| A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z |
=The Jackson Laboratory for Genomic Medicine affiliated faculty
A
Corey Acker, Assistant Professor, Center for Cell Analysis and Modeling. Ph.D., Boston University. Developing advanced quantitative techniques such as computational modeling, imaging, and electrophysiology to study neuro- and cardiac physiology in new, more direct and powerful ways.
Adam J. Adler, Professor of Immunology, Ph.D., Columbia University. Mechanisms of T cell tolerization to peripheral self-antigens, as well as the relationship between tolerance and tumor immunity.
Eran Agmon, Assistant Professor of Molecular Biology and Biophysics, Center for Cell Analysis and Modeling, Ph. D., Indiana University. Developing computational methods for combining multi-omics datasets and diverse models to create multi-scale simulations to build mechanistic simulations of whole microbiomes, which span molecular to multi-cellular scales.
Olga Anczuków-Camarda, Associate Professor of Genetics and Genome Sciences, Ph.D., Université Claude Bernard Lyon. Characterizing the role of alternative-splicing misregulation in breast and ovarian cancer by using 3D cell culture and PDX models.
Srdjan Antic, Associate Professor of Neuroscience, M.D., Belgrade University. Prefrontal and somatosensory cortex; pyramidal neurons; synaptic transmission; excitatory neurotransmitters; the role of dendrites in synaptic integration; and dopaminergic modulation of dendritic excitability.
Andrew Arnold, Professor of Medicine and Genetics and Genome Sciences, Murray-Heilig Chair in Molecular Medicine, Director, Center for Molecular Medicine, M.D., Harvard University. Pathogenesis of parathyroid and other endocrine tumors, and role of the cyclin D1 oncogene in neoplasia, including breast cancer.
B
Byoung-Il Bae, Assistant Professor of Neuroscience, Ph.D., Johns Hopkins University. Understanding the molecular and cellular mechanisms underlying human cortical development by comparing humans, ferrets, and mice with the same genetic mutation but with strikingly different phenotypes using state-of-the-art tools.
Jenna Bartley, Assistant Professor of Immunology, Ph.D., University of Connecticut. Uncovering common pathways among the aging process and developing potential interventions to prevent age-related declines in immune responses and help older adults maintain their independence into late life.
Lance Bauer, Professor of Psychiatry. Ph.D., Washington University. Genetic and personality risk factors for addiction and their neurophysiological correlates.
Dashzeveg Bayarsaihan, Associate Professor of Reconstructive Sciences, Ph.D., Wesleyan University. Research interests are complex human disorders using stem cell technology, functional genomics and animal models to understand chromatin architecture and epigenetic modifications.
Jean-Denis Beaudoin, Assistant Professor of Genetics and Genome Sciences, Ph.D., Université de Sherbrooke. RNA structure and function in gene regulation during vertebrate development using zebrafish and stem cell models.
Christine Beck, Associate Professor of Genetics and Genome Sciences, Ph.D., University of Michigan. Identifying regions susceptible to non-recurrent human form of SV and investigating the enzymes that limit or promote Alu-mediated rearrangements via computational, molecular biological and genomic techniques.
Irina Bezsonova, Assistant Professor of Molecular Biology and Biophysics, Ph.D., University of Toronto. Structural and biochemical characterization of proteins and protein complexes of p53 pathway, especially, proteins responsible for maintenance of an appropriate level of p53 in the cell.
Mikhail Blinov, Associate Professor of Genetics and Genome Sciences, Ph.D., Weizmann Institute of Science. Computational Biology: Modeling of signal transcription systems and protein-DNA interactions. Bioinformatics: Data mining and visualization. Developing software tools and mathematical methods for rule-based modeling of signal transduction systems.
Margaret Briggs-Gowan, Associate Professor of Psychiatry. Ph.D. Yale University. Mental health problems in young children, including identifying risk factors and pinpointing underlying genetic, stress-response, and neurocognitive factors involved in these processes.
Stefan Brocke, Associate Professor of Cell Biology, M.D., Freie Universistaet Berlin School of Medicine. Cellular and molecular mechanisms of brain injury in inflammatory and inflammation-associated disorders of the central nervous system.
Alice Burghard, Assistant Professor of Neuroscience, Ph.D., University of Veterinary Medicine Hannover. Neurobiology of auditory systems.
C
Melissa Caimano, Associate Professor of Medicine, Ph.D., University of Alabama at Birmingham. The regulatory pathways and molecular mechanisms underlying mammalian host adaptation and maintenance of Borrelia burgdorferi within its natural enzootic cycle.
Margaret Callahan, Associate Professor, Chief of Hematology and Oncology, Neag Cancer Center, M.D., Ph.D., UConn Health. Use of immunotherapies to treat melanoma and other cancers. Understanding how immunotherapies work in patients with the goal of characterizing facets of the human immune system that help or hinder the anti-tumor activity of current and novel agents.
Ernesto Canalis, Professor of Orthopaedic Surgery and Medicine, M.D., Universidad Peruana Cayetano Heredia. The role of growth factors and their antagonists in skeletal function, such as osteoblast cell fate and function. The role of Notch and Nuclear factor of activated T cells (NFAT) in osteoblasts in vivo and in vitro, and in disease models for Hajdu Cheney Syndrome and Lateral Meningocele Syndrome.
Gordon G. Carmichael, Professor of Genetics and Genome Sciences, Ph.D., Harvard University. Regulation of gene expression in eukaryotes.
Leslie Caromile, Assistant Professor of Cell Biology, Ph.D., University of Washington. Investigating the mechanistic role of prostate specific membrane antigen (PSMA) in prostate cancer tumor vascularization, progression and metastasis; SNPs in PSMA and prostate cancer health disparities; novel PSMA targeted therapy using 3D bioprinted human prostate cancer tumor models.
Manuel Castro-Alamancos, Professor of Neuroscience, Ph.D., Cajal Institute and University Complutense. Synaptic, cellular and network mechanisms involved in sensorimotor information transmission, coding and storage during motivated behaviors.
I-Ping Chen, Professor, Oral Health and Diagnostic Sciences, D.D.S., Ph.D., UConn Health. Generation of induced pluripotent stem (iPS) cells from craniometaphyseal dysplasia (CMD) patients and investigation of osteoclast biology in the human stem cell system as well as in CMD mouse models.
Steven Z. Chou, Assistant Professor, Molecular Biology and Biophysics, Ph.D., Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences. Discovering new knowledge in actin-based cell motility, cell division, and transmembrane signaling.
Jeffrey Chuang, Professor, Genetics and Genome Sciences, Ph.D., Massachusetts Institute of Technology. Computational biology and bioinformatics; genomics, gene regulation, molecular evolution, and metabolomics. Post-transcriptional regulation and cancer genomics.
Kevin Claffey, Professor of Cell Biology, Ph.D., Boston University School of Medicine. Angiogenesis in cancer progression and metastasis; vascular endothelial growth factor (VEGF) expression; hypoxia-mediated gene regulation.
Robert B. Clark, Professor of Immunology, M.D., Stanford. Autoimmunity; immune regulation; regulatory T cells.
Jessica Costa, Assistant Research Professor, Center for Molecular Oncology, D.M.D/Ph.D., UConn Health; Pathogenesis of craniofacial tumors and the role of the HRPT2/CDC73 tumor suppressor gene in neoplasia.
Stephen J. Crocker, Associate Professor of Neuroscience, Ph.D., University of Ottawa. Stem cells, glia, metalloproteinases, cytokines, development, pathology, tissue culture.
D
Asis K. Das, Professor of Medicine, Ph.D., University of Calcutta. Genetics, genomics and mechanisms of bacterial adaptive response; genetic control of bacteriophage lysogeny and lysis; and non-coding RNAs in prokaryotic development.
Caroline N. Dealy, Professor, Department of Orthodontics, Ph.D., University of Connecticut. Regulation of articular cartilage differentiation and homeostasis by matrix and growth factors; genetic control of skeletal development and regeneration; stem cells for repair or regeneration of cartilage or limb tissue; stem cells as models for cartilage disease.
Abhijit Deb Roy, Assistant Professor of Cell Biology, Ph.D., UConn Health. investigating molecular signaling pathways and cytoskeletal dynamics involved in mechanobiology and cell migration.
Anne Delany, Professor of Medicine, Ph.D., Dartmouth College. Regulation of osteoblast and osteoclast gene expression by microRNAs; Molecular mechanisms controlling bone remodeling.
Alix Deymier, Assistant Professor, Ph.D., Northwestern University. Elucidating the relationship between the musculoskeletal system and the acid/base balance in the body.
Breno Diniz, Associate Professor of Psychiatry, Ph.D., University of Sao Paulo. How age-related changes in biological processes (the Pillars of Biological Aging) affect the development and outcomes of late-life mental and neuropsychiatric disorders and how it translates into the repurpose or development of novel interventions to treat and prevent these disorders across the lifespan.
Kimberly Dodge-Kafka, Professor of Cell Biology/Center for Cardiology and Cardiovascular Research, Ph.D., University of Texas Health Science Center-Houston. Molecular mechanism of signaling pathways in the heart.
Anna Dongari-Bagtzoglou, Professor, Department of Oral Health and Diagnostic Sciences, D.D.S., Aristotle University, Greece, Ph.D., University of Texas, San Antonio. Pathogenesis of oral opportunistic infections in the immunocompromised host. Regulation of oral mucosal inflammation in response to bacterial or fungal infection. Innate immune factors which limit oral mucosal infection and invasion.
Madison Doolittle, Assistant Professor, Center for Regenerative Medicine and Skeletal Development, Ph.D., University of Rochester. Interrelated mechanisms of senescence, aging, and osteoimmunology within the bone microenvironment.
E
Jeremy Egbert, Assistant Professor of Cell Biology, Ph.D., Washington State University. Physiological mechanisms of hormone signaling in the ovary, both within and between cells.
Paul Epstein, Associate Professor of Cell Biology, Ph.D., Albert Einstein College of Medicine. Targeting the cAMP signaling pathway for treatment of leukemia and breast cancer.
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Zhichao Fan, Assistant Professor of Immunology, Ph.D., Fudan University. The development of a comprehensive understanding of the mechanism of integrin activation and leukocyte recruitment and how they contribute to human disease, especially inflammation in cardiovascular diseases.
Guo-Hua Fong, Professor of Cell Biology, Ph.D., University of Illinois. Developmental biology of the vascular system, VEGF-A receptor signal transduction, embryonic stem cells and gene knock-out in mice.
Julian Ford, Professor of Psychiatry. Ph.D., SUNY-Stony Brook. Developing and validating psychometric assessments and psychosocial interventions for youth, adults and families who are at risk or have experienced traumatic adversity; clinical epidemiological studies of youth/adult traumatic victimization and healthcare utilization.
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Emily Germain-Lee, Professor of Pediatrics, M.D. Johns Hopkins University. Albright hereditary osteodystrophy (AHO).
Mallika Ghosh, Assistant Professor of Cell Biology, Ph.D., Indian Institute of Chemical Biology. Elucidating the role of a multifunctional transmembrane peptidase CD13 in cell-cell and cell-ECM communication and osteoclast and multinucleated giant cell fusion under pathological conditions.
Brenton R. Graveley, Professor of Genetics and Genome Sciences, Ph.D., University of Vermont. Regulation of alternative pre-mRNA splicing.
Andres D. Grosmark, Assistant Professor of Neuroscience, Ph.D., Rutgers University. Utilizing cutting-edge two-photon imaging, electrophysiology, genetic targeting and closed-loop optogenetic manipulations together with advanced behavioral paradigms to dissect the initial formation and subsequent evolution of long-term memories.
Michael Gryk, Associate Professor of Molecular Biology and Biophysics, Ph.D., Stanford University. Three dimensional structure and function of proteins involved in DNA repair.
Michael Guertin, Associate Professor of Genetics and Genome Sciences. Ph.D., Cornell University. Using molecular biology, systems biology, and genomics to study transcription regulation. A goal of the group is to identify and characterize transcription factors that are dysregulated in disease states, maintain homeostasis, and promote differentiation.
Arthur Günzl, Professor of Genetics and Genome Sciences and Center for Microbial Pathogenesis, Ph.D., University of Tübingen. Transcription and Antigenic Variation in the mammalian parasite Trypanosoma brucei.
Xiaoyan Guo, Assistant Professor of Genetics and Genome Sciences. Ph.D., Texas A&M University. Understanding how mitochondria cross talk with the rest of the cell in health and diseases using CRISPR-based functional genomics.
Kshitiz Gupta, Assistant Professor, Department of Biomedical Engineering. Ph.D., Johns Hopkins School of Medicine. Unraveling the language cells employ to converse with each other, how the grammar and the content of the langage adapt to the environment, and how cells behave in response.
Rosaria Guzzo, Assistant Professor, Ph.D., University of Ottowa. Identification of key epigenetic mechanisms that modulate the cartilage-forming potential of human iPS cells.
H
David Han, Associate Professor of Cell Biology, Ph.D., Washington University. Apoptosis signaling using proteomics and mass spectrometry and bioinformatics technologies.
Marc Hansen, Professor of Medicine, Ph.D., University of Cincinnati College of Medicine. Molecular genetics of osteosarcoma and related bone diseases.
Bing Hao, Associate Professor of Molecular Biology and Biophysics, Ph.D., Ohio State University. Understanding how the cell cycle is regulated by ubiquitin-mediated proteolysis using x-ray crystallography as a primary tool.
Kelly L. Hawley, Assistant Professor, Ph.D., University of Massachusetts. Exploring the antigenic nature and variability of T. pallidum outer membrane proteins to select syphilis vaccine candidates.
Laura Haynes, Professor of Immunology, Ph.D., University of Rochester School of Medicine. How aging influences immune responses, especially to infectious diseases such as influenza and bacterial pneumonia. Mechanisms involved in specific age-related changes in the immune system and how these changes influence the generation of protective immunity following infection or vaccination.
Christopher Heinen, Professor of Medicine, Ph.D., University of Cincinnati. Biochemical and cellular defects of the DNA mismatch repair pathway during tumorigenesis.
J. Travis Hinson, Associate Professor of Cardiology and Genetics and Genome Sciences, M.D., Harvard University. Human iPS disease modeling of cardiovascular disorders, functional genomics, regenerative medicine related to the heart, and CRISPR/CAS9 genomewide screens in iPS-cell assays.
Jeff Hoch, Professor of Molecular Biology and Biophysics and Director of Gregory P. Mullen NMR Structural Biology Facility, Ph.D., Harvard University. Biophysical chemistry of proteins.
Xiangyou Hu, Assistant Professor of Neuroscience, Ph.D., University of Science and Technology of China. Investigating the BACE1 biological functions and the roles of BACE1 in the pathogenesis of Alzheimer’s disease using both conditional and constitutional BACE1 knockout mice.
Marja Hurley, Professor of Medicine, M.D., UConn School of Medicine. Molecular mechanisms by which members of the fibroblast growth factor (FGFs) and fibroblast growth factor receptor (FGFR) families, (produced by osteoblasts, osteoclasts and stromal cells) regulate bone development, remodeling and disorders of bone. Fgf2 knockout and Fgf2 transgenic mice are utilized in loss and gain of function experiments to elucidate the role of FGF-2 in disorders of bone including osteoporosis.
I
Mayu Inaba-Oguro, Assistant Professor of Cell Biology, Ph.D., Kyushu University, M.D., Ehime University School of Medicine. Molecular and cellular mechanisms that regulate the asymmetric cell-fate determination with a special emphasis on transcriptional regulation, chromatin organization, and translational regulation of stem-cell-specific genes. How endogenous transposable elements contribute to the evolution of stem cell systems.
J
Laurinda A. Jaffe, Professor of Cell Biology, Ph.D., UCLA. The cell biology of fertilization, and the regulation of meiosis and ovulation in ovarian follicles.
Sasan Jalili, Assistant Professor of Immunology, Ph.D., Harvard University. Interrogating the host immunity, microbiome and their interface using different engineering tools in the context of infectious diseases, autoimmunity and cancer.
Evan Jellison, Assistant Professor of Immunology, Ph.D., University of Massachusetts.
K
Sivapriya Kailasan Vanaja, Assistant Professor of Immunology, Ph.D. Michigan State University. Mechanisms by which bacterial pathogens modulate host immune responses.
Ivo Kalajzic, Professor of Reconstructive Sciences, and Genetics and Genome Sciences, M.D., Ph.D., University of Zagreb School of Medicine, Croatia. Bone biology, differentiation of the osteoblast lineage cells.
Yusuf Khan, Associate Professor of Orthopaedic Surgery and Chemical, Materials and Biomolecular Engineering, Ph.D., Drexel University. Strategies to synthesize scaffolds that are also capable of delivering proteins and growth factors essential for complete and adequate healing of bone defects through the use of biodegradable polymers alone and in combination with ceramic materials.
Adam Kim, Assistant Professor of Medicine, Ph.D., Johns Hopkins University. The role of C-type lectin receptors in liver inflammation.
Stephen M. King, Professor of Molecular Biology and Biophysics, Ph.D., University College, London. Cell Biology, Structure and Function of Molecular Motors, Dynein biochemistry and Cell Biology, Structural Biology.
Dmitry Korzhnev, Associate Professor, Molecular Biology and Biophysics, Ph.D., Moscow Institute of Physics and Technology. Liquid-state nuclear magnetic resonance (NMR) studies of structure and dynamics of proteins and their assemblies; multi-protein complexes involved in DNA replication and repair; protein folding.
Barbara Kream, Professor of Medicine, and Genetics and Genome Sciences, Ph.D., Yale University. Hormonal regulation of bone remodeling.
George Kuchel, Professor of Medicine, M.D., McGill University. Biology of aging and its contribution to altered mobility, voiding, cognition and host defense with aging. Design and validation of geroscience-guided interventions into aging and common chronic diseases of aging.
Liisa T. Kuhn, Professor of Biomedical Engineering, Ph.D., University of California-Santa Barbara. Biomaterials for drug delivery and bone regeneration and repair.
Sangamesh Kumbar, Professor of Orthopaedic Surgery, Ph.D., Karnatak University. Synthesis and characterization of novel biomaterials/polymers for tissue engineering and drug delivery applications.
L
Ching Lau, Professor of Pediatrics, M.D., Ph.D., Harvard University. Developing personalized medicine approach in pediatric oncology
Cato Laurencin, University Professor, Van Dusen Distinguished Endowed Professor of Orthopaedic Surgery, Professor of Craniofacial Sciences, Professor of Chemical and Biomedical Engineering and Materials Science, M.D., Harvard Medical School, Ph.D., Massachusetts Institute of Technology. Regenerative Engineering using biomaterials, stem cells, physics, and developmental biology.
Se-Jin Lee, Professor of Genetics and Genome Sciences, M.D., Ph.D., Johns Hopkins University. Understanding the role of signaling molecules in regulating embryonic development and adult tissue homeostasis.
Youngmok Lee, Assistant Professor of Medicine, Seoul National University.
Eric S. Levine, Professor of Neuroscience, Ph.D., Princeton University. Synaptic physiology and plasticity, roles of nerve growth factors and endogenous cannabinoids in hippocampus and cortex.
Guangfu Li, Associate Professor of Surgery, Ph.D., Nanjing Medical University. Using human biopsies and different animal models that faithfully reflect typical features of human diseases to elucidate the cellular and molecular mechanisms underlying these diseases and their resistance to different treatments.
James Li, Professor of Genetics and Genome Sciences, Ph.D., University of Texas. Mechanisms underlying normal and abnormal development of the central nervous system; stem cell biology.
Shuzhao Li, Associate Professor, Ph.D. University of Southern Mississippi. Metabolomics for precision medicine; ImmunoMetabolomics and multi-omics modeling of immune system.
Bruce Liang, Professor of Medicine, M.D., Harvard Medical School. Signal transduction, cardiac and vascular cell biology, receptors, G proteins, transgenic mice.
Changchun Liu, Associate Professor of Biomedical Engineering, Ph.D., Chinese Academy of Science. Fundamental and applied research at the interface of molecular biology, CRISPR technology, synthetic biology, clinical microbiology and engineering; Using biomedical findings to address current challenges in biomedicine, such as disease diagnostics, medical therapeutics, and personalized medicine.
Edison T. Liu, Professor of Genetics and Genome Sciences, M.D. Stanford University. Pediatric brain and bone tumor research. His clinical interests include neuro-oncology, solid tumors, and osteosarcoma.
Leslie M. Loew, Professor of Cell Biology, and Computer Science and Engineering, Ph.D., Cornell. Morphological determinants of cell physiology; image-based computational models of cellular biology; synapse biophysics; new optical methods for probing living cells.
Alan G. Lurie, Professor of Oral Health and Diagnostic Sciences, Head, Division of Oral and Maxillofacial Radiology, D.D.S., UCLA, Ph.D., University of Rochester. Digital imaging analysis of dental and bone diseases.
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Xin-Ming Ma, Professor of Neuroscience, Ph.D., Beijing University School of Medicine. Synaptogenesis and spine plasticity in hippocampal neurons; estrogen hormones, cocaine, stress and synaptic plasticity.
Mark Maciejewski, Associate Professor of Molecular Biology and Biophysics, Ph.D., Ohio State University. Utilizing NMR to characterize the three dimensional structure, function and dynamics of proteins from a wide range of important biological systems.
David Martinelli, Assistant Professor of Neuroscience, Ph.D., Johns Hopkins University. Understanding the molecular logic of how synaptic adhesion proteins orchestrate synaptic formation, modification, and function, and ultimately providing an explanation for how these events influence behaviors, in particular the aberrant behaviors associated with neuropsychiatric diseases.
Nilanjana Maulik, Professor of Surgery, Ph.D., University of Calcutta. Molecular and Cellular signaling during myocardial ischemia and reperfusion.
Peter Maye, Associate Professor of Reconstructive Sciences, Ph.D., Wesleyan University. Isolation, characterization and differentiation of embryonic and adult skeletal stem cells down the osteogenic lineage.
Bruce J. Mayer, Professor of Genetics and Genome Sciences, Ph.D., Rockefeller University. Mechanisms of signal transduction.
Lisa M. Mehlmann, Associate Professor of Cell Biology, Ph.D., Kent State University. The regulation of meiosis in mammalian oocytes, as well as the cytoplasmic events that occur during the time an oocyte transitions from an immature cell to a mature egg capable of fertilization.
Pedro Mendes, Professor, Center for Quantitative Medicine; Ph.D., University of Wales. Computational systems biology: better understanding biological systems through the use of computer models.
Mina Mina, Professor of Craniofacial Sciences, D.M.D., National University of Iran, Ph.D., University of Connecticut. Origin, maintenance, proliferation and differentiation of adult stem cells in dental pulp.
Pedro Miura, Associate Professor of Genetics and Genome Sciences, Ph.D., University of Ottawa. Alternative polyadenylation and circRNAs, using flies, worms, cultured cells, and mice to investigate questions in these two general topics.
Royce Mohan, Professor of Neuroscience, Ph.D., The Ohio State University. Schwann cells in corneal axonal regeneration and fibrosis; retinal Muller glia in age-related macular degeneration. Genetic and pharmacological approaches for discovery of druggable targets in the CNS and PNS; chemical probes for in vivo imaging.
William A. Mohler, Associate Professor of Genetics and Genome Sciences, Ph.D., Stanford University. Developmental cell fusion; C. elegans genetics; multidimensional imaging of developmental and cell biological processes.
Wendy Mok, Assistant Professor of Molecular Biology and Biophysics, Ph.D. McMaster University. Bacterial persisters: rare cell types in a population that can tolerate lethal doses of antibiotics that kill their genetically identical kin.
Ion Moraru, Professor of Cell Biology, Ph.D., Carol Davila University of Medicine. Understanding signal transduction mechanisms, in particular related to calcium and phosphoinositides.
Patrick Murphy, Associate Professor of Cell Biology, Ph.D., University of California-San Francisco. Unraveling the complex interplay between recruited immune cells and the endothelial lining of the vasculature in chronic inflammation, with a focus on alternative splicing and changes in the sub-endothelial matrix as critical determinants of that interaction.
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Lakshmi Nair, Professor of Orthopaedic Surgery and Chemical, Materials and Biomolecular Engineering, Ph.D., SCTIMST, India. Design and development of regenerative biomaterials to favorably modulate the responses of a variety of cell types involved in tissue regeneration and repair.
Masako Nakanishi, Assistant Professor in Residence, Center for Molecular Oncology, Ph.D., UConn Health. Pathogenesis of gastrointestinal inflammation and cancer, mouse tumor models, the role of lipid metabolism, microbiome, nutritional intervention.
Rachael Norris, Assistant Professor in Residence, Cell Biology, Ph.D., UConn Health. Investigating the trafficking of cellular signaling proteins in mouse ovarian follicles, by combining immunolabeling with serial section electron microscopy.
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Hideyuki Oguro, Assistant Professor of Cell Biology, Ph.D., University of Tokoyo. Molecular and cellular mechanisms that regulate blood-forming hematopoietic stem cell (HSC) development, self-renewal, mobilization, and malignant transformation; Generation of HSCs from human induced pluripotent stem cells.
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Joel S. Pachter, Professor of Immunology, Ph.D., NYU. Use of laser capture microdissection for gene profiling of the neurovascular unit in health and disease.
Sathish Padi, Assistant Professor, Ph.D., North Dakota State University. Understanding comprehensive signaling pathways and mechanisms contributing to drug resistance in cancer cells.
Rebecca Page, Professor of Cell Biology, Ph.D., Princeton University. Cell signaling, focusing on the chemical language that directs how extracellular and intracellular signals are communicated to and within the cell in both space and time.
Karolina Palucka, Professor of Immunology, Ph.D., Karolinska Institute. Human immunology with a focus on experimental immunotherapy.
Joana Paulino, Assistant Professor of Molecular biology and Biophysics, Ph.D., Florida State University. Viral-host protein interactions that allow viruses to bypass the host’s native immunity.
Silke Paust, Associate Professor of Immunology, Ph.D., Harvard University. Development and testing of novel immunotherapies that elicit clinically relevant Natural Killer cell-mediated anti-pathogen or anti-tumor immunity.
Wolfgang Peti, Profesor of Molecular Biology and Biophysics, Ph.D., University of Frankfurt. Molecular and cellular understanding of eukaryotic and prokaryotic signaling pathways.
Stefan Pinter, Assistant Professor of Genetics and Genomic Sciences, Ph.D., Princeton University. How chromosome topology, non-coding (nc)RNA and chromatin modifiers orchestrate gene expression.
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Justin D. Radolf, Professor of Medicine and Center for Microbial Pathogenesis, M.D., University of California-San Francisco. Molecular pathogenesis and immunobiology of spirochetal infections.
T.V. Rajan, Professor of Pathology and Laboratory Medicine, Ph.D., Albert Einstein College of Medicine, M.D., All India Institute of Medical Sciences. Parasitology; filariasisl molecular immunoparasitology.
Vijay Rathinam, Assistant Professor of Immunology, Ph.D., Michigan State University. Understand the immunologic basis of infectious and inflammatory diseases.
Ernst Reichenberger, Professor of Reconstructive Sciences, Ph.D., University of Erlangen. Our laboratory is interested in the complex processes required for generating and maintaining skin and bones. We study rate human genetic disorders where such mechanisms are disrupted on a genetic and functional level from gene discovery to in vitro and in vivo models.
Paul Robson, Professor of Genetics and Genome Sciences, Ph.D., University of Toronto. Single cell transcriptomics, primate/human early embryonic development, maternal-fetal medicine, fetal programming, pluripotent cell biology, regulatory networks, tumor heterogeneity, circulating tumor cells.
Annabelle Rodriguez-Oquendo, Professor of Cell Biology, M.D., New Jersey Medical School. Genetic link between healthy HDL cholesterol, heart disease, and infertility in women.
Blanka Rogina, Professor of Genetics and Genome Sciences, Ph.D., Zagreb University School of Medicine. Biology of aging including the molecular genetic determinants of aging and longevity.
Daniel W. Rosenberg, Professor of Medicine, Ph.D., University of Michigan. Molecular genetics of colorectal cancer; signaling pathways in the development of tumors; toxicogenomics.
David Rowe, Professor of Reconstructive Sciences, Director of Center for Regenerative Medicine and Skeletal Development, M.D., University of Vermont. Identification and characterization of cells within the mesenchymal lineages that lead to formation and maintenance skeletal tissues. Murine models for assessing cell based therapies for regeneration of adult skeletal structures.
Jianbin Ruan, Assistant Professor of Immunology, Ph.D., University of Science and Technology of China. Elucidating the molecular mechanisms of innate immune signaling, especially signal transduction pathways of pyroptosis and inflammation; host-pathogen interactions by elucidating the mechanisms how pore-forming proteins/toxins recognize the specific receptors.
Danielle Rux, Assistant Professor of Orthopedic Surgery, Ph.D., University of Michigan. Mechanisms of primary cilia in murine articular cartilage morphogenesis.
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Juan C. Salazar, Professor of Pediatrics, M.D., Universidad Javeriana. Analysis of the immunologic interactions between syphilis and HIV and the pathogenesis of spirochetal diseases including Lyme disease.
Archana Sanjay, Associate Professor of Orthopaedic Surgery, Ph.D., University of Bombay. Regulation of bone remodeling; osteoblast and osteoclast differentiation and function.
Sarvenaz Sarabipour, Assistant Professor of Cell Biology, Ph.D., Johns Hopkins University. Building multi-scale models of cells from their molecular interactions to their function in tissue to identify signal transduction mechanisms that contribute to cellular proliferation and migration in vascular and neuronal cells.
Mansoor Sarfarazi, Professor of Surgery, Ph.D., University of wales College of Medicine. Positional mapping and mutation analysis of human genetic disorders; primary open angle glaucoma, primary congenital glaucoma, synpolydactyly, dyslexia, mitral valve prolapse and ascending aortic aneurysm.
Vanessa M. Scanlon, Assistant Professor of Reconstructive Sciences, Ph.D. UConn Health. Understanding the role the bone marrow microenvironment on hematopoietic progenitor cell fate.
Tannin Schmidt, Associate Professor, Ph.D., University of California-San Diego. Understanding the fundamental mechanisms and properties of proteoglycan 4 (PRG4), also known as lubricin (a critical lubricating protein found throughout the human body, recently discovered to also have anti-inflammatory properties), at relevant bio interfaces and biomaterials.
Adam Schuyler, Assistant Professor of Molecular Biology and Biophysics, Ph.D., Johns Hopkins University. Computational modeling of molecular dynamics and allosteric activation; nonuniform sampling techniques for multidimensional NMR experiments.
Peter Setlow, Board of Trustees Distinguished Professor of Molecular Biology and Biophysics, Ph.D., Brandeis University. Biochemistry of bacterial spore germination.
Linda Shapiro, Professor of Cell Biology, Ph.D., University of Michigan. Molecular mechanisms by which large cell surface peptidases regulate numerous pathologic processes ranging from angiogenesis, tumor cell invasion, chronic and acute inflammatory diseases and cardiovascular disease.
Benjamin Sinder, Assistant Professor of Orthopedic Surgery, Ph.D. University of Michigan. Bone disorders, including OI, and their treatment by pharmacologic and cell therapeutics. The factors regulating the accrual of bone mass and related impact on therapeutic efficacy. Translational orthopaedics and modulation of growth.
Boris Slepchenko, Associate Professor of Cell Biology, Ph.D., Ural State University. Developing and testing numerical algorithms for applications in cell biology, particularly related to the Virtual Cell software project.
Henry Smilowitz, Associate Professor of Cell Biology, Ph.D., Massachusetts Institute of Technology. Pre-clinical experimental therapeutics of cancer using glioma, intracerebral melanoma, as well as breast, head and neck and bladder cancer models. A.) Gold nanoparticles as radiation enhancers (with an emphasis on glioma), B.) Gold and iron nanoparticles for hyperthermia and hyperthermia mediated radiation enhancement (with an emphasis on head and neck cancer), C.) Combination of radiation therapy and immunotherapy for intracerebral tumors.
Timothy Spellman, Assistant Professor of Neuroscience, Ph.D., Columbia University. Physiological substrates of executive functioning within higher-order association areas of the brain.
Pramod K. Srivastava, Professor of Medicine, Ph.D., Center for Cellular and Molecular Biology, Hyderabad, India. Heat shock proteins as peptide chaperones, roles in antigen presentation and applications in immunotherapy of cancer, infectious diseases and autoimmune disorders.
David Steffens, Professor of Psychiatry, M.D., University of Texas Health Science Center at Houston. Links between late life depression and subsequent cognitive decline and development of dementia.
Michael Stitzel, Associate Professor of Genetics and Genome Sciences, Ph.D., Johns Hopkins University. Human pancreatic islet cells and the genetic and environmental bases of type 2 diabetes.
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Ali Tamayol, Associate Professor of Biomedical Engineering, Ph.D., Simon Fraser University. Microengineered scaffolds carrying patient-specific cells and growth factors for the treatment of volumetric muscle loss.
Mark R. Terasaki, Associate Professor of Cell Biology, Ph.D., University of California, Berkeley. Mechanism of nuclear envelope breakdown; structure and function of the endoplasmic reticulum.
Suzy V. Torti, Professor of Molecular Biology and Biophysics, Ph.D., Tufts University. Regulation of iron metabolism and the relationship between iron and cancer.
Feliks (Ephraim) Trakhtenberg, Assistant Professor of Neuroscience, Ph.D., University of Miami. Molecular mechanisms of neuronal development and regeneration in the CNS.
Sebnem Tuncdemir, Assistant Professor of Neuroscience, Ph.D., NYU School of Medicine. Understanding how the neural circuits that encode specific features of contexts are organized in adults and to elucidate the key developmental mechanisms by which this network is formed.
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Duygu Ucar, Assistant Professor of Genetics and Genome Sciences, Ph.D., Ohio State. Developing computational models to take advantage of existing datasets to study the dynamics and mechanisms of transcriptional gene regulation and propose testable hypotheses.
Derya Unutmaz, Professor of Immunology, M.D., Mamara University Medical School. Decoding the functional and differentiation programs of different human T lymphocyte subsets. Developing various approaches towards development of T cells for cancer immunotherapy, HIV infection and regeneration during aging. Mapping the immune profiles in cancer, HIV and other inflammatory diseases to translate this knowledge as potential diagnostics.
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Oscar Vargas-Rodriguez, Assistant Professor of Molecular Biology and Biophysics, Ph.D., The Ohio State University. How pathogenic bacteria alter the expression of their genetic code during infection and disease.
Frederick Varn, Assistant Professor of Genetics and Genome Sciences, Ph.D., Dartmouth College. Integrating genomic and spatial biology approaches to investigate how the tumor microenvironment drives development and treatment resistance in brain tumors.
Anthony T. Vella, Professor of Immunology, Ph.D., Cornell University. T-cell immunity; costimulation; adjuvants and cytokines.
Rajkumar Verma, Assistant Professor of Neuroscience. Ph.D., Birla Institute of Technology. Cause-effect-relationships of stroke outcome.
Paola Vera-Licona, Assistant Professor of Cell Biology, Ph.D., Virginia Polytechnic Institute and State University. Computational systems biology of cancer, reverse-engineering of biological networks, network theory, development and application of algorithms for mathematical modeling and analysis of biological networks, and discovery and development of combinations of targeted therapies.
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Eric Wang, Assistant Professor of genetics and Genome Sciences, Ph.D., NYU Sackler Institute of Biomedical Science. Investigating mechanisms of drug resistance in hematological malignancies with the main goal to develop new therapeutic strategies and providing a blueprint for clinically relevant biomarkers.
Kepeng Wang, Assistant Professor of Immunology, Ph.D., Hong Kong University of Science and Technology. Understanding the role of IL-17 in the development, immune regulation, and treatment of colorectal cancer.
Lihong Wang, Associate Professor of Psychiatry. M.D., Bethune Medical University, Ph.D., Yokohama City University School of Medicine. Neural signatures of depression vulnerability and neural plasticity in patients with late-life depression and mild cognitive decline.
Penghua Wang, Assistant Professor of Immunology, Ph.D., The National University of Singapore. Understanding pathogenic mechanisms of viral infection at the cellular and animal levels, and studying the molecular function of host genes that influence viral pathogenesis and the disease outcomes.
Yanlin Wang, Professor of Medicine, Division of Nephrology, M.D., Weifang Medical University, Ph.D., The University of Texas Medical Branch. Cellular and molecular mechanisms underlying the pathogenesis of kidney disease with a focus on the roles of inflammatory cells and fibroblasts in the pathogenesis of kidney injury and fibrosis.
Zhao-Wen Wang, Professor of Neuroscience, Ph.D., Michigan State University. Cellular and molecular mechanisms of neurotransmitter release; potassium and calcium channel function; Synaptic localization of potassium channels.
Yi Wu, Associate Professor of Genetics and Genome Sciences, Ph.D., Northwestern University. Developing quantitative imaging tools that are capable of revealing dynamics of cellular signaling at high spatial and temporal resolution (biosensors), or that enable optical control of signaling proteins at precise times and subcellular locations (optogenetics).
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Liping Xiao, Assistant Professor of Medicine and Psychiatry, M.D., Heibei Medical University, Ph.D., Tianjin Medical University.
Yulan Xiong, Assistant Professor of Neuroscience. Ph.D., Lancaster University (U.K.), Mechanisms underlying aging and neurodegenerative diseases, with specific emphasis on Parkinson’s disease (PD).
Ming Xu, Assistant Professor of Genetics and Genome Sciences, Ph.D., University of Kansas Medical Center. Using novel mouse models, primary human cells, and human tissues to study the role of cellular senescence in aging and obesity, with a goal to devise therapeutic interventions targeting senescent cells to slow down aging process, and alleviate various age-related diseases simultaneously.
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Ping Yan, Assistant Professor, Center for Cell Analysis and Modeling, Ph.D., Columbia University. Developing membrane potential probes to image neuronal and cardiac activities, using synthetic organiz chemistry, genetic techniques, optical spectroscopy, and microscopy to decode cells’ secrets.
Riqiang Yan, Professor and Chair, Neuroscience, Ph.D., University of Kentucky. How Alzheimer’s disease (AD) patients develop the pathologies in their brains; therapeutic treatment for this most common neurodegenerative disease.
Siu-Pok Yee, Associate Professor of Cell Biology, Ph.D., McMaster University. Specialties include molecular biology, mouse genetics and mouse developmental biology.
Ji Yu, Associate Professor of Genetics and Genome Sciences, Ph.D., University of Texas-Austin. Optical imaging technology; regulation mechanisms in dendritic RNA translation; cytoskeletal dynamics.
Lixia Yue, Professor of Cell Biology, Center for Cardiology and Cardiovascular Biology, Ph.D., McGill University. TRP channels and Ca2+ signaling mechanisms; Physiological and pathological functions of TRP channels in heart, brain, and kidney.
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Beiyan Zhou, Associate Professor of Immunology, Ph.D., Northwestern University. Understanding the systemic network governed by epigenetic factors in immune cell development and function in obesity, incorporating animal models and OMICs-technologies to address the critical questions in the field, including mechanisms underlying histone modification factors and non-coding RNAs in modulating tissue specific stem cell features and immune cell interactions within the host tissue niche.
Dong Zhou, Assistant Professor of Medicine, Ph.D., Nanjing University of Chinese Medicine. Exploring the mechanisms of the transition from acute kidney injury (AKI) to chronic kidney diseases (CKD).
Yanjiao Zhou, Assistant Professor of Medicine, Ph.D., Tianjin Medical University, M.D., Zhangjiakou Medical College. Developing microbiome-based diagnostics and therapeutics for multiple sclerosis as well as other diseases, with a focus on how nutrition and microbial metabolites influence the gut-brain axis.
=The Jackson Laboratory for Genomic Medicine affiliated faculty