How a Key Enzyme Switches On and Off—And How a Rare Mutation Pushes It Into Overdrive

 

Activation dynamics of ubiquitin-specific protease 7

Differences in structure, dynamics, and zinc coordination between isoforms of human ubiquitin ligase UBE3A

Gianluca Arianna, Dane Geddes-Buehre and Daniel Fairchild participated in the 3rd MBB Student SciArt Contest.

Check out their creative works!

Our paper describes “A novel interaction between RAD23A/B and Y-family DNA Polymerases”.

A collaboration with Roger Woodgate lab.

Read the paper.

PML nuclear bodies form in response to oxidative stress. Bregnard et al. identify B-box1 as a redox-sensitive domain of PML and propose a molecular mechanism for its sensitivity.