Our goal is to understand the molecular mechanisms of neuronal development and regeneration, and to utilize gained knowledge in developing translational approaches for repairing injured central nervous system (CNS) circuits.
An image of immature retinal ganglion cell neuron from Dr. Trakhtenberg's research, adapted for a cover page of the International Review of Neurobiology volume on Axon Growth and Regeneration (Goldberg & Trakhtenberg, Eds, 2012, Vol 106: Academic Press).
UConn Health press release on recent discoveries from our lab, New insights into how axons grow could lead to effective therapies for blindness, paralysis, was covered in the news outlets:
UConn undergraduate student, Ashiti Damania, who did her honors thesis and was a research assistant in our lab over the past 3 years through graduation this Spring, won a prestigious University Scholar Award and co-authored 4 published research articles.
Graduate students from our lab presented three posters on their latest discoveries at the Department of Neuroscience Annual Retreat, which featured keynote speaker Dr. Marina Picciotto from Yale University.
Two research articles from our lab were published in Brain Research: Transcriptomic profiling of retinal cells reveals a subpopulation of microglia/macrophages expressing Rbpms marker of retinal ganglion cells (RGCs) that confound identification of RGCs and Experimental gene expression of developmentally downregulated Crmp1, Crmp4, and Crmp5 promotes axon regeneration and retinal ganglion cell survival after optic nerve injury.
Two research articles from our lab were published in Development: Post-injury born oligodendrocytes incorporate into the glial scar and contribute to the inhibition of axon regeneration and Pten inhibition dedifferentiates long-distance axon-regenerating intrinsically photosensitive retinal ganglion cells and upregulates mitochondria-associated Dynlt1a and Lars2. These discoveries were highlighted and selected for a published interview: The people behind the papers – Jian Xing, Agnieszka Lukomska, Bruce Rheaume and Ephraim Trakhtenberg.
Graduate student, Matthew Frost, presented a poster on our lab's latest discoveries at the Vision Injury Research Forum (VIRF), co-hosted by The Department of Defense (DOD), Vision Research Program (VRP), and Vision Center of Excellence (VCE).
Graduate student, Matthew Frost, won Lightning Talk 2nd place award on presentation of our lab's latest discoveries at the 8th Military Vision Symposium (MVS): Innovation and Unmet Needs for Ocular Injury, Boston, MA.
Postdoctoral fellow, Agnieszka Lukomska, and graduate student, Jian Xing, won Travel Awards and presented two posters on our lab's latest discoveries at the Society for Neuroscience conference, San Diego.
Graduate student, Bruce Rheaume, defended his Ph.D. thesis, and returned to the medical school to complete M.D./Ph.D. training.
Dr. Trakhtenberg's research recognized in the National Glaucoma Research Report by the BrightFocus Foundation, which funds his research on investigating novel gene therapy approach towards developing neuroregenerative treatments for restoring vision after certain types of glaucoma and other types of optic neuropathies.
Preprint of a research article from our lab is now available at Retroactive analysis of single cell transcriptome profiles using next-generation algorithms revised the identification of several resilient retinal ganglion cell types
A research article from our lab was published in Neuroscience Letters: Developmentally upregulated Transcriptional Elongation Factor A like 3 suppresses axon regeneration after optic nerve injury. Covered in the news by the BrightFocus Foundation.
A research article in collaboration with Royce Mohan’s lab was published in the Journal of Neuroscience Research Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers
Dr. Trakhtenberg received UConn Health's Faculty Spotlight recognition for “Research Excellence”, which includes being awarded an NIH grant for his novel research approach to restoring vision loss.
Bruce Rheaume, MD/PhD Candidate, won Biomedical Science Program Mentorship Award for outstanding mentorship by a student in the biomedical science program.
Dr. Trakhtenberg was awarded a 2 million 5-year R01 grant by the National Institutes of Health's Eye Institute (NEI) to investigate how small non-coding RNAs regulate retinal ganglion cell maturation and to utilize their potential for regenerating the optic nerve axons damaged in optic neuropathies.
Our lab in collaboration with JAX published in Nature Communications first molecular classification of retinal ganglion cells into subtypes, covered in the news.
Dr. Trakhtenberg and Dr. Wu were awarded a Research Excellence Program Grant by The Office of the Vice President for Research, UConn School of Medicine and School of Dental Medicine.
Our lab published in Scientific Reports that the extent of non-atrophic extra-axonal tissue damage determines the success of experimental axon regeneration targeting neuronal intrinsic mechanisms.
Dr. Trakhtenberg and Dr. Rouge were awarded a PITCH Seed Award Grant by the PITCH, featured in UConnToday news.
Dr. Trakhtenberg has received Artificial Intelligence Molecular Screen (AIMS) Award, Atomwise Inc (San Francisco, CA) .
An MD-PhD student, Bruce Rheaume, presented a poster from the lab, "Axotomized adult retinal ganglion cells stimulated by extrinsic cues in a permissive environment survive and regenerate axons", at the international annual meeting of the Society for Neuroscience (SFN) in Washington, DC.
Dr. Trakhtenberg’s awards and his lab were featured in UConnToday news.
Dr. Trakhtenberg (lead PI) and Dr. Crocker (co-PI) were awarded a seed grant by the Connecticut Institute for the Brain and Cognitive Sciences (IBaCS). The grant will fund a research project to test a novel hypothesis regarding why axonal connections, through which neurons in the brain communicate with each other over long distances, do not regenerate after traumatic or stroke injury.
Dr. Trakhtenberg was awarded a research grant by the BrightFocus Foundation under the National Glaucoma Research Program. The grant will fund a research project aimed at investigating novel gene therapy approach towards developing neuroregenerative treatments for restoring vision after angle-closure glaucoma and other types of optic neuropathies, which lead to complete or partial blindness.
Dr. Trakhtenberg was selected by the New York Academy of Sciences and the Japan Agency for Medical Research and Development to participate at the Interstellar Initiative for “the world's most promising Early Career Investigators”, where along with a collaborator, Dr. Kumiko Hayashi, they won First Place Award for a research solution proposal in the field of neuroscience.
Graduate Rotation Student
Projects in the lab revolve around fundamental questions in neuronal development and regeneration in the CNS. We integrate cutting edge molecular, biochemical, genetic, bioinformatics, and translational approaches, which involve:
- Histology and neuroanatomical analysis using confocal microscopy
- Rodent CNS in vivo injury models and gene therapy
- Neuronal cell culture and transfection
- Next-generation sequencing and neuro-bioinformatics