Congratulations to Daniel Fairchild, Irina Semenova, and Dane Geddes-Buehre on the new Nucleic Acids Research publication! “PXL: a nucleic acid-binding module of the promyelocytic leukemia protein” Read our newest paper here: https://academic.oup.com/nar/article/54/19/gkag966/8913151

UConn Health Postdoc a Projected Top-10 Draft Pick

Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7).    Functional spectrum of USP7 pathogenic variants in Hao-Fountain syndrome: Insights into the enzyme’s activity, stability, and allosteric modulation.

Dr. Korchak presented her work on functional characterization and rescue of USP7 variants associated with Hao-Fountain syndrome.

 The C-Terminal Tail of Ubiquitin-Specific Protease 7 Facilitates Ubiquitin Release and Ensures Efficient Catalytic Turnover. 

How a Key Enzyme Switches On and Off—And How a Rare Mutation Pushes It Into Overdrive  

Activation dynamics of ubiquitin-specific protease 7

Differences in structure, dynamics, and zinc coordination between isoforms of human ubiquitin ligase UBE3A