Faculty Publications | The Cato T. Laurencin Institute for Regenerative Engineering

Paulos Y. Mengsteab, Takayoshi Otsuka, Aneesah McClinton, Nikoo Saveh Shemshaki, Shiv Shah, Ho-Man Kan, Elifho Obopilwe, Anthony T. Vella, Lakshmi Nair, Cato T. Laurencin

Graphene‐Based Biomaterials for Bone Regenerative Engineering: A Comprehensive Review of the Field and Considerations Regarding Biocompatibility and Biodegradation

Leila Daneshmandi, Mohammed Barajaa, Armin Tahmasbi Rad, Stefanie A. Sydlik, Cato T. Laurencin

Ligament Regenerative Engineering: Braiding Scalable and Tunable Bioengineered Ligaments Using a Bench-Top Braiding Machine

Paulos Y. Mengsteab, Joseph Freeman, Mohammed A. Barajaa, Lakshmi S. Nair & Cato T. Laurencin

Biomedical Applications of Polyphosphazenes

Kenneth S. Ogueri, Kennedy S. Ogueri, Chinedu C. Ude, Harry R. Allcock & Cato T. Laurencin

Nanofiber Technology for Regenerative Engineering

Kenneth S. Ogueri & Cato T. Laurencin

Robust phenotypic maintenance of limb cells during heterogeneous culture in a physiologically relevant polymeric-based constructed graft system

Mohammed A. Barajaa, Lakshmi S. Nair & Cato T. Laurencin

Emergence of the Stem Cell Secretome in Regenerative Engineering

Leila Daneshmandi, Shiv Shah, Tahereh Jafari, Nikoo Saveh-Shemshaki, Kevin W-H Lo, Cato T. Laurencin

Spatial alignment of 3D printed scaffolds modulates genotypic expression in pre-osteoblasts

Naveen Nagiah, Maumita Bhatacharjee, Christopher J. Murdock, Ho-Man Khan, Mohammed Barajaa, Cato T. Laurencin

George Q. Daley, Gilda A. Barabino, Olujimi A. Ajijola, cedric M. Bright, Valerie Montogmery Rice, Cato T. Laurencin

Health Café Series: a Potential Platform to Reduce Health Disparities

Kevin Lo, Cato T. Laurencin

Unconscious Bias, Racism, and Trauma-Informed Policing: an Address and Message to the Connecticut Racial Profiling Prohibition Project Advisory Board

Cato T. Laurencin

We Are the First to Applaud You Regarding Your Efforts in COVID-19: A Message from the African Diaspora to Our Brothers and Sisters of Africa

Cato T. Laurencin, Aneesah McClinton

APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort

Chia-Ling Kuo, PhD, Luke C Pilling, PhD, Janice L Atkins, PhD, Jane A H Masoli, MBChB, João Delgado, PhD, George A Kuchel, MD, David Melzer, MBBCh PhD

Xiaohua Yu, Paulos Mengsteab, Garesh Narayanan, Lakshmi S. Nair, Cato T. Laurencin

Graphene for Regenerative Engineering

Cato T. Laurencin, Leila Daneshmandi

The COVID-19 Pandemic: a Call to Action to Identify and Address Racial and Ethnic Disparities

Cato T. Laurencin, Aneesah McClinton

Bioinspired Scaffold Designs for Regenerating Musculoskeletal Tissue Interfaces

Mohammed Barajaa, Lakshmi S. Nair, Cato T. Laurencin

Polyphosphazene Polymers: The Next Generation of Biomaterials for Regenerative Engineering and Therapeutic Drug Delivery System

Kenneth S. Ogueri, Kennedy S. Ogueri, Harry R. Allcock, Cato T. Laurencin

Racial Profiling Is a Public Health and Health Disparities Issue

Cato T. Laurencin, Joanne M. Walker

Evaluation of a bioengineered ACL matrix’s osteointegration with BMP-2 supplementation

Paulos Y. Mengsteab, Patrick Conroy, Mary Badon, Takayoshi Otsuka, Ho-Man Kan, Anthony T. Vella, Lakshmi S. Nair, Cato T. Laurencin

Sources of Variability in Clinical Translation of Regenerative Engineering Products: Insights from the National Academies Forum on Regenerative Medicine

Beachy, S.H., Nair, L., Laurencin, C. Tsokas, K.A., Lundberg, M.S.

Nail Matrix Regenerative Engineering: In Vitro Evaluation of Poly(lactide-co-glycolide)/Gelatin Fibrous Substrates

Montgomery, A, McClinton, A, Nair, L, Laurencin, CT.

Regenerative engineered vascularized bone mediated by calcium peroxide

Leila Daneshmandi, Cato T. Laurencin

Regenerative Cell-Based Therapies: Cutting Edge, Bleeding Edge, and Off the Edge

Laurencin Cato T., McClinton Aneesah

A Regenerative Polymer Blend Composed of Glycylglycine Ethyl Ester-Substituted Polyphosphazene and Poly(lactic-co-glycolic acid)

Ogueri KS, Ogueri KS, Allcock HR, Laurencin CT. ACS Applied Polymer Materials

Matrix-based Bone Regenerative Engineering

Ogueri KS, Laurencin CT. Elsevier Encyclopedia of Bone Biology

Identification of Heparan-Sulfate Rich Cells in the Loose Connective Tissues of the Axolotl (Ambystoma mexicanum) with the Potential to Mediate Growth Factor Signaling during Regeneration

T. Otsuka, A.Q. Phan, C.T. Laurencin, J.D. Esko, S.V. Bryant, D. M. Gardiner

2019

Ishita Matai, Gurvinder Kaur, Amir Seyedsalehi, Aneesah McClinton, Cato T. Laurencin

The Longevity Associated SH2B3 (LNK) Genetic Variant: Selected Aging Phenotypes in 379,758 Subjects

Chia-Ling Kuo, PhD, Micaella Joaquim, George A Kuchel, MD, CM, Luigi Ferrucci, MD, PhD, Lorna Harries, PhD, Luke C Pilling, PhD, David Melzer, MB, ChB, PhD

Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants

Chia‐Ling Kuo Luke C. Pilling George A. Kuchel Luigi Ferrucci David Melzer

Generational Biodegradable and Regenerative Polyphosphazene Polymers and Their Blends with Poly (Lactic-Co-Glycolic Acid)

Kenneth S. Ogueri, Harry R. Allcock, Cato T. Laurencin. Progress in Polymer Science

Synthesis, Physicochemical Analysis, and Side Group Optimization of Degradable Dipeptide-Based Polyphosphazenes as Potential Regenerative Biomaterials.

Ogueri Kenneth S, Escobar Ivirico Jorge L, Li Zhongjing, Blumenfield Riley H, Allcock Harry R, Laurencin Cato T. American Chemical Society Applied Polymer Materials

Nanofiber-based Matrices for Rotator Cuff Regenerative Engineering.

Nikoo Saveh-Shemshaki N, Laurencin CT. Acta Biomaterialia

Polyphosphazene Polymer.

Ogueri KS, Allcock HR, Laurencin CT. Encyclopedia of Polymer Science and Technology

Phosphate graphene as an intrinsically osteoinductive scaffold for stem cell-driven bone regeneration.

Arnold, A., Holt, B., Daneshmandi, L., Laurencin, C., Sydlik, S. Proceedings of the National Academy of Sciences of the United States of America

Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank.

Pilling LC, Tamosauskaite J, Jones G, Wood AR, Jones L, Kuo CL, Kuchel GA, Ferrucci L, Melzer D. British Medical Journal

Sarcopenia and variation in the human leukocyte antigen complex.

Jones G, Pilling LC, Kuo CL, Kuchel GA, Ferrucci L, Melzer D. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences (in press)

Hereditary hemochromatosis associations with frailty, sarcopenia and chronic pain: evidence from 200,975 older UK Biobank participants.

Tamosauskaite J, Atkins JL, Pilling LC, Kuo CL, Kuchel GA, Ferrucci L, Melzer D. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences (in press)

Analysis of activating GCM2 sequence variants in sporadic parathyroid adenomas.

Riccardi A, Aspir T, Shen L, Kuo CL, Brown TC, Korah R, Murtha TD, Bellizzi J, Parham K, Carling T, Costa-Guda J, Arnold A. The Journal of clinical endocrinology and metabolism (in press)

Repositioning Tacrolimus: Evaluation of the Effect of Short-Term Tacrolimus Treatment on Osteoprogenitor Cells and Primary Cells for Bone Regenerative Engineering. Assay Drug Dev Technol.

O’Neill E, Rajpura K, Carbone EJ, Awale G, Kan HM, Lo KW.-H. doi: 10.1089/adt.2018.876. [Epub ahead of print]

2018

Polymeric Biomaterials For Scaffold-Based Bone Tissue Regeneration.

Ogueri, K.S., Escobar Ivirico, J. L., Jafari, T., Laurencin, C. T. Regenerative Engineering and Translational Medicine/Springer.

Polyphosphazene-based biomaterials for regenerative engineering.

Ogueri, K.S., Laurencin, C.T.; American Chemical Society (ACS) book.

Evaluation of a guideline directed medical therapy titration program in patients with heart failure with reduced ejection fraction.

Balakumaran K, Patil A, Marsh S, Ingrassia J, Kuo CL, Jacoby DL, Arora S, Soucier R. International Journal of Cardiology: Heart & Vasculature

Injectable nanocomposite analgesic delivery system for musculoskeletal pain management.

Khanal, Manakamana; Gohil, Shalini V; Kuyinu, Emmanuel; Kan, Ho-Man; Knight, Brittany E; Baumbauer, Kyle M; Lo, Kevin W-H; Walker, Joseph; Laurencin, Cato T; Nair, Lakshmi S Acta biomaterialia.

Biodegradable Piezoelectric Force Sensor.

Curry, Eli J; Ke, Kai; Chorsi, Meysam T; Wrobel, Kinga S; Miller, Albert N; Patel, Avi; Kim, Insoo; Feng, Jianlin; Yue, Lixia; Wu, Qian; Kuo, Chia-Ling; Lo, Kevin W-H; Laurencin, Cato T; Ilies, Horea; Purohit, Prashant K; Nguyen, Thanh D, Proceedings of the National Academy of Sciences of the United States of America.

Growth factor delivery strategies for rotator cuff repair and regeneration.
Prabhath, Anupama; Vernekar, Varadraj N; Sanchez, Enid; Laurencin, Cato T, International journal of pharmaceutics.

Racial/Ethnic Disparities in Morbidity and Mortality for Preterm Neonates Admitted to a Tertiary Neonatal Intensive Care Unit.

Townsel C, Keller R, Kuo CL, Campbell WA, Hussain N., J Racial Ethn Health Disparities.

Bone Regenerative Engineering Using a Protein Kinase A-Specific Cyclic AMP Analogue Administered for Short Term.

Okechukwu Clinton, Ifegwu, Guleid Awale, Ho Man Kan, Komal Rajpura, Edward O’Neill, Chia-Ling Kuo, Kevin W.-H. Lo., Regenerative Engineering and Translational Medicine.

Outcomes of an early childhood obesity prevention program in a low‐income community: a pilot, randomized trial.

M. M. Cloutier J, F. Wiley, C. ‐L. Kuo, T. Cornelius, Z. Wang, A. A. Gorin. Pediatric Obesity.

Associations of dietary fat with risk of early neoplasia in the proximal colon in a population-based case-control study.

Mo A, Wu R, Grady JP, Hanley MP, ToroM, Swede H, Devers TJ, Hartman TJ, Rosenberg DW8. Cancer Causes & Control

Training for Failure: A Simulation Program for Emergency Medicine Residents to Improve Communication Skills in Service Recovery.

Alise Frallicciardi, Seth Lotterman, Matthew Ledford, Ilana Prenovitz, Rochelle Van Meter, Chia-Ling Kuo, Thomas Nowicki, Robert Fuller, Sam Clarke. ARM Education & Training.

Opioid Prescribing Patterns among Otolaryngologists.

Schwartz MA, Naples JG, Kuo CL, Falcone TE. Otolaryngol Head Neck Surg.

Endoscopic Features of Mucous Cap Polyps: A Way to Predict Serrated Polyps.

Moy BT, Forouhar F, Kuo CL, Devers TJ. Clin Endosc.

Unconditional or Conditional Logistic Regression Model for Age-Matched Case-Control Data?,

Kuo CL, Duan Y, Grady J. Front Public Health.

Advertising Content, Platform Characteristics and the Appeal of Beer Advertising on a Social Networking Site.

Noel JK, Babor TF, Grady JJ. Alcohol Alcohol.

Tamsulosin and the risk of dementia in older men with benign prostatic hyperplasia.

Duan Y, Grady JJ, Albertsen PC, Helen Wu Z. Pharmacoepidemiol Drug Saf.

Clinical Factors Affecting the Accuracy of Guided Implant Surgery-A Systematic Review and Meta-analysis.

Zhou W, Liu Z, Song L, Kuo CL, Shafer DM. J Evid Based Dent Pract.

Proximal Aberrant Crypt Foci Associate with Synchronous Neoplasia and Are Primed for Neoplastic Progression.

Drew DA, Mo A, Grady JJ, Stevens RG, Levine JB, Brenner BM, Anderson JC, Forouhar F, O’Brien MJ, Devers TJ, Rosenberg DW. Mol Cancer Res.

A novel bioactive derivative of eicosapentaenoic acid (EPA) suppresses intestinal tumor development in ApcΔ14/+ mice.

Nakanishi M, Hanley MP, Zha R, Igarashi Y, Hull MA, Mathias G, Sciavolino F, Grady JJ, Rosenberg DW. Carcinogenesis.

Molecular testing practices and perceptions among dermatopathologists.

Torre K, Jhorar P, Wu R, Pfeifer J, Elaba Z, Murphy M. Journal of Cutaneous Pathology.

Which orthodontic appliance is best for oral hygiene? A randomized clinical trial.

Chhibber A, Agarwal S, Yadav S, Kuo CL, Upadhyay M. Am J Orthod Dentofacial Orthop.

Differences in Lip Support with and without Labial Flanges in a Maxillary Edentulous Population Part 3: Unblinded and Discriminatory Subjective Analysis.

Bidra AS, Nguyen V, Manzotti A, Kuo CL. J Prosthodont.

The Roles of Ions on Bone Regeneration.

O’Neill, E., Awale, G., Daneshmandi, L., Umerah, O, and Lo K.W.-H. Drug Discov Today 23: 879-890.

Development of Targeted Nanoscale Drug Delivery System for Osteoarthritic Cartilage Tissue.

Jiang, T., Kan, H.M., Rajpura, K., Carbone, E.J., Li, Y., and Lo K.W.-H. J Nanosci Nanotechnol 18: 2310-2317.

2017

Biodegradable Polyphosphazene-based Blends For Regenerative Engineering.

Ogueri, K.S., Escobar Ivirico, J. L., Nair, L. S., Allcock, H. R., Laurencin, C. T; Regenerative Engineering and Translational Medicine/Springer 2017.

Microsphere-Based Scaffolds in Regenerative Engineering.

Gupta, Vineet; Khan, Yusuf; Berkland, Cory J; Laurencin, Cato T; Detamore, Michael S Annual review of biomedical engineering

Engineered stem cell niche matrices for rotator cuff tendon regenerative engineering.

Peach, M Sean; Ramos, Daisy M; James, Roshan; Morozowich, Nicole L; Mazzocca, Augustus D; Doty, Steven B; Allcock, Harry R; Kumbar, Sangamesh G; Laurencin, Cato T PloS

Proximal Aberrant Crypt Foci Associate with Synchronous Neoplasia and are Primed for Neoplastic Progression.

Drew DA, Mo A, Grady JJ, Stevens RG, Levine JB, Brenner BM, Anderson JC, Forouhar F, O’Brien MJ, Devers TJ, Rosenberg DW. Mol Cancer Res.

Human longevity: 25 genetic loci associated in 389,166 UK biobank participants.

Pilling LC, Kuo CL, Sicinski K, Tamosauskaite J, Kuchel GA, Harries LW, Herd P, Wallace R, Ferrucci L, Melzer D. Aging.

Presence of neuroticism and antidepressant remission rates in late-life depression: results from the Neurobiology of Late-Life Depression (NBOLD) study

Steffens DC, Wu R, Grady JJ, Manning KJ. Int Psychogeriatr.

A novel bioactive derivative of eicosapentaenoic acid (EPA) suppresses intestinal tumor development in ApcΔ14/+ mice.

M, Hanley MP, Zha R, Igarashi Y, Hull MA, Mathias G, Sciavolino F, Grady JJ, Rosenberg DW. Carcinogenesis.

Does the difference in fascial closure technique affect post-operative pain? J Minim Invasive Gynecol.

Lyapis A, Ulrich A, LaMonica R, Kuo CL, Kaye L, Luciano D. Elsevier Inc.

Racial/ethnic disparities in morbidity and mortality for preterm neonates admitted to a tertiary neonatal intensive care unit.

Townsel C, Keller R, Kuo CL, Campbell WA, Hussain N. J Racial Ethn Health Disparities.

Statin and Its Association With Delirium in the Medical ICU.

Mather JF, Corradi JP, Waszynski C, Noyes A, Duan Y, Grady J, Dicks R. Crit Care Med.

Red Blood Cell Distribution Width: genetic evidence for aging pathways in 116,666 volunteers.

Pilling LC, Atkins JL, Duff MO, Beaumont RN, Jones SE, Tyrrell J, Kuo CL, Ruth KS, Tuke MA, Yaghootkar H, Freathy RM, Wood AR, Murray A, Weedon MN, Harries LW, Kuchel GA, Ferrucci L, Frayling TM, Melzer D. PLoS One.

Prevention of complications in glycogenstorage disease type Ia with optimization of metabolic control.

DambskaM, Labrador EB, Kuo CL, Weinstein DA. Pediatr Diabetes.

Acute Effects of Moderate Alcohol Consumption on Postural Stability in Older Adults.

Wu Z, Barry L, Duan Y, Bohannon R, Covault JM, Grady JJ. Percept Mot Skills.

Metformin Use in Practice: Compliance With Guidelines for Patients With Diabetes and Preserved Renal Function.

Salber GJ, Wang YB, Lynch JT, Pasquale KM, Rajan TV, Stevens RG, Grady JJ, Kenny AM. Clin Diabetes.

Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing.

Babapoor S, Wu R, Kozubek J, Auidi D, Grant-Kels JM, Dadras SS. Lab Invest.

Differences in Lip Support with and without Labial Flanges in a Maxillary Edentulous Population. Part 1: Objective Analysis.

Bidra AS, Zapata G, Agar JR, Taylor TD, Grady J. J Prosthodont.

Endoscopic features of mucous cap polyps during colonoscopy: A retrospective study predicting serrated polyps.

Moy BT, Forouhar F, Kuo CL, Devers TJ. Clin Endosc.

Correlates of electronic cigarettes use before and during pregnancy.

Oncken C, Ricci KA, Kuo CL, Dornelas E, Kranzler HR, Sankey HZ. Nicotine Tob Res.

Comparison of Initial Vasopressors Used for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage.

Roy B, McCullough LD, Dhar R, Grady J, Wang YB, Brown RJ. Cerebrovasc Dis.

Normal and non-normal data simulations for the evaluation of twosample location tests.

Hoag JR, Kuo CL. Chapter 3: Monte Carlo Simulation-Based Statistical Modeling. Springer Singapore, 41-57.

Renal Function, Weaning, and Survival in Patients With Ventilator-Dependent Respiratory Failure.

Datta D, Foley RJ, Wu R, Grady J, Scalise P. J Intensive Care Med.

Engineered Bone Tissue with Naturally-Derived Small Molecules.

Awale, G., Wong, E., Rajpura, K. and Lo, K.W.-H. Curr Pharm Des 23: 3585-3594.

Osteotropic Nanoscale Drug Delivery Systems Based On Small Molecule Bone-Targeting Moieties.

Carbone, E.J., Rajpura, K., Allen, B.N., Cheng, E., Ulery, B.D., and Lo, K.W.-H., Nanomedicine 13 :37-47.

Osteotropic Nanoscale Drug Delivery System via a Single Aspartic Acid as the Bone-targeting Moiety.

Carbone, E.J., Rajpura, K., Jiang, T., Kan, H.-M., Yu, X., and Lo, K.W.-H., J Nanosci Nanotechnol 17: 1747-1752.

Mechanically Loading Cell/Hydrogel Constructs with Low Intensity Pulsed Ultrasound for Bone Repair.

Veronick JA, Assanah F, Piscopo N, Kutes Y, Vyas V, Nair LS, Huey BD, Khan Y. Tissue Engineering.

Dual Growth Factor Delivery from Biofunctionalized Allografts: Sequential VEGF and BMP-2 Release to Stimulate Allograft Remodeling.

Sharmin F, McDermott C, Lieberman J, Sanjay A, Khan Y. J Orthop Res. 35(5), 1086-1095.

2016

The past, present and future of ligament regenerative engineering.
Mengsteab, Paulos Y; Nair, Lakshmi S; Laurencin, Cato T Regenerative medicine

Nanofiber technology: its transformative role in nanomedicine.
James, Roshan; Laurencin, Cato T Nanomedicine (London, England)

Animal models of osteoarthritis: classification, update, and measurement of outcomes.
Kuyinu, Emmanuel L; Narayanan, Ganesh; Nair, Lakshmi S; Laurencin, Cato T Journal of orthopaedic surgery and research

Translation of the Care of Persons with Dementia in their Environments (COPE) intervention in a publicly-funded home care context: Rationale and research design.

Fortinsky RH, Gitlin LN, Pizzi LT, Piersol CV, Grady J, Robison JT, Molony S. Contemp Clin Trials.

Neck recurrence and mortality in esthesioneuroblastoma: Implications for management of the N0 neck.

Naples JG, Spiro J, Tessema B, Kuwada C, Kuo CL, Brown SM. Laryngoscope.

Costimplications for subsequent perinatal outcomes after IVF stratiﬁed by number of embryos transferred: A ﬁve year analysis of Vermont data.

Carpinnello OJ, Casson PR, Kuo CL, Raj RS, Sills ES, Jones CA. Appl Health Econ Health Policy.

Can Creatinine Height Index Predict Weaning and Survival Outcomes in Patients on Prolonged Mechanical Ventilation After Critical Illness?

Datta D, Foley R, Wu R, Grady J, Scalise P. J Intensive Care Med.

Prospective cohort pilot study of 2-visit CAD/CAM monolithic complete dentures and implant-retained overdentures: Clinical and patientcentered outcomes.

Bidra AS, Farrell K, Burnham D, Dhingra A, Taylor TD, Kuo CL. J Prosthet Dent.

Evaluation of the donor cell contribution in rhBMP2 mediated bone formation with chitosan thermogels using ﬂuorescent protein reporter mice.

Gohil SV, Kuo CL, Adams DJ, Maye P, Rowe DW, Nair LS. J Biomed Mater Res A.

Patient Controlled Analgesia for Adults with Sickle Cell Disease Awaiting Admission from the Emergency Department.

Santos J, Jones S, Wakefield D, Grady J, Andemariam B. Pain Res Manag.

Knot Security- How is it Affected by Suture Technique, Material, Size, and Number of Throws?

Silver E, Wu R, Grady J, Song L. J Oral Maxillofac Surg.

Traumatic Exposure History as a Risk Factor for Chronic Pain in Adult Patients with Sickle Cell Disease.

Works T, Jones S, Grady JJ, Andemariam B. Health Soc Work.

MicroRNA in situ hybridization for miR-211 detection as an ancillary test in melanoma diagnosis.

Babapoor S, Horwich M, Wu R, Levinson S, Gandhi M, Makkar H, Kristjansson A, Chang M, Dadras SS.Mod Pathol.

Colorectal polyp prevention by daily aspirin use is abrogated among active smokers.

Drew DA, Goh G, Mo A, Grady JJ, Forouhar F, Egan G, Swede H, Rosenberg DW, Stevens RG, Devers TJ. Cancer Causes Control.

Effectiveness and Safety of a Clinical Decision Rule to Reduce Repeat Ionized Calcium Testing: a PRE/POST Test Intervention.

Salman M, Pike D, Wu R, Oncken C. Connecticut Medicine.

Ranking question designs and analysis methods.

Hoag JR, Kuo CL.J Med Stat Inform.

The Effect of Acoustic Radiation Force on Osteoblasts in Cell/Hydrogel Constructs for Bone Repair. Exp. Biol. & Med.

Veronick J, Assanah F, Nair LS, Vyas V, Huey B, Khan Y. 241(10):1149-56.

2015

Biofunctionalizing Devitalized Bone Allografts through Polymer-Mediated Short and Long Term Growth Factor Delivery.

Sharmin F, Adams D, Pensak M, Dukas A, Lieberman J, Khan Y. J Biomed Mater. Res. 103(9):2847-54.

Biomaterials for Bone Regenerative Engineering.

Yu, Xiaohua; Tang, Xiaoyan; Gohil, Shalini V; Laurencin, Cato T Advanced healthcare materials

Methodology and preliminary results from the neurobiology of late-life depression study.

Steffens DC, Manning KJ, Wu R, Grady JJ, Fortinsky RH, Tennen HA. Int Psychogeriatr.

Traumatic Exposure History as a Risk Factor for Chronic Pain in Adult Patients with Sickle Cell Disease.

Works, T., Jones. S., Grady, JJ, Andemariam, B. Health & Social Work.

Sleep quality among low income young women predicts changes in perceived stress before and after Hurricane Ike in Southeast Texas.

Wu, Z.H., Stevens R., Tennen H., North C.S., Grady JJ, Holzer, C. Sleep

2014

Simple signaling molecules for inductive bone regenerative engineering.

Cushnie, Emily K; Ulery, Bret D; Nelson, Stephen J; Deng, Meng; Sethuraman, Swaminathan; Doty, Stephen B; Lo, Kevin W H; Khan, Yusuf M; Laurencin, Cato T PloS

Functionalized carbon nanotube reinforced scaffolds for bone regenerative engineering: fabrication, in vitro and in vivo evaluation.
Mikael, Paiyz E; Amini, Ami R; Basu, Joysurya; Josefina Arellano-Jimenez, M; Laurencin, Cato T; Sanders, Mary M; Barry Carter, C; Nukavarapu, Syam P Biomedical materials (Bristol, England)

Delivery of small molecules for bone regenerative engineering: preclinical studies and potential clinical applications.
Laurencin, Cato T; Ashe, Keshia M; Henry, Nicole; Kan, Ho Man; Lo, Kevin W-H Drug discovery today

Small-molecule based musculoskeletal regenerative engineering.
Lo, Kevin W-H; Jiang, Tao; Gagnon, Keith A; Nelson, Clarke; Laurencin, Cato T Trends in biotechnology

A novel miR-451a isomiR, associated with amelanotypic phenotype, acts a tumor suppressor in melanoma by retarding cell migration and invation.

Babapoor S, Fleming E, Wu R, Dadras SS. PLoS One.

Novel protective role of endogenous cardiac myocyte P2X4 receptors in heart failure.

Yang, T., Shen, J.-B., Yang, R., Redden, J., Dodge-Kafka, K., Grady, J.J., Jacobson, K.A.b, Liang, B.T. Circulation: Heart Failure.

First Trimester Aneuploidy Screening Markers in Women with Pre-Gestational Diabetes Mellitus.

Gurram, P., Benn, P., Grady, J.J., Prabulos, A.M., and Campbell, W. J. Clin. Med.

Identification of risk factors for an unsuccessful transition from pediatric to adult sickle cell disease care.

Andemariam B, Owarish-Gross J, Grady JJ, Boruchov D, Thrall RS, Hagstrom JN. Pediatr Blood Cancer.

Cardiovascular morbidity associated with gonadotropin releasing hormone agonists and an antagonist.

Albertsen, P.C., Klotz, L., Tombal, B., Grady, J.J., Olesen, T.K., Nilsson, J. European Urology.

Poly-aspartic Acid Peptide Linked PLGA-based Nanoscale Particles: Potential for Bone-targeting Drug Delivery Applications.

Jiang, T., Yu, X., Carbone, E.J., Nelson, C., Kan, H.-M., and Lo, K.W.-H. Int J. Pharm 475: 547-557.

Small molecule delivery through nanofibrous scaffolds for musculoskeletal regenerative engineering.

Carbone, E.J., Jiang, T., Nelson, C., Henry, N., and Lo, K.W.-H. Nanomedicine 10: 1691-1699.

Live Cell Imaging Reveals Differential Modifications to Cytoplasmic Dynein Properties by Phospho- and Dephospho-mimic Mutations of the Intermediate Chain 2C S84.

Mitchell, D., Blasier, K., Jeffery, E., Ross, M., Pullikuth, A., Suo, D., Park, J., Smiley, W., Lo K.W.-H., and Pfister, K.K. J Neurosci Res 92:1143-1154.

2013

Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics.

Ulery, Bret D; Kan, Ho-Man; Williams, Bryce A; Narasimhan, Balaji; Lo, Kevin W-H; Nair, Lakshmi S; Laurencin, Cato T Advanced healthcare materials

One-day treatment of small molecule 8-bromo-cyclic AMP analogue induces cell-based VEGF production for in vitro angiogenesis and osteoblastic differentiation.
Lo, Kevin W-H; Kan, Ho Man; Gagnon, Keith A; Laurencin, Cato T Journal of tissue engineering and regenerative medicine

Nano-ceramic composite scaffolds for bioreactor-based bone engineering.
Lv, Qing; Deng, Meng; Ulery, Bret D; Nair, Lakshmi S; Laurencin, Cato T Clinical orthopaedics and related research

Short-term administration of small molecule phenamil induced a protracted osteogenic effect on osteoblast-like MC3T3-E1 cells.
Lo, Kevin W-H; Kan, Ho Man; Laurencin, Cato T Journal of tissue engineering and regenerative medicine

Micro- and nanofabrication of chitosan structures for regenerative engineering.
Jiang, Tao; Deng, Meng; James, Roshan; Nair, Lakshmi S; Laurencin, Cato T Acta biomaterialia

Cellulose and collagen derived micro-nano structured scaffolds for bone tissue engineering.
Aravamudhan, Aja; Ramos, Daisy M; Nip, Jonathan; Harmon, Matthew D; James, Roshan; Deng, Meng; Laurencin, Cato T; Yu, Xiaojun; Kumbar, Sangamesh G Journal of biomedical nanotechnology

A chitosan thermogel for delivery of ropivacaine in regional musculoskeletal anesthesia.
Foley, Patricia L; Ulery, Bret D; Kan, Ho M; Burks, Martin V; Cui, Zhanwu; Wu, Qian; Nair, Lakshmi S; Laurencin, Cato T Biomaterials

Bacterial lipodipeptide, Lipid 654, is a microbiome-associated biomarker for multiple sclerosis.

Farrokhi V, Nemati R, Nichols FC, Yao X, Anstadt E, Fujiwara M, Grady JJ, Wakefield D, Castro W, Donaldson J, and Clark RB. Clinical & Translational Immunology.

A novel food pantry program: food security, self-sufficiency, and diet-quality outcomes.

Martin KS, Wu R, Wolff M, Colantonio AG, Grady J.Am J Prev Med.

In-depth characterization of microRNA transcriptome in melanoma.

Kozubek J, Ma Z, Fleming E, Duggan T, Wu R, Shin DG, Dadras SS. PLoS One.

Nanoproteomic analysis of extracellular receptor kinase-1/2 post-translational activation in microdissected human hyperplastic colon lesions.

Drew DA, Devers T, Horelik N, Yang S, O’Brien M, Wu R, Rosenberg DW. Proteomics.

2012

Regenerative engineering.

Laurencin, Cato T; Khan, Yusuf Science translational medicine

VEGF-incorporated biomimetic poly(lactide-co-glycolide) sintered microsphere scaffolds for bone tissue engineering.

Jabbarzadeh, Ehsan; Deng, Meng; Lv, Qing; Jiang, Tao; Khan, Yusuf M; Nair, Lakshmi S; Laurencin, Cato T Journal of biomedical materials research. Part B, Applied biomaterials

Differential analysis of peripheral blood- and bone marrow-derived endothelial progenitor cells for enhanced vascularization in bone tissue engineering.

Amini, Ami R; Laurencin, Cato T; Nukavarapu, Syam P Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Injectable thermogelling chitosan for the local delivery of bone morphogenetic protein.

McLaughlin, Shaun W; Cui, Zhanwu; Starnes, Trevor; Laurencin, Cato T; Kan, Ho-Man; Wu, Qian; Nair, Lakshmi S Journal of materials science. Materials in medicine

Studies of bone morphogenetic protein-based surgical repair.

Lo, Kevin W-H; Ulery, Bret D; Ashe, Keshia M; Laurencin, Cato T Advanced drug delivery reviews

Polyphosphazene functionalized polyester fiber matrices for tendon tissue engineering: in vitro evaluation with human mesenchymal stem cells.

Peach, M Sean; James, Roshan; Toti, Udaya S; Deng, Meng; Morozowich, Nicole L; Allcock, Harry R; Laurencin, Cato T; Kumbar, Sangamesh G Biomedical materials (Bristol, England)

Evaluating the feasibility of utilizing the small molecule phenamil as a novel biofactor for bone regenerative engineering.

Lo, Kevin W-H; Ulery, Bret D; Kan, Ho Man; Ashe, Keshia M; Laurencin, Cato T Journal of tissue engineering and regenerative medicine

Optimally porous and biomechanically compatible scaffolds for large-area bone regeneration.

Amini, Ami R; Adams, Douglas J; Laurencin, Cato T; Nukavarapu, Syam P Tissue engineering. Part A

The role of small molecules in musculoskeletal regeneration.

Lo, Kevin W-H; Ashe, Keshia M; Kan, Ho Man; Laurencin, Cato T Regenerative medicine

Nanostructured polymeric scaffolds for orthopaedic regenerative engineering.

Deng, Meng; James, Roshan; Laurencin, Cato T; Kumbar, Sangamesh G IEEE transactions on nanobioscience

Design and optimization of polyphosphazene functionalized fiber matrices for soft tissue regeneration.

Peach, M Sean; Kumbar, Sangamesh G; James, Roshan; Toti, Udaya S; Balasubramaniam, Deepak; Deng, Meng; Ulery, Bret; Mazzocca, Augustus D; McCarthy, Mary Beth; Morozowich, Nicole L; Allcock, Harry R; Laurencin, Cato T Journal of biomedical nanotechnology

The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization.

Lo, Kevin W-H; Kan, Ho Man; Ashe, Keshia M; Laurencin, Cato T Journal of tissue engineering and regenerative medicine

Area under the curve as a tool to measure kinetics of tumor growth in experimental animals.

Duan F, Simeone S, Wu R, Grady J, Mandoiu I, Srivastava PK. J Immunol Methods.

2011

Novel mechanically competent polysaccharide scaffolds for bone tissue engineering.

Kumbar, S G; Toti, U S; Deng, M; James, R; Laurencin, C T; Aravamudhan, A; Harmon, M; Ramos, D M Biomedical materials (Bristol, England)

Improved bio-implant using ultrafast laser induced self-assembled nanotexture in titanium.

Bush, Joshua R; Nayak, Barada K; Nair, Lakshmi S; Gupta, Mool C; Laurencin, Cato T Journal of biomedical materials research. Part B, Applied biomaterials

Activation of cyclic amp/protein kinase: a signaling pathway enhances osteoblast cell adhesion on biomaterials for regenerative engineering.

Lo, Kevin W-H; Ashe, Keshia M; Kan, Ho Man; Lee, Duron A; Laurencin, Cato T Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Tendon tissue engineering: adipose-derived stem cell and GDF-5 mediated regeneration using electrospun matrix systems.

James, R; Kumbar, S G; Laurencin, C T; Balian, G; Chhabra, A B Biomedical materials (Bristol, England)

Evaluation of a hydrogel-fiber composite for ACL tissue engineering.

Freeman, Joseph W; Woods, Mia D; Cromer, Damond A; Ekwueme, Emmanuel C; Andric, Tea; Atiemo, Emmanuel A; Bijoux, Christian H; Laurencin, Cato T Journal of biomechanics

2010 Panel on the biomaterials grand challenges.

Reichert, William Monty; Ratner, Buddy D; Anderson, James; Coury, Art; Hoffman, Allan S; Laurencin, Cato T; Tirrell, David Journal of biomedical materials research. Part A

Biomimetic Structures: Biological Implications of Dipeptide-Substituted Polyphosphazene–Polyester Blend Nanofiber Matrices for Load-Bearing Bone Regeneration.

Deng M, Kumbar SG, Nair LS, Weikel AL, Allcock HR, Laurencin CT Advanced Functional Materials

Development and characterization of biodegradable nanocomposite injectables for orthopaedic applications based on polyphosphazenes.

Sethuraman, Swaminathan; Nair, Lakshmi S; El-Amin, Saadiq; Nguyen, My-Tien; Singh, Anurima; Greish, Yaser E; Allcock, Harry R; Brown, Paul W; Laurencin, Cato T Journal of biomaterials science. Polymer edition

Electrospun nanofibrous scaffolds for engineering soft connective tissues.

James, Roshan; Toti, Udaya S; Laurencin, Cato T; Kumbar, Sangamesh G Methods in molecular biology (Clifton, N.J.)

Nanocomposites and bone regeneration.

James R, Deng M, Laurencin CT, Kumbar SG Frontiers of Materials Science

Polyphosphazene containing vitamin substituents: synthesis, characterization and hydrolytic sensitivity.

Morozowich NL, Weikel AL, Nichol JL, Chen C, Nair LS, Laurencin CT, Allcock HR Macromolecules

2010

Composite scaffolds: bridging nanofiber and microsphere architectures to improve bioactivity of mechanically competent constructs.

Brown, Justin L; Peach, M Sean; Nair, Lakshmi S; Kumbar, Sangamesh G; Laurencin, Cato T Journal of biomedical materials research. Part A

Novel nanostructured scaffolds as therapeutic replacement options for rotator cuff disease.

Taylor, Erica D; Nair, Lakshmi S; Nukavarapu, Syam P; McLaughlin, Shaun; Laurencin, Cato T The Journal of bone and joint surgery. American volume

The indications and use of bone morphogenetic proteins in foot, ankle, and tibia surgery.

El-Amin, Saadiq F; Hogan, MaCalus V; Allen, Answorth A; Hinds, Jonathan; Laurencin, Cato T Foot and ankle clinics

Miscibility of choline-substituted polyphosphazenes with PLGA and osteoblast activity on resulting blends.

Weikel, Arlin L; Owens, Steven G; Morozowich, Nicole L; Deng, Meng; Nair, Lakshmi S; Laurencin, Cato T; Allcock, Harry R Biomaterials

In Situ Porous Structures: A Unique Polymer Erosion Mechanism in Biodegradable Dipeptide-based Polyphosphazene and Polyester Blends Producing Matrices for Regenerative Engineering.

Deng, Meng; Nair, Lakshmi S; Nukavarapu, Syam P; Kumbar, Sangamesh G; Jiang, Tao; Weikel, Arlin L; Krogman, Nicholas R; Allcock, Harry R; Laurencin, Cato T Advanced functional materials

Chitosan-poly(lactide-co-glycolide) microsphere-based scaffolds for bone tissue engineering: in vitro degradation and in vivo bone regeneration studies.

Jiang, Tao; Nukavarapu, Syam P; Deng, Meng; Jabbarzadeh, Ehsan; Kofron, Michelle D; Doty, Stephen B; Abdel-Fattah, Wafa I; Laurencin, Cato T Acta biomaterialia

Tissue-engineered matrices as functional delivery systems: adsorption and release of bioactive proteins from degradable composite scaffolds.

Cushnie, Emily K; Khan, Yusuf M; Laurencin, Cato T Journal of biomedical materials research. Part A

Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering.

Deng, Meng; Nair, Lakshmi S; Nukavarapu, Syam P; Jiang, Tao; Kanner, William A; Li, Xudong; Kumbar, Sangamesh G; Weikel, Arlin L; Krogman, Nicholas R; Allcock, Harry R; Laurencin, Cato T Biomaterials

Functionalization of chitosan/poly(lactic acid-glycolic acid) sintered microsphere scaffolds via surface heparinization for bone tissue engineering.

Jiang, Tao; Khan, Yusuf; Nair, Lakshmi S; Abdel-Fattah, Wafa I; Laurencin, Cato T Journal of biomedical materials research. Part A

Mechanical properties and osteocompatibility of novel biodegradable alanine based polyphosphazenes: Side group effects.

Sethuraman, Swaminathan; Nair, Lakshmi S; El-Amin, Saadiq; Nguyen, My-Tien; Singh, Anurima; Krogman, Nick; Greish, Yaser E; Allcock, Harry R; Brown, Paul W; Laurencin, Cato T Acta biomaterialia

Wang, Junping; Valmikinathan, Chandra M; Liu, Wei; Laurencin, Cato T; Yu, Xiaojun Journal of biomedical materials research. Part A

Multipotential differentiation of human anulus fibrosus cells: an in vitro study.

Feng, Gang; Yang, Xinlin; Shang, Hulan; Marks, Ian W; Shen, Francis H; Katz, Adam; Arlet, Vincent; Laurencin, Cato T; Li, Xudong The Journal of bone and joint surgery. American volume

Biomimetic, bioactive etheric polyphosphazene-poly(lactide-co-glycolide) blends for bone tissue engineering.

Deng, Meng; Nair, Lakshmi S; Nukavarapu, Syam P; Kumbar, Sangamesh G; Brown, Justin L; Krogman, Nicholas R; Weikel, Arlin L; Allcock, Harry R; Laurencin, Cato T Journal of biomedical materials research. Part A

Hydrogen bonding in blends of polyesters with dipeptide-containing polyphosphazenes.

Krogman NR, Weikel AL, Nguyen NQ, Kristhart KA, Nukavarapu SP, Nair LS, Laurencin CT, Allcock HR Journal of Applied Polymer Science

Hydrolysable polylactide-Polyphosphazene block copolymers for biomedical applications: Synthesis, Characterization and composites with Poly(lactide-co-glycolic acid).

Weikel A, Cho SY, Morozowich NL, Nair LS, Laurencin CT, Allcock HR Polym Chem