On August 23rd, we were honored to have Joseph W. Freeman, Associate Professor of Biomedical Engineering at Rutgers University, as the first speaker in the Raymond and Beverly Sackler Seminar Series. Dr. Freeman delivered a talk entitled “Novel Approaches to Musculoskeletal Tissue Repair, Replacement, and Regeneration.” The Sackler Seminar Series is but one of several activities funded through our center endowed by the Raymond and Beverly Sackler Foundation.

After receiving a bachelor’s degree in Chemical Engineering from Princeton University, Dr. Freeman earned his Ph.D. in Biomedical Engineering from Rutgers University and the University of Medicine and Dentistry of New Jersey. Dr. Freeman then joined my laboratory at the University of Virginia as a postdoctoral fellow. He worked on the use of novel biomaterials in bone regeneration, the development of new scaffolds for ligament repair, the use of hydrogels for ligament repair, and the design and construction of a braiding machine for ligament graft construction.

Dr. Freeman’s areas of research interest involve developing and evaluating new implantable scaffolds for the regeneration of musculoskeletal tissues, use of molecular modeling to investigate collagen structure and function, and develop tumor engineering models.

I was pleased Dr. Freeman agreed to speak as part of the Sackler Seminar Series and enjoyed catching up with him. We look forward to bringing other innovative leaders to speak here at the Health Center.

Last month, the Journal of Biomaterials and Tissue Engineering (JBT) published a special issue on nanobiomaterials for tissue engineering in North America edited by Dr. Lakshmi S. Nair, a faculty member in the Institute for Regenerative Engineering. This issue summarizes current perspectives on the use of nanobiomaterials, as well as evaluating other strategies such as stem cell technology for musculoskeletal regenerative engineering. The special issue has been published electronically by American Scientific Publishers.

In addition to editing this issue, Dr. Nair is currently co-editing the second edition of Nanotechnology and Tissue Engineering. Her current research focuses on developing regenerative biomaterials and drug/cell delivery strategy.

I am happy to report that the Institute for Regenerative Engineering received a major award from the NSF last month. This is one of the largest grant efforts in the history of the UConn Health Center. This is also our second EFRI grant. To our knowledge, we are the only research group in the country to have two active EFRI grants.

The focus of EFRI program supports transformative ideas that represent an opportunity for a significant shift in fundamental engineering knowledge with a strong potential for long term impact on national needs or a grand challenge. The abstract of the award is posted on the NSF website.
As the Principal Investigator for the grant, I thank everyone involved in this application for their phenomenal work during the past several months in getting this grant successfully funded. I would especially like to thank the co-principal investigators and the senior personnel listed below. It was a great pleasure working with all of you in putting together this fine proposal.

Co-Principal Investigators
Dr. Sangamesh Kumbar, Orthopaedic Surgery, UConn Health Center
Dr. Kevin Lo, Medicine, UConn Health Center

Senior Personnel
Dr. Yusuf Khan, Orthopaedic Surgery, UConn Health Center
Dr. David Goldhamer, Molecular and Cell Biology, UConn, Storrs
Dr. Pouran Faghri, Allied Health Sciences, UConn, Storrs
Dr. Nathan Swami, Electrical Engineering, University of Virginia

It is my great pleasure to announce a special issue of Current Pharmaceutical Design will focus on Bone Morphogenetic Proteins for Bone Regeneration and Their Alternatives. This issue summarizes current perspectives on the use of bioactive molecules, as well as evaluating other strategies such as stem cells, biomaterials, vascularization, and gene therapy for bone regenerative engineering. We thank our outstanding contributors for participating, including our colleagues here at the Health Center, Drs. Marja Hurley and Sangamesh Kumbar. In addition, I would like to acknowledge the efforts of guest editor Dr. Kevin Lo, a faculty member here in the Institute for Regenerative Engineering. Without his time and effort, this issue would not have been possible.

The Special Issue has been published electronically by Bentham Science Publishers. The print version will be available very soon.

On April 11, I was so humbled by receiving the Technology Innovation and Development Award from the Society for Biomaterials (SFB). The award ceremony was held at the SFB annual meeting in Boston, MA. This award recognizes an individual or team who provided key scientific and technical innovation and leadership in a novel product in which biomaterials played an important and enabling role.

For more than three decades, I have conducted research studies on biomaterials for musculoskeletal tissue engineering, nanotechnology, and drug delivery. I began research in this field in the late 1980s, and was influenced by my Ph.D. mentor, Dr. Robert Langer, an Institution Professor at M.I.T. On behalf of my research team, I thank you sincerely. To be selected by the SFB is indeed a great honor.

I am very excited to announce that Paiyz Mikael has been selected as one of the finalists for the 2013 Women of Innovation Awards. Every year, the Connecticut Technology Council recognizes women for their innovations, mentoring, leadership in technology, and contributions to the STEM field. These awards also include high-school and college-level students.

Paiyz’s graduate study was supported by a prestigious National Science Foundation GK-12 Fellowship for two years. As a GK-12 Fellow, she was embedded at Hartford’s A.I. Prince Technical High School, where she worked closely with teachers and students to bring fun, hands-on activities to the classroom that reinforced the applications of science and technology while exciting students in STEM subjects. She introduced projects including the design and construction of a working greenhouse, compost and recycling apparatuses, as well as a moon buggy design for a NASA competition. Paiyz also integrated her own research project into the classroom activities. The students learned how to make microspheres using items available at home. These projects immerse students in science lessons involving energy, efficiency and sustainability. Under her guidance, a Prince Tech student team won a $5,000 award from a local energy company to establish a better, greener recycling system. Prince Tech serves a population underrepresented in engineering: 95% minority students and 51% females. As a recent immigrant from Iraqi Kurdistan, Paiyz has been embraced by Prince Tech students. She is passionate about mentoring and helping them realize their potential. She is proudest of her success in initiating a mentoring collaboration between A.I. Prince Tech students and children in a nearby charter elementary/middle school. This partnership fosters strong mentoring skills among the high school students while providing STEM support for the younger children. Above all, Paiyz is most excited about her role as a mother to a beautiful 6-year-old daughter, Rojan; and she truly believes that raising and mentoring children is a privilege and an honor.

Paiyz joined the Institute for Regenerative Engineering under the guidance of Dr. Syam P. Nukavarapu in the Biomedical Engineering Program at the University of Connecticut. She focused on developing mechanically superior polymeric-carbon nanotube composite scaffolds for the regeneration of segmental bone defects. Prior to that, she graduated with honors from Southern Connecticut State University where she completed her thesis project titled “Study of chemotherapy responses in transformed murine cell line containing a temperature-sensitive mutation in the p53 gene.” Currently, Paiyz is a third-year Ph.D. candidate in the Material Science and Engineering program here at UConn. Her research focuses on exploiting the regeneration of bone tissue through a process that naturally takes place during fetal development (Endochondral ossification). For this, she is working on developing a polymeric-hydrogel hybrid scaffold system that is mechanically compatible with bone; furthermore, the hydrogel phase acts as a natural extracellular matrix on which cells will reside and differentiate further.

The Journal of Biomedical Materials Research (JBMR) has just published its 100th volume, Progress in Biomaterials, which features the top 25 papers it has published in its 50+ years. I am happy to report that one of our lab’s papers, “Electrospun nanofibrous structure: A novel scaffold for tissue engineering” was selected for inclusion. This article has been cited more than 1100 times. According to JBMR, the major criteria for inclusion of papers in this virtual issue was “the identification of articles that, in their time, were considered novel, original, state-of-the-art, groundbreaking, led to clinical application, and opened new areas of biomaterials research.” The editors commented “this pioneering paper by Laurencin showed that biodegradable electrospun nanofiber structures were capable of supporting cell attachment and proliferation and indicated that cells seeded on this structure could maintain phenotypic shape and guide growth according to nanofiber orientation.” Perhaps even more exciting, the editors chose figure 2 of our paper for the cover of the 100th Volume Celebration Edition.

Congratulations to all.

Image was adpated from http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-4981/homepage/VirtualIssuesPage.html.

To further facilitate collaborations between UConn and internationally renowned experts, it was our great honor to host Ronald W. Rousseau, chair of the School of Chemical and Biomolecular Engineering at Georgia Institute of Technology. Dr. Rousseau, the Cecil J. “Pete” Silas Endowed Chair, delivered a talk entitled “Chirally Pure Pharmaceutical Products: The Role of Crystallization” in the Department of Chemical, Materials and Biomolecular Engineering at Storrs. His research focuses on separation processes and has resulted in more than 200 publications. Dr. Rousseau has received numerous awards including the prestigious Warren K. Lewis Award from the American Institute of Chemical Engineers (AIChE), the Clarence G. Gerhold Award from the AIChE’s Separations Division and the AIChE’s Forest Products Award. He is a fellow of both AIChE and the American Association for the Advancement of Science (AAAS). It was an honor having Dr. Rousseau at UConn, and we look forward to collaborating with him in the future.

I am happy to report that the University of Connecticut submitted an Institutional Clinical and Translational Science Award (CTSA) application last week. This is the largest organized grant effort in the history of the university with over 150 faculty members participating throughout the region.

The CTSA program supports a national consortium of medical research institutions that are transforming the way biomedical research is conducted. Its goals are to accelerate the translation of laboratory discoveries into treatments for patients, to engage communities in clinical research efforts, and to train a new generation of clinical and translational researchers.
As the Principal Investigator for the grant, I would like to thank and acknowledge everyone who has been involved in this application for their phenomenal work during the past several months in getting this grant successfully completed and submitted. Especially, I would like to thank the CTSA executive leadership group, the sector directors, core leaders, and my administrative staff listed below. It was a great pleasure working with you in putting together this fine proposal.

Co-Investigators, and CTSA Executive Leadership Group:
Canalis, Ernesto, Co-Investigator
Hesselbrock, Victor M., Co-Investigator
Hurley, Marja, Co-Investigator
Kuchel, George, Co-Investigator
Liu, Edison, Co-Investigator
Oncken, Cheryl, Co-Investigator
Srivastava, Pramod K., Co-Investigator

Sector and Key Core Directors, Co-Directors, and Associate Directors:
Agresta, Thomas, Co-Director, Biomedical Informatics Division
Babor, Thomas, Director, Tracking & Evaluation
Barry, Linda, Associate Director, Pilot and Collaborative Translational and Clinical Studies
Chapman, Audrey R., Co-Director, Clinical Research Ethics
Cherniack, Martin, Co-Director, Gateway
Demurjian, Steven, Co-Director, Biomedical Informatics Division
Ford, Julian, Co-Director, Regulatory Knowledge and Support & Clinical Ethics
Grady, James, Director, Biostatistics, Epidemiology, and Research Design Resource
Knaus, William, Director, Biomedical Informatics Division
Lalande, Marc, Chair, Scientific Advisory Board
Liang, Bruce, Co-Chair, Scientific Advisory Board
Makoul, Gregory, Co-Director, Community Engagement, Saint Francis Hospital and Medical Center
McCullough, Louise, Co-Director, Clinical and Translational Resources and Services (CTRS)
Nair, Lakshmi S., Associate Director, Gateway
Oncken, Cheryl, Director, Pilot and Collaborative Translational and Clinical Studies
Ruaño, Gualberto, Co-Director, Community Engagement, Hartford Hospital
Schensul, Jean, Co-Director, Community Engagement, Institute for Community Research
Skolnik, Paul, Director, Gateway
Steffens, David, Director, Clinical and Translational Resources and Services (CTRS)
Weller, Sandra, Co-Director, Pilot and Collaborative Translational and Clinical Studies
Wrensford, Granville, Director, Education, Training, and Career Development
Yasnoff, William, Associate Director, Biomedical Informatics Division

CTSA Core Administrative Staff:
Burian, Linda, Regulatory Specialist
Donaldson, Trisha, CICATS Administrative Officer
Schwager, Julie, Director, Research Services
Serra, Debra, CICATS Administrative Program Coordinator
Steciak, Cheryl, CICATS Administrative Coordinator

I am very pleased to announce that Dr. Tao Jiang, CICATS Investigator Advocate and Assistant Professor of Medicine, has been appointed to the faculty of the Institute for Regenerative Engineering. Dr. Jiang received a B.S. in Chemical Engineering in 1999 and an M.S. in Materials Science in 2001, both from Tsinghua University in Beijing.

He then went on to pursue his doctoral degree and received a Ph.D. in chemical engineering from the University of Virginia, Charlottesville, VA. His doctoral research, under my supervision, focused on the design, development, and evaluation of novel hybrid scaffolds from natural polymer chitosan and synthetic polymer PLGA for bone-tissue engineering.

Dr. Jiang joined Zimmer, Inc., one of the world’s leading medical device companies, as a senior research scientist immediately after obtaining his Ph.D. At Zimmer, he played a variety of leading roles in evaluating and exploring cutting-edge technologies for the regeneration of musculoskeletal tissues including bone, cartilage, ligament, and tendon. In addition, he played a key role in developing Chondrofix Allograft for cartilage repair. Fully launched in the U.S. in 2011, it was the first Zimmer biological product developed in-house.

Dr. Jiang has over 20 peer-reviewed publications in journals such as Biomaterials, Journal of Biomedical Materials Research, Acta Biomaterialia, and PNAS, as well as many conference presentations. He has six issued/pending patents and invention disclosures.

At the University of Virginia, Dr. Jiang was awarded the 2008 Faculty Award for Excellence in Doctoral Studies. At Zimmer, he received a Zimmer Publication Award from the chief scientific officer and a Zimmer Impact Award from the company.

Dr. Jiang serves as a peer reviewer for a number of high-impact scientific journals including Biomaterials, Carbohydrate Polymers, and Materials Science and Engineering.

Dr. Jiang’s research interests include advanced biomaterials, drug delivery, tissue engineering, and therapies for musculoskeletal diseases.

Speaking for all of the Institute faculty, we are excited to have him join us, and we look forward to working with our newest faculty colleague.