Prefrontal and somatosensory cortex; pyramidal neurons; synaptic transmission; excitatory neurotransmitters; the role of dendrites in synaptic integration; and dopaminergic modulation of dendritic excitability.
Understanding the molecular and cellular mechanisms underlying human cortical development by comparing humans, ferrets, and mice with the same genetic mutation but with strikingly different phenotypes using state-of-the-art tools.
Multiple Sclerosis, signaling mechanisms that regulate development, myelination, demyelination and remyelination in transgenic mouse models and in tissue culture.
Leslie R. Bernstein
Behavioral neuroscience: psychoacoustics.
Genetic correlates of alcohol use disorders and the role of neuroactive steroids in the effects of alcohol.
Stephen J. Crocker
Stem cells; glia; metalloproteinases; cytokines; development; pathology; tissue culture.
Identification of key epigenetic mechanisms that modulate the cartilage-forming potential of human iPS cells.
Eric S. Levine
Synaptic physiology and plasticity, roles of nerve growth factors and endogenous cannabinoids in hippocampus and cortex.
Mechanisms underlying normal and abnormal development of the central nervous system; stem cell biology.
Morphological determinants of cell physiology; image-based computational models of cellular biology; spatial variations of cell membrane electrophysiology; new optical methods for probing living cells.
Synaptogenesis and spine plasticity in hippocampal neurons; estrogen hormones, cocaine, stress and synaptic plasticity.
Understanding the molecular logic of how synaptic adhesion proteins orchestrate synaptic formation, modification, and function, and ultimately providing an explanation for how these events influence behaviors, in particular the aberrant behaviors associated with neuropsychiatric diseases.
Chemical genetic approaches in corneal angiogenesis, fibrosis and retinal gliosis.
Douglas L. Oliver
Synaptic organization; parallel information processing in the central nervous system; Ionic currents and channel expression and their role in information processing; neurocytology, morphology, and cellular physiology of CNS sensory systems; biology of hearing and deafness.
Lower urinary tract physiology and dysfunction, especially in the context of aging.
Feliks (Ephraim) Trakhtenberg
Molecular mechanisms of neuronal development and regeneration in the CNS.
Cause-effect-relationships of stroke outcome.
Cellular and molecular mechanisms of neurotransmitter release; potassium and calcium channel function; Synaptic localization of potassium channels.
Using novel mouse models, primary human cells, and human tissues to study the role of cellular senescence in aging and obesity, with a goal to devise therapeutic interventions targeting senescent cells to slow down aging process, and alleviate various age-related diseases simultaneously.
How Alzheimer’s disease (AD) patients develop the pathologies in their brains; therapeutic treatment for this most common neurodegenerative disease.
RP channels and Ca2+ signaling mechanisms; Physiological and pathological functions of TRP channels in heart, brain, and kidney.
Optical imaging technology; regulation mechanisms in dendritic RNA translation; cytoskeletal dynamics.