Drs. Reinhard Laubenbacher and Pedro Mendes of the Center for Quantitative Medicine, and Dr. Anna Dongari-Bagtzoglou of The Division of Periodontology UConn School of Dental Medicine, have been awarded over $2.20 million over the next four years from the National Institutes of Health (NIH) for “Control of heterogeneous microbial communities using model-based multi-objective optimization” (1R01GM127909-01). A novel mathematical approach to an important use of Agent-based models (ABMs) as a means to model-based control biological system. Rather than viewing the ABM as a model, it is to be viewed as a surrogate for the actual system.