Author: Melanie L Burnat

Top Research Article in the Journal of Biomedical Materials Research

 Progress in BiomaterialsThe Journal of Biomedical Materials Research (JBMR) has just published its 100th volume, Progress in Biomaterials, which features the top 25 papers it has published in its 50+ years. I am happy to report that one of our lab’s papers, “Electrospun nanofibrous structure: A novel scaffold for tissue engineering” was selected for inclusion. This article has been cited more than 1100 times. According to JBMR, the major criteria for inclusion of papers in this virtual issue was “the identification of articles that, in their time, were considered novel, original, state-of-the-art, groundbreaking, led to clinical application, and opened new areas of biomaterials research.” The editors commented “this pioneering paper by Laurencin showed that biodegradable electrospun nanofiber structures were capable of supporting cell attachment and proliferation and indicated that cells seeded on this structure could maintain phenotypic shape and guide growth according to nanofiber orientation.” Perhaps even more exciting, the editors chose figure 2 of our paper for the cover of the 100th Volume Celebration Edition.

Congratulations to all.

Image was adpated from http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1552-4981/homepage/VirtualIssuesPage.html.

The Institute for Regenerative Engineering Welcomes New Fellow, Roshan James, Ph.D.

Roshan James, Ph.D.I am pleased to announce that Dr. Roshan James recently joined the Institute for Regenerative Engineering as a postdoctoral fellow. His current research focuses on the design and fabrication of novel biomaterials for musculoskeletal tissue engineering. His research interests include biomaterials, integrated tissues, and regenerative engineering.

Dr. James received his bachelor degree from the Indian Institute of Technology, Kharagpur in India, and completed his doctoral thesis under my mentorship at the University of Virginia (UVa) in 2012. His Ph.D. thesis focused on the design of mechanically competent polyester-based matrices for tendon tissue regeneration. In addition, he worked on developing a growth factor delivery system that provided bioactive physiologically relevant doses to modulate cellular responses in adipose stromal cells along the tendonogenic lineage.

Dr. James received a number of awards from UVa where he presented at university-wide research competitions. In, 2012, he was a finalist in the UVa Presidential Research Competition. In addition, he was recently selected as a New Investigator Recognition Awards (NIRA) finalist at the 2013 Orthopaedic Research Society Conference in San Antonio. His talk was entitled ‘Combined Treatment of a Tendon Gap with a Biomimetic Electrospun Scaffold, Stromal Cells and GDF5,’ and his presentation focused on in vivo characterization of biodegradable biomaterials designed to mimic the structure of the tendon extracellular matrix.

Tendon gap PowerPoint screenIt is worth noting that Dr. James has made a significant impact on tendon tissue engineering. He has successfully developed a novel tubular scaffold system to regenerate a large gap defect in tendon tissue due to severe injuries. The scaffold system can also deliver adipose stromal cells and growth factors that facilitate the regenerative process resulting in new tendon tissue formation.

Everyone in the Institute for Regenerative Engineering welcomes Roshan and looks forward to working with him here at UConn.

The Institute for Regenerative Engineering Hosts Ronald W. Rousseau, Ph.D.

Ronald W. Rousseau, chair of the School of Chemical and Biomolecular Engineering at Georgia Institute of TechnologyTo further facilitate collaborations between UConn and internationally renowned experts, it was our great honor to host Ronald W. Rousseau, chair of the School of Chemical and Biomolecular Engineering at Georgia Institute of Technology. Dr. Rousseau, the Cecil J. “Pete” Silas Endowed Chair, delivered a talk entitled “Chirally Pure Pharmaceutical Products: The Role of Crystallization” in the Department of Chemical, Materials and Biomolecular Engineering at Storrs. His research focuses on separation processes and has resulted in more than 200 publications. Dr. Rousseau has received numerous awards including the prestigious Warren K. Lewis Award from the American Institute of Chemical Engineers (AIChE), the Clarence G. Gerhold Award from the AIChE’s Separations Division and the AIChE’s Forest Products Award. He is a fellow of both AIChE and the American Association for the Advancement of Science (AAAS). It was an honor having Dr. Rousseau at UConn, and we look forward to collaborating with him in the future.

Clinical and Translational Science Award

I am happy to report that the University of Connecticut submitted an Institutional Clinical and Translational Science Award (CTSA) application last week. This is the largest organized grant effort in the history of the university with over 150 faculty members participating throughout the region.

The CTSA program supports a national consortium of medical research institutions that are transforming the way biomedical research is conducted. Its goals are to accelerate the translation of laboratory discoveries into treatments for patients, to engage communities in clinical research efforts, and to train a new generation of clinical and translational researchers.
As the Principal Investigator for the grant, I would like to thank and acknowledge everyone who has been involved in this application for their phenomenal work during the past several months in getting this grant successfully completed and submitted. Especially, I would like to thank the CTSA executive leadership group, the sector directors, core leaders, and my administrative staff listed below. It was a great pleasure working with you in putting together this fine proposal.

Co-Investigators, and CTSA Executive Leadership Group:
Canalis, Ernesto, Co-Investigator
Hesselbrock, Victor M., Co-Investigator
Hurley, Marja, Co-Investigator
Kuchel, George, Co-Investigator
Liu, Edison, Co-Investigator
Oncken, Cheryl, Co-Investigator
Srivastava, Pramod K., Co-Investigator

Sector and Key Core Directors, Co-Directors, and Associate Directors:
Agresta, Thomas, Co-Director, Biomedical Informatics Division
Babor, Thomas, Director, Tracking & Evaluation
Barry, Linda, Associate Director, Pilot and Collaborative Translational and Clinical Studies
Chapman, Audrey R., Co-Director, Clinical Research Ethics
Cherniack, Martin, Co-Director, Gateway
Demurjian, Steven, Co-Director, Biomedical Informatics Division
Ford, Julian, Co-Director, Regulatory Knowledge and Support & Clinical Ethics
Grady, James, Director, Biostatistics, Epidemiology, and Research Design Resource
Knaus, William, Director, Biomedical Informatics Division
Lalande, Marc, Chair, Scientific Advisory Board
Liang, Bruce, Co-Chair, Scientific Advisory Board
Makoul, Gregory, Co-Director, Community Engagement, Saint Francis Hospital and Medical Center
McCullough, Louise, Co-Director, Clinical and Translational Resources and Services (CTRS)
Nair, Lakshmi S., Associate Director, Gateway
Oncken, Cheryl, Director, Pilot and Collaborative Translational and Clinical Studies
Ruaño, Gualberto, Co-Director, Community Engagement, Hartford Hospital
Schensul, Jean, Co-Director, Community Engagement, Institute for Community Research
Skolnik, Paul, Director, Gateway
Steffens, David, Director, Clinical and Translational Resources and Services (CTRS)
Weller, Sandra, Co-Director, Pilot and Collaborative Translational and Clinical Studies
Wrensford, Granville, Director, Education, Training, and Career Development
Yasnoff, William, Associate Director, Biomedical Informatics Division

CTSA Core Administrative Staff:
Burian, Linda, Regulatory Specialist
Donaldson, Trisha, CICATS Administrative Officer
Schwager, Julie, Director, Research Services
Serra, Debra, CICATS Administrative Program Coordinator
Steciak, Cheryl, CICATS Administrative Coordinator

The Basore Distinguished Lecture at Auburn University

Cato Laurencin, Professor Mario R. Eden, Chairman of the Chemical EngineeringLast month, I was honored to deliver the Basore Lecture at Auburn. I appreciated the warm hospitality provided by the entire school. I want to thank Professor Mario R. Eden, Chairman of the Chemical Engineering for hosting me. During the visit, I also had the opportunity to join my friend and colleague, Dr. James Andrews a world-renowned orthopaedic surgeon on the Auburn football team sidelines.

Elizabeth Hurlock Beckman Award

Elizabeth Hurlock Beckman AwardI was proud to receive the prestigious Elizabeth Hurlock Beckman Award last month in Atlanta, Georgia. It recognizes individuals who have worked to inspire their students to be mentors themselves. I was nominated by my former student Dr. Saadiq El-Amin who is currently a professor of orthopaedic surgery at Southern Illinois University who is mentoring a new generation of students and individuals in the community. I am grateful to Dr. El-Amin and the Elizabeth Hurlock Beckman Award Advisory Committee for this award.

Elizabeth Hurlock Beckman Award

Pirkey Lectureship at the University of Texas, Austin

Pirkey LectureshipIt was my honor and privilege to serve as Visiting Professor in the Department of Chemical Engineering at the University of Texas, Austin. During the visit, I delivered the Pirkey lectureship entitled “Musculoskeletal Regenerative Engineering: Taking on the Grand Challenges.” My talk highlighted the tremendous work being carried out here at the Institute for Regenerative Engineering. More specifically, I discussed the unprecedented strides predicted for the next decade in regenerating musculoskeletal tissues, a move from an era of advanced prosthetics to what we terms “Regenerative Engineering.”

I so appreciated the hospitality provided by the university and I thank Professor Nicholas A. Peppas, Professor of Chemical Engineering, Biomedical Engineering and Pharmacy Chair of the Department of Biomedical Engineering, in particular, for inviting me to visit this great institution.

Professor Tao Jiang Joins the Faculty of the Institute for Regenerative Engineering

Tao Jiang, Ph.D., M.B.A.I am very pleased to announce that Dr. Tao Jiang, CICATS Investigator Advocate and Assistant Professor of Medicine, has been appointed to the faculty of the Institute for Regenerative Engineering. Dr. Jiang received a B.S. in Chemical Engineering in 1999 and an M.S. in Materials Science in 2001, both from Tsinghua University in Beijing.

He then went on to pursue his doctoral degree and received a Ph.D. in chemical engineering from the University of Virginia, Charlottesville, VA. His doctoral research, under my supervision, focused on the design, development, and evaluation of novel hybrid scaffolds from natural polymer chitosan and synthetic polymer PLGA for bone-tissue engineering.

Dr. Jiang joined Zimmer, Inc., one of the world’s leading medical device companies, as a senior research scientist immediately after obtaining his Ph.D. At Zimmer, he played a variety of leading roles in evaluating and exploring cutting-edge technologies for the regeneration of musculoskeletal tissues including bone, cartilage, ligament, and tendon. In addition, he played a key role in developing Chondrofix Allograft for cartilage repair. Fully launched in the U.S. in 2011, it was the first Zimmer biological product developed in-house.

Dr. Jiang has over 20 peer-reviewed publications in journals such as Biomaterials, Journal of Biomedical Materials Research, Acta Biomaterialia, and PNAS, as well as many conference presentations. He has six issued/pending patents and invention disclosures.

At the University of Virginia, Dr. Jiang was awarded the 2008 Faculty Award for Excellence in Doctoral Studies. At Zimmer, he received a Zimmer Publication Award from the chief scientific officer and a Zimmer Impact Award from the company.

Dr. Jiang serves as a peer reviewer for a number of high-impact scientific journals including Biomaterials, Carbohydrate Polymers, and Materials Science and Engineering.

Dr. Jiang’s research interests include advanced biomaterials, drug delivery, tissue engineering, and therapies for musculoskeletal diseases.

Speaking for all of the Institute faculty, we are excited to have him join us, and we look forward to working with our newest faculty colleague.

Keynote at the 9th World Biomaterials Congress

World Biomaterials Congress in Chengdu, ChinaIn early June, I was honored to give a keynote address at the World Biomaterials Congress in Chengdu, China. During my talk, “Hierarchical Nanostructures for Tissue Regeneration,” I highlighted the elegant work done by the Institute for Regenerative Engineering, including my students and fellows. The symposium, Hierarchical 3-Dimensional Structures for Tissue Regeneration, was chaired by my former graduate student, Professor Justin Brown from the Department of Bioengineering, Pennsylvania State University. In addition, Dr. Lakshmi Nair, Dr. Sangamesh Kumbar and Dr. Meng Deng, also from the Institute, gave talks during the symposium. This was my first visit to Chengdu, I was deeply impressed by its natural beauty, as well as its historical and culture treasures. I so appreciated the hospitality provided by the planners. I also want to thank Professor Xingdong Zhang, chairman of the 9th WBC organizing committee, for arranging a wonderful conference.

Congratulations to Ami and Ashley Amini, the Institute for Regenerative Engineering’s Combined D.M.D./Ph.D. Students!

Ami and Ashley Amini

In June, they successfully defended their Ph.D. theses and completed their Ph.D. work. Not only did they produce outstanding research work in our institute resulting in papers published in several prestigious journals, they each competed for and received highly selective NIH individual grants for their training. Ami and Ashley are now focused on their D.M.D. program. I am very proud of Ami and Ashley and applaud their achievements.