Publications

2017

Using Kalirin conditional knockout mice to distinguish its role in dopamine receptor mediated behaviors. 
LaRese TP, Yan Y, Eipper BA, Mains RE.
BMC Neurosci. 2017 May 23;18(1):45. doi: 10.1186/s12868-017-0363-2.
PMID:28535798

A bioactive peptide amidating enzyme is required for ciliogenesis. 
Kumar D, Strenkert D, Patel-King RS, Leonard MT, Merchant SS, Mains RE, King SM, Eipper BA.
Elife. 2017 May 17;6. pii: e25728. doi: 10.7554/eLife.25728.
PMID:28513435

Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity.    
Miller MB, Yan Y, Machida K, Kiraly DD, Levy AD, Wu YI, Lam TT, Abbott T, Koleske AJ, Eipper BA, Mains RE.
ACS Chem Neurosci. 2017 Apr 25. doi: 10.1021/acschemneuro.7b00076. [Epub ahead of print]
PMID:28418645

The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together.   
Bäck N, Kanerva K, Kurutihalli V, Yanik A, Ikonen E, Mains RE, Eipper BA.
Eur J Cell Biol. 2017 Mar 28. pii: S0171-9335(17)30005-5. doi: 10.1016/j.ejcb.2017.03.007. [Epub ahead of print]
PMID:28377049

2016

Alternate promoter usage generates two subpopulations of the neuronal RhoGEF Kalirin-7.
Miller MB, Yan Y, Wu Y, Hao B, Mains RE, Eipper BA.
J Neurochem. 2017 Mar;140(6):889-902. doi: 10.1111/jnc.13749. Epub 2016 Sep 6.
PMID:27465683

Copper, zinc and calcium: imaging and quantification in anterior pituitary secretory granules.
Bonnemaison ML, Duffy ME, Mains RE, Vogt S, Eipper BA, Ralle M.
Metallomics. 2016 Sep 1;8(9):1012-22. doi: 10.1039/c6mt00079g. Epub 2016 Jul 18.
PMID: 27426256

Early eukaryotic origins for cilia-associated bioactive peptide-amidating activity.
Kumar D, Blaby-Haas CE, Merchant SS, Mains RE, King SM, Eipper BA.
J Cell Sci. 2016 Mar 1;129(5):943-56.
PMID: 26787743

60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin C.
Kumar D, Mains RE, Eipper BA.
J Mol Endocrinol. 2016 May;56(4):T63-76.
PMID: 26667899

Kalirin is required for BDNF-TrkB stimulated neurite outgrowth and branching.
Yan Y, Eipper BA, Mains RE.
Neuropharmacology. 2016 Mar 30;107:227-238. doi: 10.1016/j.neuropharm.2016.03.050. [Epub ahead of print]
PMID:27036892

O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic Trafficking.
Vishwanatha KS, Bäck N, Lam TT, Mains RE, Eipper BA.
J Biol Chem. 2016 Mar 9. pii: jbc.M115.711838. [Epub ahead of print]
PMID:26961877

Early eukaryotic origins for cilia-associated bioactive peptide-amidating activity.
Kumar D, Blaby-Haas CE, Merchant SS, Mains RE, King SM,Eipper BA.
J Cell Sci. 2016 Mar 1;129(5):943-56. doi: 10.1242/jcs.177410. Epub 2016 Jan 19.
PMID:26787743

2015

A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease.
Puigdellívol M, Cherubini M, Brito V, Giralt A, Suelves N, Ballesteros J, Zamora-Moratalla A, Martín ED, Eipper BA, Alberch J, Ginés S.
Hum Mol Genet. 2015 Dec 20;24(25):7265-85. doi: 10.1093/hmg/ddv426. Epub 2015 Oct 12.

60 YEARS OF POMC: From POMC and αMSH to PAM, molecular oxygen, copper and vitamin C.
Kumar D, Mains RE, Eipper E.
J Mol Endocrinol. 2015 Dec 14. pii: JME-15-0266. [Epub ahead of print]
PMID:26667899

Kalirin-9 and Kalirin-12 Play Essential Roles in Dendritic Outgrowth and Branching.
Yan Y, Eipper BA, Mains RE.
Cereb Cortex. 2015 Oct;25(10):3487-501. doi: 10.1093/cercor/bhu182. Epub 2014 Aug 21.
PMID:25146373

Optimizing production of Fc-amidated peptides by Chinese hamster ovary cells.
Carlson K, Pomerantz SC, Vafa O, Naso M, Strohl W, Mains RE,Eipper BA.
BMC Biotechnol. 2015 Oct 16;15:95. doi: 10.1186/s12896-015-0210-4.
PMID:26475607

Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells.
Simpson PD, Eipper BA, Katz MJ, Gandara L, Wappner P, Fischer R, Hodson EJ, Ratcliffe PJ, Masson N.
J Biol Chem. 2015 Oct 9;290(41):24891-901. doi: 10.1074/jbc.M115.667246. Epub 2015 Aug 19.

Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine α-Amidating Monooxygenase, a Luminal Cuproenzyme.
Bonnemaison ML, Bäck N, Duffy ME, Ralle M, Mains RE, Eipper BA.
J Biol Chem. 2015 Aug 28;290(35):21264-79. doi: 10.1074/jbc.M115.641027. Epub 2015 Jul 13.
PMID:26170456

Secretion of Fc-amidated peptide fusion proteins by Chinese hamster ovary cells.
Carlson KR, Pomerantz SC, Li J, Vafa O, Naso M, Strohl W, Mains RE, Eipper BA.
BMC Biotechnol. 2015 Jun 27;15:61. doi: 10.1186/s12896-015-0173-5.
PMID:26116580

An N-terminal Amphipathic Helix Binds Phosphoinositides and Enhances Kalirin Sec14 Domain-mediated Membrane Interactions.
Miller MB, Vishwanatha KS, Mains RE, Eipper BA.
J Biol Chem. 2015 May 22;290(21):13541-55. doi: 10.1074/jbc.M115.636746. Epub 2015 Apr 10.
PMID:25861993

A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.
Lu J, Luo C, Bali KK, Xie RG, Mains RE, Eipper BA, Kuner R.
Nat Commun. 2015 Apr 13;6:6820. doi: 10.1038/ncomms7820.
PMID:25865668

2014

AP-1A controls secretory granule biogenesis and trafficking of membrane secretory granule proteins.
Bonnemaison M, Bäck N, Lin Y, Bonifacino JS, Mains R, Eipper B.
Traffic. 2014 Oct;15(10):1099-121. doi: 10.1111/tra.12194. Epub 2014 Aug 15.
PMID:25040637

Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum.
Gaier ED, Kleppinger A, Ralle M, Covault J, Mains RE, Kenny AM,Eipper BA.
BMC Endocr Disord. 2014 Jul 15;14:58. doi: 10.1186/1472-6823-14-58.
PMID:25022877

Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning.
Mandela P, Yan Y, LaRese T, Eipper BA, Mains RE.
Horm Behav. 2014 Jul;66(2):430-8. doi: 10.1016/j.yhbeh.2014.07.001. Epub 2014 Jul 9.
PMID:25014196

A Histidine-rich Linker Region in Peptidylglycine α-Amidating Monooxygenase Has the Properties of a pH Sensor
Vishwanatha K, Bäck N, Mains RE, Eipper BA.
J hem. 2014 May 2;289(18):12404-20. doi: 10.1074/jbc.M113.545947. Epub 2014 Mar 13.

Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl Mol Biol
Ma XM, Miller MB, Vishwanatha KS, Gross MJ, Wang Y, Abbott T, Lam TT, Mains RE, Eipper BA.
Cell. 2014 May;25(9):1458-71. doi: 10.1091/mbc.E13-04-0215. Epub 2014 Mar 5.

Pam heterozygous mice reveal essential role for Cu in amygdalar behavioral and synaptic function.
Gaier ED, Eipper BA, Mains RE.
Ann N Y Acad Sci. 2014 May;1314(1):15-23. doi: 10.1111/nyas.12378. Epub 2014 Mar 4.

In vivo and in vitro analyses of amygdalar function reveal a role for copper.
Gaier ED, Rodriguiz RM, Zhou J, Ralle M, Wetsel WC, Eipper BA, Mains RE.
J Neurophysiol. 2014 May 15;111(10):1927-39. doi: 10.1152/jn.00631.2013. Epub 2014 Feb 19.

The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.
Huang S1, Eleniste PP1, Wayakanon K1, Mandela P2, Eipper BA2, Mains RE2, Allen MR3, Bruzzaniti A4.
Bone. 2014 Mar;60:235-45. doi: 10.1016/j.bone.2013.12.023. Epub 2013 Dec 28.

2012

Mandela P, Yankova M, Conti LH, Ma XM, Grady J, Eipper BA, Mains RE.
Kalrn plays key roles within and outside of the nervous system. BMC Neurosci. 2012 Nov 1;13:136. doi: 10.1186/1471-2202-13-136.

Gaier ED, Eipper BA, Mains RE.
Copper signaling in the mammalian nervous system: synaptic effects. Neurosci Res. 2013 Jan;91(1):2-19. doi: 10.1002/jnr.23143. Epub 2012 Nov 1.

Eipper-Mains JE, Kiraly DD, Duff MO, Horowitz MJ, McManus CJ, Eipper BA, Graveley BR, Mains RE.
Effects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome. Genes Brain Behav. 2013 Feb;12(1):21-33. doi: 10.1111/j.1601-183X.2012.00873.x. Epub 2012 Nov 27.

Mazzone CM, Larese TP, Kiraly DD, Eipper BA, Mains RE.
Analysis of kalirin-7 knockout mice reveals different effects in female mice. Mol Pharmacol. 2012 Dec;82(6):1241-9. doi: 10.1124/mol.112.080838. Epub 2012 Sep 18.

Ma XM, Huang JP, Xin X, Yan Y, Mains RE, Eipper BA.
A role for kalirin in the response of rat medium spiny neurons to cocaine. Mol Pharmacol. 2012 Oct;82(4):738-45. Epub 2012 Jul 24.

Vishwanatha KS, Wang YP, Keutmann HT, Mains RE, Eipper BA.
Structural Organization of the Nine Spectrin Repeats of Kalirin. Biochemistry. 2012 Jul 6. [Epub ahead of print] PMID:22738176.

Eipper-Mains JE, Eipper BA, Mains RE.
Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression. Front Genet. 2012;3:109. Epub 2012 Jun 13. PMID:22707957.

Rajagopal C, Mains RE, Eipper BA.
Signaling from the secretory granule to the nucleus. Crit Rev Biochem Mol Biol. 2012 Jul;47(4):391-406. Epub 2012 Jun 8. PMID:22681236.

Gaier ED, Kleppinger A, Ralle M, Mains RE, Kenny AM, Eipper BA.
High serum Cu and Cu/Zn ratios correlate with impairments in bone density, physical performance and overall health in a population of elderly men with frailty characteristics. Exp Gerontol. 2012 Jul;47(7):491-6. Epub 2012 Mar 29. PMID:22484083.

2010

Hostager BS, Fox DK, Whitten D, Wilkerson CG, Eipper BA, Francone VP, Rothman PB, Colgan JD.
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. J Neurosci. 2010 Dec 8;30(49):16651-61.

Chen B, Ge Q, Xia XM, Liu P, Wang SJ, Zhan H, Eipper BA, Wang ZW.
A novel auxiliary subunit critical to BK channel function in Caenorhabditis elegans. J Neurosci. 2010 Dec 8;30(49):16651-61.

Chufán EE, Prigge ST, Siebert X, Eipper BA, Mains RE, Amzel LM.
Differential reactivity between two copper sites in peptidylglycine α-hydroxylating monooxygenase. J Am Chem Soc. 2010 Nov 10;132(44):15565-72.

Gaier ED, Rodriguiz RM, Ma XM, Sivaramakrishnan S, Bousquet-Moore D, Wetsel WC, Eipper BA, Mains RE.
Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. J Neurosci. 2010 Oct 13;30(41):13656-69.

Rajagopal C, Stone KL, Mains RE, Eipper BA.
Secretion stimulates intramembrane proteolysis of a secretory granule membrane enzyme. J Biol Chem. 2010 Nov 5;285(45):34632-42. Epub 2010 Sep 3.

Bousquet-Moore D, Mains RE, Eipper BA.
Peptidylgycine alpha-amidating monooxygenase and copper: a gene-nutrient interaction critical to nervous system function. J Neurosci Res. 2010 Sep;88(12):2535-45. Review.

Hostager BS, Fox DK, Whitten D, Wilkerson CG, Eipper BA, Francone VP, Rothman PB, Colgan JD.
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One. 2010 Jun 30;5(6):e11380.

Francone VP, Ifrim MF, Rajagopal C, Leddy CJ, Wang Y, Carson JH, Mains RE, Eipper BA.
Signaling from the secretory granule to the nucleus: Uhmk1 and PAM. Mol Endocrinol. 2010 Aug;24(8):1543-58. Epub 2010 Jun 23.

Atkinson LE, McVeigh P, Kimber MJ, Marks NJ, Eipper BA, Mains RE, Day TA, Maule AG.
A PAL for Schistosoma mansoni PHM. Mol Biochem Parasitol. 2010 Oct;173(2):97-106. Epub 2010 May 19.

Kiraly DD, Ma XM, Mazzone CM, Xin X, Mains RE, Eipper BA.
Behavioral and morphological responses to cocaine require kalirin7. Biol Psychiatry. 2010 Aug 1;68(3):249-55. Epub 2010 May 10.

Bäck N, Rajagopal C, Mains RE, Eipper BA.
Secretory granule membrane protein recycles through multivesicular bodies. Traffic. 2010 Jul 1;11(7):972-86. Epub 2010 Apr 1.

Ma XM, Huang JP, Kim EJ, Zhu Q, Kuchel GA, Mains RE, Eipper BA.
Kalirin-7, an important component of excitatory synapses, is regulated by estradiol in hippocampal neurons. Hippocampus. 2010 Mar 23. [Epub ahead of print]
Sobota JA, Mohler WA, Cowan AE, Eipper BA, Mains RE.
Dynamics of peptidergic secretory granule transport are regulated by neuronal stimulation. BMC Neurosci. 2010 Mar 4;11(1):32.
Bousquet-Moore D, Prohaska JR, Nillni EA, Czyzyk T, Wetsel WC, Mains RE, Eipper BA.
Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. Neurobiol Dis. 2010 Jan;37(1):130-40. Epub 2009 Oct 6.
Kiraly DD, Eipper-Mains JE, Mains RE, Eipper BA
Synaptic Plasticity, a Symphony in GEF. ACS Chemical Neuroscience, 2010 May 19;1(5):348-365.

2007

De M, Ciccotosto GD, Mains RE, Eipper BA.
Trafficking of a secretory granule membrane protein is sensitive to copper. J Biol Chem. 2007;282:23362-71.

Niciu MJ, Ma XM, El Meskini R, Pachter JS, Mains RE, Eipper BA.
Altered ATP7A expression and other compensatory responses in a murine model of Menkes disease. Neurobiol Dis. 2007;27:278-91.

Nyasae L, Bustos R, Braiterman L, Eipper BA, Hubbard A
Dynamics of endogenous Atp7A (Menkes Protein) in intestinal epithelial cells, Am J Physiol, GI and Liver Physiology 2007 292: G1181-1194.

Linz R, Barnes N, Zimnica A, Eipper B, Kaplan J, Lutsenko S
The Intracellular Targeting of Copper-Transporting ATPase ATP7A in a Normal and ATP7B-/- Kidney, 2007 Am J Physiol (Renal Physiol), PMID: 17928409.

Koo TH, Eipper BA, Donaldson JG.
Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation. BMC Cell Biol. 2007;8:29.

Ferraro F, Ma XM, Sobota JA, Eipper BA, Mains RE.
Kalirin/Trio RhoGEFs Regulate a Novel Step in Secretory Granule Maturation. Mol Biol Cell. 2007 Dec;18(12):4813-25.

El Meskini R, Crabtree KL, Cline LB, Mains RE, Eipper BA, Ronnett GV.
ATP7A (Menkes protein) functions in axonal targeting and synaptogenesis. Mol Cell Neurosci. 2007;34:409-21.

2005

Czyzyk TA, Ning Y, Hsu MS, Peng B, Mains RE, Eipper BA, Pintar JE.
Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse. Dev Biol. 2005 Nov 15;287(2):301-13. Epub 2005 Oct 12.

El Meskini R, Cline LB, Eipper BA, Ronnett GV.
The developmentally regulated expression of Menkes protein ATP7A suggests a role in axon extension and synaptogenesis. Dev Neurosci. 2005;27(5):333-48.

Siebert X, Eipper BA, Mains RE, Prigge ST, Blackburn NJ, Amzel LM.
The catalytic copper of Peptidylglycine alpha-Hydroxylating Monooxygenase also plays a critical structural role. Biophys J. 2005 Aug 12; [Epub ahead of print]

Schiller MR, Blangy A, Huang J, Mains RE, Eipper BA.
Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity.
Exp Cell Res. 2005 Jul 15;307(2):402-17. Epub 2005 Apr 21.

Ferraro F, Eipper BA, Mains RE.
Retrieval and reuse of pituitary secretory granule proteins. J Biol Chem. 2005 Jul 8;280(27):25424-35. Epub 2005 May 19.

Rabiner CA, Mains RE, Eipper BA.
Kalirin: a dual Rho guanine nucleotide exchange factor that is so much more than the sum of its many parts. Neuroscientist. 2005 Apr;11(2):148-60. Review.

McPherson CE, Eipper BA, Mains RE
Multiple novel isoforms of Trio are expressed in the developing rat brain. Gene. 2005 Feb 28;347(1):125-35.

Ma, X, Huang JP, Eipper, BA, Mains RE
Expression of Trio, a member of the Dbl family of Rho GEFs in the developing rat brain. 2005 J Comp Neurol 482: 333-348.

2001

Gozes I, Brenneman DE, Geppetti P, Kastin AJ, Mains RE, Moody TW, Seroogy K, Spier AD, Zimmermann M.
Neuropeptides: brain messengers of many faces. Trends Neurosci. 2001 Dec;24(12):687-90.

Penzes P, Johnson RC, Kambampati V, Mains RE, Eipper BA.
Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology. J Neurosci. 2001 Nov 1;21(21):8426-34.

Hansel DE, Eipper BA, Ronnett GV.
Regulation of olfactory neurogenesis by amidated neuropeptides. J Neurosci Res. 2001 Oct 1;66(1):1-7. Review.

Steveson TC, Zhao GC, Keutmann HT, Mains RE, Eipper BA.
Access of a membrane protein to secretory granules is facilitated by phosphorylation. J Biol Chem. 2001 Oct 26;276(43):40326-37. Epub 2001 Aug 27.

Hansel DE, May V, Eipper BA, Ronnett GV.
Pituitary adenylyl cyclase-activating peptides and alpha-amidation in olfactory neurogenesis and neuronal survival in vitro. J Neurosci. 2001 Jul 1;21(13):4625-36.

Oyarce AM, Steveson TC, Jin L, Eipper BA.
Dopamine beta-monooxygenase signal/anchor sequence alters trafficking of peptidylglycine alpha-hydroxylating monooxygenase. J Biol Chem. 2001 Aug 31;276(35):33265-72. Epub 2001 Jun 19.

Hansel DE, Quinones ME, Ronnett GV, Eipper BA.
Kalirin, a GDP/GTP exchange factor of the Dbl family, is localized to nerve, muscle, and endocrine tissue during embryonic rat development. J Histochem Cytochem. 2001 Jul;49(7):833-44.

Bell-Parikh LC, Eipper BA, Mains RE.
Response of an integral granule membrane protein to changes in pH. J Biol Chem. 2001 Aug 10;276(32):29854-63. Epub 2001 Jun 06.

Hansel DE, Eipper BA, Ronnett GV.
Neuropeptide Y functions as a neuroproliferative factor. Nature. 2001 Apr 19;410(6831):940-4.

Alam MR, Steveson TC, Johnson RC, Back N, Abraham B, Mains RE, Eipper BA.
Signaling mediated by the cytosolic domain of peptidylglycine alpha-amidating monooxygenase. Mol Biol Cell. 2001 Mar;12(3):629-44.

Penzes P, Johnson RC, Sattler R, Zhang X, Huganir RL, Kambampati V, Mains RE, Eipper BA.
The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Neuron. 2001 Jan;29(1):229-42.

Ma XM, Johnson RC, Mains RE, Eipper BA.
Expression of kalirin, a neuronal GDP/GTP exchange factor of the trio family, in the central nervous system of the adult rat. J Comp Neurol. 2001 Jan 15;429(3):388-402.

El Meskini R, Galano GJ, Marx R, Mains RE, Eipper BA.
Targeting of membrane proteins to the regulated secretory pathway in anterior pituitary endocrine cells. J Biol Chem. 2001 Feb 2;276(5):3384-93. Epub 2000 Nov 01.

2000

Prigge ST, Mains RE, Eipper BA, Amzel LM.
New insights into copper monooxygenases and peptide amidation: structure, mechanism and function. Cell Mol Life Sci. 2000 Aug;57(8-9):1236-59. Review.

Jiang N, Kolhekar AS, Jacobs PS, Mains RE, Eipper BA, Taghert PH.
PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila.
Dev Biol. 2000 Oct 1;226(1):118-36.

El Meskini R, Mains RE, Eipper BA.
Cell type-specific metabolism of peptidylglycine alpha-amidating monooxygenase in anterior pituitary. Endocrinology. 2000 Aug;141(8):3020-34.

Driscoll WJ, Konig S, Fales HM, Pannell LK, Eipper BA, Mueller GP.
Peptidylglycine-alpha-hydroxylating monooxygenase generates two hydroxylated products from its mechanism-based suicide substrate, 4-phenyl-3-butenoic acid.Biochemistry. 2000 Jul 11;39(27):8007-16.

Johnson RC, Penzes P, Eipper BA, Mains RE.
Isoforms of kalirin, a neuronal Dbl family member, generated through use of different 5'- and 3'-ends along with an internal translational initiation site. J Biol Chem. 2000 Jun 23;275(25):19324-33.

Penzes P, Johnson RC, Alam MR, Kambampati V, Mains RE, Eipper BA.
An isoform of kalirin, a brain-specific GDP/GTP exchange factor, is enriched in the postsynaptic density fraction.
J Biol Chem. 2000 Mar 3;275(9):6395-403.

Oyarce AM, Eipper BA.
Cell type-specific storage of dopamine beta-monooxygenase. J Biol Chem. 2000 Feb 4;275(5):3270-8.

Ciccotosto GD, Hand TA, Mains RE, Eipper BA.
Breeding stock-specific variation in peptidylglycine alpha-amidating monooxygenase messenger ribonucleic acid splicing in rat pituitary. Endocrinology. 2000 Feb;141(2):476-86.

1999

Caldwell BD, Darlington DN, Penzes P, Johnson RC, Eipper BA, Mains RE.
The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase. J Biol Chem. 1999 Dec 3;274(49):34646-56.

Prigge ST, Kolhekar AS, Eipper BA, Mains RE, Amzel LM.
Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase. Nat Struct Biol. 1999 Oct;6(10):976-83.

Marx R, El Meskini R, Johns DC, Mains RE.
Differences in the ways sympathetic neurons and endocrine cells process, store, and secrete exogenous neuropeptides and peptide-processing enzymes. J Neurosci. 1999 Oct 1;19(19):8300-11.

Bruzzaniti A, Marx R, Mains RE.
Activation and routing of membrane-tethered prohormone convertases 1 and 2. J Biol Chem. 1999 Aug 27;274(35):24703-13.

Mueller GP, Driscoll WJ, Eipper BA.
In vivo inhibition of peptidylglycine-alpha-hydroxylating monooxygenase by 4-phenyl-3-butenoic acid. J Pharmacol Exp Ther. 1999 Sep;290(3):1331-6.

Steveson TC, Keutmann HT, Mains RE, Eipper BA.
Phosphorylation of cytosolic domain Ser(937) affects both biosynthetic and endocytic trafficking of peptidylglycine alpha-amidating monooxygenase. J Biol Chem. 1999 Jul 23;274(30):21128-38.

Driscoll WJ, Mueller SA, Eipper BA, Mueller GP.
Differential regulation of peptide alpha-amidation by dexamethasone and disulfiram. Mol Pharmacol. 1999 Jun;55(6):1067-76.

Fass DM, Takimoto K, Mains RE, Levitan ES.
Tonic dopamine inhibition of L-type Ca2+ channel activity reduces alpha1D Ca2+ channel gene expression. J Neurosci. 1999 May 1;19(9):3345-52.

Spijker S, Smit AB, Eipper BA, Malik A, Mains RE, Geraerts WP.
A molluscan peptide alpha-amidating enzyme precursor that generates five distinct enzymes. FASEB J. 1999 Apr;13(6):735-48.

Johns DC, Marx R, Mains RE, O'Rourke B, Marban E.
Inducible genetic suppression of neuronal excitability. J Neurosci. 1999 Mar 1;19(5):1691-7.

Ciccotosto GD, Schiller MR, Eipper BA, Mains RE.
Induction of integral membrane PAM expression in AtT-20 cells alters the storage and trafficking of POMC and PC1. J Cell Biol. 1999 Feb 8;144(3):459-71.

Mains RE, Alam MR, Johnson RC, Darlington DN, Back N, Hand TA, Eipper BA.
Kalirin, a multifunctional PAM COOH-terminal domain interactor protein, affects cytoskeletal organization and ACTH secretion from AtT-20 cells. J Biol Chem. 1999 Jan 29;274(5):2929-37.

Ratovitski EA, Alam MR, Quick RA, McMillan A, Bao C, Kozlovsky C, Hand TA, Johnson RC, Mains RE, Eipper BA, Lowenstein CJ.
Kalirin inhibition of inducible nitric-oxide synthase. J Biol Chem. 1999 Jan 8;274(2):993-9.

1997

Zhang J, Zheng M, Eipper BA, Pintar JE.
Embryonic and uterine expression patterns of peptidylglycine alpha-amidating monooxygenase transcripts suggest a widespread role for amidated peptides in development. Dev Biol. 1997 Dec 15;192(2):375-91.

Darlington DN, Schiller MR, Mains RE, Eipper BA.
The expression of regulated endocrine-specific protein of 18 kDa in peptidergic cells of rat peripheral endocrine tissues and in blood.J Endocrinol. 1997 Nov;155(2):329-41.

Hubbard FC, Goodrow TL, Liu SC, Brilliant MH, Basset P, Mains RE, Klein-Szanto AJ.
Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability. Cancer Res. 1997 Dec 1;57(23):5226-31.

Marx R, Mains RE.
Adenovirally encoded prohormone convertase-1 functions in atrial myocyte large dense core vesicles.
Endocrinology. 1997 Dec;138(12):5108-18.

Schiller MR, Mains RE, Eipper BA.
A novel neuroendocrine intracellular signaling pathway. Mol Endocrinol. 1997 Nov;11(12):1846-57.

Prigge ST, Kolhekar AS, Eipper BA, Mains RE, Amzel LM.
Amidation of bioactive peptides: the structure of peptidylglycine alpha-hydroxylating monooxygenase. Science. 1997 Nov 14;278(5341):1300-5.

Kolhekar AS, Keutmann HT, Mains RE, Quon AS, Eipper BA.
Phosphorylation of cytosolic domain Ser(937) affects both biosynthetic and endocytic trafficking of peptidylglycine alpha-amidating monooxygenase. J Biol Chem. 1999 Jul 23;274(30):21128-38.

Darlington DN, Schiller MR, Mains RE, Eipper BA.
Expression of RESP18 in peptidergic and catecholaminergic neurons. J Histochem Cytochem. 1997 Sep;45(9):1265-77.

Alam MR, Johnson RC, Darlington DN, Hand TA, Mains RE, Eipper BA.
Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme. J Biol Chem. 1997 May 9;272(19):12667-75.

Milgram SL, Kho ST, Martin GV, Mains RE, Eipper BA.
Localization of integral membrane peptidylglycine alpha-amidating monooxygenase in neuroendocrine cells.
J Cell Sci. 1997 Mar;110 ( Pt 6):695-706.

Kolhekar AS, Roberts MS, Jiang N, Johnson RC, Mains RE, Eipper BA, Taghert PH.
Neuropeptide amidation in Drosophila: separate genes encode the two enzymes catalyzing amidation. J Neurosci. 1997 Feb 15;17(4):1363-76.

Mains RE, Berard CA, Denault JB, Zhou A, Johnson RC, Leduc R.
PACE4: a subtilisin-like endoprotease with unique properties. Biochem J. 1997 Feb 1;321 ( Pt 3):587-93.

Kolhekar AS, Mains RE, Eipper BA.
Peptidylglycine alpha-amidating monooxygenase: an ascorbate-requiring enzyme. Methods Enzymol. 1997;279:35-43. Review. No abstract available.