Welcome to Structural Biology Lab!

At the Bezsonova Lab, we investigate enzymes of the ubiquitin pathway—key regulators frequently disrupted in cancer and neurodegenerative diseases. Our goal is to uncover the molecular mechanisms that govern their function and to inform the development of novel therapeutic strategies.

We apply an integrated structural biology approach, combining NMR spectroscopy and X-ray crystallography with a range of biochemical and biophysical techniques. This allows us to determine high-resolution 3D structures of proteins, map their interactions with binding partners, and explore their conformational dynamics in solution.

By gaining detailed insight into protein structure and function, we aim to support the rational design of targeted anti-cancer drugs.

Graduate Student positions are available. Apply