Olga Anczuków-Camarda, Assistant Professor of Genetics and Genome Sciences, Ph.D., Université Claude Bernard Lyon. Characterizing the role of alternative-splicing misregulation in breast and ovarian cancer by using 3D cell culture and PDX models.
Andrew Arnold, M.D., Professor of Medicine and Genetics and Genome Sciences, Murray-Heilig Chair in Molecular Medicine. The molecular genetic underpinnings of tumors of the endocrine glands. Role of cyclin D1 in tumorigenesis.
Jean-Denis Beaudoin, Assistant Professor of Genetics and Genome Sciences, Ph.D., Université de Sherbrooke. RNA structure and function in gene regulation during vertebrate development using zebrafish and stem cell models.
Christine Beck, Assistant Professor of Genetics and Genome Sciences, Ph.D. Identifying regions susceptible to non-recurrent human form of SV and investigating the enzymes that limit or promote Alu-mediated rearrangements via computational, molecular biological and genomic techniques.
Michael Blinov, Assistant Professor of Genetics and Genome Sciences, Ph.D., Weizmann Institute of Science. Computational Biology: Modeling of signal transcription systems and protein-dna interactions. Bioinformatics: Data mining and visualization. Developing software tools and mathematical methods for rule-based modeling of signal transduction systems.
Gordon Carmichael, Ph.D., Professor of Molecular, Microbial and Structural Biology, Regulation of gene expression in eukaryotes.
Jeffrey Chuang, Associate Professor, Genetics and Genome Sciences, Ph.D., Massachusetts Institute of Technology. Computational biology and bioinformatics; genomics, gene regulation, molecular evolution, and metabolomics. Post-transcriptional regulation and cancer genomics.
Kevin Claffey, Ph.D., Professor of Physiology. Angiogenesis in cancer progression and metastasis; Vascular endothelial growth factor (VEGF) expression; Hypoxia-mediated gene regulation.
Justin Cotney, Assistant Professor, Ph.D. Emory University. Determining how gene regulatory elements, namely enhancers, control gene expression during mammalian development.
Jonathan Covault, Professor of Psychiatry, M.D., Ph.D., University of Iowa. Genetic correlates of alcohol use disorders and the role of neuroactive steroids in the effects of alcohol.
Asis K. Das, Professor of Molecular, Microbial and Structural Biology, B.Sc., M.Sc., Ph.D., University of Calcutta. Genetics, genomics and mechanisms of bacterial adaptive response; genetic control of bacteriophage lysogeny and lysis; and non-coding RNAs in prokaryotic development.
Caroline N. Dealy, Ph.D., Associate Professor of Biostructure and Function. The molecular regulation of limb development in the vertebrate embryo, from early stages where the limb is initially formed, to limb patterning and outgrowth, to skeletogenesis.
Paul Epstein, Associate Professor of Cell Biology; Ph.D., Albert Einstein College of Medicine. Targeting the cAMP signaling pathway for treatment of leukemia and breast cancer.
Guo-Hua Fong, Ph.D., Associate Professor of Cell Biology. Developmental biology of the vascular system, VEGF-A receptor signal transduction, embryonic stem cells and gene knock-out in mice.
Brenton R. Graveley, Ph.D., Professor of Genetics and Genome Sciences. Regulation of alternative pre-mRNA splicing.
Michael Guertin, Ph.D., Associate Professor of Genetics and Genome Sciences. Using molecular biology, systems biology, and genomics to study transcription regulation. A goal of the group is to identify and characterize transcription factors that are dysregulated in disease states, maintain homeostasis, and promote differentiation.
Arthur Günzl, Ph.D., Professor of Genetics and Genome Sciences and Center for Microbial Pathogenesis. Transcription and Antigenic Variation in the mammalian parasite Trypanosoma brucei.
Marc Hansen, Ph.D., Professor of Medicine. Molecular genetics of osteosarcoma and related bone diseases.
Laura Haynes, Professor of Immunology, Ph.D., University of Rochester School of Medicine. How aging influences immune responses, especially to infectious diseases such as influenza and bacterial pneumonia. Mechanisms involved in specific age-related changes in the immune system and how these changes influence the generation of protective immunity following infection or vaccination.
J. Travis Hinson, Assistant Professor of Cardiology and Genetics, M.D., Harvard. Human iPS disease modeling of cardiovascular disorders, functional genomics, regenerative medicine related to the heart, and CRISPR/CAS9 genomewide screens in iPS-cell assays.
Mayu Inaba-Oguro, Assistant Professor of Cell Biology, Ph.D., Kyushu University, M.D., Ehime University School of Medicine. Molecular and cellular mechanisms that regulate the asymmetric stem cell division; how niche signal is the spatially restricted with the emphasis on the novel stem cell specific structure, MT (microtubule based) -nanotubes.
Laurinda Jaffe, Ph.D., Professor of Cell Biology. The cell biology of fertilization, and the regulation of meiosis in oocytes.
Barbara Kream, Ph.D., Professor of Medicine and Genetics and Genome Sciences. Hormonal regulation of bone remodeling.
George Kuchel, M.D., Professor of Medicine. Biology of aging and its contribution to altered mobility, voiding, cognition and host defense with aging. Design and validation of geroscience-guided interventions into aging and common chronic diseases of aging.
Ching Lau, Professor of Pediatrics, M.D., Ph.D., Harvard University. Developing personalized medicine approach in pediatric oncology.
Se-Jin Lee, Professor of Genetics and Genome Sciences, M.D., Ph.D., Johns Hopkins University. Understanding the role of signaling molecules in regulating embryonic development and adult tissue homeostasis.
Youngmok Lee, Assistant Professor of Medicine, Seoul National University.
James Li, Ph.D., Associate Professor. Mechanisms underlying normal and abnormal development of the central nervous system; stem cell biology.
Sheng Li, Assistant Professor of Genetics and Genome Sciences. Assessing the performance of next-generation sequencing techniques in accurate genome/epigenome/transcriptome profiling and understanding the clinical and functional role of epigenome heterogeneity in the cancer evolution.
Changchun Liu, Associate Professor of Biomedical Engineering, Ph.D., Chinese Academy of Science. Fundamental and applied research at the interface of molecular biology, CRISPR technology, synthetic biology, clinical microbiology and engineering; Using biomedical findings to address current challenges in biomedicine, such as disease diagnostics, medical therapeutics, and personalized medicine.
Peter Maye, Associate Professor of Reconstructive Sciences, Ph.D., Wesleyan University. Isolation, characterization and differentiation of embryonic and adult skeletal stem cells down the osteogenic lineage.
Bruce J. Mayer, Professor of Genetics and Genome Sciences, Ph.D., Rockefeller University, Mechanisms of signal transduction.
Mina Mina, D.M.D., Ph.D., Professor of Pediatric Dentistry. Characterization of genetic and epigenetic influences involved in pattern formation and skeletogenesis of the chick mandible and mouse tooth germ.
Pedro Miura, Associate Professor of Genetics and Genome Sciences, Ph.D., University of Ottawa. Regulation and function of alternative transcripts in the nervous system in a dish using ES-derived neurons and in vivo using Drosophila.
William A. Mohler, Ph.D., Associate Professor of Genetics and Genome Sciences. Developmental cell fusion; C. elegans genetics; multidimensional imaging of developmental and cell biological processes.
Julia Oh, Assistant Professor of Genetics and Genome Sciences, Ph.D., Stanford University. Potential of the human microbiome—the diverse bacteria, fungi, and viruses that inhabit our bodies—to deliver treatments for infectious and other diseases.
Carol C. Pilbeam, Professor of Medicine; Ph.D., Yale University, 1982. M.D., Yale School of Medicine. Mechanisms of regulation of bone formation and resorption.
Stefan Pinter, Assistant Professor of Genetics and Genomic Sciences, Ph.D., Princeton University. How chromosome topology, non-coding (nc)RNA and chromatin modifiers orchestrate gene expression.
Justin D. Radolf, M.D., Professor of Medicine and Center for Microbial Pathogenesis. Molecular pathogenesis and immunobiology of spirochetal infections.
Peter N. Robinson, Professor of Computational Biology, M.D., University of Pennsylvania, M.Sc., Columbia University. Developing algorithms and software for the analysis of exome and genome sequences.
Paul Robson, Associate Professor of Genetics and Genome Sciences, Ph.D. University of Toronto. Single cell transcriptomics, primate/human early embryonic development, maternal-fetal medicine, fetal programming, pluripotent cell biology, regulatory networks, tumor heterogeneity, circulating tumor cells.
Blanka Rogina, Associate Professor of Genetics and Genome Sciences, Ph.D., Zagreb University School of Medicine. Biology of aging including the molecular genetic determinants of aging and longevity.
Daniel W. Rosenberg, Ph.D., Professor of Medicine. Molecular genetics of colorectal cancer; signaling pathways in the development of tumors; toxicogenomics,
Archana Sanjay, ASsociate Professor of Orthopaedic Surgery, School of Medicine, Ph.D. Regulation of bone remodeling; osteoblast and osteoclast differentiation and function.
Mansoor Sarfarazi, Ph.D., Professor of Surgery. Positional mapping and mutation analysis of human genetic disorders; primary open angle glaucoma, primary congenital glaucoma, synpolydactyly, dyslexia, mitral valve prolapse and ascending aortic aneurysm.
Michael Stitzel, Assistant Professor, Ph.D., Johns Hopkins University. Human pancreatic islet cells and the genetic and environmental bases of type 2 diabetes.
Duygu Ucar, Assistant Professor of Genetics, Ph.D., Ohio State. Developing computational models to take advantage of existing datasets to study the dynamics and mechanisms of transcriptional gene regulation and propose testable hypotheses.
Anthony T. Vella, Professor of Immunology, Ph.D., Cornell University. T-cell immunity; costimulation; adjuvants and cytokines.
Roel Verhaak,, Professor of Genetics and Genome Sciences, Ph.D., Erasmus University Medical Center. The analysis of cancer genomics data to improve our understanding of cancer biology, specializing in understanding disease progression of brain tumors, particularly glioblastoma and glioma.
Zhao-Wen Wang, Associate Professor of Neuroscience, Ph.D. Function and regulation of potassium channels and gap junctions; mechanisms of synaptic transmission.
Chia-Lin Wei, Director of Genome Technologies, The Jackson Laboratory for Genomic Medicine, Ph.D., University of California-Davis. Developing genomic and sequencing technologies and applying them to interrogate genomic and epigenomic elements pertinent to genome function and biology.
George Weinstock, Associate Director for Microbial Genomics [Professor], The Jackson Laboratory for Genomic Medicine, Ph.D., Massachusetts Institute of Technology.
Bruce White, Ph.D., Professor of Cell Biology. Control of prolactin gene expression at pretranslational level in GH3 cells; control of aromatase gene expression in ovarian and testicular tissues.
Adam Williams, Assistant Professor of Genetics, Ph.D., University College London. The role of non-coding RNAs in regulating gene expression relating to immune cell function, in particular, CD4+ T cells.
George Y. Wu, Professor of Medicine; Chief, Hepatology Section, Herman Lopata Chair in Hepatitis Research; M.D./Ph.D., Albert Einstein College of Medicine. Targeted delivery of biological substances specifically to liver cells, viral hepatitis B and C, steatohepatitis, and mitochondrial damage in liver diseases. Details of HCV replication, immunocompetent rat model of HCV infection, targeted DNA delivery, and targeted transplantation of mitochondria to hepatocytes.
Yi Wu, Associate Professor of Genetics and Genome Sciences. Developing quantitative imaging tools that are capable of revealing dynamics of cellular signaling at high spatial and temporal resolution (biosensors), or that enable optical control of signaling proteins at precise times and subcellular locations (optogenetics).
Ming Xu, Assistant Professor of Genetics and Genome Sciences, Ph.D., University of Kansas Medical Center. Using novel mouse models, primary human cells, and human tissues to study the role of cellular senescence in aging and obesity, with a goal to devise therapeutic interventions targeting senescent cells to slow down aging process, and alleviate various age-related diseases simultaneously.
Ji Yu, Associate Professor of Genetics and Genome Sciences, Ph.D., University of Texas, Austin. Optical imaging technology; regulation mechanisms in dendritic RNA translation; cytoskeletal dynamics.
Beiyan Zhou, Associate Professor of Immunology, Ph.D., Northwestern University. Understanding the systemic network governed by epigenetic factors in immune cell development and function in obesity, incorporating animal models and OMICs-technologies to address the critical questions in the field, including mechanisms underlying histone modification factors and non-coding RNAs in modulating tissue specific stem cell features and immune cell interactions within the host tissue niche.