The UConn Partnership for Excellence in Structural Biology held a Science Café on Structural Biology Meets Drug Discovery on September 11, 2017 at the Nathan Hale Inn on the UConn Storrs campus. The Keynote Speaker was Dr. Jonathan Moore, Senior Research Fellow and Vice President of Vertex Pharmaceuticals in Boston. Dr. Moore’s insightful remarks focused on the intersection of structural biology and drug discovery and touched on targeting disordered proteins as a new mode of action. Dr. Dennis Wright, of UConn Pharmacy, briefed the group on the PITCH and NPDD academic drug discovery initiatives at UConn. The Science Café attracted a broad cross section of interested faculty as well as administrators, who engaged in a lively discussion of challenges and opportunities.