How a Key Enzyme Switches On and Off—And How a Rare Mutation Pushes It Into Overdrive

https://www.growkudos.com/publications/10.1073%25252Fpnas.2426632122/reader

USP7 is an important enzyme whose activity is tightly controlled in cells. Using advanced NMR techniques, researchers gained a rare glimpse into how the enzyme’s movements regulate its function. They discovered that a mutation linked to a rare neurodevelopmental disorder increases these movements, causing the enzyme to become overactive.