Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7).    Functional spectrum of USP7 pathogenic variants in Hao-Fountain syndrome: Insights into the enzyme’s activity, stability, and allosteric modulation.

Dr. Korchak presented her work on functional characterization and rescue of USP7 variants associated with Hao-Fountain syndrome.

 The C-Terminal Tail of Ubiquitin-Specific Protease 7 Facilitates Ubiquitin Release and Ensures Efficient Catalytic Turnover. 

How a Key Enzyme Switches On and Off—And How a Rare Mutation Pushes It Into Overdrive  

Activation dynamics of ubiquitin-specific protease 7

Differences in structure, dynamics, and zinc coordination between isoforms of human ubiquitin ligase UBE3A

Gianluca Arianna, Dane Geddes-Buehre and Daniel Fairchild participated in the 3rd MBB Student SciArt Contest. Check out their creative works!

Our paper describes “A novel interaction between RAD23A/B and Y-family DNA Polymerases”. A collaboration with Roger Woodgate lab. Read the paper.