Publications

  1. Ashton NW, Jaiswal N, Moreno NC, Semenova IV, D'Orlando DA, Latancia MT, McIntyre J, Woodgate R, Bezsonova I. A Novel Interaction Between RAD23A/B and Y-family DNA Polymerases. J Mol Biol. 2023 Dec 15;435(24):168353. doi: 10.1016/j.jmb.2023.168353. Epub 2023 Nov 5. PubMed PMID: 37935254; PubMed Central PMCID: PMC10842004.
  2. Bregnard TA, Fairchild D, Erlandsen H, Semenova IV, Szczepaniak R, Ahmed A, Weller SK, Korzhnev DM, Bezsonova I. Conformational exchange at a C(2)H(2) zinc-binding site facilitates redox sensing by the PML protein. Structure. 2023 Sep 7;31(9):1086-1099.e6. doi: 10.1016/j.str.2023.06.014. Epub 2023 Jul 19. PubMed PMID: 37473756; PubMed Central PMCID: PMC10528520.
  3. Valles GJ, Jaiswal N, Korzhnev DM, Bezsonova I. Activation Dynamics of Ubiquitin Specific Protease 7. bioRxiv. 2023 Jan 12;. doi: 10.1101/2023.01.11.523550. PubMed PMID: 36711877; PubMed Central PMCID: PMC9882073.
  4. Valles G, Pozhidaeva A, Korzhnev DM, Bezsonova I. Backbone and ILV side-chain NMR resonance assignments of the catalytic domain of human deubiquitinating enzyme USP7. Biomol NMR Assign. 2022 Oct;16(2):197-203. doi: 10.1007/s12104-022-10079-2. Epub 2022 May 10. PubMed PMID: 35536398; PubMed Central PMCID: PMC9529858.
  5. Bregnard T, Ahmed A, Semenova IV, Weller SK, Bezsonova I. The B-box1 domain of PML mediates SUMO E2-E3 complex formation through an atypical interaction with UBC9. Biophys Chem. 2022 Aug;287:106827. doi: 10.1016/j.bpc.2022.106827. Epub 2022 May 18. PubMed PMID: 35667129; PubMed Central PMCID: PMC9491232.
  6. Dusek CO, Dash RC, McPherson KS, Calhoun JT, Bezsonova I, Korzhnev DM, Hadden MK. DNA Sequence Specificity Reveals a Role of the HLTF HIRAN Domain in the Recognition of Trinucleotide Repeats. Biochemistry. 2022 May 24;. doi: 10.1021/acs.biochem.2c00027. [Epub ahead of print] PubMed PMID: 35608245; PubMed Central PMCID: PMC9684356.
  7. Mahdi S, Bezsonova I, Beuning PJ, Korzhnev DM. NMR resonance assignments for the nucleotide binding domains of the E. coli clamp loader complex γ subunit. Biomol NMR Assign. 2021 Oct;15(2):281-285. doi: 10.1007/s12104-021-10018-7. Epub 2021 Mar 24. PubMed PMID: 33761093; PubMed Central PMCID: PMC8460709.
  8. McPherson KS, Zaino AM, Dash RC, Rizzo AA, Li Y, Hao B, Bezsonova I, Hadden MK, Korzhnev DM. Structure-Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis. ChemMedChem. 2021 Apr 8;16(7):1126-1132. doi: 10.1002/cmdc.202000893. Epub 2021 Jan 28. PubMed PMID: 33314657; PubMed Central PMCID: PMC8035318.
  9. Valles GJ, Ashton NW, Jaiswal N, Woodgate R, Bezsonova I. Nuclear magnetic resonance spectral data of the USP7 TRAF and UBL1-2 domains in complex with DNA polymerase ι peptides. Data Brief. 2021 Feb;34:106680. doi: 10.1016/j.dib.2020.106680. eCollection 2021 Feb. PubMed PMID: 33437851; PubMed Central PMCID: PMC7788100.
  10. Ashton NW, Valles GJ, Jaiswal N, Bezsonova I, Woodgate R. DNA Polymerase ι Interacts with Both the TRAF-like and UBL1-2 Domains of USP7. J Mol Biol. 2021 Jan 22;433(2):166733. doi: 10.1016/j.jmb.2020.166733. Epub 2020 Dec 3. PubMed PMID: 33279577; PubMed Central PMCID: PMC7873624.
  11. Valles GJ, Bezsonova I, Woodgate R, Ashton NW. USP7 Is a Master Regulator of Genome Stability. Front Cell Dev Biol. 2020;8:717. doi: 10.3389/fcell.2020.00717. eCollection 2020. Review. PubMed PMID: 32850836; PubMed Central PMCID: PMC7419626.
  12. Adlakha M, Livingston CM, Bezsonova I, Weller SK. The Herpes Simplex Virus 1 Immediate Early Protein ICP22 Is a Functional Mimic of a Cellular J Protein. J Virol. 2020 Jan 31;94(4). doi: 10.1128/JVI.01564-19. Print 2020 Jan 31. PubMed PMID: 31748398; PubMed Central PMCID: PMC6997750.
  13. Pozhidaeva A, Bezsonova I. USP7: Structure, substrate specificity, and inhibition. DNA Repair (Amst). 2019 Apr;76:30-39. doi: 10.1016/j.dnarep.2019.02.005. Epub 2019 Feb 16. Review. PubMed PMID: 30807924; PubMed Central PMCID: PMC6481172.
  14. Machado LESF, De Paula VS, Pustovalova Y, Bezsonova I, Valente AP, Korzhnev DM, Almeida FCL. Conformational Dynamics of a Cysteine-Stabilized Plant Defensin Reveals an Evolutionary Mechanism to Expose Hydrophobic Residues. Biochemistry. 2018 Oct 9;57(40):5797-5806. doi: 10.1021/acs.biochem.8b00753. Epub 2018 Sep 24. PubMed PMID: 30207151.
  15. Kumar S, Caimano MJ, Anand A, Dey A, Hawley KL, LeDoyt ME, La Vake CJ, Cruz AR, Ramirez LG, Paštěková L, Bezsonova I, Šmajs D, Salazar JC, Radolf JD. Sequence Variation of Rare Outer Membrane Protein β-Barrel Domains in Clinical Strains Provides Insights into the Evolution of Treponema pallidum subsp. pallidum, the Syphilis Spirochete. mBio. 2018 Jun 12;9(3). doi: 10.1128/mBio.01006-18. PubMed PMID: 29895642; PubMed Central PMCID: PMC6016234.
  16. Zambrello MA, Schuyler AD, Maciejewski MW, Delaglio F, Bezsonova I, Hoch JC. Nonuniform sampling in multidimensional NMR for improving spectral sensitivity. Methods. 2018 Apr 1;138-139:62-68. doi: 10.1016/j.ymeth.2018.03.001. Epub 2018 Mar 6. PubMed PMID: 29522805; PubMed Central PMCID: PMC5984134.
  17. Pozhidaeva A, Valles G, Wang F, Wu J, Sterner DE, Nguyen P, Weinstock J, Kumar KGS, Kanyo J, Wright D, Bezsonova I. USP7-Specific Inhibitors Target and Modify the Enzyme's Active Site via Distinct Chemical Mechanisms. Cell Chem Biol. 2017 Dec 21;24(12):1501-1512.e5. doi: 10.1016/j.chembiol.2017.09.004. Epub 2017 Oct 19. PubMed PMID: 29056420.
  18. Groshong AM, Dey A, Bezsonova I, Caimano MJ, Radolf JD. Peptide Uptake Is Essential for Borrelia burgdorferi Viability and Involves Structural and Regulatory Complexity of its Oligopeptide Transporter. mBio. 2017 Dec 19;8(6). doi: 10.1128/mBio.02047-17. PubMed PMID: 29259089; PubMed Central PMCID: PMC5736914.
  19. Wang F, Wang L, Wu J, Sokirniy I, Nguyen P, Bregnard T, Weinstock J, Mattern M, Bezsonova I, Hancock WW, Kumar S. Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60. PLoS One. 2017;12(12):e0189744. doi: 10.1371/journal.pone.0189744. eCollection 2017. PubMed PMID: 29236775; PubMed Central PMCID: PMC5728538.
  20. Korzhnev DM, Neculai D, Dhe-Paganon S, Arrowsmith CH, Bezsonova I. Solution NMR structure of the HLTF HIRAN domain: a conserved module in SWI2/SNF2 DNA damage tolerance proteins. J Biomol NMR. 2016 Nov;66(3):209-219. doi: 10.1007/s10858-016-0070-9. Epub 2016 Oct 22. PubMed PMID: 27771863.
  21. Pozhidaeva AK, Mohni KN, Dhe-Paganon S, Arrowsmith CH, Weller SK, Korzhnev DM, Bezsonova I. Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1. J Biol Chem. 2015 Sep 18;290(38):22907-18. doi: 10.1074/jbc.M115.664805. Epub 2015 Jul 29. PubMed PMID: 26224631; PubMed Central PMCID: PMC4645603.
  22. Kile AC, Chavez DA, Bacal J, Eldirany S, Korzhnev DM, Bezsonova I, Eichman BF, Cimprich KA. HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal. Mol Cell. 2015 Jun 18;58(6):1090-100. doi: 10.1016/j.molcel.2015.05.013. Epub 2015 Jun 4. PubMed PMID: 26051180; PubMed Central PMCID: PMC4475461.
  23. Rizzo AA, Salerno PE, Bezsonova I, Korzhnev DM. NMR structure of the human Rad18 zinc finger in complex with ubiquitin defines a class of UBZ domains in proteins linked to the DNA damage response. Biochemistry. 2014 Sep 23;53(37):5895-906. doi: 10.1021/bi500823h. Epub 2014 Sep 15. PubMed PMID: 25162118.
  24. Bezsonova I. Solution NMR structure of the DNA-binding domain from Scml2 (sex comb on midleg-like 2). J Biol Chem. 2014 May 30;289(22):15739-49. doi: 10.1074/jbc.M113.524009. Epub 2014 Apr 10. PubMed PMID: 24727478; PubMed Central PMCID: PMC4140928.
  25. Machado LE, Pustovalova Y, Kile AC, Pozhidaeva A, Cimprich KA, Almeida FC, Bezsonova I, Korzhnev DM. PHD domain from human SHPRH. J Biomol NMR. 2013 Aug;56(4):393-9. doi: 10.1007/s10858-013-9758-2. Epub 2013 Aug 2. PubMed PMID: 23907177; PubMed Central PMCID: PMC3905319.
  26. Bezsonova I, Rujan I, Bobenchik AM, Gorbatyuk V, Maciejewski MW, Gorbatyuk O, Hao B, Arthanari H, Mamoun CB, Hoch JC. (1)H, (13)C, and (15)N chemical shift assignments for PfPMT, a phosphoethanolamine methyltransferase from Plasmodium falciparum. Biomol NMR Assign. 2013 Apr;7(1):17-20. doi: 10.1007/s12104-012-9372-3. Epub 2012 Mar 6. PubMed PMID: 22392340; PubMed Central PMCID: PMC3882757.
  27. Pustovalova Y, Bezsonova I, Korzhnev DM. The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase η and Rev7 subunit of polymerase ζ. FEBS Lett. 2012 Sep 21;586(19):3051-6. doi: 10.1016/j.febslet.2012.07.021. Epub 2012 Jul 22. PubMed PMID: 22828282; PubMed Central PMCID: PMC3572780.
  28. Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietlispach D, Barsukov I, Lian LY, Middleton D, Blumenschein T, Moore G, Campbell I, Schnell J, Vakonakis IJ, Watts A, Conte MR, Mason J, Pfuhl M, Sanderson MR, Craven J, Williamson M, Dominguez C, Roberts G, Günther U, Overduin M, Werner J, Williamson P, Blindauer C, Crump M, Driscoll P, Frenkiel T, Golovanov A, Matthews S, Parkinson J, Uhrin D, Williams M, Neuhaus D, Oschkinat H, Ramos A, Shaw DE, Steinbeck C, Vendruscolo M, Vuister GW, Walters KJ, Weinstein H, Wüthrich K, Yokoyama S. In support of the BMRB. Nat Struct Mol Biol. 2012 Sep;19(9):854-60. doi: 10.1038/nsmb.2371. PubMed PMID: 22955930.
  29. Pozhidaeva A, Pustovalova Y, D'Souza S, Bezsonova I, Walker GC, Korzhnev DM. NMR structure and dynamics of the C-terminal domain from human Rev1 and its complex with Rev1 interacting region of DNA polymerase η. Biochemistry. 2012 Jul 10;51(27):5506-20. doi: 10.1021/bi300566z. Epub 2012 Jun 28. PubMed PMID: 22691049; PubMed Central PMCID: PMC3732116.
  30. Lemak A, Yee A, Bezsonova I, Dhe-Paganon S, Arrowsmith CH. Zn-binding AZUL domain of human ubiquitin protein ligase Ube3A. J Biomol NMR. 2011 Sep;51(1-2):185-90. doi: 10.1007/s10858-011-9552-y. Epub 2011 Sep 27. PubMed PMID: 21947926.
  31. Bezsonova I, Walker JR, Bacik JP, Duan S, Dhe-Paganon S, Arrowsmith CH. Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins. Biochemistry. 2009 Nov 10;48(44):10542-8. doi: 10.1021/bi901131u. PubMed PMID: 19791798.
  32. Korzhnev DM, Bezsonova I, Lee S, Chalikian TV, Kay LE. Alternate binding modes for a ubiquitin-SH3 domain interaction studied by NMR spectroscopy. J Mol Biol. 2009 Feb 20;386(2):391-405. doi: 10.1016/j.jmb.2008.11.055. Epub 2008 Dec 6. PubMed PMID: 19111555.
  33. Bezsonova I, Bruce MC, Wiesner S, Lin H, Rotin D, Forman-Kay JD. Interactions between the three CIN85 SH3 domains and ubiquitin: implications for CIN85 ubiquitination. Biochemistry. 2008 Aug 26;47(34):8937-49. doi: 10.1021/bi800439t. Epub 2008 Aug 5. PubMed PMID: 18680311.
  34. Bezsonova I, Forman-Kay JD, Prosser RS. Molecular oxygen as a paramagnetic NMR probe of protein solvent exposure and topology. Concepts in Magnetic Resonance Part A. 2008 July; 32A(4):239. doi: 0.1002/cmr.a.20118.
  35. Lundström P, Teilum K, Carstensen T, Bezsonova I, Wiesner S, Hansen DF, Religa TL, Akke M, Kay LE. Fractional 13C enrichment of isolated carbons using [1-13C]- or [2- 13C]-glucose facilitates the accurate measurement of dynamics at backbone Calpha and side-chain methyl positions in proteins. J Biomol NMR. 2007 Jul;38(3):199-212. doi: 10.1007/s10858-007-9158-6. Epub 2007 Jun 7. PubMed PMID: 17554498.
  36. Bezsonova I, Evanics F, Marsh JA, Forman-Kay JD, Prosser RS. Oxygen as a paramagnetic probe of clustering and solvent exposure in folded and unfolded states of an SH3 domain. J Am Chem Soc. 2007 Feb 14;129(6):1826-35. doi: 10.1021/ja065173o. PubMed PMID: 17253684.
  37. Evanics F, Kitevski JL, Bezsonova I, Forman-Kay J, Prosser RS. 19F NMR studies of solvent exposure and peptide binding to an SH3 domain. Biochim Biophys Acta. 2007 Feb;1770(2):221-30. doi: 10.1016/j.bbagen.2006.10.017. Epub 2006 Nov 11. PubMed PMID: 17182189.
  38. Evanics F, Bezsonova I, Marsh J, Kitevski JL, Forman-Kay JD, Prosser RS. Tryptophan solvent exposure in folded and unfolded states of an SH3 domain by 19F and 1H NMR. Biochemistry. 2006 Nov 28;45(47):14120-8. doi: 10.1021/bi061389r. PubMed PMID: 17115707.
  39. Korzhnev DM, Bezsonova I, Evanics F, Taulier N, Zhou Z, Bai Y, Chalikian TV, Prosser RS, Kay LE. Probing the transition state ensemble of a protein folding reaction by pressure-dependent NMR relaxation dispersion. J Am Chem Soc. 2006 Apr 19;128(15):5262-9. doi: 10.1021/ja0601540. PubMed PMID: 16608362.
  40. Bezsonova I, Korzhnev DM, Prosser RS, Forman-Kay JD, Kay LE. Hydration and packing along the folding pathway of SH3 domains by pressure-dependent NMR. Biochemistry. 2006 Apr 18;45(15):4711-9. doi: 10.1021/bi060177r. PubMed PMID: 16605239.
  41. Bezsonova I, Singer A, Choy WY, Tollinger M, Forman-Kay JD. Structural comparison of the unstable drkN SH3 domain and a stable mutant. Biochemistry. 2005 Nov 29;44(47):15550-60. doi: 10.1021/bi0512795. PubMed PMID: 16300404.