NSF Louis Stokes Alliance for Minority Participation (LSAMP) Program

April 12, 2013

I am happy to announce that Ms. Deborah Dorcemus, an IRE graduate student, was recently awarded the National Science Foundation’s prestigious LSAMP Bridge to the Doctorate Fellowship. The LSAMP program is funded by the National Science Foundation and focuses on strengthen the participation, representation and success of underrepresented minorities in the science, technology, engineering, and mathematics (STEM) fields. Fellows receive two years of funding under the program with an additional three years provided by their advisors.

After graduating high school in 2008, Deborah chose to attend the University of Connecticut for her degree in Biomedical Engineering. Throughout her four years of undergraduate work, Deborah was heavily involved with several organizations that promote the professional development and academic success of students and minorities interested in the STEM fields. Deborah also held the positions of secretary, vice president, and president of the UConn chapter of the National Society of Black Engineers.

Upon receiving her Bachelor of Science in May 2012, she decided to continue on her academic path and enrolled in UConn’s Graduate program for her Master’s Degree in Biomedical Engineering with a focus in Tissue Engineering and Regenerative Medicine. With the support of her advisor, Dr. Syam P. Nukavarapu (IRE faculty member), she is nearing completion of her first year of graduate studies. In addition to her lab and school work, Deborah volunteers with the Engineering Graduate Dean’s Office, under the supervision of Aida Ghiaei, and works with students from technical high schools who come to UConn in hopes of becoming engineers. Deborah’s thesis work involves utilizing tissue engineering strategies to develop 3D matrixes that would regenerate osteochondral (functional bone and cartilage) tissue. In order to achieve this, she will use a polymer-hydrogel matrix to deliver growth factors that would cue the tissue to a specific formation. In the end, this structure will serve to replace damaged or arthritic tissue which is an area of great need among the elderly as well as athletes.

Dean’s Distinguished Seminar Series – University of Colorado Denver

March 27, 2013

On March 19, I served as a guest speaker at the University of Colorado Denver’s School of Medicine. Each year, speakers in various disciples from across the country are invited to participate in the Dean’s Distinguished Seminar series. I spoke on musculoskeletal regenerative engineering and the challenges facing tissue engineering. I also highlighted the emergence of regenerative engineering as a promising new technology to regenerate tissues and organs for our bodies. My thanks to everyone at University of Colorado Denver for their hospitality. I look forward to collaborating with them in the future.

A Woman of Innovation

March 15, 2013

Paiyz MikaelI am very excited to announce that Paiyz Mikael has been selected as one of the finalists for the 2013 Women of Innovation Awards. Every year, the Connecticut Technology Council recognizes women for their innovations, mentoring, leadership in technology, and contributions to the STEM field. These awards also include high-school and college-level students.

Paiyz’s graduate study was supported by a prestigious National Science Foundation GK-12 Fellowship for two years. As a GK-12 Fellow, she was embedded at Hartford’s A.I. Prince Technical High School, where she worked closely with teachers and students to bring fun, hands-on activities to the classroom that reinforced the applications of science and technology while exciting students in STEM subjects. She introduced projects including the design and construction of a working greenhouse, compost and recycling apparatuses, as well as a moon buggy design for a NASA competition. Paiyz also integrated her own research project into the classroom activities. The students learned how to make microspheres using items available at home. These projects immerse students in science lessons involving energy, efficiency and sustainability. Under her guidance, a Prince Tech student team won a $5,000 award from a local energy company to establish a better, greener recycling system. Prince Tech serves a population underrepresented in engineering: 95% minority students and 51% females. As a recent immigrant from Iraqi Kurdistan, Paiyz has been embraced by Prince Tech students. She is passionate about mentoring and helping them realize their potential. She is proudest of her success in initiating a mentoring collaboration between A.I. Prince Tech students and children in a nearby charter elementary/middle school. This partnership fosters strong mentoring skills among the high school students while providing STEM support for the younger children. Above all, Paiyz is most excited about her role as a mother to a beautiful 6-year-old daughter, Rojan; and she truly believes that raising and mentoring children is a privilege and an honor.

Paiyz Mikael in the laboratory

Paiyz joined the Institute for Regenerative Engineering under the guidance of Dr. Syam P. Nukavarapu in the Biomedical Engineering Program at the University of Connecticut. She focused on developing mechanically superior polymeric-carbon nanotube composite scaffolds for the regeneration of segmental bone defects. Prior to that, she graduated with honors from Southern Connecticut State University where she completed her thesis project titled “Study of chemotherapy responses in transformed murine cell line containing a temperature-sensitive mutation in the p53 gene.” Currently, Paiyz is a third-year Ph.D. candidate in the Material Science and Engineering program here at UConn. Her research focuses on exploiting the regeneration of bone tissue through a process that naturally takes place during fetal development (Endochondral ossification). For this, she is working on developing a polymeric-hydrogel hybrid scaffold system that is mechanically compatible with bone; furthermore, the hydrogel phase acts as a natural extracellular matrix on which cells will reside and differentiate further.

American Association for the Advancement of Science Mentor Award

March 4, 2013

In mid-February, I was so honored to receive the American Association for the Advancement of Science (AAAS) Mentor Award at a ceremony held during the 2013 AAAS Annual Meeting in Boston. The Mentor Award honors AAAS members who have mentored significant numbers of underrepresented students (such as women, minorities, and persons with disabilities) achieve Ph.D. degrees in the sciences as well as encouraging scholarship, activism, and community-building in science, technology, engineering, and mathematics fields. A very heartfelt thank you to the AAAS for selecting me for this award. I would also like to thank all the students, fellows, residents, and faculty members who have worked with me over the years.

Dr. Laurencin receiving the mentor award

Dr. Laurencin receiving the mentor award

Top Research Article in the Journal of Biomedical Materials Research

February 21, 2013

 Progress in BiomaterialsThe Journal of Biomedical Materials Research (JBMR) has just published its 100th volume, Progress in Biomaterials, which features the top 25 papers it has published in its 50+ years. I am happy to report that one of our lab’s papers, “Electrospun nanofibrous structure: A novel scaffold for tissue engineering” was selected for inclusion. This article has been cited more than 1100 times. According to JBMR, the major criteria for inclusion of papers in this virtual issue was “the identification of articles that, in their time, were considered novel, original, state-of-the-art, groundbreaking, led to clinical application, and opened new areas of biomaterials research.” The editors commented “this pioneering paper by Laurencin showed that biodegradable electrospun nanofiber structures were capable of supporting cell attachment and proliferation and indicated that cells seeded on this structure could maintain phenotypic shape and guide growth according to nanofiber orientation.” Perhaps even more exciting, the editors chose figure 2 of our paper for the cover of the 100th Volume Celebration Edition.

Congratulations to all.

Image was adpated from http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-4981/homepage/VirtualIssuesPage.html.

The Institute for Regenerative Engineering Welcomes New Fellow, Roshan James, Ph.D.

February 14, 2013

Roshan James, Ph.D.I am pleased to announce that Dr. Roshan James recently joined the Institute for Regenerative Engineering as a postdoctoral fellow. His current research focuses on the design and fabrication of novel biomaterials for musculoskeletal tissue engineering. His research interests include biomaterials, integrated tissues, and regenerative engineering.

Dr. James received his bachelor degree from the Indian Institute of Technology, Kharagpur in India, and completed his doctoral thesis under my mentorship at the University of Virginia (UVa) in 2012. His Ph.D. thesis focused on the design of mechanically competent polyester-based matrices for tendon tissue regeneration. In addition, he worked on developing a growth factor delivery system that provided bioactive physiologically relevant doses to modulate cellular responses in adipose stromal cells along the tendonogenic lineage.

Dr. James received a number of awards from UVa where he presented at university-wide research competitions. In, 2012, he was a finalist in the UVa Presidential Research Competition. In addition, he was recently selected as a New Investigator Recognition Awards (NIRA) finalist at the 2013 Orthopaedic Research Society Conference in San Antonio. His talk was entitled ‘Combined Treatment of a Tendon Gap with a Biomimetic Electrospun Scaffold, Stromal Cells and GDF5,’ and his presentation focused on in vivo characterization of biodegradable biomaterials designed to mimic the structure of the tendon extracellular matrix.

Tendon gap PowerPoint screenIt is worth noting that Dr. James has made a significant impact on tendon tissue engineering. He has successfully developed a novel tubular scaffold system to regenerate a large gap defect in tendon tissue due to severe injuries. The scaffold system can also deliver adipose stromal cells and growth factors that facilitate the regenerative process resulting in new tendon tissue formation.

Everyone in the Institute for Regenerative Engineering welcomes Roshan and looks forward to working with him here at UConn.

The Institute for Regenerative Engineering Hosts Ronald W. Rousseau, Ph.D.

February 5, 2013

Ronald W. Rousseau, chair of the School of Chemical and Biomolecular Engineering at Georgia Institute of TechnologyTo further facilitate collaborations between UConn and internationally renowned experts, it was our great honor to host Ronald W. Rousseau, chair of the School of Chemical and Biomolecular Engineering at Georgia Institute of Technology. Dr. Rousseau, the Cecil J. “Pete” Silas Endowed Chair, delivered a talk entitled “Chirally Pure Pharmaceutical Products: The Role of Crystallization” in the Department of Chemical, Materials and Biomolecular Engineering at Storrs. His research focuses on separation processes and has resulted in more than 200 publications. Dr. Rousseau has received numerous awards including the prestigious Warren K. Lewis Award from the American Institute of Chemical Engineers (AIChE), the Clarence G. Gerhold Award from the AIChE’s Separations Division and the AIChE’s Forest Products Award. He is a fellow of both AIChE and the American Association for the Advancement of Science (AAAS). It was an honor having Dr. Rousseau at UConn, and we look forward to collaborating with him in the future.

Clinical and Translational Science Award

January 11, 2013

I am happy to report that the University of Connecticut submitted an Institutional Clinical and Translational Science Award (CTSA) application last week. This is the largest organized grant effort in the history of the university with over 150 faculty members participating throughout the region.

The CTSA program supports a national consortium of medical research institutions that are transforming the way biomedical research is conducted. Its goals are to accelerate the translation of laboratory discoveries into treatments for patients, to engage communities in clinical research efforts, and to train a new generation of clinical and translational researchers.
As the Principal Investigator for the grant, I would like to thank and acknowledge everyone who has been involved in this application for their phenomenal work during the past several months in getting this grant successfully completed and submitted. Especially, I would like to thank the CTSA executive leadership group, the sector directors, core leaders, and my administrative staff listed below. It was a great pleasure working with you in putting together this fine proposal.

Co-Investigators, and CTSA Executive Leadership Group:
Canalis, Ernesto, Co-Investigator
Hesselbrock, Victor M., Co-Investigator
Hurley, Marja, Co-Investigator
Kuchel, George, Co-Investigator
Liu, Edison, Co-Investigator
Oncken, Cheryl, Co-Investigator
Srivastava, Pramod K., Co-Investigator

Sector and Key Core Directors, Co-Directors, and Associate Directors:
Agresta, Thomas, Co-Director, Biomedical Informatics Division
Babor, Thomas, Director, Tracking & Evaluation
Barry, Linda, Associate Director, Pilot and Collaborative Translational and Clinical Studies
Chapman, Audrey R., Co-Director, Clinical Research Ethics
Cherniack, Martin, Co-Director, Gateway
Demurjian, Steven, Co-Director, Biomedical Informatics Division
Ford, Julian, Co-Director, Regulatory Knowledge and Support & Clinical Ethics
Grady, James, Director, Biostatistics, Epidemiology, and Research Design Resource
Knaus, William, Director, Biomedical Informatics Division
Lalande, Marc, Chair, Scientific Advisory Board
Liang, Bruce, Co-Chair, Scientific Advisory Board
Makoul, Gregory, Co-Director, Community Engagement, Saint Francis Hospital and Medical Center
McCullough, Louise, Co-Director, Clinical and Translational Resources and Services (CTRS)
Nair, Lakshmi S., Associate Director, Gateway
Oncken, Cheryl, Director, Pilot and Collaborative Translational and Clinical Studies
Ruaño, Gualberto, Co-Director, Community Engagement, Hartford Hospital
Schensul, Jean, Co-Director, Community Engagement, Institute for Community Research
Skolnik, Paul, Director, Gateway
Steffens, David, Director, Clinical and Translational Resources and Services (CTRS)
Weller, Sandra, Co-Director, Pilot and Collaborative Translational and Clinical Studies
Wrensford, Granville, Director, Education, Training, and Career Development
Yasnoff, William, Associate Director, Biomedical Informatics Division

CTSA Core Administrative Staff:
Burian, Linda, Regulatory Specialist
Donaldson, Trisha, CICATS Administrative Officer
Schwager, Julie, Director, Research Services
Serra, Debra, CICATS Administrative Program Coordinator
Steciak, Cheryl, CICATS Administrative Coordinator

The Basore Distinguished Lecture at Auburn University

January 8, 2013

Cato Laurencin, Professor Mario R. Eden, Chairman of the Chemical EngineeringLast month, I was honored to deliver the Basore Lecture at Auburn. I appreciated the warm hospitality provided by the entire school. I want to thank Professor Mario R. Eden, Chairman of the Chemical Engineering for hosting me. During the visit, I also had the opportunity to join my friend and colleague, Dr. James Andrews a world-renowned orthopaedic surgeon on the Auburn football team sidelines.

Elizabeth Hurlock Beckman Award

December 21, 2012

Elizabeth Hurlock Beckman AwardI was proud to receive the prestigious Elizabeth Hurlock Beckman Award last month in Atlanta, Georgia. It recognizes individuals who have worked to inspire their students to be mentors themselves. I was nominated by my former student Dr. Saadiq El-Amin who is currently a professor of orthopaedic surgery at Southern Illinois University who is mentoring a new generation of students and individuals in the community. I am grateful to Dr. El-Amin and the Elizabeth Hurlock Beckman Award Advisory Committee for this award.

Elizabeth Hurlock Beckman Award