Skeletal Biology and Regeneration AoC Faculty

Andrew Arnold, Professor of Medicine and Murray-Heilig Chair in Molecular Medicine, M.D., Harvard University. The molecular genetic underpinnings of tumors of the endocrine glands. Role of cyclin D1 in tumorigenesis.

Dashzeveg Bayarsaihan, Associate Professor, Ph.D., Wesleyan University. Research interests are complex human disorders using stem cell technology, functional genomics and animal models to understand chromatin architecture and epigenetic modifications.

Ernesto Canalis, Professor of Orthopaedic Surgery and Medicine, M.D., Universidad Peruana Cayetano Heredia. The role of growth factors and their antagonists in skeletal function, such as osteoblast cell fate and function. The role of Notch and Nuclear factor of activated T cells (NFAT) in osteoblasts in vivo and in vitro, and in disease models for Hajdu Cheney Syndrome and Lateral Meningocele Syndrome.

I-Ping Chen, Assistant Professor, Oral Health and Diagnostic Sciences, D.D.S., PhD., UConn Health. Generation of induced pluripotent stem (iPS) cells from craniometaphyseal dysplasia (CMD) patients and investigation of osteoclast biology in the human stem cell system as well as in CMD mouse models.

Jessica Costa, Assistant Research Professor, Center for Molecular Oncology, D.M.D/Ph.D., UConn Health; Pathogenesis of craniofacial tumors and the role of the HRPT2/CDC73 tumor suppressor gene in neoplasia.

Justin Cotney, Assistant Professor, Ph.D., Emory University. Determining how gene regulatory elements, namely enhancers, control gene expression during mammalian development.

Caroline N. Dealy, Associate Professor of Reconstructive Sciences, Center for Regenerative Medicine and Skeletal Development, Ph.D., University of Connecticut. Regulation of articular cartilage differentiation and homeostasis by matrix and growth factors; genetic control of skeletal development and regeneration; stem cells for repair or regeneration of cartilage or limb tissue; stem cells as models for cartilage disease.

Anne Delany, Associate Professor of Medicine, Ph.D., Dartmouth College. Regulation of osteoblast and osteoclast gene expression by microRNAs; Molecular mechanisms controlling bone remodeling.

Alix Deymier, Assistant Professor, Ph.D., Northwestern University. Elucidating the relationship between the musculoskeletal system and the acid/base balance in the body.

Anna Dongari-Bagtzoglou, Professor, Department of Oral Health and Diagnostic Sciences, Division of Periodontology, D.D.S., Aristotle University, Greece, M.S., University of California, Los Angeles, Ph.D., University of Texas, San Antonio. Pathogenesis of oral opportunistic infections in the immunocompromised host. Regulation of oral mucosal inflammation in response to bacterial or fungal infection. Innate immune factors which limit oral mucosal infection and invasion.

Paul Epstein, Associate Professor of Cell Biology, Ph.D., Albert Einstein College of Medicine. Targeting the cAMP signaling pathway for treatment of leukemia and breast cancer.

Emily Germain-Lee, Professor of Pediatrics, M.D. Johns Hopkins University. Albright hereditary osteodystrophy (AHO).

Rosaria Guzzo, Assistant Professor, Ph.D., University of Ottowa. Identification of key epigenetic mechanisms that modulate the cartilage-forming potential of human iPS cells.

Marc Hansen, Professor of Medicine, M.S., University of Wisconsin, Ph.D., University of Cincinnati College of Medicine. Molecular genetics of osteosarcoma and related bone diseases.

Marja Hurley, Professor of Medicine, M.D., University of Connecticut School of Medicine. Molecular mechanisms by which members of the fibroblast growth factor (FGFs) and fibroblast growth factor receptor (FGFR) families, (produced by osteoblasts, osteoclasts and stromal cells) regulate bone development, remodeling and disorders of bone. Fgf2 knockout and Fgf2 transgenic mice are utilized in loss and gain of function experiments to elucidate the role of FGF-2 in disorders of bone including osteoporosis.

Ivo Kalajzic, Associate Professor, Department of Reconstructive Sciences and Department of Genetics and Developmental Biology, M.D., Ph.D., University of Zagreb School of Medicine, Croatia. Bone biology, differentiation of the osteoblast lineage cells.

Yusuf Khan, Associate Professor of Orthopaedic Surgery and Chemical, Materials and Biomolecular Engineering, Ph.D., Drexel University. Strategies to synthesize scaffolds that are also capable of delivering proteins and growth factors essential for complete and adequate healing of bone defects through the use of biodegradable polymers alone and in combination with ceramic materials.

Barbara Kream, Professor of Medicine and Genetics and Developmental Biology, Ph.D., Yale University. Hormonal regulation of bone remodeling.

Liisa T. Kuhn, Associate Professor of Reconstructive Sciences, Center for Regenerative Medicine and Skeletal Development, Ph.D., University of California-Santa Barbara. Biomaterials for drug delivery and bone regeneration and repair.

Sangamesh Kumbar, Assistant Professor of Orthopaedic Surgery, Ph.D., Karnatak University. Synthesis and characterization of novel biomaterials/polymers for tissue engineering and drug delivery applications.

Cato Laurencin, M.D., Ph.D., University Professor, Van Dusen Distinguished Endowed Professor of Orthopaedic Surgery, Professor of Craniofacial Sciences, Professor of Chemical and Biomedical Engineering and Materials Science. Regenerative Engineering using biomaterials, stem cells, physics, and developmental biology.

Sun-Kyeong Lee, Associate Professor of Medicine, Ph.D., University of Connecticut. Osteoclast biology and molecular and cellular regulation by cytokines in osteoclastogenesis.

Alan G. Lurie, Professor of Oral Health and Diagnostic Sciences, Head, Division of Oral and Maxillofacial Radiology, D.D.S., UCLA, Ph.D., University of Rochester. Digital imaging analysis of dental and bone diseases.

Peter Maye, Associate Professor of Reconstructive Sciences, Ph.D., Wesleyan University. Isolation, characterization and differentiation of embryonic and adult skeletal stem cells down the osteogenic lineage.

Mina Mina, Professor of Craniofacial Sciences, Division of Pediatric Dentistry, D.M.D., National University of Iran, Ph.D., University of Connecticut.  Origin, maintenance, proliferation and differentiation of adult stem cells in dental pulp.

Lakshmi Nair, Assistant Professor of Orthopaedic Surgery and Chemical, Materials and Biomolecular Engineering, Ph.D., SCTIMST, India. Design and development of regenerative biomaterials to favorably modulate the responses of a variety of cell types involved in tissue regeneration and repair.

Ernst Reichenberger, Professor of Reconstructive Sciences, Center for Regenerative Medicine and Skeletal Development,  Ph.D., University of Erlangen. Our laboratory is interested in the complex processes required for generating and maintaining skin and bones.  We study rate human genetic disorders where such mechanisms are disrupted on a genetic and functional level from gene discovery to in vitro and in vivo models.

Blanka Rogina, Associate Professor of Genetics and Developmental Biology, Ph.D., Zagreb University School of Medicine. Biology of aging including the molecular genetic determinants of aging and longevity.

David W. Rowe, Professor of Reconstructive Sciences, Director of Center for Regenerative Medicine and Skeletal Development, M.D., University of Vermont. Identification and characterization of cells within the mesenchymal lineages that lead to formation and maintenance skeletal tissues. Murine models for assessing cell based therapies for regeneration of adult skeletal structures.

Danielle Rux, Assistant Professor of Orthopedic Surgery, Ph.D., University of Michigan. Mechanisms of primary cilia in murine articular cartilage morphogenesis.

Archana Sanjay, Associate Professor of Orthopaedic Surgery, Ph.D., UConn School of Medicine. Regulation of bone remodeling; osteoblast and osteoclast differentiation and function.

Vanessa M. Scanlon, Assistant Professor of Reconstructive Sciences, Ph.D. UConn Health. Understanding the role the bone marrow microenvironment on hematopoietic progenitor cell fate.

Tannin Schmidt, Associate Professor, Ph.D., University of California-San Diego. Understanding the fundamental mechanisms and properties of proteoglycan 4 (PRG4), also known as lubricin (a critical lubricating protein found throughout the human body, recently discovered to also have anti-inflammatory properties), at relevant bio interfaces and biomaterials.

Benjamin Sinder, Assistant Professor of Orthopedic Surgery, Ph.D. University of Michigan.  Bone disorders, including OI, and their treatment by pharmacologic and cell therapeutics. The factors regulating the accrual of bone mass and related impact on therapeutic efficacy. Translational orthopaedics and modulation of growth.

Ali Tamayol, Associate Professor of Biomedical Engineering, Ph.D., Simon Fraser University. Microengineered scaffolds carrying patient-specific cells and growth factors for the treatment of volumetric muscle loss.

Liping Xiao, Assistant Professor of Medicine and Psychiatry, M.D., Heibei Medical University, Ph.D., Tianjin Medical University.

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