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Upcoming Events

9/24 Neuroscience Seminar Speaker - Menuz

Neuroscience Seminar Speaker - Menuz

Thursday, September 24th, 2026

11:00 AM

Low Learning Center (UConn Health)

Sponsored by the Kim Family
“Conserved molecules that regulate olfaction in insects”
Karen Menuz, PhD
Associate Professor, Department of Physiology and Neurobiology
University of Connecticut, Storrs, CT

Contact Information:
Barbara Paquette paquette@uchc.edu

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10/1 Neuroscience Seminar Series - Chandra

Neuroscience Seminar Series - Chandra

Thursday, October 1st, 2026

11:00 AM

Low Learning Center (UConn Health)

Sponsored by the Kim Family

Sreeganga Chandra, PhD
Professor, Departments of Neurobiology and Neuroscience
Yale University, New Haven, CT

Contact Information:
Barbara Paquette, paquette@uchc.edu

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10/1 CCAM Seminar Series - Dr. Timothy Duerr

CCAM Seminar Series - Dr. Timothy Duerr

Thursday, October 1st, 2026

04:00 PM

CGSB, 400 Farmington Ave

CCAM Seminar Series
Speaker: Dr. Timothy Duerr Ph.D., Assistant Professor, Department of Orthopaedic Surgery, UConn Health
Title: “Cellular and molecular mechanisms regulating proximodistal positional identity during axolotl limb regeneration”
Abstract: Axolotl salamanders can regenerate their limbs following amputation anywhere along the proximodistal (PD) axis. During this process, resident connective tissue cells, including dermal fibroblasts and periskeletal cells, dedifferentiate and accumulate at the limb stump to form a blastema. Blastema cells retain their genetically encoded PD positional identity, enabling them to redifferentiate and regenerate the appropriate PD limb structures. Retinoic acid (RA) signaling is essential for establishing PD positional identity, as elevated levels of RA instruct blastema cells to adopt a proximal limb identity. We found that RA concentration along the PD axis is regulated by Cyp26b1 expression, which degrades excess RA to generate distal identity during limb regeneration. These differences in RA concentration lead to differential expression of homeobox genes that provide blastema cells with the correct PD positional identity. One such gene identified was Shox, which we show is required for activation of the PTHrP/IHH feedback loop in regenerating chondrocytes of proximally amputated limbs. Once blastema cells genetically adopt positional identity via RA, they express PD-specific cell surface proteins that modify cellular adhesivity. This enables self-sorting with cells of similar positional identities. We have identified several cell surface proteins, including LPHN2, TENM4, and FLRT3 that follow the same spatiotemporal expression patterns as 5’ Hox genes and are both RA responsive and differentially expressed between proximally and distally amputated limbs. Collectively, our results support a model whereby RA directs blastema cells to establish PD identity through transcription factors that regulate the expression of positional identity-specific cell surface proteins.

Contact Information:
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10/6 Molecular Biology and Biophysics Seminar: Dr. Nele Hollmann

Molecular Biology and Biophysics Seminar: Dr. Nele Hollmann

Tuesday, October 6th, 2026

12:00 PM - 01:00 PM

Low Learning Center and Webex

Dr. Nele Hollman, Principal Investigator, Biochemistry and Molecular Biology, University of Georgia
Title: “Decoding viral RNPs through integrative structural biology”
Host: Dr. Bernd Simon

Contact Information:
Bridget Clancy-Tenan, 860-679-2108, clancy@uchc.edu

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10/7 Researcher Privacy for Graduate Students
Researcher Privacy for Graduate Students

Wednesday, October 7th, 2026

11:00 AM - 12:00 PM
In today’s increasingly connected academic landscape, researchers face unique privacy and security challenges. This session will provide you with practical strategies to assess and protect your digital footprint, implement essential privacy measures, and respond effectively to potential issues. From managing your scholarly identity to handling controversial research areas, learn how to balance academic visibility with personal privacy.

Learning Outcomes:
Assess your digital footprint and identify potential vulnerabilities specific to your academic work and online presence
Implement essential privacy protection strategies including password management, identity compartmentalization, and data removal techniques
Develop a personalized response plan for managing potential privacy threats related to your research activities
See more about all Timely Topics offered by The Graduate School.
Please register to receive a Teams link for this event.
Contact Information:
Megan Petsa - megan.petsa@uconn.edu

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