Using an unsupervised approach, we mapped molecularly distinct Purkinje cell (PC) subtypes in the embryonic cerebellum into 3D space and linked them to the stripes and lobules of the adult cerebellum. We also examined how PC diversity shapes cerebellar morphogenesis, uncovering a subpopulation of PCs that may be critical for hemisphere formation and evolutionary expansion.

Our open-access paper is now available : FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis. Nature Neuroscience, 10.1038/s41593-025-02042-w.