of p27. Mol Cancer Res. 2016 Dec;14(12):1182-1194. Epub 2016 Sep 16. PubMed PMID: 27638620.