2023
Mains RE, Eipper BA. 2023. Neuropeptides. In Basic Neurochemistry: Principles of molecular, cellular and medical neurobiology, 9th Ed. Brady ST & Carson MJ (Eds), Elsevier, in press.
Structure of the Sec14 domain of Kalirin reveals a distinct class of lipid-binding module in RhoGEFs.
Li Y, Pustovalova Y, Doukov TI, Hoch JC, Mains RE, Eipper BA, Hao B. 2023. Nat Commun 14:96. doi: 10.1038/s41467-022-35678-4. PMID: 36609407
Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion.
Trivellin G, Daly AF, Hernández-Ramírez LC, Araldi E, Tatsi C, Dale RK, Fridell G, Mittal A, Faucz FR, Iben JR, Li T, Vitali E, Stojilkovic SS, Kamenicky P, Villa C, Baussart B, Chittiboina P, Toro C, Gahl WA, Eugster EA, Naves LA, Jaffrain-Rea ML, de Herder WW, Neggers SJ, Petrossians P, Beckers A, Lania AG, Mains RE, Eipper BA, Stratakis CA. 2023. Front Endocrinol: 1:q1166076. DOI:10.3389/fendo.2023.1166076. PMID: 36711613.
2022
Peptidylglycine a-amidating monooxygenase as a therapeutic target or biomarker.
Merkler DJ, Hawley AJ, Eipper BA, Mains RE. 2022. Br J Pharmacol. 179:3306-3324. doi: 10.1111/bph.15815. Epub 2022 Feb 28. PMID: 35124797
2021
Multiple roles for peptidylglycine α-amidating monooxygenase in the response to hypoxia.
Rao VKS, Eipper BA, Mains RE. 2021. J Cell Physiol. 236:7745-7758. PMID: 34061983
PAM: diverse roles in neuroendocrine cells, cardiomyocytes and green algae.
Bäck N, Mains RE, Eipper BA. 2021. FEBS J. 289: 4470-4496. doi: 10.1111/febs.16049. Epub 2021 Jun 22. PMID: 34089560
Peptidylglycine α-Amidating Monooxygenase (PAM).
Commentary on: Peptidylglycine α-amidating Monooxygenase is Required for Atrial Secretory Granule Formation.
Bartels ED, Gøtze JP, Mains RE, Eipper BA. 2021. J Clin Cardiol. 2021;2(4):75-80. doi: 10.33696/cardiology.2.022.PMID: 35098246
Cell-type specific knockout of peptidylglycine α-amidating monooxygenase reveals specific behavioral roles in excitatory forebrain neurons and cardiomyocytes.
Powers KG, Ma XM, Eipper BA, Mains RE. 2021. Genes Brain Behav. 2021 Feb;20(2):e12699. doi: 10.1111/gbb.12699. Epub 2020 Sep 24. PMID: 32902163
2020
Cell-type specific knockout of peptidylglycine α-amidating monooxygenase reveals specific behavioral roles in excitatory forebrain neurons and cardiomyocytes.
Powers KG, Ma XM, Eipper BA, Mains RE.
Genes Brain Behav. 2020 Sep 9:e12699. doi: 10.1111/gbb.12699. Online ahead of print. PMID: 32902163
Role of Kalirin and mouse strain in retention of spatial memory training in an Alzheimer's disease model mouse line.
Russo-Savage L, Rao VKS, Eipper BA, Mains RE.
Neurobiol Aging. 2020 Nov;95:69-80. doi: 10.1016/j.neurobiolaging.2020.07.006. Epub 2020 Jul 14.
PMID: 32768866
Peptidylglycine α-amidating monooxygenase is required for atrial secretory granule formation.
Bäck N, Luxmi R, Powers KG, Mains RE, Eipper BA.
Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):17820-17831. doi: 10.1073/pnas.2004410117. Epub 2020 Jul 13.
PMID: 32661174
PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma.
Soni H, Bode J, Nguyen CDL, Puccio L, Neßling M, Piro RM, Bub J, Phillips E, Ahrends R, Eipper BA,
Tews B, Goidts V. Oncogenesis. 2020 Feb 13;9(2):18. doi: 10.1038/s41389-020-0201-8.
PMID: 32054826 Free PMC article.
PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice.
Chen YC, Mains RE, Eipper BA, Hoffman BG, Czyzyk TA, Pintar JE, Verchere CB.
Diabetologia. 2020 Mar;63(3):561-576. doi: 10.1007/s00125-019-05060-z. Epub 2020 Jan 27.
PMID: 31984442
Role of Kalirin and mouse strain in retention of spatial memory training in an Alzheimer's disease model mouse line.
Russo-Savage L, Rao VKS, Eipper BA, Mains RE. 2020. Neurobiol Aging. Nov;95:69-80. doi: 10.1016/j.neurobiolaging.2020.07.006. Epub 2020 Jul 14. PMID: 32768866
2019
Transcriptional Profiling of Non-injured Nociceptors After Spinal Cord Injury Reveals Diverse Molecular Changes.
Yasko JR, Moss IL, Mains RE.
Front Mol Neurosci. 2019 Nov 26;12:284. doi: 10.3389/fnmol.2019.00284. eCollection 2019. PMID:
32038157 Free PMC article.
Cilia-based peptidergic signaling. Luxmi R, Kumar D, Mains RE, King SM, Eipper BA.
PLoS Biol. 2019 Dec 6;17(12):e3000566. doi: 10.1371/journal.pbio.3000566. eCollection 2019 Dec.
PMID: 31809498 Free PMC article.
Identifying roles for peptidergic signaling in mice. Powers KG, Ma XM, Eipper BA, Mains RE.
Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):20169-20179. doi: 10.1073/pnas.1910495116. Epub 2019
Aug 27. PMID: 31455734 Free PMC article.
Ciliary and cytoskeletal functions of an ancient monooxygenase essential for bioactive amidated peptide synthesis.
Kumar D, Mains RE, Eipper BA, King SM. Cell Mol Life Sci. 2019 Jun;76(12):2329-2348. doi: 10.1007/s00018-019-03065-w. Epub 2019 Mar 16. Review.
PMID:30879092
A pH-sensitive luminal His-cluster promotes interaction of PAM with V-ATPase along the secretory and endocytic pathways of peptidergic cells.
Rao VK, Zavala G, Deb Roy A, Mains RE, Eipper BA.
J Cell Physiol. 2019 Jun;234(6):8683-8697. doi: 10.1002/jcp.27528. Epub 2018 Oct 14.
PMID:30317586
Sex-Specific Gene Expression in the Mouse Nucleus Accumbens Before and After Cocaine Exposure.
LaRese TP, Rheaume BA, Abraham R, Eipper BA, Mains RE.
J Endocr Soc. 2019 Jan 14;3(2):468-487. doi: 10.1210/js.2018-00313. eCollection 2019 Feb 1.
PMID:30746506
2018
Kalirin/Trio Rho GDP/GTP exchange factors regulate proinsulin and insulin secretion.
Dufurrena Q, Bäck N, Mains RE, Hodgson L, Tanowitz H, Mandela P, Eipper E, Kuliawat R.
J Mol Endocrinol. 2018 Nov 1. pii: JME-18-0048.R2. doi: 10.1530/JME-18-0048. [Epub ahead of print]
PMID:30407917
Proteases Shape the Chlamydomonas Secretome: Comparison to Classical Neuropeptide Processing Machinery.
Luxmi R, Blaby-Haas C, Kumar D, Rauniyar N, King SM, Mains RE, Eipper BA.
Proteomes. 2018 Sep 23;6(4). pii: E36. doi: 10.3390/proteomes6040036.
PMID:30249063
Changes in Corticotrope Gene Expression Upon Increased Expression of Peptidylglycine α-Amidating Monooxygenase.
Mains RE, Blaby-Haas C, Rheaume BA, Eipper BA.
Endocrinology. 2018 Jul 1;159(7):2621-2639. doi: 10.1210/en.2018-00235.
PMID:29788427
Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase.
Maheshwari S, Shimokawa C, Rudzka K, Kline CD, Eipper BA, Mains RE, Gabelli SB, Blackburn N, Amzel LM.
Commun Biol. 2018 Jun 25;1:74. doi: 10.1038/s42003-018-0082-y. eCollection 2018.
PMID:30271955
Microvillar and ciliary defects in zebrafish lacking an actin-binding bioactive peptide amidating enzyme.
Kumar D, Thomason RT, Yankova M, Gitlin JD, Mains RE, Eipper BA, King SM.
Sci Rep. 2018 Mar 14;8(1):4547. doi: 10.1038/s41598-018-22732-9.
PMID:29540787
Chronic pain following spinal cord injury: current approaches to cellular and molecular mechanisms.
Yasko JR, Mains RE.
Trends in cell & molecular biology. 2018;13:67-84
2017
Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity.
Katrancha SM, Wu Y, Zhu M, Eipper BA, Koleske AJ, Mains RE.
Hum Mol Genet. 2017 Dec 1;26(23):4728-4740. doi: 10.1093/hmg/ddx355.
PMID:28973398
The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together.
Bäck N, Kanerva K, Kurutihalli V, Yanik A, Ikonen E, Mains RE, Eipper BA.
Eur J Cell Biol. 2017 Aug;96(5):407-417. doi: 10.1016/j.ejcb.2017.03.007. Epub 2017 Mar 28.
PMID:28377049
Using Kalirin conditional knockout mice to distinguish its role in dopamine receptor mediated behaviors.
LaRese TP, Yan Y, Eipper BA, Mains RE.
BMC Neurosci. 2017 May 23;18(1):45. doi: 10.1186/s12868-017-0363-2.
PMID:28535798
A bioactive peptide amidating enzyme is required for ciliogenesis.
Kumar D, Strenkert D, Patel-King RS, Leonard MT, Merchant SS, Mains RE, King SM, Eipper BA.
Elife. 2017 May 17;6. pii: e25728. doi: 10.7554/eLife.25728.
PMID:28513435
Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity.
Miller MB, Yan Y, Machida K, Kiraly DD, Levy AD, Wu YI, Lam TT, Abbott T, Koleske AJ, Eipper BA, Mains RE.
ACS Chem Neurosci. 2017 Apr 25. doi: 10.1021/acschemneuro.7b00076. [Epub ahead of print]
PMID:28418645
The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together.
Bäck N, Kanerva K, Kurutihalli V, Yanik A, Ikonen E, Mains RE, Eipper BA.
Eur J Cell Biol. 2017 Mar 28. pii: S0171-9335(17)30005-5. doi: 10.1016/j.ejcb.2017.03.007. [Epub ahead of print]
PMID:28377049
2016
Alternate promoter usage generates two subpopulations of the neuronal RhoGEF Kalirin-7.
Miller MB, Yan Y, Wu Y, Hao B, Mains RE, Eipper BA.
J Neurochem. 2017 Mar;140(6):889-902. doi: 10.1111/jnc.13749. Epub 2016 Sep 6.
PMID:27465683
Copper, zinc and calcium: imaging and quantification in anterior pituitary secretory granules.
Bonnemaison ML, Duffy ME, Mains RE, Vogt S, Eipper BA, Ralle M.
Metallomics. 2016 Sep 1;8(9):1012-22. doi: 10.1039/c6mt00079g. Epub 2016 Jul 18.
PMID: 27426256
Early eukaryotic origins for cilia-associated bioactive peptide-amidating activity.
Kumar D, Blaby-Haas CE, Merchant SS, Mains RE, King SM, Eipper BA.
J Cell Sci. 2016 Mar 1;129(5):943-56.
PMID: 26787743
60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin C.
Kumar D, Mains RE, Eipper BA.
J Mol Endocrinol. 2016 May;56(4):T63-76.
PMID: 26667899
Kalirin is required for BDNF-TrkB stimulated neurite outgrowth and branching.
Yan Y, Eipper BA, Mains RE.
Neuropharmacology. 2016 Mar 30;107:227-238. doi: 10.1016/j.neuropharm.2016.03.050. [Epub ahead of print]
PMID:27036892
O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic Trafficking.
Vishwanatha KS, Bäck N, Lam TT, Mains RE, Eipper BA.
J Biol Chem. 2016 Mar 9. pii: jbc.M115.711838. [Epub ahead of print]
PMID:26961877
Early eukaryotic origins for cilia-associated bioactive peptide-amidating activity.
Kumar D, Blaby-Haas CE, Merchant SS, Mains RE, King SM,Eipper BA.
J Cell Sci. 2016 Mar 1;129(5):943-56. doi: 10.1242/jcs.177410. Epub 2016 Jan 19.
PMID:26787743
2015
A role for Kalirin-7 in corticostriatal synaptic dysfunction in Huntington's disease.
Puigdellívol M, Cherubini M, Brito V, Giralt A, Suelves N, Ballesteros J, Zamora-Moratalla A, Martín ED, Eipper BA, Alberch J, Ginés S.
Hum Mol Genet. 2015 Dec 20;24(25):7265-85. doi: 10.1093/hmg/ddv426. Epub 2015 Oct 12.
60 YEARS OF POMC: From POMC and αMSH to PAM, molecular oxygen, copper and vitamin C.
Kumar D, Mains RE, Eipper E.
J Mol Endocrinol. 2015 Dec 14. pii: JME-15-0266. [Epub ahead of print]
PMID:26667899
Kalirin-9 and Kalirin-12 Play Essential Roles in Dendritic Outgrowth and Branching.
Yan Y, Eipper BA, Mains RE.
Cereb Cortex. 2015 Oct;25(10):3487-501. doi: 10.1093/cercor/bhu182. Epub 2014 Aug 21.
PMID:25146373
Optimizing production of Fc-amidated peptides by Chinese hamster ovary cells.
Carlson K, Pomerantz SC, Vafa O, Naso M, Strohl W, Mains RE,Eipper BA.
BMC Biotechnol. 2015 Oct 16;15:95. doi: 10.1186/s12896-015-0210-4.
PMID:26475607
Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells.
Simpson PD, Eipper BA, Katz MJ, Gandara L, Wappner P, Fischer R, Hodson EJ, Ratcliffe PJ, Masson N.
J Biol Chem. 2015 Oct 9;290(41):24891-901. doi: 10.1074/jbc.M115.667246. Epub 2015 Aug 19.
Adaptor Protein-1 Complex Affects the Endocytic Trafficking and Function of Peptidylglycine α-Amidating Monooxygenase, a Luminal Cuproenzyme.
Bonnemaison ML, Bäck N, Duffy ME, Ralle M, Mains RE, Eipper BA.
J Biol Chem. 2015 Aug 28;290(35):21264-79. doi: 10.1074/jbc.M115.641027. Epub 2015 Jul 13.
PMID:26170456
Secretion of Fc-amidated peptide fusion proteins by Chinese hamster ovary cells.
Carlson KR, Pomerantz SC, Li J, Vafa O, Naso M, Strohl W, Mains RE, Eipper BA.
BMC Biotechnol. 2015 Jun 27;15:61. doi: 10.1186/s12896-015-0173-5.
PMID:26116580
An N-terminal Amphipathic Helix Binds Phosphoinositides and Enhances Kalirin Sec14 Domain-mediated Membrane Interactions.
Miller MB, Vishwanatha KS, Mains RE, Eipper BA.
J Biol Chem. 2015 May 22;290(21):13541-55. doi: 10.1074/jbc.M115.636746. Epub 2015 Apr 10.
PMID:25861993
A role for Kalirin-7 in nociceptive sensitization via activity-dependent modulation of spinal synapses.
Lu J, Luo C, Bali KK, Xie RG, Mains RE, Eipper BA, Kuner R.
Nat Commun. 2015 Apr 13;6:6820. doi: 10.1038/ncomms7820.
PMID:25865668
2014
AP-1A controls secretory granule biogenesis and trafficking of membrane secretory granule proteins.
Bonnemaison M, Bäck N, Lin Y, Bonifacino JS, Mains R, Eipper B.
Traffic. 2014 Oct;15(10):1099-121. doi: 10.1111/tra.12194. Epub 2014 Aug 15.
PMID:25040637
Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum.
Gaier ED, Kleppinger A, Ralle M, Covault J, Mains RE, Kenny AM,Eipper BA.
BMC Endocr Disord. 2014 Jul 15;14:58. doi: 10.1186/1472-6823-14-58.
PMID:25022877
Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning.
Mandela P, Yan Y, LaRese T, Eipper BA, Mains RE.
Horm Behav. 2014 Jul;66(2):430-8. doi: 10.1016/j.yhbeh.2014.07.001. Epub 2014 Jul 9.
PMID:25014196
A Histidine-rich Linker Region in Peptidylglycine α-Amidating Monooxygenase Has the Properties of a pH Sensor
Vishwanatha K, Bäck N, Mains RE, Eipper BA.
J hem. 2014 May 2;289(18):12404-20. doi: 10.1074/jbc.M113.545947. Epub 2014 Mar 13.
Nonenzymatic domains of Kalirin7 contribute to spine morphogenesis through interactions with phosphoinositides and Abl Mol Biol
Ma XM, Miller MB, Vishwanatha KS, Gross MJ, Wang Y, Abbott T, Lam TT, Mains RE, Eipper BA.
Cell. 2014 May;25(9):1458-71. doi: 10.1091/mbc.E13-04-0215. Epub 2014 Mar 5.
Pam heterozygous mice reveal essential role for Cu in amygdalar behavioral and synaptic function.
Gaier ED, Eipper BA, Mains RE.
Ann N Y Acad Sci. 2014 May;1314(1):15-23. doi: 10.1111/nyas.12378. Epub 2014 Mar 4.
In vivo and in vitro analyses of amygdalar function reveal a role for copper.
Gaier ED, Rodriguiz RM, Zhou J, Ralle M, Wetsel WC, Eipper BA, Mains RE.
J Neurophysiol. 2014 May 15;111(10):1927-39. doi: 10.1152/jn.00631.2013. Epub 2014 Feb 19.
The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts.
Huang S1, Eleniste PP1, Wayakanon K1, Mandela P2, Eipper BA2, Mains RE2, Allen MR3, Bruzzaniti A4.
Bone. 2014 Mar;60:235-45. doi: 10.1016/j.bone.2013.12.023. Epub 2013 Dec 28.
2013
Gaier ED, Miller MB, Ralle M, Aryal D, Wetsel WC, Mains RE, Eipper BA.
Peptidylglycine α-amidating monooxygenase heterozygosity alters brain copper handling with region specificity. J Neurochem. 2013 Dec;127(5):605-19. doi: 10.1111/jnc.12438. Epub 2013 Oct 13.
Bonnemaison ML, Eipper BA, Mains RE.
Role of adaptor proteins in secretory granule biogenesis and maturation. Front Endocrinol (Lausanne). 2013 Aug 14;4:101. doi: 10.3389/fendo.2013.00101. eCollection 2013.
Kiraly DD, Nemirovsky NE, LaRese TP, Tomek SE, Yahn SL, Olive MF, Eipper BA, Mains RE.
Constitutive knockout of kalirin-7 leads to increased rates of cocaine self-administration. Mol Pharmacol. 2013 Oct;84(4):582-90. doi: 10.1124/mol.113.087106. Epub 2013 Jul 26.
Miller MB, Yan Y, Eipper BA, Mains RE.
Neuronal Rho GEFs in synaptic physiology and behavior. Neuroscientist. 2013 Jun;19(3):255-73. doi: 10.1177/1073858413475486. Epub 2013 Feb 11.<
Wu JH, Fanaroff AC, Sharma KC, Smith LS, Brian L, Eipper BA, Mains RE, Freedman NJ, Zhang L.
Kalirin promotes neointimal hyperplasia by activating Rac in smooth muscle cells.Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):702-8. doi: 10.1161/ATVBAHA.112.300234. Epub 2013 Jan 3.
Rudzka K, Moreno DM, Eipper B, Mains R, Estrin DA, Amzel LM.
Coordination of peroxide to the Cu(M) center of peptidylglycine α-hydroxylating monooxygenase (PHM): structural and computational study. J Biol Inorg Chem. 2013 Feb;18(2):223-32. doi: 10.1007/s00775-012-0967-z. Epub 2012 Dec 18.
2012
Mandela P, Yankova M, Conti LH, Ma XM, Grady J, Eipper BA, Mains RE.
Kalrn plays key roles within and outside of the nervous system. BMC Neurosci. 2012 Nov 1;13:136. doi: 10.1186/1471-2202-13-136.
Gaier ED, Eipper BA, Mains RE.
Copper signaling in the mammalian nervous system: synaptic effects. Neurosci Res. 2013 Jan;91(1):2-19. doi: 10.1002/jnr.23143. Epub 2012 Nov 1.
Eipper-Mains JE, Kiraly DD, Duff MO, Horowitz MJ, McManus CJ, Eipper BA, Graveley BR, Mains RE.
Effects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome. Genes Brain Behav. 2013 Feb;12(1):21-33. doi: 10.1111/j.1601-183X.2012.00873.x. Epub 2012 Nov 27.
Mazzone CM, Larese TP, Kiraly DD, Eipper BA, Mains RE.
Analysis of kalirin-7 knockout mice reveals different effects in female mice. Mol Pharmacol. 2012 Dec;82(6):1241-9. doi: 10.1124/mol.112.080838. Epub 2012 Sep 18.
Ma XM, Huang JP, Xin X, Yan Y, Mains RE, Eipper BA.
A role for kalirin in the response of rat medium spiny neurons to cocaine. Mol Pharmacol. 2012 Oct;82(4):738-45. Epub 2012 Jul 24.
Vishwanatha KS, Wang YP, Keutmann HT, Mains RE, Eipper BA.
Structural Organization of the Nine Spectrin Repeats of Kalirin. Biochemistry. 2012 Jul 6. [Epub ahead of print] PMID:22738176.
Eipper-Mains JE, Eipper BA, Mains RE.
Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression. Front Genet. 2012;3:109. Epub 2012 Jun 13. PMID:22707957.
Rajagopal C, Mains RE, Eipper BA.
Signaling from the secretory granule to the nucleus. Crit Rev Biochem Mol Biol. 2012 Jul;47(4):391-406. Epub 2012 Jun 8. PMID:22681236.
Gaier ED, Kleppinger A, Ralle M, Mains RE, Kenny AM, Eipper BA.
High serum Cu and Cu/Zn ratios correlate with impairments in bone density, physical performance and overall health in a population of elderly men with frailty characteristics. Exp Gerontol. 2012 Jul;47(7):491-6. Epub 2012 Mar 29. PMID:22484083.
2011
Yin P, Bousquet-Moore D, Annangudi SP, Southey BR, Mains RE, Eipper BA, Sweedler JV.
Probing the production of amidated peptides following genetic and dietary copper manipulations. PLoS One. 2011;6(12):e28679. Epub 2011 Dec 16. PMID:22194882.
Lemtiri-Chlieh F, Zhao L, Kiraly DD, Eipper BA, Mains RE, Levine ES.
Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity. BMC Neurosci. 2011 Dec 19;12:126.PMID:22182308.
Deinhardt K, Kim T, Spellman DS, Mains RE, Eipper BA, Neubert TA, Chao MV, Hempstead BL.
Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Sci Signal. 2011 Dec 6;4(202):ra82. PMID:22155786.
Kiraly DD, Lemtiri-Chlieh F, Levine ES, Mains RE, Eipper BA.
Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. J Neurosci. 2011 Aug 31;31(35):12554-65. PMID:21880917.
Eipper-Mains JE, Kiraly DD, Palakodeti D, Mains RE, Eipper BA, Graveley BR.
microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs. RNA. 2011 Aug;17(8):1529-43. Epub 2011 Jun 27. PMID:21708909.
Kiraly DD, Stone KL, Colangelo CM, Abbott T, Wang Y, Mains RE, Eipper BA.
Identification of kalirin-7 as a potential post-synaptic density signaling hub. J Proteome Res. 2011 Jun 3;10(6):2828-41. Epub 2011 Apr 25.
Mains RE, Kiraly DD, Eipper-Mains JE, Ma XM, Eipper BA.
Kalrn promoter usage and isoform expression respond to chronic cocaine exposure. BMC Neurosci. 2011 Feb 17;12:20.
2010
Hostager BS, Fox DK, Whitten D, Wilkerson CG, Eipper BA, Francone VP, Rothman PB, Colgan JD.
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. J Neurosci. 2010 Dec 8;30(49):16651-61.
Chen B, Ge Q, Xia XM, Liu P, Wang SJ, Zhan H, Eipper BA, Wang ZW.
A novel auxiliary subunit critical to BK channel function in Caenorhabditis elegans. J Neurosci. 2010 Dec 8;30(49):16651-61.
Chufán EE, Prigge ST, Siebert X, Eipper BA, Mains RE, Amzel LM.
Differential reactivity between two copper sites in peptidylglycine α-hydroxylating monooxygenase. J Am Chem Soc. 2010 Nov 10;132(44):15565-72.
Gaier ED, Rodriguiz RM, Ma XM, Sivaramakrishnan S, Bousquet-Moore D, Wetsel WC, Eipper BA, Mains RE.
Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. J Neurosci. 2010 Oct 13;30(41):13656-69.
Rajagopal C, Stone KL, Mains RE, Eipper BA.
Secretion stimulates intramembrane proteolysis of a secretory granule membrane enzyme. J Biol Chem. 2010 Nov 5;285(45):34632-42. Epub 2010 Sep 3.
Bousquet-Moore D, Mains RE, Eipper BA.
Peptidylgycine alpha-amidating monooxygenase and copper: a gene-nutrient interaction critical to nervous system function. J Neurosci Res. 2010 Sep;88(12):2535-45. Review.
Hostager BS, Fox DK, Whitten D, Wilkerson CG, Eipper BA, Francone VP, Rothman PB, Colgan JD.
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex. PLoS One. 2010 Jun 30;5(6):e11380.
Francone VP, Ifrim MF, Rajagopal C, Leddy CJ, Wang Y, Carson JH, Mains RE, Eipper BA.
Signaling from the secretory granule to the nucleus: Uhmk1 and PAM. Mol Endocrinol. 2010 Aug;24(8):1543-58. Epub 2010 Jun 23.
Atkinson LE, McVeigh P, Kimber MJ, Marks NJ, Eipper BA, Mains RE, Day TA, Maule AG.
A PAL for Schistosoma mansoni PHM. Mol Biochem Parasitol. 2010 Oct;173(2):97-106. Epub 2010 May 19.
Kiraly DD, Ma XM, Mazzone CM, Xin X, Mains RE, Eipper BA.
Behavioral and morphological responses to cocaine require kalirin7. Biol Psychiatry. 2010 Aug 1;68(3):249-55. Epub 2010 May 10.
Bäck N, Rajagopal C, Mains RE, Eipper BA.
Secretory granule membrane protein recycles through multivesicular bodies. Traffic. 2010 Jul 1;11(7):972-86. Epub 2010 Apr 1.
Ma XM, Huang JP, Kim EJ, Zhu Q, Kuchel GA, Mains RE, Eipper BA.
Kalirin-7, an important component of excitatory synapses, is regulated by estradiol in hippocampal neurons. Hippocampus. 2010 Mar 23. [Epub ahead of print]
Sobota JA, Mohler WA, Cowan AE, Eipper BA, Mains RE.
Dynamics of peptidergic secretory granule transport are regulated by neuronal stimulation. BMC Neurosci. 2010 Mar 4;11(1):32.
Bousquet-Moore D, Prohaska JR, Nillni EA, Czyzyk T, Wetsel WC, Mains RE, Eipper BA.
Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction. Neurobiol Dis. 2010 Jan;37(1):130-40. Epub 2009 Oct 6.
Kiraly DD, Eipper-Mains JE, Mains RE, Eipper BA
Synaptic Plasticity, a Symphony in GEF. ACS Chemical Neuroscience, 2010 May 19;1(5):348-365.
2009
Sobota JA, Bäck N, Eipper BA, Mains RE.
Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins. J Cell Sci. 2009 Oct 1;122(Pt 19):3542-53. Epub 2009 Sep 8.
Rajagopal C, Stone KL, Francone VP, Mains RE, Eipper BA.
Secretory granule to the nucleus: role of a multiply phosphorylated intrinsically unstructured domain. J Biol Chem. 2009 Sep 18;284(38):25723-34. Epub 2009 Jul 27.
Chufán EE, De M, Eipper BA, Mains RE, Amzel LM.
Amidation of bioactive peptides: the structure of the lyase domain of the amidating enzyme. Structure. 2009 Jul 15;17(7):965-73.
Xin X, Rabiner CA, Mains RE, Eipper BA.
Kalirin12 interacts with dynamin. BMC Neurosci. 2009 Jun 17;10:61.
Bousquet-Moore D, Ma XM, Nillni EA, Czyzyk TA, Pintar JE, Eipper BA, Mains RE.
Reversal of physiological deficits caused by diminished levels of peptidylglycine alpha-amidating monooxygenase by dietary copper. Endocrinology. 2009 Apr;150(4):1739-47. Epub 2008 Nov 20.
2008
Ma XM, Kiraly DD, Gaier ED, Wang Y, Kim EJ, Levine ES, Eipper BA, Mains RE.
Kalirin-7 is required for synaptic structure and function. J Neurosci. 2008 Nov 19;28(47):12368-82.
Gauthier DJ, Sobota JA, Ferraro F, Mains RE, Lazure C.
Flow cytometry-assisted purification and proteomic analysis of the corticotropes dense-core secretory granules.Proteomics. 2008 Sep;8(18):3848-61.
Xin X, Wang Y, Ma XM, Rompolas P, Keutmann HT, Mains RE, Eipper BA.
Regulation of Kalirin by Cdk5. J Cell Sci. 2008 Aug 1;121(Pt 15):2601-11. Epub 2008 Jul 15.
Schiller MR, Ferraro F, Wang Y, Ma XM, McPherson CE, Sobota JA, Schiller NI, Mains RE, Eipper BA.
Autonomous functions for the Sec14p/spectrin-repeat region of Kalirin.Exp Cell Res. 2008 Aug 15;314(14):2674-91. Epub 2008 May 29.
Ma XM, Wang Y, Ferraro F, Mains RE, Eipper BA.
Is an Essential Component of both Shaft and Spine Excitatory Synapses in Hippocampal Interneurons. J Neurosci. 2008 Jan 16;28(3):711-24.
2007
De M, Ciccotosto GD, Mains RE, Eipper BA.
Trafficking of a secretory granule membrane protein is sensitive to copper. J Biol Chem. 2007;282:23362-71.
Niciu MJ, Ma XM, El Meskini R, Pachter JS, Mains RE, Eipper BA.
Altered ATP7A expression and other compensatory responses in a murine model of Menkes disease. Neurobiol Dis. 2007;27:278-91.
Nyasae L, Bustos R, Braiterman L, Eipper BA, Hubbard A
Dynamics of endogenous Atp7A (Menkes Protein) in intestinal epithelial cells, Am J Physiol, GI and Liver Physiology 2007 292: G1181-1194.
Linz R, Barnes N, Zimnica A, Eipper B, Kaplan J, Lutsenko S
The Intracellular Targeting of Copper-Transporting ATPase ATP7A in a Normal and ATP7B-/- Kidney, 2007 Am J Physiol (Renal Physiol), PMID: 17928409.
Koo TH, Eipper BA, Donaldson JG.
Arf6 recruits the Rac GEF Kalirin to the plasma membrane facilitating Rac activation. BMC Cell Biol. 2007;8:29.
Ferraro F, Ma XM, Sobota JA, Eipper BA, Mains RE.
Kalirin/Trio RhoGEFs Regulate a Novel Step in Secretory Granule Maturation. Mol Biol Cell. 2007 Dec;18(12):4813-25.
El Meskini R, Crabtree KL, Cline LB, Mains RE, Eipper BA, Ronnett GV.
ATP7A (Menkes protein) functions in axonal targeting and synaptogenesis. Mol Cell Neurosci. 2007;34:409-21.
2006
Sobota JA, Ferraro F, Back N, Eipper BA, Mains RE.
Not all secretory granules are created equal: Partitioning of soluble content proteins. Mol Biol Cell. 2006 Dec;17(12):5038-52. Epub 2006 Sep 27. PMID: 17005911.
De M, Bell J, Blackburn NJ, Mains RE, Eipper BA.
J Biol Chem. 2006 Jul 28;281(30):20873-82. Epub 2006 May 16. PMID: 16704972.
Schiller MR, Chakrabarti K, King GF, Schiller NI, Eipper BA, Maciejewski MW.
Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions. J Biol Chem. 2006 Jul 7;281(27):18774-86. Epub 2006 Apr 27. PMID: 16644733 [PubMed - indexed for MEDLINE]
Niciu MJ., Ma XM., El Meskini R, Ronnett GV., Mains RE,Eipper BA, .
Developmental changes in the expression of ATP7A define a critical period in postnatal neurodevelopment. Neuroscience. 2006;139(3):947-64. Epub 2006 Mar 23.
2005
Czyzyk TA, Ning Y, Hsu MS, Peng B, Mains RE, Eipper BA, Pintar JE.
Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse. Dev Biol. 2005 Nov 15;287(2):301-13. Epub 2005 Oct 12.
El Meskini R, Cline LB, Eipper BA, Ronnett GV.
The developmentally regulated expression of Menkes protein ATP7A suggests a role in axon extension and synaptogenesis. Dev Neurosci. 2005;27(5):333-48.
Siebert X, Eipper BA, Mains RE, Prigge ST, Blackburn NJ, Amzel LM.
The catalytic copper of Peptidylglycine alpha-Hydroxylating Monooxygenase also plays a critical structural role. Biophys J. 2005 Aug 12; [Epub ahead of print]
Schiller MR, Blangy A, Huang J, Mains RE, Eipper BA.
Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity.
Exp Cell Res. 2005 Jul 15;307(2):402-17. Epub 2005 Apr 21.
Ferraro F, Eipper BA, Mains RE.
Retrieval and reuse of pituitary secretory granule proteins. J Biol Chem. 2005 Jul 8;280(27):25424-35. Epub 2005 May 19.
Rabiner CA, Mains RE, Eipper BA.
Kalirin: a dual Rho guanine nucleotide exchange factor that is so much more than the sum of its many parts. Neuroscientist. 2005 Apr;11(2):148-60. Review.
McPherson CE, Eipper BA, Mains RE
Multiple novel isoforms of Trio are expressed in the developing rat brain. Gene. 2005 Feb 28;347(1):125-35.
Ma, X, Huang JP, Eipper, BA, Mains RE
Expression of Trio, a member of the Dbl family of Rho GEFs in the developing rat brain. 2005 J Comp Neurol 482: 333-348.
2004
Back N, Litonius E, Mains RE, Eipper BA.
Fluoride causes reversible dispersal of Golgi cisternae and matrix in neuroendocrine cells. Eur J Cell Biol 83: 389-402.
Xin X, Ferraro F, Back N, Eipper BA, Mains RE.
MCdk5 and Trio modulate endocrine cell exocytosis.J Cell Sci. 2004 Sep 15;117:4739-48.
Xin X, Mains RE, Eipper BA.
Monooxygenase X: A member of the Cu-dependent monooxygenase family localized to the endoplasmic reticulum. 2004 Aug 26 J Biol Chem 279:48159-48167.
Han M, Park D, Vanderzalm PJ, Mains RE, Eipper BA, Taghert PH.
Drosophila uses two distinct neuropeptide amidating enzymes, dPAL1 and dPAL2. J Neurochem. 2004 Jul;90(1):129-41.
Chen P, Bell J, Eipper BA, Solomon EI.
Oxygen activation by the noncoupled binuclear copper site in peptidylglycine alpha-hydroxylating monooxygenase. Spectroscopic definition of the resting sites and the putative CuIIM-OOH intermediate. Biochemistry. 2004 May 18;43(19):5735-47.
Prigge ST, Eipper BA, Mains RE, Amzel LM.
Dioxygen binds end-on to mononuclear copper in a precatalytic enzyme complex.Science. 2004 May 7;304(5672):864-7.
McPherson CE, Eipper BA, Mains RE
Kalirin expression is regulated by multiple promoters. J Mol Neurosci 22: 51-62.
Mair GR, Niciu MJ, Stewart MT, Brennan G, Omar H, Halton DW, Mains R, Eipper BA, Maule AG, Day TA
A functionally atypical amidating enzyme from the human parasite Schistosoma mansoni. FASEB J 18:114-21.
2003
Ma XM, Huang J, Wang Y, Eipper BA, Mains RE
Kalirin, a multifunctional Rho GEF, is necessary for maintenance of hippocampal pyramidal neuron dendrites and dendritic spines. J Neurosci 23: 10593-603.
Chei FY, Eipper BA, Mains RE, Fricker LD
Quantitative peptidomics of pituitary glands from mice deficient in copper transport. Cell Mol Biol 49:713-22.
Bell J, El Meskini R, D'Amato D, Mains RE, Eipper BA.
Mechanistic investigation of peptidylglycine alpha-hydroxylating monooxygenase via intrinsic tryptophan fluorescence and mutagenesis. Biochemistry. 2003 Jun 17;42(23):7133-42.
Penzes P, Beeser A, Chernoff J, Schiller MR, Eipper BA, Mains RE, Huganir RL.
Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron. 2003 Jan 23;37(2):263-74.
El Meskini R, Culotta VC, Mains RE, Eipper BA.
Supplying copper to the cuproenzyme peptidylglycine alpha-amidating monooxygenase. J Biol Chem. 2003 Apr 4;278(14):12278-84. Epub 2003 Jan 14.
Steveson TC, Ciccotosto GD, Ma XM, Mueller GP, Mains RE, Eipper BA.
Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase. Endocrinology. 2003 Jan;144(1):188-200.
2002
Jaron S, Mains RE, Eipper BA, Blackburn NJ.
The catalytic role of the copper ligand H172 of peptidylglycine alpha-hydroxylating monooxygenase (PHM): a spectroscopic study of the H172A mutant. Biochemistry. 2002 Nov 5;41(44):13274-82.
Kolhekar AS, Bell J, Shiozaki EN, Jin L, Keutmann HT, Hand TA, Mains RE, Eipper BA.
Essential features of the catalytic core of peptidyl-alpha-hydroxyglycine alpha-amidating lyase. Biochemistry. 2002 Oct 15;41(41):12384-94.
May V, Schiller MR, Eipper BA, Mains RE.
Kalirin Dbl-homology guanine nucleotide exchange factor 1 domain initiates new axon outgrowths via RhoG-mediated mechanisms. J Neurosci. 2002 Aug 15;22(16):6980-90.
Bruzzaniti A, Mains RE.
Enzymatic activity of soluble and membrane tethered peptide pro-hormone convertase 1. Peptides. 2002 May;23(5):863-75.
Ma XM, Mains RE, Eipper BA.
Plasticity in hippocampal peptidergic systems induced by repeated electroconvulsive shock. Neuropsychopharmacology. 2002 Jul;27(1):55-71.
Marx R, Mains RE.
Routing of membrane proteins to large dense core vesicles in PC12 cells. J Mol Neurosci. 2002 Feb-Apr;18(1-2):113-27.
McPherson CE, Eipper BA, Mains RE.
Genomic organization and differential expression of Kalirin isoforms. Gene. 2002 Feb 6;284(1-2):41-51.
2001
Gozes I, Brenneman DE, Geppetti P, Kastin AJ, Mains RE, Moody TW, Seroogy K, Spier AD, Zimmermann M.
Neuropeptides: brain messengers of many faces. Trends Neurosci. 2001 Dec;24(12):687-90.
Penzes P, Johnson RC, Kambampati V, Mains RE, Eipper BA.
Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology. J Neurosci. 2001 Nov 1;21(21):8426-34.
Hansel DE, Eipper BA, Ronnett GV.
Regulation of olfactory neurogenesis by amidated neuropeptides. J Neurosci Res. 2001 Oct 1;66(1):1-7. Review.
Steveson TC, Zhao GC, Keutmann HT, Mains RE, Eipper BA.
Access of a membrane protein to secretory granules is facilitated by phosphorylation. J Biol Chem. 2001 Oct 26;276(43):40326-37. Epub 2001 Aug 27.
Hansel DE, May V, Eipper BA, Ronnett GV.
Pituitary adenylyl cyclase-activating peptides and alpha-amidation in olfactory neurogenesis and neuronal survival in vitro. J Neurosci. 2001 Jul 1;21(13):4625-36.
Oyarce AM, Steveson TC, Jin L, Eipper BA.
Dopamine beta-monooxygenase signal/anchor sequence alters trafficking of peptidylglycine alpha-hydroxylating monooxygenase. J Biol Chem. 2001 Aug 31;276(35):33265-72. Epub 2001 Jun 19.
Hansel DE, Quinones ME, Ronnett GV, Eipper BA.
Kalirin, a GDP/GTP exchange factor of the Dbl family, is localized to nerve, muscle, and endocrine tissue during embryonic rat development. J Histochem Cytochem. 2001 Jul;49(7):833-44.
Bell-Parikh LC, Eipper BA, Mains RE.
Response of an integral granule membrane protein to changes in pH. J Biol Chem. 2001 Aug 10;276(32):29854-63. Epub 2001 Jun 06.
Hansel DE, Eipper BA, Ronnett GV.
Neuropeptide Y functions as a neuroproliferative factor. Nature. 2001 Apr 19;410(6831):940-4.
Alam MR, Steveson TC, Johnson RC, Back N, Abraham B, Mains RE, Eipper BA.
Signaling mediated by the cytosolic domain of peptidylglycine alpha-amidating monooxygenase. Mol Biol Cell. 2001 Mar;12(3):629-44.
Penzes P, Johnson RC, Sattler R, Zhang X, Huganir RL, Kambampati V, Mains RE, Eipper BA.
The neuronal Rho-GEF Kalirin-7 interacts with PDZ domain-containing proteins and regulates dendritic morphogenesis. Neuron. 2001 Jan;29(1):229-42.
Ma XM, Johnson RC, Mains RE, Eipper BA.
Expression of kalirin, a neuronal GDP/GTP exchange factor of the trio family, in the central nervous system of the adult rat. J Comp Neurol. 2001 Jan 15;429(3):388-402.
El Meskini R, Galano GJ, Marx R, Mains RE, Eipper BA.
Targeting of membrane proteins to the regulated secretory pathway in anterior pituitary endocrine cells. J Biol Chem. 2001 Feb 2;276(5):3384-93. Epub 2000 Nov 01.
2000
Prigge ST, Mains RE, Eipper BA, Amzel LM.
New insights into copper monooxygenases and peptide amidation: structure, mechanism and function. Cell Mol Life Sci. 2000 Aug;57(8-9):1236-59. Review.
Jiang N, Kolhekar AS, Jacobs PS, Mains RE, Eipper BA, Taghert PH.
PHM is required for normal developmental transitions and for biosynthesis of secretory peptides in Drosophila.
Dev Biol. 2000 Oct 1;226(1):118-36.
El Meskini R, Mains RE, Eipper BA.
Cell type-specific metabolism of peptidylglycine alpha-amidating monooxygenase in anterior pituitary. Endocrinology. 2000 Aug;141(8):3020-34.
Driscoll WJ, Konig S, Fales HM, Pannell LK, Eipper BA, Mueller GP.
Peptidylglycine-alpha-hydroxylating monooxygenase generates two hydroxylated products from its mechanism-based suicide substrate, 4-phenyl-3-butenoic acid.Biochemistry. 2000 Jul 11;39(27):8007-16.
Johnson RC, Penzes P, Eipper BA, Mains RE.
Isoforms of kalirin, a neuronal Dbl family member, generated through use of different 5'- and 3'-ends along with an internal translational initiation site. J Biol Chem. 2000 Jun 23;275(25):19324-33.
Penzes P, Johnson RC, Alam MR, Kambampati V, Mains RE, Eipper BA.
An isoform of kalirin, a brain-specific GDP/GTP exchange factor, is enriched in the postsynaptic density fraction.
J Biol Chem. 2000 Mar 3;275(9):6395-403.
Oyarce AM, Eipper BA.
Cell type-specific storage of dopamine beta-monooxygenase. J Biol Chem. 2000 Feb 4;275(5):3270-8.
Ciccotosto GD, Hand TA, Mains RE, Eipper BA.
Breeding stock-specific variation in peptidylglycine alpha-amidating monooxygenase messenger ribonucleic acid splicing in rat pituitary. Endocrinology. 2000 Feb;141(2):476-86.
1999
Caldwell BD, Darlington DN, Penzes P, Johnson RC, Eipper BA, Mains RE.
The novel kinase peptidylglycine alpha-amidating monooxygenase cytosolic interactor protein 2 interacts with the cytosolic routing determinants of the peptide processing enzyme peptidylglycine alpha-amidating monooxygenase. J Biol Chem. 1999 Dec 3;274(49):34646-56.
Prigge ST, Kolhekar AS, Eipper BA, Mains RE, Amzel LM.
Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenase. Nat Struct Biol. 1999 Oct;6(10):976-83.
Marx R, El Meskini R, Johns DC, Mains RE.
Differences in the ways sympathetic neurons and endocrine cells process, store, and secrete exogenous neuropeptides and peptide-processing enzymes. J Neurosci. 1999 Oct 1;19(19):8300-11.
Bruzzaniti A, Marx R, Mains RE.
Activation and routing of membrane-tethered prohormone convertases 1 and 2. J Biol Chem. 1999 Aug 27;274(35):24703-13.
Mueller GP, Driscoll WJ, Eipper BA.
In vivo inhibition of peptidylglycine-alpha-hydroxylating monooxygenase by 4-phenyl-3-butenoic acid. J Pharmacol Exp Ther. 1999 Sep;290(3):1331-6.
Steveson TC, Keutmann HT, Mains RE, Eipper BA.
Phosphorylation of cytosolic domain Ser(937) affects both biosynthetic and endocytic trafficking of peptidylglycine alpha-amidating monooxygenase. J Biol Chem. 1999 Jul 23;274(30):21128-38.
Driscoll WJ, Mueller SA, Eipper BA, Mueller GP.
Differential regulation of peptide alpha-amidation by dexamethasone and disulfiram. Mol Pharmacol. 1999 Jun;55(6):1067-76.
Fass DM, Takimoto K, Mains RE, Levitan ES.
Tonic dopamine inhibition of L-type Ca2+ channel activity reduces alpha1D Ca2+ channel gene expression. J Neurosci. 1999 May 1;19(9):3345-52.
Spijker S, Smit AB, Eipper BA, Malik A, Mains RE, Geraerts WP.
A molluscan peptide alpha-amidating enzyme precursor that generates five distinct enzymes. FASEB J. 1999 Apr;13(6):735-48.
Johns DC, Marx R, Mains RE, O'Rourke B, Marban E.
Inducible genetic suppression of neuronal excitability. J Neurosci. 1999 Mar 1;19(5):1691-7.
Ciccotosto GD, Schiller MR, Eipper BA, Mains RE.
Induction of integral membrane PAM expression in AtT-20 cells alters the storage and trafficking of POMC and PC1. J Cell Biol. 1999 Feb 8;144(3):459-71.
Mains RE, Alam MR, Johnson RC, Darlington DN, Back N, Hand TA, Eipper BA.
Kalirin, a multifunctional PAM COOH-terminal domain interactor protein, affects cytoskeletal organization and ACTH secretion from AtT-20 cells. J Biol Chem. 1999 Jan 29;274(5):2929-37.
Ratovitski EA, Alam MR, Quick RA, McMillan A, Bao C, Kozlovsky C, Hand TA, Johnson RC, Mains RE, Eipper BA, Lowenstein CJ.
Kalirin inhibition of inducible nitric-oxide synthase. J Biol Chem. 1999 Jan 8;274(2):993-9.
1998
Kolhekar AS, Quon AS, Berard CA, Mains RE, Eipper BA.
Post-translational N-glycosylation of a truncated form of a peptide processing enzyme. J Biol Chem. 1998 Sep 4;273(36):23012-8.
Zhu X, Muller L, Mains RE, Lindberg I.
Structural elements of PC2 required for interaction with its helper protein 7B2. J Biol Chem. 1998 Jan 9;273(2):1158-64.
1997
Zhang J, Zheng M, Eipper BA, Pintar JE.
Embryonic and uterine expression patterns of peptidylglycine alpha-amidating monooxygenase transcripts suggest a widespread role for amidated peptides in development. Dev Biol. 1997 Dec 15;192(2):375-91.
Darlington DN, Schiller MR, Mains RE, Eipper BA.
The expression of regulated endocrine-specific protein of 18 kDa in peptidergic cells of rat peripheral endocrine tissues and in blood.J Endocrinol. 1997 Nov;155(2):329-41.
Hubbard FC, Goodrow TL, Liu SC, Brilliant MH, Basset P, Mains RE, Klein-Szanto AJ.
Expression of PACE4 in chemically induced carcinomas is associated with spindle cell tumor conversion and increased invasive ability. Cancer Res. 1997 Dec 1;57(23):5226-31.
Marx R, Mains RE.
Adenovirally encoded prohormone convertase-1 functions in atrial myocyte large dense core vesicles.
Endocrinology. 1997 Dec;138(12):5108-18.
Schiller MR, Mains RE, Eipper BA.
A novel neuroendocrine intracellular signaling pathway. Mol Endocrinol. 1997 Nov;11(12):1846-57.
Prigge ST, Kolhekar AS, Eipper BA, Mains RE, Amzel LM.
Amidation of bioactive peptides: the structure of peptidylglycine alpha-hydroxylating monooxygenase. Science. 1997 Nov 14;278(5341):1300-5.
Kolhekar AS, Keutmann HT, Mains RE, Quon AS, Eipper BA.
Phosphorylation of cytosolic domain Ser(937) affects both biosynthetic and endocytic trafficking of peptidylglycine alpha-amidating monooxygenase. J Biol Chem. 1999 Jul 23;274(30):21128-38.
Darlington DN, Schiller MR, Mains RE, Eipper BA.
Expression of RESP18 in peptidergic and catecholaminergic neurons. J Histochem Cytochem. 1997 Sep;45(9):1265-77.
Alam MR, Johnson RC, Darlington DN, Hand TA, Mains RE, Eipper BA.
Kalirin, a cytosolic protein with spectrin-like and GDP/GTP exchange factor-like domains that interacts with peptidylglycine alpha-amidating monooxygenase, an integral membrane peptide-processing enzyme. J Biol Chem. 1997 May 9;272(19):12667-75.
Milgram SL, Kho ST, Martin GV, Mains RE, Eipper BA.
Localization of integral membrane peptidylglycine alpha-amidating monooxygenase in neuroendocrine cells.
J Cell Sci. 1997 Mar;110 ( Pt 6):695-706.
Kolhekar AS, Roberts MS, Jiang N, Johnson RC, Mains RE, Eipper BA, Taghert PH.
Neuropeptide amidation in Drosophila: separate genes encode the two enzymes catalyzing amidation. J Neurosci. 1997 Feb 15;17(4):1363-76.
Mains RE, Berard CA, Denault JB, Zhou A, Johnson RC, Leduc R.
PACE4: a subtilisin-like endoprotease with unique properties. Biochem J. 1997 Feb 1;321 ( Pt 3):587-93.
Kolhekar AS, Mains RE, Eipper BA.
Peptidylglycine alpha-amidating monooxygenase: an ascorbate-requiring enzyme. Methods Enzymol. 1997;279:35-43. Review. No abstract available.